메뉴 건너뛰기




Volumn 51, Issue 12, 1999, Pages 1339-1357

Evaluation and prediction of drug permeation

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPY; ARTICLE; ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DEVELOPMENT; DRUG PENETRATION; DRUG SCREENING; DRUG TARGETING; DRUG TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; INTESTINE MUCOSA PERMEABILITY; LIPOPHILICITY; NONHUMAN; SKIN ABSORPTION; SKIN PERMEABILITY;

EID: 0033383568     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991777164     Document Type: Article
Times cited : (68)

References (219)
  • 1
    • 0000596384 scopus 로고
    • Studies of an immortalized brain endothelial cell line: Characterization, permeability and transport
    • Greenwood, J., Begley, D. J., Segal, M. B. (eds) Plenum, New York
    • Abbott, N. J., Couraud, P. O., Roux, F., Begley, D. J. (1995) Studies of an immortalized brain endothelial cell line: characterization, permeability and transport. In: Greenwood, J., Begley, D. J., Segal, M. B. (eds) New Concepts of a Blood-brain Barrier. Plenum, New York, pp 239-249
    • (1995) New Concepts of a Blood-brain Barrier , pp. 239-249
    • Abbott, N.J.1    Couraud, P.O.2    Roux, F.3    Begley, D.J.4
  • 2
    • 0031048588 scopus 로고    scopus 로고
    • On the partition of ampholytes: Application to blood-brain distribution
    • Abraham, M. H., Takacs-Novak, K., Mitchell, R. C. (1997) On the partition of ampholytes: application to blood-brain distribution. J. Pharm. Sci. 86: 310-315
    • (1997) J. Pharm. Sci. , vol.86 , pp. 310-315
    • Abraham, M.H.1    Takacs-Novak, K.2    Mitchell, R.C.3
  • 3
    • 0023397173 scopus 로고
    • Validation of a flow-through diffusion cell for use in transdermal research
    • Addicks, W. J., Flynn, G. L., Weiner, N. (1987) Validation of a flow-through diffusion cell for use in transdermal research. Pharm. Res. 4: 337-341
    • (1987) Pharm. Res. , vol.4 , pp. 337-341
    • Addicks, W.J.1    Flynn, G.L.2    Weiner, N.3
  • 4
    • 0028080058 scopus 로고
    • Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
    • Adson, A., Raub, T. J., Burton, P. S., Barsuhn, C. L., Hilgers, A. R., Audus, K. L., Ho, N. F. H. (1994) Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. J. Pharm. Sci. 83: 1529-1536
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1529-1536
    • Adson, A.1    Raub, T.J.2    Burton, P.S.3    Barsuhn, C.L.4    Hilgers, A.R.5    Audus, K.L.6    Ho, N.F.H.7
  • 7
    • 0018383835 scopus 로고
    • Percutaneous absorption: In-vivo experiments
    • Albery, W. J., Hadgraft, J. (1979) Percutaneous absorption: in-vivo experiments. J. Pharm. Pharmacol. 31: 140-147
    • (1979) J. Pharm. Pharmacol. , vol.31 , pp. 140-147
    • Albery, W.J.1    Hadgraft, J.2
  • 8
    • 0002192652 scopus 로고
    • Immobilized artificial membrane chromatography. Prediction of drug transport across biological barriers
    • Ngo, T. T. (ed.) Plenum, New York
    • Alvarez, F. M., Bottom, C. B., Chikhale, P., Pidgeon, C. (1993) Immobilized artificial membrane chromatography. Prediction of drug transport across biological barriers. In: Ngo, T. T. (ed.) Molecular Interactions in Bioseparations. Plenum, New York, pp 151-167
    • (1993) Molecular Interactions in Bioseparations , pp. 151-167
    • Alvarez, F.M.1    Bottom, C.B.2    Chikhale, P.3    Pidgeon, C.4
  • 9
    • 0023471290 scopus 로고
    • Astrocyte-mediated induction of tight junctions in brain capillary endothelium: An efficient in-vitro model
    • Arthur, P. E., Shivers, R. R., Bowman, P. D. (1987) Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in-vitro model. Brain Res. 433: 155-159
    • (1987) Brain Res. , vol.433 , pp. 155-159
    • Arthur, P.E.1    Shivers, R.R.2    Bowman, P.D.3
  • 10
    • 0026321138 scopus 로고
    • Cell cultures as models for drug absorption across the intestinal mucosa
    • Artursson, P. (1991) Cell cultures as models for drug absorption across the intestinal mucosa. Crit. Rev. Ther. Drug Carrier Syst. 8: 305-330
    • (1991) Crit. Rev. Ther. Drug Carrier Syst. , vol.8 , pp. 305-330
    • Artursson, P.1
  • 11
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson, P., Karlsson, J. (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175: 880-885
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 12
    • 0030588714 scopus 로고    scopus 로고
    • Caco-2 mono-layers in experimental and theoretical predictions of drug transport
    • Artursson, P., Palm, K., Luthman, K. (1996) Caco-2 mono-layers in experimental and theoretical predictions of drug transport. Adv. Drug Deliv. Rev. 22: 67-84
    • (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 67-84
    • Artursson, P.1    Palm, K.2    Luthman, K.3
  • 13
    • 0025102678 scopus 로고
    • The use of cultured epithelial and endothelial cells for drug transport and metabolism studies
    • Audus, K. L., Bartel, R. L., Hidalgo, I. J., Borchardt, R. T. (1990) The use of cultured epithelial and endothelial cells for drug transport and metabolism studies. Pharm. Res. 7: 435-451
    • (1990) Pharm. Res. , vol.7 , pp. 435-451
    • Audus, K.L.1    Bartel, R.L.2    Hidalgo, I.J.3    Borchardt, R.T.4
  • 14
  • 15
    • 0029100542 scopus 로고
    • Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles
    • Austin, R. P., Davis, A. M., Manners, C. N. (1995) Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles. J. Pharm. Sci. 84: 1180-1183
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1180-1183
    • Austin, R.P.1    Davis, A.M.2    Manners, C.N.3
  • 16
    • 0027245634 scopus 로고
    • pH-Metric log, P. II. Refinement of partition coefficients and ionization constants of multiprotic substances
    • Avdeef, A. (1993) pH-Metric log, P. II. Refinement of partition coefficients and ionization constants of multiprotic substances. J. Pharm. Sci. 82: 183-190
    • (1993) J. Pharm. Sci. , vol.82 , pp. 183-190
    • Avdeef, A.1
  • 18
    • 0029911418 scopus 로고    scopus 로고
    • Octanol-, chloroform-, and propylene glycol dipelargonate-water partitioning of morphine-6-glucuronide and other related opiates
    • Avdeef, A., Barrett, A., Shaw, P. N., Knaggs, R. D., Davis, S. S. (1996) Octanol-, chloroform-, and propylene glycol dipelargonate-water partitioning of morphine-6-glucuronide and other related opiates. J. Med. Chem. 39: 4377-4381
    • (1996) J. Med. Chem. , vol.39 , pp. 4377-4381
    • Avdeef, A.1    Barrett, A.2    Shaw, P.N.3    Knaggs, R.D.4    Davis, S.S.5
  • 19
    • 0031942688 scopus 로고    scopus 로고
    • pH-metric log P. 10. Determination of vesicle membrane-water partition coefficients of ionizable drugs
    • Avdeef, A., Box, K. J., Comer, J. E. A., Hibbert, C., Tam, K. Y. (1998) pH-metric log P. 10. Determination of vesicle membrane-water partition coefficients of ionizable drugs. Pharm. Res. 15: 209-215
    • (1998) Pharm. Res. , vol.15 , pp. 209-215
    • Avdeef, A.1    Box, K.J.2    Comer, J.E.A.3    Hibbert, C.4    Tam, K.Y.5
  • 20
    • 0029871246 scopus 로고    scopus 로고
    • Chromatographic indices determined on an immobilized artificial membrane (IAM) column as descriptors of lipophilic and polar interactions of 4-phenyldihydropyridine calcium-channel blockers with biomembranes
    • Barbato, F., La Rotonda, M. I., Quaglia, F. (1996) Chromatographic indices determined on an immobilized artificial membrane (IAM) column as descriptors of lipophilic and polar interactions of 4-phenyldihydropyridine calcium-channel blockers with biomembranes. Eur. J. Med. Chem. 31: 311-318
    • (1996) Eur. J. Med. Chem. , vol.31 , pp. 311-318
    • Barbato, F.1    La Rotonda, M.I.2    Quaglia, F.3
  • 21
    • 0031058727 scopus 로고    scopus 로고
    • Interactions of nonsteroidal antiinflammatory drugs with phospholipids: Comparison between octanol/buffer partition coefficients and chromatographic indexes on immobilized artificial membranes
    • Barbato, F., La Rotonda, M. I., Quaglia, F. (1997) Interactions of nonsteroidal antiinflammatory drugs with phospholipids: comparison between octanol/buffer partition coefficients and chromatographic indexes on immobilized artificial membranes. J. Pharm. Sci. 86: 225-229
    • (1997) J. Pharm. Sci. , vol.86 , pp. 225-229
    • Barbato, F.1    La Rotonda, M.I.2    Quaglia, F.3
  • 22
    • 0008652579 scopus 로고
    • Structure, function, diseases and topical treatment of human skin
    • Barry, B. W. (ed.) Dekker, New York
    • Barry, B. W. (1983a) Structure, function, diseases and topical treatment of human skin. In: Barry, B. W. (ed.) Dermatological Formulations. Percutaneous Absorption. Dekker, New York, pp 1-48
    • (1983) Dermatological Formulations. Percutaneous Absorption , pp. 1-48
    • Barry, B.W.1
  • 23
    • 0003065234 scopus 로고
    • Properties that influence percutaneous absorption
    • Barry, B. W. (ed.) Dekker, New York
    • Barry, B. W. (1983b) Properties that influence percutaneous absorption. In: Barry, B. W. (ed.) Dermatological Formulations. Percutaneous Absorption. Dekker, New York, pp 127-233
    • (1983) Dermatological Formulations. Percutaneous Absorption , pp. 127-233
    • Barry, B.W.1
  • 24
    • 0017727702 scopus 로고
    • Permeation of oestrone, oestradiol, oestriol and dexamethasone across cellulose acetate membrane
    • Barry, B. W., Brace, A. R. (1977) Permeation of oestrone, oestradiol, oestriol and dexamethasone across cellulose acetate membrane. J. Pharm. Pharmacol. 29: 397-400
    • (1977) J. Pharm. Pharmacol. , vol.29 , pp. 397-400
    • Barry, B.W.1    Brace, A.R.2
  • 25
    • 0017291074 scopus 로고
    • Influence of non-ionic surfactants on permeation of hydrocortisone, dexamethasone, testosterone and progesterone across cellulose
    • Barry, B. W., El Eini, D. I. (1976) Influence of non-ionic surfactants on permeation of hydrocortisone, dexamethasone, testosterone and progesterone across cellulose. J. Pharm. Pharmacol. 28: 219-227
    • (1976) J. Pharm. Pharmacol. , vol.28 , pp. 219-227
