메뉴 건너뛰기




Volumn 5, Issue , 2006, Pages 425-452

Lipophilicity, polarity, and hydrophobicity

Author keywords

[No Author keywords available]

Indexed keywords


EID: 77449143179     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (27)

References (153)
  • 9
    • 0003114426 scopus 로고    scopus 로고
    • Lipophilicity Profiles: Theory and Measurement
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zürich
    • Comer, J. E.; Tam, K. Y Lipophilicity Profiles: Theory and Measurement. In Pharmacokinetic Optimization in Drug Research; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zürich, 2001, pp 275-304.
    • (2001) Pharmacokinetic Optimization in Drug Research; , pp. 275-304
    • Comer, J.E.1    Tam, K.Y.2
  • 10
    • 84958669671 scopus 로고    scopus 로고
    • Lipophilicity of Metabolites and its Role in Biotransformation
    • In, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim
    • Walther, B.; Vis, P; Taylor, A. Lipophilicity of Metabolites and its Role in Biotransformation. In Lipophilicity in Drug Action and Toxicology, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, pp 253-261.
    • (1996) Lipophilicity in Drug Action and Toxicology , pp. 253-261
    • Walther, B.1    Vis, P.2    Taylor, A.3
  • 11
    • 0002565849 scopus 로고    scopus 로고
    • Structure-Metabolism Relations, and the Challenge of Predicting Biotransformation
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-Verlag Helvetica Chimica Acta: Zürich
    • Testa, B.; Cruciani, G. Structure-Metabolism Relations, and the Challenge of Predicting Biotransformation. In Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Chemistry; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-Verlag Helvetica Chimica Acta: Zürich, 2001, pp 65-84.
    • (2001) Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Chemistry , pp. 65-84
    • Testa, B.1    Cruciani, G.2
  • 12
    • 0000270186 scopus 로고
    • Drug Metabolism
    • In, 5th ed.; Wolff, M. E., Ed.; Wiley: New York
    • Testa, B. Drug Metabolism. In Burger's Medicinal Chemistry and Drug Discovery, 5th ed.; Wolff, M. E., Ed.; Wiley: New York, 1995; Vol. 1, pp 129-180.
    • (1995) Burger's Medicinal Chemistry and Drug Discovery , vol.1 , pp. 129-180
    • Testa, B.1
  • 14
    • 84958593100 scopus 로고    scopus 로고
    • Assessment of Distribution-pH Profiles
    • In, ; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim
    • Avdeef, A. Assessment of Distribution-pH Profiles. In Lipophilicity in Drug Action and ; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, pp 109-139.
    • (1996) Lipophilicity in Drug Action and , pp. 109-139
    • Avdeef, A.1
  • 16
    • 0008893051 scopus 로고    scopus 로고
    • Electrochemical Aspects of Drug Partitioning
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds. ; Verlag Helvetica Chimica Acta: Zürich
    • Reymond, F; Gobry, V; Bouchard, G. ; Girault, H. H. Electrochemical Aspects of Drug Partitioning. In Pharmacokinetic Optimization in Drug Research; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds. ; Verlag Helvetica Chimica Acta: Zürich, 2001, pp 327-349.
    • (2001) Pharmacokinetic Optimization in Drug Research; , pp. 327-349
    • Reymond, F.1    Gobry, V.2    Bouchard, G.3    Girault, H.H.4
  • 24
    • 0000785514 scopus 로고
    • The Treatment of Ionizable Compounds in QSAR Studies with Special Consideration to Ion [Pair] Partitioning
    • In, Magee, P S., Kohn, G. K., Menn, G. G., Eds.; American Chemical Society: Washington, DC
    • Scherrer, R. A. The Treatment of Ionizable Compounds in QSAR Studies with Special Consideration to Ion [Pair] Partitioning. In Pesticide Synthesis Through Rational Approaches; Magee, P S., Kohn, G. K., Menn, G. G., Eds.; American Chemical Society: Washington, DC, 1984, pp 225-246.
    • (1984) Pesticide Synthesis Through Rational Approaches; , pp. 225-246
