Partial resistance of E. coli mutants against 2,4-diamino-5- benzylpyrimidines by interactions with bacterial membrane lipopolysaccharides. Derivation of quantitative structure-binding relationships

European Journal of Medicinal Chemistry

Volumn 35, Issue 6, 2000, Pages 619-634

  Schop, Heinrich ^a   Wiese, Michael ^b   Cordes, Hans Peter ^a   Seydel, Joachim K ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

2,4 diamino 5 benzylpyrimidines; Binding studies; E. coli resistance; Lipopolysaccharides; QSAR

Indexed keywords

A 44733; ANTIINFECTIVE AGENT; DIHYDROFOLATE REDUCTASE; GH 101; GH 306; K 107; K 130; K 150; K 96; KC 1303; KC 1307; KC 1308; KC 1310; KC 1311; KC 142; RO 18958; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BINDING AFFINITY; ESCHERICHIA COLI; GROWTH INHIBITION; MEMBRANE BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0033935719     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00159-8     Document Type: Article

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