    • Barry, B.W.1    El Eini, D.I.2
  • 26
    • 0030803801 scopus 로고    scopus 로고
    • Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients
    • Barton, P., Davis, A. M., McCarthy, D. J., Webborn, P. J. H. (1997) Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients. J. Pharm. Sci. 86: 1034-1039
    • (1997) J. Pharm. Sci. , vol.86 , pp. 1034-1039
    • Barton, P.1    Davis, A.M.2    McCarthy, D.J.3    Webborn, P.J.H.4
  • 28
    • 0024958034 scopus 로고
    • Ethanol and water sorption into stratum corneum and model systems
    • Berner, B., Juang, R. H., Mazzenga, G. C. (1989) Ethanol and water sorption into stratum corneum and model systems. J. Pharm. Sci. 78: 472-476
    • (1989) J. Pharm. Sci. , vol.78 , pp. 472-476
    • Berner, B.1    Juang, R.H.2    Mazzenga, G.C.3
  • 29
    • 0012043154 scopus 로고    scopus 로고
    • Thermodynamics of partitioning of nonsteroidal anti-inflammatory drugs in the n-octanol/buffer and liposome systems
    • Betageri, G. V., Nayernama, A., Habib, M. J. (1996) Thermodynamics of partitioning of nonsteroidal anti-inflammatory drugs in the n-octanol/buffer and liposome systems. Int. J. Quant. Chem. 1: 310-319
    • (1996) Int. J. Quant. Chem. , vol.1 , pp. 310-319
    • Betageri, G.V.1    Nayernama, A.2    Habib, M.J.3
  • 30
    • 0022381060 scopus 로고
    • Penetration of benzene through human skin
    • Blank, I. H., McAuliffe, D. J. (1985) Penetration of benzene through human skin. J. Invest. Dermatol. 85: 522-526
    • (1985) J. Invest. Dermatol. , vol.85 , pp. 522-526
    • Blank, I.H.1    McAuliffe, D.J.2
  • 31
    • 0025828769 scopus 로고
    • Visualization of in-vitro percutaneous penetration of mercuric chloride; transport through intercellular space versus cellular uptake through desmosomes
    • Boddé, H. E., Koerten, H. K., De Haan, F. H. N. (1991) Visualization of in-vitro percutaneous penetration of mercuric chloride; transport through intercellular space versus cellular uptake through desmosomes. J. Contr. Rel. 15: 227-236
    • (1991) J. Contr. Rel. , vol.15 , pp. 227-236
    • Boddé, H.E.1    Koerten, H.K.2    De Haan, F.H.N.3
  • 32
    • 0026788293 scopus 로고
    • Factors to be considered in the evaluation of bioavailability and bioequivalence of topical formulations
    • Borsiada, S., Ghanem, A. H., Seta, Y., Higuchi, W. I., Flynn, G. L., Behl, C. R., Shah, V. P. (1992) Factors to be considered in the evaluation of bioavailability and bioequivalence of topical formulations. Skin Pharmacol. 5: 129-145
    • (1992) Skin Pharmacol. , vol.5 , pp. 129-145
    • Borsiada, S.1    Ghanem, A.H.2    Seta, Y.3    Higuchi, W.I.4    Flynn, G.L.5    Behl, C.R.6    Shah, V.P.7
  • 33
    • 0030176301 scopus 로고    scopus 로고
    • Novel diffusion cell for in-vitro transdermal permeation, compatible with automated dynamic sampling
    • Bosman, I. J., Lawant, A. L., Avegaart, S. R., Ensing, K., De Zeeuw, R. A. (1996) Novel diffusion cell for in-vitro transdermal permeation, compatible with automated dynamic sampling. J. Pharm. Biomed. Anal. 14: 1015-1023
    • (1996) J. Pharm. Biomed. Anal. , vol.14 , pp. 1015-1023
    • Bosman, I.J.1    Lawant, A.L.2    Avegaart, S.R.3    Ensing, K.4    De Zeeuw, R.A.5
  • 34
    • 0031722109 scopus 로고    scopus 로고
    • Prediction of intestinal drug absorption properties by three-dimensional solubility parameters
    • Breitkreutz, J. (1998) Prediction of intestinal drug absorption properties by three-dimensional solubility parameters. Pharm. Res. 15: 1370-1375
    • (1998) Pharm. Res. , vol.15 , pp. 1370-1375
    • Breitkreutz, J.1
  • 36
    • 0021925628 scopus 로고
    • Methods of in-vitro percutaneaous absorption studies. IV. The flow-through diffusion cell
    • Bronaugh, R. L., Stewart, R. F. (1985) Methods of in-vitro percutaneaous absorption studies. IV. The flow-through diffusion cell. J. Pharm. Sci. 74: 64-67
    • (1985) J. Pharm. Sci. , vol.74 , pp. 64-67
    • Bronaugh, R.L.1    Stewart, R.F.2
  • 37
    • 0028855654 scopus 로고
    • A new method for estimating dermal absorption from chemical exposure. 2. Effect of molecular weight and octanol-water partitioning
    • Bunge, A. L., Cleek, R. L. (1995) A new method for estimating dermal absorption from chemical exposure. 2. Effect of molecular weight and octanol-water partitioning. Pharm. Res. 12: 88-95
    • (1995) Pharm. Res. , vol.12 , pp. 88-95
    • Bunge, A.L.1    Cleek, R.L.2
  • 38
    • 0011274162 scopus 로고
    • The influence of molecular volume and hydrogen-bonding on peptide transport epithelial membranes. Reply to the comments by Drs Potts and Guy
    • Burton, P. S., Ho, N. F. H., Conradi, R. A., Hilgers, A. R. (1993) The influence of molecular volume and hydrogen-bonding on peptide transport epithelial membranes. Reply to the comments by Drs Potts and Guy. Pharm. Res. 10: 636-637
    • (1993) Pharm. Res. , vol.10 , pp. 636-637
    • Burton, P.S.1    Ho, N.F.H.2    Conradi, R.A.3    Hilgers, A.R.4
  • 39
    • 0030458462 scopus 로고    scopus 로고
    • How structural features influence the biomembrane permeability of peptides
    • Burton, P. S., Conradi, R. A., Ho, N. F. H., Hilgers, A. R., Borchardt, R. T. (1996) How structural features influence the biomembrane permeability of peptides. J. Pharm. Sci. 85: 1336-1340
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1336-1340
    • Burton, P.S.1    Conradi, R.A.2    Ho, N.F.H.3    Hilgers, A.R.4    Borchardt, R.T.5
  • 40
    • 0032571576 scopus 로고    scopus 로고
    • Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions
    • Caldwell, G. W., Massucci, J. A., Evangelisto, M., White, R. (1998) Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions. J. Chromatogr. A 800: 161-169
    • (1998) J. Chromatogr. A , vol.800 , pp. 161-169
    • Caldwell, G.W.1    Massucci, J.A.2    Evangelisto, M.3    White, R.4
  • 41
    • 0030296370 scopus 로고    scopus 로고
    • Review of theoretical passive absorption models: Historical background, recent developments and limitations
    • Camenisch, G., Folkers, G., van de Waterbeemd, H. (1996) Review of theoretical passive absorption models: historical background, recent developments and limitations. Pharm. Acta Helv. 71: 309-327
    • (1996) Pharm. Acta Helv. , vol.71 , pp. 309-327
    • Camenisch, G.1    Folkers, G.2    Van De Waterbeemd, H.3
  • 42
    • 0025826820 scopus 로고
    • Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity
    • Carrupt, P. A., Testa, B., Bechalany, A., El Tayar, N., Descas, P., Perrissoud, D. (1991a) Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity. J. Med. Chem. 34: 1272-1275
    • (1991) J. Med. Chem. , vol.34 , pp. 1272-1275
    • Carrupt, P.A.1    Testa, B.2    Bechalany, A.3    El Tayar, N.4    Descas, P.5    Perrissoud, D.6
  • 43
    • 0026344775 scopus 로고
    • Molecular electrostatic potentials for characterizing drug-biosystem interactions
    • Carrupt, P. A., El Tayar, N., Karlen, A., Testa, B. (1991b) Molecular electrostatic potentials for characterizing drug-biosystem interactions. Methods Enzymol. 203: 638-677
    • (1991) Methods Enzymol. , vol.203 , pp. 638-677
    • Carrupt, P.A.1    El Tayar, N.2    Karlen, A.3    Testa, B.4
  • 44
    • 0031517389 scopus 로고    scopus 로고
    • Computational approaches to lipophilicity: Methods and applications
    • Boyd, D. B., Lipkowitz, K. B. (eds) Wiley-VCH, New York
    • Carrupt, P. A., Testa, B., Gaillard, P. (1997) Computational approaches to lipophilicity: methods and applications. In: Boyd, D. B., Lipkowitz, K. B. (eds) Reviews in Computational Chemistry. Volume 11, Wiley-VCH, New York, pp 241-315
    • (1997) Reviews in Computational Chemistry , vol.11
    • Carrupt, P.A.1    Testa, B.2    Gaillard, P.3
  • 45
    • 0026533707 scopus 로고
    • Uptake of basic amino acids and peptides into liposomes in response to transmembrane pH gradients
    • Chakrabarti, A. C., Clark-Lewis, I., Harrigan, P. R., Cullis, P. R. (1992) Uptake of basic amino acids and peptides into liposomes in response to transmembrane pH gradients. Biophys. J. 61: 228-234
    • (1992) Biophys. J. , vol.61 , pp. 228-234
    • Chakrabarti, A.C.1    Clark-Lewis, I.2    Harrigan, P.R.3    Cullis, P.R.4
  • 46
    • 0028142381 scopus 로고
    • Influence of charge, charge distribution, and hydrophobicity on the transport of short peptides into liposomes in response to transmembrane pH gradients
    • Chakrabarti, A. C., Clark-Lewis, I., Cullis, P. R. (1994) Influence of charge, charge distribution, and hydrophobicity on the transport of short peptides into liposomes in response to transmembrane pH gradients. Biochemistry 33: 8479-8485
    • (1994) Biochemistry , vol.33 , pp. 8479-8485
    • Chakrabarti, A.C.1    Clark-Lewis, I.2    Cullis, P.R.3
  • 47
    • 0028270064 scopus 로고
    • Hydrogen bonding potential as a determinant of the in-vitro and in-situ blood-brain barrier permeability of peptides
    • Chikhale, E. G., Ng, K. Y., Burton, P. S., Borchardt, R. T. (1994) Hydrogen bonding potential as a determinant of the in-vitro and in-situ blood-brain barrier permeability of peptides. Pharm. Res. 11: 412-419
    • (1994) Pharm. Res. , vol.11 , pp. 412-419
    • Chikhale, E.G.1    Ng, K.Y.2    Burton, P.S.3    Borchardt, R.T.4
  • 48
    • 0028932174 scopus 로고
    • The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: Kinetic evidence for an apically polarized efflux mechanism
    • Chikhale, E. G., Burton, P. S., Borchardt, R. T. (1995) The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism. J. Pharmacol. Exp. Ther. 273: 298-303
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 298-303
    • Chikhale, E.G.1    Burton, P.S.2    Borchardt, R.T.3
  • 49
    • 0025082551 scopus 로고
    • The liposome as a model membrane in correlations of partitioning with α-adreno-receptor agonist activities
    • Choi, Y. W., Rogers, J. A. (1990) The liposome as a model membrane in correlations of partitioning with α-adreno-receptor agonist activities. Pharm. Res. 7: 508-512