    • Scherrer, R.A.1
  • 25
    • 23244431693 scopus 로고    scopus 로고
    • a Values and the Lipophilicity of Ampholites and Ion Pairs
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zürich
    • a Values and the Lipophilicity of Ampholites and Ion Pairs. In Pharmacokinetic Optimization in Drug Research; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zürich, 2001, pp 351-381.
    • (2001) Pharmacokinetic Optimization in Drug Research; , pp. 351-381
    • Scherrer, R.A.1
  • 26
    • 84906427452 scopus 로고    scopus 로고
    • Automated Titrations in KCl/Water-Saturated Octanol
    • In, Testa, B., Kraemer, S., Wunderli-Allenspach, H., Folkers, G., Eds.; Verlag Helvetica Chimica Acta: Zürich, (Presentation A35 included on CD)
    • Scherrer, R. A. Automated Titrations in KCl/Water-Saturated Octanol. In Pharmacokinetic Profiling in Drug Research, Biological, Physicochemical and Computational Strategies; Testa, B., Kraemer, S., Wunderli-Allenspach, H., Folkers, G., Eds.; Verlag Helvetica Chimica Acta: Zürich, 2004 (Presentation A35 included on CD).
    • (2004) Pharmacokinetic Profiling in Drug Research, Biological, Physicochemical and Computational Strategies;
    • Scherrer, R.A.1
  • 30
    • 84906447078 scopus 로고
    • 2nd ed.; Breslow, R.; Goodenough, J. B.; Halpern, J.; Rowlinson, J. S., Eds.; International Series of Monographs on Chemistry; Oxford University Press: New York
    • Maitland, G. C.; Rigby, M.; Smith, E. B.; Wakeham, W A. Intermolecular Forces, 2nd ed.; Breslow, R.; Goodenough, J. B.; Halpern, J.; Rowlinson, J. S., Eds.; International Series of Monographs on Chemistry; Oxford University Press: New York, 1987, pp. 1-88.
    • (1987) Intermolecular Forces , pp. 1-88
    • Maitland, G.C.1    Rigby, M.2    Smith, E.B.3    Wakeham, W.A.4
  • 33
  • 35
    • 0001938735 scopus 로고
    • The Parametrization of Lipophilicity and Other Structural Properties in Drug Design
    • In, Testa, B., Ed.; Academic Press: London
    • Van de Waterbeemd, H.; Testa, B. The Parametrization of Lipophilicity and Other Structural Properties in Drug Design. In Advances in Drug Research; Testa, B., Ed.; Academic Press: London, 1987; Vol. 16, pp 87-227.
    • (1987) Advances in Drug Research; , vol.16 , pp. 87-227
    • Van de Waterbeemd, H.1    Testa, B.2
  • 36
    • 0002368625 scopus 로고    scopus 로고
    • Intramolecular Interactions Encoded in Lipophilicity: Their Nature and Significance
    • In, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, Chapter 4
    • Testa, B.; Carrupt, P A.; Gaillard, P; Tsai, R. S. Intramolecular Interactions Encoded in Lipophilicity: Their Nature and Significance. In Lipophilicity in Drug Action and Toxicology; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, Chapter 4, pp 49-71
    • (1996) Lipophilicity in Drug Action and Toxicology; , pp. 49-71
    • Testa, B.1    Carrupt, P.A.2    Gaillard, P.3    Tsai, R.S.4
  • 40
    • 84958630160 scopus 로고    scopus 로고
    • Application of a Solvation Equation to Drug Transport Properties
    • In, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim
    • Abraham, M. H.; Chadha, H. S. Application of a Solvation Equation to Drug Transport Properties. In Lipophilicity in Drug Action and Toxicology'; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, pp 311-337.
    • (1996) Lipophilicity in Drug Action and Toxicology'; , pp. 311-337
    • Abraham, M.H.1    Chadha, H.S.2
  • 49
    • 1842849791 scopus 로고    scopus 로고
    • Recent Advances in Reversed-Phase HPLC Techniques to Determine Lipophilicity
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zurich
    • Yamagami, C. Recent Advances in Reversed-Phase HPLC Techniques to Determine Lipophilicity. In Pharmacokinetic Optimization in Drug Research; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-VCH: Zurich, 2001, pp 383-400.
