Towards the predictability of drug-lipid membrane interactions: The pH- dependent affinity of propranolol to phosphatidylinositol containing liposomes

Pharmaceutical Research

Volumn 15, Issue 5, 1998, Pages 739-744

  Krämer, Stefanie D ^a   Braun, Annette ^a   Jakits Deiser, Christina ^a   Wunderli Allenspach, Heidi ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Drug lipid membrane interactions; Lipophilicity; Liposome; Partitioning; Phosphatidylinositol; Propranolol

Indexed keywords

LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PROPRANOLOL;

ARTICLE; BINDING AFFINITY; DRUG ACCUMULATION; DRUG BINDING; ELECTRICITY; EQUILIBRIUM CONSTANT; LIPID MEMBRANE; LIPID SOLUBILITY; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; PROTON TRANSPORT; ZETA POTENTIAL;

ADRENERGIC BETA-ANTAGONISTS; BINDING SITES; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MATHEMATICS; MEMBRANE LIPIDS; PHOSPHATIDYLINOSITOLS; PROPRANOLOL; RADIOPHARMACEUTICALS;

EID: 0031780283     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011923103938     Document Type: Article

References (14)

1. B. Testa, P. A. Carrupt, P. Gaillard, F. Billois, and P. Weber. Lipophilicity in molecular modeling. Pharm. Res. 13:335-343 (1996).
2. W. K. Surewicz and W. Leyko. Interaction of propranolol with model lipid membranes. Monolayer, spin label and fluorescence spectroscopy studies. Biochim. Biophys. Acta 643:387-397 (1981).
3. G.V. Betageri and J. A. Rogers. The liposome as a distribution model in QSAR studies. Int. J. Pharm. 46:95-102 (1988).
4. J. M. Canaves, J. Aleu, M. Lejarreta, J. M. Gonzalezros, and J. A. Ferragut. Effects of pH on the kinetics of the interaction between anthracyclines and lipid bilayers. Eur. Biophvs. J. 26:427-431 (1997).
5. S. D. Krämer, C. Jakits-Deiser, and H. Wunderli-Allenspach. Free fatty acids cause pH-dependent changes in drug-lipid membrane interactions around physiological pH. Pharm. Res. 14:827-832 (1997).
6. C. Ottiger. Partition behaviour of acids, bases and neutral drugs with liposomes, IAM-HPLC and 1-octanol. Dissertation ETH Zürich, Switzerland #12439 (1997).
7. 3H]Propranolol between MDCK cell lipid vesicles and buffer. Pharm. Res. 13:1851-1855 (1996).
8. M. J. Hope, M. B. Bally, G. Webb, and P. R. Cullis. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochim. Biophys. Acta 812:55-65 (1985).
9. G. M. Pauletti and H. Wunderli-Allenspach. Partition coefficients in vitro: artificial membranes as a standardized distribution model. Eur. J. Pharm. Sci. 1:273-282 (1994).
10. M. Takayama, S. Itoh, T. Nagasaki, I. Tanimizu. A new enzymatic method for the determination of serum choline-containing phospholipids. Clin. Chim. Acta 79:93-98 (1977).
11. W. W. Christie. Separation of lipid classes by high-performance liquid chromatography with the "mass detector". J. Chromatogr. 361:396-399 (1986).
12. J. A. Berden, R. W. Barker, and G. K. Radda. NMR studies on phospholipid bilayers: some factors affecting lipid distribution. Biochim. Biophys. Acta 375:186-208 (1975).
13. D. Marsh. Handbook of lipid bilayers, CRC Press, Boston, 1990.
14. R. C. MacDonald and A. D. Bangham. Comparison of double layer potentials in lipid monolayers and lipid bilayer membranes. J. Membr. Biol. 7:29-53 (1971).