    • (1990) Pharm. Res. , vol.7 , pp. 508-512
    • Choi, Y.W.1    Rogers, J.A.2
  • 50
    • 0028298970 scopus 로고
    • Epithelial cell permeability of a series of peptidic HIV protease inhibitors: Aminoterminal substituent effects
    • Conradi, R. A., Hilgers, A. R., Burton, P. S., Hester, J. B. (1994) Epithelial cell permeability of a series of peptidic HIV protease inhibitors: aminoterminal substituent effects. J. Drug Targeting 2: 167-171
    • (1994) J. Drug Targeting , vol.2 , pp. 167-171
    • Conradi, R.A.1    Hilgers, A.R.2    Burton, P.S.3    Hester, J.B.4
  • 51
    • 84958632244 scopus 로고    scopus 로고
    • Physicochemical and biological factors that influence a drug's cellular permeability by passive diffusion
    • Pliska, V., Testa, B., van de Waterbeemd, H. (eds) VCH, Weinheim
    • Conradi, R. A., Burton, P. S., Borchardt, R. T. (1996) Physicochemical and biological factors that influence a drug's cellular permeability by passive diffusion. In: Pliska, V., Testa, B., van de Waterbeemd, H. (eds) Lipophilicity in Drug Action and Toxicology. VCH, Weinheim, pp 233-252
    • (1996) Lipophilicity in Drug Action and Toxicology , pp. 233-252
    • Conradi, R.A.1    Burton, P.S.2    Borchardt, R.T.3
  • 52
    • 0021182767 scopus 로고
    • Increased skin permeability for lipophilic molecules
    • Cooper, E. R. (1984) Increased skin permeability for lipophilic molecules. J. Pharm. Sci. 73: 1153-1156
    • (1984) J. Pharm. Sci. , vol.73 , pp. 1153-1156
    • Cooper, E.R.1
  • 53
    • 0018086583 scopus 로고
    • Use of a physical multi-cell model to confirm theoretical predictions of biphasic structure-activity relationships
    • 51P
    • Dearden, J. C., Patel, K. D. (1978) Use of a physical multi-cell model to confirm theoretical predictions of biphasic structure-activity relationships. J. Pharm. Pharmacol. 30: 51P
    • (1978) J. Pharm. Pharmacol. , vol.30
    • Dearden, J.C.1    Patel, K.D.2
  • 54
    • 0025265046 scopus 로고
    • An easier, reproducible, and mass-production method to study the blood-brain barrier in-vitro
    • Dehouck, M. P., Meresse, S., Delorme, P., Fruchart, J. C., Cecchelli, R. (1990) An easier, reproducible, and mass-production method to study the blood-brain barrier in-vitro. J. Neurochem. 54: 1798-1801
    • (1990) J. Neurochem. , vol.54 , pp. 1798-1801
    • Dehouck, M.P.1    Meresse, S.2    Delorme, P.3    Fruchart, J.C.4    Cecchelli, R.5
  • 55
    • 0028818451 scopus 로고
    • Use of a novel method for determination of partition coefficients to compare the effect of local anesthetics on membrane structure
    • Depaula, E., Schreier, S. (1995) Use of a novel method for determination of partition coefficients to compare the effect of local anesthetics on membrane structure. Biochim. Biophys. Acta 1240: 25-33
    • (1995) Biochim. Biophys. Acta , vol.1240 , pp. 25-33
    • Depaula, E.1    Schreier, S.2
  • 56
    • 0031663609 scopus 로고    scopus 로고
    • Effect if different β-adrenergic agonists on the intestinal absorption of galactose and phenylalanine
    • Diez-Sampedro, A., Perez, M., Cobo, M. T., Martinez, J. A., Barber, A. (1998) Effect if different β-adrenergic agonists on the intestinal absorption of galactose and phenylalanine. J. Pharm. Pharmacol. 50: 807-911
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 807-911
    • Diez-Sampedro, A.1    Perez, M.2    Cobo, M.T.3    Martinez, J.A.4    Barber, A.5
  • 58
    • 0026064678 scopus 로고
    • Percutaneous penetration of drugs: A quantitative structure-permeability relationship study
    • El Tayar, N., Tsai, R. S., Testa, B., Carrupt, P. A., Hansch, C., Leo, A. (1991a) Percutaneous penetration of drugs: a quantitative structure-permeability relationship study. J. Pharm. Sci. 80: 744-749
    • (1991) J. Pharm. Sci. , vol.80 , pp. 744-749
    • El Tayar, N.1    Tsai, R.S.2    Testa, B.3    Carrupt, P.A.4    Hansch, C.5    Leo, A.6
  • 59
    • 0025731738 scopus 로고
    • Partitioning of solutes in different solvent systems: The contribution of hydrogen-bonding capacity and polarity
    • El Tayar, N., Tsai, R. S., Testa, B., Carrupt, P. A., Leo, A. (1991b) Partitioning of solutes in different solvent systems: the contribution of hydrogen-bonding capacity and polarity. J. Pharm. Sci. 80: 590-598
    • (1991) J. Pharm. Sci. , vol.80 , pp. 590-598
    • El Tayar, N.1    Tsai, R.S.2    Testa, B.3    Carrupt, P.A.4    Leo, A.5
  • 60
    • 0001712289 scopus 로고
    • Polar intermolecular interactions encoded in partition coefficients: An indirect estimation of hydrogen-bond parameters of polyfunctional solutes
    • El Tayar, N., Testa, B., Carrupt, P. A. (1992) Polar intermolecular interactions encoded in partition coefficients: an indirect estimation of hydrogen-bond parameters of polyfunctional solutes. J. Phys. Chem. 96: 1455-1459
    • (1992) J. Phys. Chem. , vol.96 , pp. 1455-1459
    • El Tayar, N.1    Testa, B.2    Carrupt, P.A.3
  • 61
    • 0027141121 scopus 로고
    • Solvent-dependence conformation and hydrogen-bonding capacity of cyclosporin A: Evidence from partition coefficients and molecular dynamics simulations
    • El Tayar, N., Mark, A. E., Vallat, P., Brunne, R. M., Testa, B., van Gunsteren, W. F. (1993) Solvent-dependence conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations. J. Med. Chem. 36: 3757-3764
    • (1993) J. Med. Chem. , vol.36 , pp. 3757-3764
    • El Tayar, N.1    Mark, A.E.2    Vallat, P.3    Brunne, R.M.4    Testa, B.5    Van Gunsteren, W.F.6
  • 62
    • 0347023586 scopus 로고
    • Separation of hydrogen-bonding donors in capillary electrophoresis using polyethers as matrix
    • Esaka, Y., Yamaguchi, Y., Kano, K., Goto, M., Haraguchi, H., Takahashi, J. (1994) Separation of hydrogen-bonding donors in capillary electrophoresis using polyethers as matrix. Anal. Chem. 66: 2441-2445
    • (1994) Anal. Chem. , vol.66 , pp. 2441-2445
    • Esaka, Y.1    Yamaguchi, Y.2    Kano, K.3    Goto, M.4    Haraguchi, H.5    Takahashi, J.6
  • 63
    • 0030047878 scopus 로고    scopus 로고
    • Partitioning of substituted phenols in liposome-water, biomembrane-water, and octanol-water systems
    • Escher, B. I., Schwarzenbach, R. P. (1996) Partitioning of substituted phenols in liposome-water, biomembrane-water, and octanol-water systems. Environ. Sci. Technol. 30: 260-270
    • (1996) Environ. Sci. Technol. , vol.30 , pp. 260-270
    • Escher, B.I.1    Schwarzenbach, R.P.2
  • 64
    • 0032435178 scopus 로고    scopus 로고
    • Kinetic analysis of L-glutamine transport into porcine jejunal enterocyte brush-border membrane vesicles
    • Fan, M. Z., Adeola, O., McBurney, M. I., Cheeseman, C. I. (1998) Kinetic analysis of L-glutamine transport into porcine jejunal enterocyte brush-border membrane vesicles. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 121: 411-422
    • (1998) Comp. Biochem. Physiol. A Mol. Integr. Physiol. , vol.121 , pp. 411-422
    • Fan, M.Z.1    Adeola, O.2    McBurney, M.I.3    Cheeseman, C.I.4
  • 65
    • 0028215461 scopus 로고
    • Improved barrier structure in air-exposed human keratinocyte culture systems
    • Fartasch, M., Ponec, M. (1994) Improved barrier structure in air-exposed human keratinocyte culture systems. J. Invest. Dermatol. 102: 366-374
    • (1994) J. Invest. Dermatol. , vol.102 , pp. 366-374
    • Fartasch, M.1    Ponec, M.2
  • 66
    • 0032473548 scopus 로고    scopus 로고
    • Modeling of percutaneous drug transport in-vitro using skin-imitating carbosil membrane
    • Feldstein, M. M., Raigorodskii, I. M., Iordanskii, A. L., Hadgraft, J. (1998) Modeling of percutaneous drug transport in-vitro using skin-imitating carbosil membrane. J. Contr. Rel. 52: 25-40
    • (1998) J. Contr. Rel. , vol.52 , pp. 25-40
    • Feldstein, M.M.1    Raigorodskii, I.M.2    Iordanskii, A.L.3    Hadgraft, J.4
  • 67
    • 0002584744 scopus 로고
    • Physicochemical determinants of skin absorption
    • Gerrity, T. R., Henry, C. J. (eds) Elsevier, Amsterdam
    • Flynn, G. L. (1990) Physicochemical determinants of skin absorption. In: Gerrity, T. R., Henry, C. J. (eds) Principles of Route-to-Route Extrapolation for Risk Assessment. Elsevier, Amsterdam, pp 93-127
    • (1990) Principles of Route-to-route Extrapolation for Risk Assessment , pp. 93-127
    • Flynn, G.L.1
  • 68
    • 0033528231 scopus 로고    scopus 로고
    • An improved low-permeability in-vitro model of blood-brain barrier: Transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol
    • Franke, H., Galla, H. J., Beuckmann, C. T. (1999) An improved low-permeability in-vitro model of blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol. Brain Res. 818: 65-71
    • (1999) Brain Res. , vol.818 , pp. 65-71
    • Franke, H.1    Galla, H.J.2    Beuckmann, C.T.3
  • 69
    • 0028293252 scopus 로고
    • The conformational-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential
    • Gaillard, P., Carrupt, P. A., Testa, B. (1994) The conformational-dependent lipophilicity of morphine glucuronides as calculated from their molecular lipophilicity potential. Bioorg. Med. Chem. Lett. 4: 737-742
    • (1994) Bioorg. Med. Chem. Lett. , vol.4 , pp. 737-742
    • Gaillard, P.1    Carrupt, P.A.2    Testa, B.3
  • 71
    • 0014572145 scopus 로고
    • Role of hydrogen-bonding in nonelectrolyte diffusion through dense artificial membranes
    • Garay-Bobo, C. M., DiPolo, R., Solomon, A. K. (1969) Role of hydrogen-bonding in nonelectrolyte diffusion through dense artificial membranes. J. Gen. Physiol. 54: 369-382
    • (1969) J. Gen. Physiol. , vol.54 , pp. 369-382
    • Garay-Bobo, C.M.1    DiPolo, R.2    Solomon, A.K.3
  • 72
    • 0014298456 scopus 로고
    • Evaluation, control, and prediction of drug diffusion through polymeric membranes
    • Garrett, E. R., Chembukar, P. B. (1968) Evaluation, control, and prediction of drug diffusion through polymeric membranes. J. Pharm. Sci. 57: 944-948