    • (2001) Pharmacokinetic Optimization in Drug Research; , pp. 383-400
    • Yamagami, C.1
  • 50
    • 84958623621 scopus 로고    scopus 로고
    • Lipophilicity Measurement by Reversed-Phase High Performance Liquid Chromatography
    • In, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim
    • Van de Waterbeemd, H.; Kansy, M.; Wagner, B.; Fischer, H. Lipophilicity Measurement by Reversed-Phase High Performance Liquid Chromatography. In Lipophilicity in Drug Action and Toxicology; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, pp 73-87.
    • (1996) Lipophilicity in Drug Action and Toxicology; , pp. 73-87
    • Van de Waterbeemd, H.1    Kansy, M.2    Wagner, B.3    Fischer, H.4
  • 58
    • 13244293644 scopus 로고    scopus 로고
    • High-Throughput Measurement of log D and pKa
    • In, Van de Waterbeemd, H., Lennernaes, H., Artursson, P, Eds.; Wiley-VCH: Weinheim
    • Comer, J. E. High-Throughput Measurement of log D and pKa. In Drug Bioavailability'; Van de Waterbeemd, H., Lennernaes, H., Artursson, P, Eds.; Wiley-VCH: Weinheim, 2003, pp 21-45.
    • (2003) Drug Bioavailability'; , pp. 21-45
    • Comer, J.E.1
  • 63
    • 84956630351 scopus 로고    scopus 로고
    • New Insights into the Lipophilicity of Ionized Species
    • In, Testa, B., Kraemer, S., Wunderli-Allenspach, H., Folkers, G., Eds.; Verlag Helvetica Chimica Acta: Zürich
    • Caron, G.; Ermondi, G. New Insights into the Lipophilicity of Ionized Species. In Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical and Gomputational Strategies; Testa, B., Kraemer, S., Wunderli-Allenspach, H., Folkers, G., Eds.; Verlag Helvetica Chimica Acta: Zürich, 2005, pp 165-185.
    • (2005) Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical and Gomputational Strategies; , pp. 165-185
    • Caron, G.1    Ermondi, G.2
  • 71
    • 84958623621 scopus 로고    scopus 로고
    • Lipophilicity Measurement by Reversed-Phase High Performance Liquid Chromatography
    • In, Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim
    • Van de Waterbeemd, H.; Kansy, M.; Wagner, B.; Fischer, H. Lipophilicity Measurement by Reversed-Phase High Performance Liquid Chromatography. In Lipophilieity in Drug Action and Toxicology'; Pliska, V, Testa, B., Van de Waterbeemd, H., Eds.; VCH: Weinheim, 1996, pp 73-87.
    • (1996) Lipophilieity in Drug Action and Toxicology'; , pp. 73-87
    • Van de Waterbeemd, H.1    Kansy, M.2    Wagner, B.3    Fischer, H.4
  • 93
    • 0009517227 scopus 로고    scopus 로고
    • Separation Methods in Drug Synthesis and Purification
    • In, Smith, R. M., Ed.; Elsevier: Amsterdam
    • Valko, K. Separation Methods in Drug Synthesis and Purification. In Handbook of Analytical Separations'; Smith, R. M., Ed.; Elsevier: Amsterdam, 2000, pp 539-542.
    • (2000) Handbook of Analytical Separations'; , pp. 539-542
    • Valko, K.1
  • 114
    • 0002511981 scopus 로고    scopus 로고
    • Liposome/Water Partitioning: Theory, Techniques and Applications
    • In, Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-Verlag Helvetica Chimica Acta: Zürich
    • Krämer, S. D. Liposome/Water Partitioning: Theory, Techniques and Applications. In Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Strategies'; Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. H., Eds.; Wiley-Verlag Helvetica Chimica Acta: Zürich, 2001, pp 401-428.
    • (2001) Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical and Computational Strategies'; , pp. 401-428
    • Krämer, S.D.1
  • 153
    • 0003887683 scopus 로고
    • 1; Sirius Analytical Instruments: East Sussex
    • Avdeef, A. Sirius Technical Application Notes 1; Sirius Analytical Instruments: East Sussex, 1994, pp 146-147.
    • (1994) Sirius Technical Application Notes , pp. 146-147
    • Avdeef, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.