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Volumn 47, Issue 1, 2004, Pages 224-232

Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs

Author keywords

[No Author keywords available]

Indexed keywords

BUSPIRONE; CLOXACILLIN; FLUOXETINE; NYSTATIN;

EID: 0347361638     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030267j     Document Type: Article
Times cited : (332)

References (30)
  • 1
    • 0037124196 scopus 로고    scopus 로고
    • Drugs, leads, and drug-likeness: An analysis of some recently launched drugs
    • Proudfoot, J. R. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs. Bioorg. Med. Chem. Lett. 2002, 12, 1647-1650.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 1647-1650
    • Proudfoot, J.R.1
  • 2
    • 0037404468 scopus 로고    scopus 로고
    • Selection Criteria for Drug-like Compounds
    • Muegge, I. Selection Criteria for Drug-like Compounds. Med. Res. Rev. 2003, 23, 302-321.
    • (2003) Med. Res. Rev. , vol.23 , pp. 302-321
    • Muegge, I.1
  • 3
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski, C. A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 6
    • 0035821596 scopus 로고    scopus 로고
    • Simple selection criteria for drug-like chemical matter
    • Muegge, I.; Heald, S. L.; Brittelli, D. Simple selection criteria for drug-like chemical matter. J. Med. Chem. 2001, 44, 1841-1846.
    • (2001) J. Med. Chem. , vol.44 , pp. 1841-1846
    • Muegge, I.1    Heald, S.L.2    Brittelli, D.3
  • 8
    • 0035153842 scopus 로고    scopus 로고
    • Computational methods to estimate drug development parameters
    • Podlogar, B.; Muegge, I.; Brice, L. Computational methods to estimate drug development parameters. Curr. Opin. Drug Discovery Dev. 2001, 4, 102-109.
    • (2001) Curr. Opin. Drug Discovery Dev. , vol.4 , pp. 102-109
    • Podlogar, B.1    Muegge, I.2    Brice, L.3
  • 9
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 1997, 23, 3-25.
    • (1997) Adv. Drug Delivery Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 10
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict the intestinal absorption of drugs in humans
    • Palm, K.; Stenberg, P.; Luthman, K.; Artursson, P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. 14, 568-571.
    • Pharm. Res , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 11
    • 0034872131 scopus 로고    scopus 로고
    • Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans
    • Sakaeda, T.; Okamura, N.; Nagata, S.; Yagami, T.; Horinouchi, M.; et al. Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans. Biol. Pharm. Bull. 2001, 24, 935-940.
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 935-940
    • Sakaeda, T.1    Okamura, N.2    Nagata, S.3    Yagami, T.4    Horinouchi, M.5
  • 12
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber, D. F.; Johnson, S. R.; Cheng, H. Y.; Smith, B. R.; Ward, K. W.; et al. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 2002, 45, 2615-2623.
    • (2002) J. Med. Chem. , vol.45 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3    Smith, B.R.4    Ward, K.W.5
  • 13
    • 0346593210 scopus 로고    scopus 로고
    • MDL Information Systems Inc.; San Leandro, CA
    • MDL Drug Data Report, version 2002.2; MDL Information Systems Inc.; San Leandro, CA, 2002.
    • (2002) MDL Drug Data Report, Version 2002.2
  • 16
    • 0345961903 scopus 로고    scopus 로고
    • MDL Information Systems Inc.: San Leandro, CA
    • Comprehensive Medicinal Chemistry, CMC; MDL Information Systems Inc.: San Leandro, CA, 2002.
    • (2002) Comprehensive Medicinal Chemistry, CMC
  • 17
    • 0346593208 scopus 로고    scopus 로고
    • American Chemical Society: Washington, DC
    • SciFinder, 2001 ed.; American Chemical Society: Washington, DC, 2002.
    • (2002) SciFinder, 2001 Ed.
  • 19
    • 0037468884 scopus 로고    scopus 로고
    • A comparison of physiochemical property profiles of development and marketed oral drugs
    • Wenlock, M. C.; Austin, R. P.; Barton, P.; Davis, A. M.; Leeson, P. D. A comparison of physiochemical property profiles of development and marketed oral drugs. J. Med. Chem. 2003, 46, 1250-1256.
    • (2003) J. Med. Chem. , vol.46 , pp. 1250-1256
    • Wenlock, M.C.1    Austin, R.P.2    Barton, P.3    Davis, A.M.4    Leeson, P.D.5
  • 20
    • 0345961905 scopus 로고    scopus 로고
    • Daylight Chemical Information Systems, Inc.: Mission Viejo, CA
    • CLOGP; Daylight Chemical Information Systems, Inc.: Mission Viejo, CA, 2002.
    • (2002) CLOGP
  • 21
    • 0034609833 scopus 로고    scopus 로고
    • Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
    • Ertl, P.; Rohde, B.; Selzer, P. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J. Med. Chem. 2000, 43, 3714-3717.
    • (2000) J. Med. Chem. , vol.43 , pp. 3714-3717
    • Ertl, P.1    Rohde, B.2    Selzer, P.3
  • 22
    • 0032058905 scopus 로고    scopus 로고
    • RECAP-retrosynthetic combinatorial analysis procedure: A powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry
    • Lewell, X. Q.; Judd, D. B.; Watson, S. P.; Hann, M. M. RECAP-retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry. J. Chem. Inf. Comput. Sci. 1998, 38, 511-522.
    • (1998) J. Chem. Inf. Comput. Sci. , vol.38 , pp. 511-522
    • Lewell, X.Q.1    Judd, D.B.2    Watson, S.P.3    Hann, M.M.4
  • 24
    • 0037835538 scopus 로고    scopus 로고
    • Finding multiactivity substructures by mining databases of drug-like compounds
    • Sheridan, R. P. Finding multiactivity substructures by mining databases of drug-like compounds. J. Chem. Inf. Comput. Sci. 2003, 43, 1037-1050.
    • (2003) J. Chem. Inf. Comput. Sci. , vol.43 , pp. 1037-1050
    • Sheridan, R.P.1
  • 25
    • 0347853294 scopus 로고
    • SAS Institute Inc.: Cary, NC
    • JMP, version 4.0.4; SAS Institute Inc.: Cary, NC, 1989-2001.
    • (1989) JMP, Version 4.0.4
  • 26
    • 0032714220 scopus 로고    scopus 로고
    • Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
    • Kelder, J.; Groothenhuis, P. D. J.; Bayada, D. M.; Delbressine, L. P.; Ploemen, J.-P. Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs. Pharm. Res. 1999, 16, 1514-1519.
    • (1999) Pharm. Res. , vol.16 , pp. 1514-1519
    • Kelder, J.1    Groothenhuis, P.D.J.2    Bayada, D.M.3    Delbressine, L.P.4    Ploemen, J.-P.5
  • 27
    • 0036589285 scopus 로고    scopus 로고
    • Current trends in lead discovery: Are we looking for the appropriate properties
    • Oprea, T. I. Current trends in lead discovery: Are we looking for the appropriate properties. J. Comput.-Aided Mol. Des. 2002, 16, 325-334.
    • (2002) J. Comput.-Aided Mol. Des. , vol.16 , pp. 325-334
    • Oprea, T.I.1
  • 28
    • 0037566356 scopus 로고    scopus 로고
    • Examination of the Computed Molecular Properties of Compounds Selected for Clinical Development
    • Blake, J. F. Examination of the Computed Molecular Properties of Compounds Selected for Clinical Development. BioTechniques 2003, 34, S16-S20.
    • (2003) BioTechniques , vol.34
    • Blake, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.