    • (1968) J. Pharm. Sci. , vol.57 , pp. 944-948
    • Garrett, E.R.1    Chembukar, P.B.2
  • 73
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman, M. M., Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann. Rev. Biochem. 62: 385-427
    • (1993) Ann. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 75
    • 0023612699 scopus 로고
    • Structure, biochemistry, and assembly of epithelial tight junctions
    • Gumbiner, B. (1987) Structure, biochemistry, and assembly of epithelial tight junctions. Am. J. Physiol. 253: C749-C758
    • (1987) Am. J. Physiol. , vol.253
    • Gumbiner, B.1
  • 76
    • 0018367317 scopus 로고
    • The estimation of diffusion coefficients using the rotating diffusion cell
    • Guy, R. H., Fleming, R. (1979) The estimation of diffusion coefficients using the rotating diffusion cell. Int. J. Pharm. 3: 143-149
    • (1979) Int. J. Pharm. , vol.3 , pp. 143-149
    • Guy, R.H.1    Fleming, R.2
  • 77
    • 0032459066 scopus 로고    scopus 로고
    • The selection and design of topical and transdermal agents: A review
    • Hadgraft, J., Pugh, W. J. (1998) The selection and design of topical and transdermal agents: a review. J. Invest. Dermatol. 3: 131-135
    • (1998) J. Invest. Dermatol. , vol.3 , pp. 131-135
    • Hadgraft, J.1    Pugh, W.J.2
  • 78
    • 0023949594 scopus 로고
    • Development of model membranes for percutaneous absorption measurements. II. Dipalmitoyl phosphatidylcholine, linoleic acid and tetradecane
    • Hadgraft, J., Ridout, G. (1988) Development of model membranes for percutaneous absorption measurements. II. Dipalmitoyl phosphatidylcholine, linoleic acid and tetradecane. Int. J. Pharm. 42: 97-104
    • (1988) Int. J. Pharm. , vol.42 , pp. 97-104
    • Hadgraft, J.1    Ridout, G.2
  • 79
    • 0023546523 scopus 로고
    • Hydrophobicity and central nervous system agents: On the principle of minimal hydrophobicity in drug design
    • Hansch, C., Björkroth, J. P., Leo, A. (1987) Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design. J. Pharm. Sci. 76: 663-687
    • (1987) J. Pharm. Sci. , vol.76 , pp. 663-687
    • Hansch, C.1    Björkroth, J.P.2    Leo, A.3
  • 80
    • 0028102402 scopus 로고
    • Proton migration along the membrane surface and retarded surface to bulk transfer
    • Heberle, J., Riesle, J., Thiedemann, G., Oesterhelt, D., Dencher, N. A. (1994) Proton migration along the membrane surface and retarded surface to bulk transfer. Nature 370: 379-382
    • (1994) Nature , vol.370 , pp. 379-382
    • Heberle, J.1    Riesle, J.2    Thiedemann, G.3    Oesterhelt, D.4    Dencher, N.A.5
  • 81
    • 0029947420 scopus 로고    scopus 로고
    • Non steady-state descriptions of drug permeation through stratum corneum. I. The biphasic brick-and-mortar model
    • Heisig, M., Lieckfeldt, R., Wittum, G., Mazurkevitch, G., Lee, G. (1996) Non steady-state descriptions of drug permeation through stratum corneum. I. The biphasic brick-and-mortar model. Pharm. Res. 13: 421-426
    • (1996) Pharm. Res. , vol.13 , pp. 421-426
    • Heisig, M.1    Lieckfeldt, R.2    Wittum, G.3    Mazurkevitch, G.4    Lee, G.5
  • 82
    • 0028857368 scopus 로고
    • Concentration-dependent binding of the chiral beta-blocker oxprenolol to isoelectric or negatively charged unilamellar vesicles
    • Hellwich, U., Schubert, R. (1995) Concentration-dependent binding of the chiral beta-blocker oxprenolol to isoelectric or negatively charged unilamellar vesicles. Biochem. Pharmacol. 49: 511-517
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 511-517
    • Hellwich, U.1    Schubert, R.2
  • 83
    • 0025881509 scopus 로고
    • New approaches to drug design and delivery based on drug-membrane interactions
    • Herbette, L. G., Rhodes, D. G., Mason, R. P. (1991) New approaches to drug design and delivery based on drug-membrane interactions. Drug Des. Deliv. 7: 75-118
    • (1991) Drug Des. Deliv. , vol.7 , pp. 75-118
    • Herbette, L.G.1    Rhodes, D.G.2    Mason, R.P.3
  • 84
    • 0028859318 scopus 로고
    • In-vitro systems for studying intestinal drug absorption
    • Hillgren, K. M., Kato, A., Borchardt, R. T. (1995) In-vitro systems for studying intestinal drug absorption. Med. Res. Rev. 15: 83-109
    • (1995) Med. Res. Rev. , vol.15 , pp. 83-109
    • Hillgren, K.M.1    Kato, A.2    Borchardt, R.T.3
  • 86
    • 0030844931 scopus 로고    scopus 로고
    • Iontophoretic delivery across the skin: Electroosmosis and its modulation by drug substances
    • Hirvonen, J., Guy, R. H. (1997) Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm. Res. 14: 1258-1263
    • (1997) Pharm. Res. , vol.14 , pp. 1258-1263
    • Hirvonen, J.1    Guy, R.H.2
  • 87
    • 0029558244 scopus 로고
    • A biophysical model of passive and polarized active transport processes in Caco-2 cells: Approaches to uncoupling apical and basolateral membrane events in the intact cell
    • Ho, N. F., Burton, P. S., Conradi, R. A., Barsuhn, C. L. (1995) A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell. J. Pharm. Sci. 84: 21-27
    • (1995) J. Pharm. Sci. , vol.84 , pp. 21-27
    • Ho, N.F.1    Burton, P.S.2    Conradi, R.A.3    Barsuhn, C.L.4
  • 89
    • 0030638750 scopus 로고    scopus 로고
    • Influences of 1-dodecylazacyclophan-2-one on permeation of membranes by weak electrolytes. 1. Theoretical analysis of weak electrolyte diffusion through membranes and studies involving silicone rubber membranes
    • Hou, S. Y. E., Flynn, G. L. (1997) Influences of 1-dodecylazacyclophan-2-one on permeation of membranes by weak electrolytes. 1. Theoretical analysis of weak electrolyte diffusion through membranes and studies involving silicone rubber membranes. J. Pharm. Sci. 86: 85-91
    • (1997) J. Pharm. Sci. , vol.86 , pp. 85-91
    • Hou, S.Y.E.1    Flynn, G.L.2
  • 90
    • 0000552173 scopus 로고
    • Membrane models for skin penetration studies
    • Houk, J., Guy, R. H. (1988) Membrane models for skin penetration studies. Chem. Rev 88: 455-471
    • (1988) Chem. Rev , vol.88 , pp. 455-471
    • Houk, J.1    Guy, R.H.2
  • 91
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • Hunter, J., Hirst, B. H., Simmons, N. L. (1993) Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10: 743-749
    • (1993) Pharm. Res. , vol.10 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 92
    • 0029983527 scopus 로고    scopus 로고
    • Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier
    • Hurst, R. D., Fritz, I. B. (1996) Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J. Cell. Physiol. 167: 81-88
    • (1996) J. Cell. Physiol. , vol.167 , pp. 81-88
    • Hurst, R.D.1    Fritz, I.B.2
  • 93
    • 0028016407 scopus 로고
    • Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic chromatography
    • Ishihama, Y., Oda, Y., Uchikawa, K., Asakawa, N. (1994) Correlation of octanol-water partition coefficients with capacity factors measured by micellar electrokinetic chromatography. Chem. Pharm. Bull. 42: 1525-1527
    • (1994) Chem. Pharm. Bull. , vol.42 , pp. 1525-1527
    • Ishihama, Y.1    Oda, Y.2    Uchikawa, K.3    Asakawa, N.4
  • 94
    • 0028997763 scopus 로고
    • Evaluation of solute hydrophobicity by microemulsion electrokinetic chromatography
    • Ishihama, Y., Oda, Y., Uchikawa, K., Asakawa, N. (1995) Evaluation of solute hydrophobicity by microemulsion electrokinetic chromatography. Anal. Chem. 67: 1588-1595
    • (1995) Anal. Chem. , vol.67 , pp. 1588-1595
    • Ishihama, Y.1    Oda, Y.2    Uchikawa, K.3    Asakawa, N.4
  • 95
    • 0029941382 scopus 로고    scopus 로고
    • Astrocyte contributions to blood-brain barrier (blood-brain barrier) formation by endothelial cells: A possible use of aortic endothelial cell for in-vitro blood-brain barrier model
    • Isobe, I., Watanabe, T., Yotsuyanagi, T., Hazemoto, N., Yamagata, K., Ueki, T., Nakanishi, K., Asai, K., Kato, T. (1996) Astrocyte contributions to blood-brain barrier (blood-brain barrier) formation by endothelial cells: a possible use of aortic endothelial cell for in-vitro blood-brain barrier model. Neurochem. Int. 28: 523-533
    • (1996) Neurochem. Int. , vol.28 , pp. 523-533
    • Isobe, I.1    Watanabe, T.2    Yotsuyanagi, T.3    Hazemoto, N.4    Yamagata, K.5    Ueki, T.6    Nakanishi, K.7    Asai, K.8    Kato, T.9
  • 96
    • 0025173497 scopus 로고
    • Use of shed snake skin as model membrane for in-vitro percutaneous penetration studies: Comparison with human skin
    • Itoh, T., Xia, J., Magavi, R., Nishihata, T., Rytting, J. H. (1990) Use of shed snake skin as model membrane for in-vitro percutaneous penetration studies: comparison with human skin. Pharm. Res. 7: 1021-1047
    • (1990) Pharm. Res. , vol.7 , pp. 1021-1047
    • Itoh, T.1    Xia, J.2    Magavi, R.3    Nishihata, T.4    Rytting, J.H.5
  • 97
    • 0030745358 scopus 로고    scopus 로고
    • Drug absorption: Getting it across
    • Jack, D. B. (1997) Drug absorption: getting it across. Drug News Perspect. 10: 370-373
    • (1997) Drug News Perspect. , vol.10 , pp. 370-373
    • Jack, D.B.1
  • 98
    • 0023000772 scopus 로고
    • Permeation of mouse skin and silicone rubber membranes by phenols: Relationship to in-vitro partitioning
    • Jetzer, W. E., Huq, A. S., Ho, N. F. M., Flynn, G. L., Duraiswamy, N., Condie, L. (1986) Permeation of mouse skin and silicone rubber membranes by phenols: relationship to in-vitro partitioning. J. Pharm. Sci. 75: 1098-1103
    • (1986) J. Pharm. Sci. , vol.75 , pp. 1098-1103
    • Jetzer, W.E.1    Huq, A.S.2    Ho, N.F.M.3    Flynn, G.L.4    Duraiswamy, N.5    Condie, L.6
  • 99
    • 0027423294 scopus 로고
    • The blood-brain barrier in-vitro: The second decade
    • Joo, F. (1993) The blood-brain barrier in-vitro: the second decade. Neurochem. Int. 23: 499-521
    • (1993) Neurochem. Int. , vol.23 , pp. 499-521
    • Joo, F.1
  • 100
    • 0003125492 scopus 로고
    • Isolated brain microvessels and cultured cerebral endothelial cells in blood-brain barrier research: 20 years on
