Drugs as chemical messages: Molecular structure, biological context, and structure-activity relationships

Medicinal Chemistry Research

Volumn 7, Issue 6-7, 1997, Pages 340-365

  Testa, Bernard ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001334426     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. B. Testa and L.B. Kier, "The concept of molecular structure in structure-activity relationship studies and drug design", Medicinal Res. Rev., 11, 35-48 (1991).
2. B. Testa and L.B. Kier, "Complex systems in drug research. I. The chemical levels", Complexity, 1(4), 29-36 (1995-96).
3. B. Testa, P.A. Carrupt, P. Gaillard, F. Billois and P. Weber, "Lipophilicity in molecular modeling", Pharm. Res., 13, 335-343 (1996).
4. B. Testa, P.A. Carrupt, P. Gaillard and R.S. Tsai, "Intramolecular interactions encoded in lipophilicity: Their nature and significance", In "Lipophilicity in Drug Action and Toxicology" (V. Pliska, B. Testa and H. van de Waterbeemd, eds.), VCH Publishers, Weinheim, Germany, 1996, pp. 49-71.
5. B. Testa, L.B. Kier and P.A. Carrupt, "A systems approach to molecular structure, intermolecular recognition, and emergence-dissolvence in medicinal research", Med. Res. Rev., 17, 303-326 (1997).
6. B. Testa, "Missions and finality of drug research: A personal view", Pharm. News, 3, 10-12 (1996).
7. F. Capra. The Turning Point. Science, Society and the Rising Culture. Fontana Paperbacks, London, 1983, p. 285-332.
8. L.B. Kier and B. Testa, "Complexity and Emergence in Drug Research", in "Advances in Drug Research", Vol. 26 (B. Testa and U.A. Meyer, eds), Academic Press, London, UK, 1995, pp. 1-43.
9. B. Testa, "Mechanisms of chiral recognition in xenobiotic metabolism and drug-receptor interactions", Chirality, 1, 7-9 (1989).
10. A. Scheer, F. Fanelli, T. Costa, P.G. De Benedetti and S. Cottechia, "Constitutively active mutants of the α1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation", EMBO J., 15, 3566-3578 (1966).
11. J. Cohen and I. Stewart, "The Collapse of Chaos - Discovering Simplicity in a Complex World", Penguin Books, New York, 1995, pp. 288-293.