    • Greenwood, J., Begley, D. J., Segal, M. B. (eds) Plenum, New York
    • Joo, F. (1995) Isolated brain microvessels and cultured cerebral endothelial cells in blood-brain barrier research: 20 years on. In: Greenwood, J., Begley, D. J., Segal, M. B. (eds) New Concepts of a Blood-brain Barrier. Plenum, New York, pp 229-237
    • (1995) New Concepts of a Blood-brain Barrier , pp. 229-237
    • Joo, F.1
  • 101
    • 0026665493 scopus 로고
    • Keratinized epithelial transport of β-blocking agents. I. Relationship between physicochemical properties of drugs and the flux across rat skin and hamster cheek pouch
    • Kai, T., Isami, T., Kobata, K., Kurosaki, Y., Nakayama, T., Kimura, T. (1992) Keratinized epithelial transport of β-blocking agents. I. Relationship between physicochemical properties of drugs and the flux across rat skin and hamster cheek pouch. Chem. Pharm. Bull. 40: 2498-2504
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 2498-2504
    • Kai, T.1    Isami, T.2    Kobata, K.3    Kurosaki, Y.4    Nakayama, T.5    Kimura, T.6
  • 102
    • 0027288253 scopus 로고
    • Keratinized epithelial transport of β-blocking agents. II. Evaluation of barrier property of stratum corneum by using model lipid systems
    • Kai, T., Isami, T., Kurosaki, Y., Nakayama, T., Kimura, T. (1993) Keratinized epithelial transport of β-blocking agents. II. Evaluation of barrier property of stratum corneum by using model lipid systems. Biol. Pharm. Bull. 16: 284-287
    • (1993) Biol. Pharm. Bull. , vol.16 , pp. 284-287
    • Kai, T.1    Isami, T.2    Kurosaki, Y.3    Nakayama, T.4    Kimura, T.5
  • 104
    • 0031772030 scopus 로고    scopus 로고
    • Ion mobility across human stratum corneum in-vivo
    • Kalia, Y. N., Pirot, F., Potts, R. O., Guy, R. H. (1998b) Ion mobility across human stratum corneum in-vivo. J. Pharm. Sci. 87: 1508-1511
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1508-1511
    • Kalia, Y.N.1    Pirot, F.2    Potts, R.O.3    Guy, R.H.4
  • 105
    • 0028210011 scopus 로고
    • Chromatographic hydrophobicity parameter determined on an immobilized artificial membrane column: Relationships to standard measures of hydrophobicity and bioactivity
    • Kaliszan, R., Nasal, A., Bucinski, A. (1994) Chromatographic hydrophobicity parameter determined on an immobilized artificial membrane column: relationships to standard measures of hydrophobicity and bioactivity. Eur. J. Med. Chem. 29: 163-170
    • (1994) Eur. J. Med. Chem. , vol.29 , pp. 163-170
    • Kaliszan, R.1    Nasal, A.2    Bucinski, A.3
  • 106
    • 0028800404 scopus 로고
    • Quantitative structure-retention relationships in capillary electrophoresis of inorganic cations and β-adrenolytic and sulfonamide compounds
    • Kaliszan, R., Turowski, M., Bucinski, A., Hartwick, R. A. (1995) Quantitative structure-retention relationships in capillary electrophoresis of inorganic cations and β-adrenolytic and sulfonamide compounds. Quant. Struct.-Act. Relat. 14: 356-361
    • (1995) Quant. Struct.-act. Relat. , vol.14 , pp. 356-361
    • Kaliszan, R.1    Turowski, M.2    Bucinski, A.3    Hartwick, R.A.4
  • 107
    • 33845279234 scopus 로고
    • Linear solvation energy relationships. 46. An improved equation for correlation and prediction of octanol/water partition coefficients of organic nonelectrolytes (including strong hydrogen bond donor solutes)
    • Kamlet, M. J., Doherty, R. M., Abraham, M. H., Marcus, Y., Taft, R. W. (1988) Linear solvation energy relationships. 46. An improved equation for correlation and prediction of octanol/water partition coefficients of organic nonelectrolytes (including strong hydrogen bond donor solutes). J. Phys. Chem. 92: 5244-5255
    • (1988) J. Phys. Chem. , vol.92 , pp. 5244-5255
    • Kamlet, M.J.1    Doherty, R.M.2    Abraham, M.H.3    Marcus, Y.4    Taft, R.W.5
  • 108
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high throughput screening: Parallel artificial membrane permeation assay in the description of passive absorption processes
    • Kansy, M., Senner, F., Gubernator, K. (1998) Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J. Med. Chem. 41: 1007-1010
    • (1998) J. Med. Chem. , vol.41 , pp. 1007-1010
    • Kansy, M.1    Senner, F.2    Gubernator, K.3
  • 110
    • 0031829268 scopus 로고    scopus 로고
    • Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles
    • Koga, K., Murakami, M., Kawashima, S. (1998) Effects of fatty acid sucrose esters on ceftibuten transport by rat intestinal brush-border membrane vesicles. Biol. Pharm. Bull. 21: 747-751
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 747-751
    • Koga, K.1    Murakami, M.2    Kawashima, S.3
  • 111
    • 0031780283 scopus 로고    scopus 로고
    • Towards the predictability of drug-lipid membrane interactions: The pH-dependent affinity of propranolol to phosphatidylinositol containing liposomes
    • Krämer, S. D., Braun, A., Jakits-Deiser, C., Wunderli-Allenspach, H. (1998) Towards the predictability of drug-lipid membrane interactions: the pH-dependent affinity of propranolol to phosphatidylinositol containing liposomes. Pharm. Res. 15: 739-744
    • (1998) Pharm. Res. , vol.15 , pp. 739-744
    • Krämer, S.D.1    Braun, A.2    Jakits-Deiser, C.3    Wunderli-Allenspach, H.4
  • 112
    • 0031872134 scopus 로고    scopus 로고
    • Predicting drug absorption from molecular surface properties based on molecular dynamics simulations
    • Krarup, L. H., Christensen, I. T., Hovgaard, L., Frokjaer, S. (1998) Predicting drug absorption from molecular surface properties based on molecular dynamics simulations. Pharm. Res. 15: 972-978
    • (1998) Pharm. Res. , vol.15 , pp. 972-978
    • Krarup, L.H.1    Christensen, I.T.2    Hovgaard, L.3    Frokjaer, S.4
  • 114
    • 0000130397 scopus 로고
    • The quantitative analysis of structure-activity relationships
    • Wolff, M. E. (ed.) 4th edn, Wiley, New York
    • Kubinyi, H. (1995) The quantitative analysis of structure-activity relationships. In: Wolff, M. E. (ed.) Burger's Medicinal Chemistry and Drug Discovery. Volume 1, 4th edn, Wiley, New York, pp 497-571
    • (1995) Burger's Medicinal Chemistry and Drug Discovery , vol.1 , pp. 497-571
    • Kubinyi, H.1
  • 116
    • 0027818680 scopus 로고
    • Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography
    • Lambert, W. J. (1993) Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography. J. Chromatogr. 656: 469-484
    • (1993) J. Chromatogr. , vol.656 , pp. 469-484
    • Lambert, W.J.1
  • 117
    • 0020615146 scopus 로고
    • Human epidermal lipids: Characterization and modulations during differentiation
    • Lampe, M. A., Williams, M. L., Elias, P. M. (1983) Human epidermal lipids: characterization and modulations during differentiation. J. Lipid Res. 24: 131-140
    • (1983) J. Lipid Res. , vol.24 , pp. 131-140
    • Lampe, M.A.1    Williams, M.L.2    Elias, P.M.3
  • 118
    • 0029008884 scopus 로고
    • a of membrane-bound N, N-dimethylsphingosine using deuterium NMR spectroscopy
    • a of membrane-bound N, N-dimethylsphingosine using deuterium NMR spectroscopy. Biochim. Biophys. Acta 1237: 37-42
    • (1995) Biochim. Biophys. Acta , vol.1237 , pp. 37-42
    • Lau, B.1    McDonald, P.M.2
  • 120
    • 0024523097 scopus 로고
    • Model solvent systems for QSAR. Part I. Propylene glycol dipelargonate (PGDP). A new standard solvent for use in partition coefficient determination
    • Leahy, D. E., Taylor, P. J., Wait, A. R. (1989) Model solvent systems for QSAR. Part I. Propylene glycol dipelargonate (PGDP). A new standard solvent for use in partition coefficient determination. Quant. Struct.-Act. Relat. 8: 17-31
    • (1989) Quant. Struct.-act. Relat. , vol.8 , pp. 17-31
    • Leahy, D.E.1    Taylor, P.J.2    Wait, A.R.3
  • 121
    • 37049085104 scopus 로고
    • Model solvent systems for QSAR. Part 3. An LSER analysis of the "critical quartet". New light on hydrogen bond strength and directionality
    • Leahy, D. E., Morris, J. J., Taylor, P. J., Wait, A. R. (1992a) Model solvent systems for QSAR. Part 3. An LSER analysis of the "critical quartet". New light on hydrogen bond strength and directionality. J. Chem. Soc. Perkin Trans. II 705-722
    • (1992) J. Chem. Soc. Perkin Trans. , vol.2 , pp. 705-722
    • Leahy, D.E.1    Morris, J.J.2    Taylor, P.J.3    Wait, A.R.4
  • 122
    • 37049081761 scopus 로고
    • Model solvent systems for QSAR. Part 2. Fragment values ('f-Values') for the "critical quartet"
    • Leahy, D. E., Morris, J. J., Taylor, P. J., Wait, A. R. (1992b) Model solvent systems for QSAR. Part 2. Fragment values ('f-Values') for the "critical quartet". J. Chem. Soc. Perkin Trans. II 723-731
    • (1992) J. Chem. Soc. Perkin Trans. , vol.2 , pp. 723-731
    • Leahy, D.E.1    Morris, J.J.2    Taylor, P.J.3    Wait, A.R.4
  • 123
    • 0025970591 scopus 로고
    • Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines
    • LeCluyse, E. L., Appel, L. E., Sutton, S. C. (1991) Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines. Pharm. Res. 8: 84-87
    • (1991) Pharm. Res. , vol.8 , pp. 84-87
    • LeCluyse, E.L.1    Appel, L.E.2    Sutton, S.C.3
  • 124
    • 0011623032 scopus 로고    scopus 로고
    • A new linear solvation energy relationship for the solubility of liquids in water
    • Lee, S. B. (1996) A new linear solvation energy relationship for the solubility of liquids in water. J. Pharm. Sci. 85: 348-350
    • (1996) J. Pharm. Sci. , vol.85 , pp. 348-350
    • Lee, S.B.1
  • 125
    • 0029082597 scopus 로고
    • Influence of physicochemical properties of homologous esters of nicotinic acid on skin permeability and maximum flux
    • Lee, V. H., Lippold, B. C. (1995) Influence of physicochemical properties of homologous esters of nicotinic acid on skin permeability and maximum flux. Int. J. Pharm. 124: 285-292
    • (1995) Int. J. Pharm. , vol.124 , pp. 285-292
    • Lee, V.H.1    Lippold, B.C.2
  • 126
    • 0019124032 scopus 로고
    • Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
    • Levin, V. A. (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23: 682-684
    • (1980) J. Med. Chem. , vol.23 , pp. 682-684
    • Levin, V.A.1
  • 127
    • 0026457758 scopus 로고
    • 2 receptor and binding sites for agonist and antagonist
    • 2 receptor and binding sites for agonist and antagonist. Drug Des. Discovery 9: 29-48
    • (1992) Drug Des. Discovery , vol.9 , pp. 29-48
    • Lewell, X.Q.1
  • 128
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., Feeney, P. J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23: 3-25
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 129
  • 130
    • 0025854810 scopus 로고
    • Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes
    • Mason, R. P., Rhodes, D. G., Herbette, L. G. (1991) Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes. J. Med. Chem. 34: 869-877
    • (1991) J. Med. Chem. , vol.34 , pp. 869-877
    • Mason, R.P.1    Rhodes, D.G.2    Herbette, L.G.3
  • 131
    • 0027285001 scopus 로고
    • Development of a model membrane system using stratum corneum lipids for estimations of drug skin permeability
    • Matsuzaki, K., Imaoka, T., Asano, M., Miyajima, K. (1993) Development of a model membrane system using stratum corneum lipids for estimations of drug skin permeability. Chem. Pharm. Bull. 41: 575-579
    • (1993) Chem. Pharm. Bull. , vol.41 , pp. 575-579
    • Matsuzaki, K.1    Imaoka, T.2    Asano, M.3    Miyajima, K.4
  • 132
    • 0028951149 scopus 로고
    • Functional evaluation of anchored skin equivalent cultured in-vitro: Percutaneous absorption studies and lipid analysis
    • Michel, M., Germain, L., Bélanger, P. M., Auger, F. A. (1995) Functional evaluation of anchored skin equivalent cultured in-vitro: percutaneous absorption studies and lipid analysis. Pharm. Res. 12: 455-458
    • (1995) Pharm. Res. , vol.12 , pp. 455-458
    • Michel, M.1    Germain, L.2    Bélanger, P.M.3    Auger, F.A.4
  • 133
    • 0028912161 scopus 로고
    • Mechanisms of the potent and long-lasting antihypertensive action of the new calcium channel blocker pranidipine. Evidence for strong affinity to the calcium channels or membranes
    • Miyakoda, G., Nakayama, N., Matsui, K., Yabuuchi, Y. (1995) Mechanisms of the potent and long-lasting antihypertensive action of the new calcium channel blocker pranidipine. Evidence for strong affinity to the calcium channels or membranes. Arzneim. Forsch. 45: 471-475
    • (1995) Arzneim. Forsch. , vol.45 , pp. 471-475
    • Miyakoda, G.1    Nakayama, N.2    Matsui, K.3    Yabuuchi, Y.4
  • 134
    • 0028340366 scopus 로고
    • Estimation and correlation of drug water solubility with pharmacological parameters required for biological activity
    • Morelock, M. M., Choi, L. L., Bell, G. L., Wright, J. L. (1994) Estimation and correlation of drug water solubility with pharmacological parameters required for biological activity. J. Pharm. Sci. 83: 948-952
    • (1994) J. Pharm. Sci. , vol.83 , pp. 948-952
    • Morelock, M.M.1    Choi, L.L.2    Bell, G.L.3    Wright, J.L.4
  • 135
    • 0026670330 scopus 로고
    • Prediction of skin permeability of drugs: Comparison of human and hairless rat skin
    • Morimoto, Y., Hatanaka, T., Sugibayashi, K., Omiya, H. (1992) Prediction of skin permeability of drugs: comparison of human and hairless rat skin. J. Pharm. Pharmacol. 44: 634-639
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 634-639
    • Morimoto, Y.1    Hatanaka, T.2    Sugibayashi, K.3    Omiya, H.4
  • 136
    • 0031695897 scopus 로고    scopus 로고
    • A new look at lipid-membrane structure in relation to drug research
    • Mouritsen, O. G., Jorgensen, K. (1998) A new look at lipid-membrane structure in relation to drug research. Pharm. Res. 15: 1507-1519
    • (1998) Pharm. Res. , vol.15 , pp. 1507-1519
    • Mouritsen, O.G.1    Jorgensen, K.2
  • 137
    • 0030782933 scopus 로고    scopus 로고
    • Retention indices in micellar electrokinetic chromatography
    • Muijselaar, P. G. (1997) Retention indices in micellar electrokinetic chromatography. J. Chromatogr. A 780: 117-127
    • (1997) J. Chromatogr. A , vol.780 , pp. 117-127
    • Muijselaar, P.G.1
  • 138
    • 0029357888 scopus 로고
    • 60 solubilities in terms of computed molecular surface electrostatic potentials and areas
    • 60 solubilities in terms of computed molecular surface electrostatic potentials and areas. J. Phys. Chem. 99: 12081-12083
    • (1995) J. Phys. Chem. , vol.99 , pp. 12081-12083
    • Murray, J.S.1    Gagarin, S.G.2    Politzer, P.3
  • 139
    • 0030726926 scopus 로고    scopus 로고
    • Development of immortalized human cerebromicrovascular endothelial cell line as in-vitro model of the human blood-brain barrier
    • Muruganandam, A., Herx, L. M., Monette, R., Durkin, J. P., Stanimirovic, D. B. (1997) Development of immortalized human cerebromicrovascular endothelial cell line as in-vitro model of the human blood-brain barrier. FASEB J. 11: 1187-1187
    • (1997) FASEB J. , vol.11 , pp. 1187-1187
    • Muruganandam, A.1    Herx, L.M.2    Monette, R.3    Durkin, J.P.4    Stanimirovic, D.B.5
  • 140
    • 0028848323 scopus 로고
    • Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs
    • Nakashima, E., Matsushita, R., Ohsima, T., Tsuji, A., Ichimura, F. (1995) Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs. Drug Metab. Dispos. 23: 1220-1224
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 1220-1224
    • Nakashima, E.1    Matsushita, R.2    Ohsima, T.3    Tsuji, A.4    Ichimura, F.5
  • 141
    • 0028429968 scopus 로고
    • Prediction of aqueous solubility of organic compounds
    • Nelson, T. M., Jurs, P. C. (1994) Prediction of aqueous solubility of organic compounds. J. Chem. Inf. Comput. Sci. 34: 601-609
    • (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 601-609
    • Nelson, T.M.1    Jurs, P.C.2
  • 142
    • 0018819897 scopus 로고
    • In-situ precipitation: A novel cytochemical technique for visualization of permeability pathways in mammalian stratum corneum
    • Nemanic, M. K., Elias, P. M. (1980) In-situ precipitation: a novel cytochemical technique for visualization of permeability pathways in mammalian stratum corneum. J. Histochem. Cytochem. 28: 573-578
    • (1980) J. Histochem. Cytochem. , vol.28 , pp. 573-578
    • Nemanic, M.K.1    Elias, P.M.2
  • 144
    • 0031404654 scopus 로고    scopus 로고
    • Theoretical calculation and prediction of Caco-2 cell permeability using Molsurf parametrization and PLS Statistics
    • Norinder, U., Osterberg, T., Artursson, P. (1997) Theoretical calculation and prediction of Caco-2 cell permeability using Molsurf parametrization and PLS Statistics. Pharm. Res. 14: 1786-1791
    • (1997) Pharm. Res. , vol.14 , pp. 1786-1791
    • Norinder, U.1    Osterberg, T.2    Artursson, P.3
  • 145
    • 0032979004 scopus 로고    scopus 로고
    • Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics
    • Norinder, U., Osterberg, T., Artursson, P. (1999) Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics. Eur. J. Pharm. Sci. 8: 49-56
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 49-56
    • Norinder, U.1    Osterberg, T.2    Artursson, P.3
  • 146
    • 0029065530 scopus 로고
    • Membrane partition coefficients chromatographically measured using immobilized artificial membrane surfaces
    • Ong, S., Liu, H., Qiu, X., Bhat, G., Pidgeon, C. (1995) Membrane partition coefficients chromatographically measured using immobilized artificial membrane surfaces. Anal. Chem. 67: 755-762
    • (1995) Anal. Chem. , vol.67 , pp. 755-762
    • Ong, S.1    Liu, H.2    Qiu, X.3    Bhat, G.4    Pidgeon, C.5
  • 147
    • 0029991481 scopus 로고    scopus 로고
    • Immobilized-artificial-membrane chromatography: Measurements of membrane partition coefficient and predicting drug membrane permeability
    • Ong, S., Liu, H., Pidgeon, C. (1996) Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability. J. Chromatogr. A 728: 113-128
    • (1996) J. Chromatogr. A , vol.728 , pp. 113-128
    • Ong, S.1    Liu, H.2    Pidgeon, C.3
  • 148
    • 0031008321 scopus 로고    scopus 로고
    • Ideal partition behaviour of acids and bases in a phosphatidylcholine liposome/buffer equilibrium dialysis system
    • Ottiger, C., Wunderli-Allenspach, H. (1997) Ideal partition behaviour of acids and bases in a phosphatidylcholine liposome/buffer equilibrium dialysis system. Eur. J. Pharm. Sci. 5: 223-231
    • (1997) Eur. J. Pharm. Sci. , vol.5 , pp. 223-231
    • Ottiger, C.1    Wunderli-Allenspach, H.2
  • 152
    • 0030030608 scopus 로고    scopus 로고
    • Correlation of drug absorption with molecular surface properties
    • Palm, K., Luthman, K., Ungell, A. L., Artursson, P. (1996) Correlation of drug absorption with molecular surface properties. J. Pharm. Sci. 85: 32-39
    • (1996) J. Pharm. Sci. , vol.85 , pp. 32-39
    • Palm, K.1    Luthman, K.2    Ungell, A.L.3    Artursson, P.4
  • 153
    • 84951749349 scopus 로고    scopus 로고
    • Experimental and theoretical predictions of intestinal drug absorption
    • van de Waterbeemd, H., Testa, B., Folkers, G. (eds) Wiley-VCH, Weinheim
    • Palm, K., Artursson, P., Luthman, K. (1997a) Experimental and theoretical predictions of intestinal drug absorption. In: van de Waterbeemd, H., Testa, B., Folkers, G. (eds) Computer-Assisted Lead Finding and Optimization. Wiley-VCH, Weinheim, pp 277-289
    • (1997) Computer-assisted Lead Finding and Optimization , pp. 277-289
    • Palm, K.1    Artursson, P.2    Luthman, K.3
  • 154
    • 0030914681 scopus 로고    scopus 로고
    • Polar molecular surface properties predict the intestinal absorption of drugs in humans
    • Palm, K., Stenberg, P., Luthman, K., Artursson, P. (1997b) Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. 14: 568-571
    • (1997) Pharm. Res. , vol.14 , pp. 568-571
    • Palm, K.1    Stenberg, P.2    Luthman, K.3    Artursson, P.4
  • 155
    • 0032585545 scopus 로고    scopus 로고
    • Evaluation of dynamic polar molecular surface area as predictor of drug absorption: Comparison with other computational and experimental predictors
    • Palm, K., Luthman, K., Ungell, A. L., Strandlund, G., Beigi, F., Lundhal, P., Artursson, P. (1998) Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors. J. Med. Chem. 41: 5382-5392
    • (1998) J. Med. Chem. , vol.41 , pp. 5382-5392
    • Palm, K.1    Luthman, K.2    Ungell, A.L.3    Strandlund, G.4    Beigi, F.5    Lundhal, P.6    Artursson, P.7
  • 157
    • 0028290593 scopus 로고
    • Partition coefficients in-vitro: Artificial membranes as a standardized distribution model
    • Pauletti, G. M., Wunderli-Allenspach, H. (1994) Partition coefficients in-vitro: artificial membranes as a standardized distribution model. Eur. J. Pharm. Sci. 1: 273-282
    • (1994) Eur. J. Pharm. Sci. , vol.1 , pp. 273-282
    • Pauletti, G.M.1    Wunderli-Allenspach, H.2
  • 158
    • 0014541587 scopus 로고
    • Passive permeation of organic compounds through biological tissues: A non-steady state theory
    • Penniston, J. T., Beckett, L., Bentley, D. L., Hansch, C. (1969) Passive permeation of organic compounds through biological tissues: a non-steady state theory. Mol. Pharmacol. 5: 333-341
    • (1969) Mol. Pharmacol. , vol.5 , pp. 333-341
    • Penniston, J.T.1    Beckett, L.2    Bentley, D.L.3    Hansch, C.4
  • 159
    • 0029281751 scopus 로고
    • Partitioning of 1,4-benzodiazepines into natural membranes
    • Perillo, M. A., Garcia, D. A., Arce, A. (1995) Partitioning of 1,4-benzodiazepines into natural membranes. Mol. Membr. Biol. 12: 217-224
    • (1995) Mol. Membr. Biol. , vol.12 , pp. 217-224
    • Perillo, M.A.1    Garcia, D.A.2    Arce, A.3
  • 160
    • 0026748997 scopus 로고
    • Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa
    • Peters, W. H., Boon, C. E., Roelofs, H. M., Nagengast, F. M., Kremers, P. G. (1992) Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa. Gastroenterology 103: 448-455
    • (1992) Gastroenterology , vol.103 , pp. 448-455
    • Peters, W.H.1    Boon, C.E.2    Roelofs, H.M.3    Nagengast, F.M.4    Kremers, P.G.5
  • 162
    • 0027930131 scopus 로고
    • Acidity of the environment and intracellular distribution of ionizable substances
    • Pirselova, K., Balaz, S. (1994) Acidity of the environment and intracellular distribution of ionizable substances. Chemometric Intell. Lab. Syst. 24: 193-196
    • (1994) Chemometric Intell. Lab. Syst. , vol.24 , pp. 193-196
    • Pirselova, K.1    Balaz, S.2
  • 163
    • 0027530335 scopus 로고
    • The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes
    • Potts, R. O., Guy, R. H. (1993) The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes. Comments. Pharm. Res. 10: 635-636
    • (1993) Comments. Pharm. Res. , vol.10 , pp. 635-636
    • Potts, R.O.1    Guy, R.H.2
  • 164
    • 0024956954 scopus 로고
    • In-vitro characterization of blood-brain barrier permeability do delta sleep-inducing peptide
    • Raeissi, S., Audus, K. L. (1989) In-vitro characterization of blood-brain barrier permeability do delta sleep-inducing peptide. J. Pharm. Pharmacol. 41: 848-852
    • (1989) J. Pharm. Pharmacol. , vol.41 , pp. 848-852
    • Raeissi, S.1    Audus, K.L.2
  • 165
    • 0027195886 scopus 로고
    • Barrier function of human skin and human reconstructed epidermis
    • Régnier, M., Caron, D., Reichert, U., Schaefer, H. (1993) Barrier function of human skin and human reconstructed epidermis. J. Pharm. Sci. 82: 404-407
    • (1993) J. Pharm. Sci. , vol.82 , pp. 404-407
    • Régnier, M.1    Caron, D.2    Reichert, U.3    Schaefer, H.4
  • 166
    • 0031709543 scopus 로고    scopus 로고
    • Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier
    • Reichel, A., Begley, D. J. (1998) Potential of immobilized artificial membranes for predicting drug penetration across the blood-brain barrier. Pharm. Res. 15: 1270-1274
    • (1998) Pharm. Res. , vol.15 , pp. 1270-1274
    • Reichel, A.1    Begley, D.J.2
  • 169
    • 0030063871 scopus 로고    scopus 로고
    • Mechanism of transfer of a basic drug across the water/1,2-dichloroethane interface: The case of quinidine
    • Reymond, F., Steyaert, G., Carrupt, P. A., Testa, B., Girault, H. H. (1996b) Mechanism of transfer of a basic drug across the water/1,2-dichloroethane interface: the case of quinidine. Helv. Chim. Acta 79: 101-117
    • (1996) Helv. Chim. Acta , vol.79 , pp. 101-117
    • Reymond, F.1    Steyaert, G.2    Carrupt, P.A.3    Testa, B.4    Girault, H.H.5
  • 170
  • 171
    • 0032924545 scopus 로고    scopus 로고
    • Charge and delocalisation effects on the lipophilicity of protonable drugs
    • Reymond, F., Carrupt, P. A., Testa, B., Girault, H. H. (1999a) Charge and delocalisation effects on the lipophilicity of protonable drugs. Chem. Eur. J. 5: 39-47
    • (1999) Chem. Eur. J. , vol.5 , pp. 39-47
    • Reymond, F.1    Carrupt, P.A.2    Testa, B.3    Girault, H.H.4
  • 172
    • 0032910003 scopus 로고    scopus 로고
    • The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis
    • Reymond, F., Steyaert, G., Carrupt, P. A., Morin, D., Tillement, J. P., Girault, H. H., Testa, B. (1999b) The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis. Pharm. Res. 16: 616-624
    • (1999) Pharm. Res. , vol.16 , pp. 616-624
    • Reymond, F.1    Steyaert, G.2    Carrupt, P.A.3    Morin, D.4    Tillement, J.P.5    Girault, H.H.6    Testa, B.7
  • 173
    • 0023707121 scopus 로고
    • Pharmacokinetic considerations in the use of newer transdermal formulations
    • Ridout, G., Santus, G. C., Guy, R. H. (1988) Pharmacokinetic considerations in the use of newer transdermal formulations. Clin. Pharmacokin. 15: 114-131
    • (1988) Clin. Pharmacokin. , vol.15 , pp. 114-131
    • Ridout, G.1    Santus, G.C.2    Guy, R.H.3
  • 174
    • 0026648936 scopus 로고
    • An evaluation of structure-penetration relationships in percutaneous absorption
    • Ridout, G., Houk, J., Guy, R. H., Santus, G. C., Hadgraft, J., Hall, L. H. (1992) An evaluation of structure-penetration relationships in percutaneous absorption. Farmaco 47: 869-892
    • (1992) Farmaco , vol.47 , pp. 869-892
    • Ridout, G.1    Houk, J.2    Guy, R.H.3    Santus, G.C.4    Hadgraft, J.5    Hall, L.H.6
  • 175
    • 0022547803 scopus 로고
    • Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers
    • Rim, S., Audus, K. L., Borchardt, R. T. (1986) Relationship of octanol/buffer and octanol/water partition coefficients to transcellular diffusion across brain microvessel endothelial cell monolayers. Int. J. Pharm. 32: 79-84
    • (1986) Int. J. Pharm. , vol.32 , pp. 79-84
    • Rim, S.1    Audus, K.L.2    Borchardt, R.T.3
  • 177
    • 0027207281 scopus 로고
    • The liposome partitioning system for correlating biological activities of imidazoline derivatives
    • Rogers, J. A., Choi, Y. W. (1993) The liposome partitioning system for correlating biological activities of imidazoline derivatives. Pharm. Res. 10: 913-917
    • (1993) Pharm. Res. , vol.10 , pp. 913-917
    • Rogers, J.A.1    Choi, Y.W.2
  • 178
    • 0024278757 scopus 로고
    • Hydrophobicity of the peptide C = O...H-N hydrogen-bonded group
    • Roseman, M. A. (1988) Hydrophobicity of the peptide C = O...H-N hydrogen-bonded group. J. Mol. Biol. 201: 621-623
    • (1988) J. Mol. Biol. , vol.201 , pp. 621-623
    • Roseman, M.A.1
  • 179
    • 0015868160 scopus 로고
    • 2. (tromethamine alt): Solubility behavior, surface properties, and ionization constants
    • 2. (tromethamine alt): solubility behavior, surface properties, and ionization constants. J. Pharm. Sci. 62: 1680-1685
    • (1973) J. Pharm. Sci. , vol.62 , pp. 1680-1685
    • Roseman, T.J.1    Yalkowsky, S.H.2
  • 180
    • 0028024646 scopus 로고
    • Regulation of γ-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
    • Roux, F., Durieu-Trautmann, O., Chaverot, N., Claire, M., Mailly, P., Bourre, J. M., Strosberg, A. D., Couraud, P. O. (1994) Regulation of γ-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell. Physiol. 159: 101-113
    • (1994) J. Cell. Physiol. , vol.159 , pp. 101-113
    • Roux, F.1    Durieu-Trautmann, O.2    Chaverot, N.3    Claire, M.4    Mailly, P.5    Bourre, J.M.6    Strosberg, A.D.7    Couraud, P.O.8
  • 181
    • 0027998226 scopus 로고
    • In-vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
    • Sakata, A., Tamai, I., Kawazu, K., Deguchi, Y., Ohnishi, T., Saheki, A., Tsuji, A. (1994) In-vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem. Pharmacol. 48: 1989-1992
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1989-1992
    • Sakata, A.1    Tamai, I.2    Kawazu, K.3    Deguchi, Y.4    Ohnishi, T.5    Saheki, A.6    Tsuji, A.7
  • 183
    • 0026752739 scopus 로고
    • Structure, function, and regulation of cellular tight junctions
    • Schneeberger, E. E., Lynch, R. D. (1992) Structure, function, and regulation of cellular tight junctions. Am. J. Physiol. 262: L647-L661
    • (1992) Am. J. Physiol. , vol.262
    • Schneeberger, E.E.1    Lynch, R.D.2
  • 184
    • 0028149585 scopus 로고
    • Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy and resistance
    • Seydel, J. K., Coats, E. A., Cordes, H. P., Wiese, M. (1994) Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy and resistance. Arch. Pharm. 327: 601-610
    • (1994) Arch. Pharm. , vol.327 , pp. 601-610
    • Seydel, J.K.1    Coats, E.A.2    Cordes, H.P.3    Wiese, M.4
  • 185
    • 0029014330 scopus 로고
    • Rapid determination of logarithmic partition coefficients between n-octanol and water using micellar electrokinetic capillary chromatography
    • Smith, J. T., Vinjamoori, D. V. (1995) Rapid determination of logarithmic partition coefficients between n-octanol and water using micellar electrokinetic capillary chromatography. J. Chromatogr. B 669: 59-66
    • (1995) J. Chromatogr. B , vol.669 , pp. 59-66
    • Smith, J.T.1    Vinjamoori, D.V.2
  • 187
    • 0029025533 scopus 로고
    • Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions
    • Smith, S. W., Anderson, B. D. (1995) Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions. J. Pharm. Sci. 84: 551-556
    • (1995) J. Pharm. Sci. , vol.84 , pp. 551-556
    • Smith, S.W.1    Anderson, B.D.2
  • 188
    • 0011316542 scopus 로고
    • Permeability screen for synthetic peptide combinatorial libraries using Caco-2 cell monolayers and LC/MS/MS
    • Stevenson, C. L., Augustijns, P. F., Hendren, R. W. (1995) Permeability screen for synthetic peptide combinatorial libraries using Caco-2 cell monolayers and LC/MS/MS. Pharm. Res. 12: S-94
    • (1995) Pharm. Res. , vol.12
    • Stevenson, C.L.1    Augustijns, P.F.2    Hendren, R.W.3
  • 189
    • 0031024172 scopus 로고    scopus 로고
    • Discrimination between drug candidates using models for evaluation of intestinal absorption
    • Stewart, B. H., Chan, O. H., Jezyk, N., Fleisher, D. (1997) Discrimination between drug candidates using models for evaluation of intestinal absorption. Adv. Drug Deliv. Rev. 23: 27-45
    • (1997) Adv. Drug Deliv. Rev. , vol.23 , pp. 27-45
    • Stewart, B.H.1    Chan, O.H.2    Jezyk, N.3    Fleisher, D.4
  • 190
    • 0031782048 scopus 로고    scopus 로고
    • Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: Application and significance to drug transport
    • Stewart, B. H., Chung, F. Y., Tait, B., John, C., Chan, O. E. (1998) Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: application and significance to drug transport. Pharm. Res. 15: 1401-1406
    • (1998) Pharm. Res. , vol.15 , pp. 1401-1406
    • Stewart, B.H.1    Chung, F.Y.2    Tait, B.3    John, C.4    Chan, O.E.5
  • 194
    • 0029562420 scopus 로고
    • Proton-cotransport of pravastatin across intestinal brush-border membrane
    • Tamai, I., Takanaga, H., Maeda, H., Ogihara, T., Yoneda, M., Tsuji, A. (1995) Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm. Res. 12: 1727-1732
    • (1995) Pharm. Res. , vol.12 , pp. 1727-1732
    • Tamai, I.1    Takanaga, H.2    Maeda, H.3    Ogihara, T.4    Yoneda, M.5    Tsuji, A.6
  • 195
    • 0031036481 scopus 로고    scopus 로고
    • New design of a flow-through permeation cell for studying in-vitro permeation studies across biological membranes
    • Tanojo, H., Roemelé, P. E. H., van Veen, G. H., Stieltjes, H., Junginger, H. E., Boddé, H. E. (1997) New design of a flow-through permeation cell for studying in-vitro permeation studies across biological membranes. J. Contr. Rel. 45: 41-47
    • (1997) J. Contr. Rel. , vol.45 , pp. 41-47
    • Tanojo, H.1    Roemelé, P.E.H.2    Van Veen, G.H.3    Stieltjes, H.4    Junginger, H.E.5    Boddé, H.E.6
  • 196
    • 0026669192 scopus 로고
    • Functional involvement of P-glycoprotein in blood-brain barrier
    • Tatsuta, T., Naito, M., Ohhara, T., Sugawara, I., Tsuruo, T. (1992) Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267: 20383-20391
    • (1992) J. Biol. Chem. , vol.267 , pp. 20383-20391
    • Tatsuta, T.1    Naito, M.2    Ohhara, T.3    Sugawara, I.4    Tsuruo, T.5
  • 198
    • 85023437012 scopus 로고
    • The hydrogen bonding of drugs: Its experimental determination and role in pharmacokinetics and pharmacodynamics
    • Angeli, P., Gulini, U., Quaglia, W. (eds) Elsevier, Amsterdam
    • Testa, B., El Tayar, N., Altomare, C., Carrupt, P. A., Tsai, R. S., Carotti, A. (1992) The hydrogen bonding of drugs: its experimental determination and role in pharmacokinetics and pharmacodynamics. In: Angeli, P., Gulini, U., Quaglia, W. (eds) Trends in Receptor Research. Elsevier, Amsterdam, pp 61-72
    • (1992) Trends in Receptor Research , pp. 61-72
    • Testa, B.1    El Tayar, N.2    Altomare, C.3    Carrupt, P.A.4    Tsai, R.S.5    Carotti, A.6
  • 199
    • 0030757952 scopus 로고    scopus 로고
    • A systems approach to molecular structure, intermolecular recognition, and emergence-dissolvence in medicinal research
    • Testa, B., Kier, L. B., Carrupt, P. A. (1997) A systems approach to molecular structure, intermolecular recognition, and emergence-dissolvence in medicinal research. Med. Res. Rev. 17: 303-327
    • (1997) Med. Res. Rev. , vol.17 , pp. 303-327
    • Testa, B.1    Kier, L.B.2    Carrupt, P.A.3
  • 200
    • 0017652917 scopus 로고
    • Lipophilicity and brain disposition of clonidine and structurally related imidazolidines
    • Timmermans, P. B. M. W. M., Brands, A., van Zwieten, N. S. (1977) Lipophilicity and brain disposition of clonidine and structurally related imidazolidines. Arch. Pharm. 300: 217-226
    • (1977) Arch. Pharm. , vol.300 , pp. 217-226
    • Timmermans, P.B.M.W.M.1    Brands, A.2    Van Zwieten, N.S.3
  • 201
    • 0025107709 scopus 로고
    • Astrocyte-mediated induction of alkaline phosphatase activity in human umbilical cord vein endothelium: An in-vitro model
    • Tio, S., Deenen, M., Marani, E. (1990) Astrocyte-mediated induction of alkaline phosphatase activity in human umbilical cord vein endothelium: an in-vitro model. Eur. J. Morphol. 28: 289-300
    • (1990) Eur. J. Morphol. , vol.28 , pp. 289-300
    • Tio, S.1    Deenen, M.2    Marani, E.3
  • 202
    • 0003317332 scopus 로고
    • A rapid method for generating pH-solubility profiles for new chemical entities
    • San Diego
    • Todd, D., Winnike, R. A. (1994) A rapid method for generating pH-solubility profiles for new chemical entities. In: Abstr. 9th Ann. Meeting. Am. Assoc. Pharm. Sci, San Diego
    • (1994) Abstr. 9th Ann. Meeting. Am. Assoc. Pharm. Sci
    • Todd, D.1    Winnike, R.A.2
  • 203
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • Tsuji, A., Tamai, I. (1996) Carrier-mediated intestinal transport of drugs. Pharm. Res. 13: 963-977
    • (1996) Pharm. Res. , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 204
    • 0028297760 scopus 로고
    • Local anesthetics destabilize lipid membranes by breaking hydration shell: Infrared and calorimetry studies
    • Ueda, I., Chiou, J. S., Krishna, P. R., Kamaya, H. (1994) Local anesthetics destabilize lipid membranes by breaking hydration shell: infrared and calorimetry studies. Biochim. Biophys. Acta 1190: 421-429
    • (1994) Biochim. Biophys. Acta , vol.1190 , pp. 421-429
    • Ueda, I.1    Chiou, J.S.2    Krishna, P.R.3    Kamaya, H.4
  • 205
    • 0031843610 scopus 로고    scopus 로고
    • Understanding and estimating membrane/water partition coefficients: Approaches to derive quantitative structure property relationships
    • Vaes, W. H. J., Ramos, E. U., Verhaar, H. J. M., Cramer, C. J., Hermens, J. L. M. (1998) Understanding and estimating membrane/water partition coefficients: approaches to derive quantitative structure property relationships. Chem. Res. Toxicol. 11: 847-854
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 847-854
    • Vaes, W.H.J.1    Ramos, E.U.2    Verhaar, H.J.M.3    Cramer, C.J.4    Hermens, J.L.M.5
  • 206
    • 0026802097 scopus 로고
    • Drug transport across the blood-brain barrier. I. Anatomical and physiological aspects
    • van Bree, J. B. M. M., de Boer, A. G., Danhof, M., Breimer, D. D. (1992a) Drug transport across the blood-brain barrier. I. Anatomical and physiological aspects. Pharm. Weekblad Sci. Ed. 14: 305-310
    • (1992) Pharm. Weekblad Sci. Ed. , vol.14 , pp. 305-310
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Danhof, M.3    Breimer, D.D.4
  • 207
    • 0027070478 scopus 로고
    • Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport
    • van Bree, J. B. M. M., de Boer, A. G., Danhof, M., Breimer, D. D. (1992b) Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Pharm. Weekblad Sci. Ed. 14: 338-348
    • (1992) Pharm. Weekblad Sci. Ed. , vol.14 , pp. 338-348
    • Van Bree, J.B.M.M.1    De Boer, A.G.2    Danhof, M.3    Breimer, D.D.4
  • 208
    • 21144467893 scopus 로고
    • Hydrogen-bonding capacity and brain penetration
    • van de Waterbeemd, H., Kansy, M. (1992) Hydrogen-bonding capacity and brain penetration. Chimia 46: 299-303
    • (1992) Chimia , vol.46 , pp. 299-303
    • Van De Waterbeemd, H.1    Kansy, M.2
  • 209
    • 0001938735 scopus 로고
    • The parametrization of lipophilicity and other structural properties in drug design
    • Testa, B. (ed.) Academic Press, London
    • van de Waterbeemd, H., Testa, B. (1987) The parametrization of lipophilicity and other structural properties in drug design. In: Testa, B. (ed.) Advances in Drug Research. Volume 16, Academic Press, London, pp 87-227
    • (1987) Advances in Drug Research , vol.16 , pp. 87-227
    • Van De Waterbeemd, H.1    Testa, B.2
  • 212
    • 0022476714 scopus 로고
    • Permeability of small nonelectrolytes through lipid bilayer membranes
    • Walter, A., Gutknecht, J. (1986) Permeability of small nonelectrolytes through lipid bilayer membranes. J. Membr. Biol. 90: 207-217
    • (1986) J. Membr. Biol. , vol.90 , pp. 207-217
    • Walter, A.1    Gutknecht, J.2
  • 213
    • 0027987065 scopus 로고
    • Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
    • Wils, P., Phung-Ba, V., Warnery, A., Lechardeur, D., Raeissi, S., Hidalgo, I. J., Scherman, D. (1994a) Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem. Pharmacol. 48: 1528-1530
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1528-1530
    • Wils, P.1    Phung-Ba, V.2    Warnery, A.3    Lechardeur, D.4    Raeissi, S.5    Hidalgo, I.J.6    Scherman, D.7
  • 214
    • 0028242843 scopus 로고
    • High lipophilicity decreases drug transport across intestinal epithelial cells
    • Wils, P., Warnery, A., Phung-Ba, V., Legrain, S., Scherman, D. (1994b) High lipophilicity decreases drug transport across intestinal epithelial cells. J. Pharmacol. Exp. Ther. 269: 654-658
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 654-658
    • Wils, P.1    Warnery, A.2    Phung-Ba, V.3    Legrain, S.4    Scherman, D.5
  • 215
    • 0027049617 scopus 로고
    • Rule of desolvation energy in the nonfacilitated membrane permeability of dideoxyribose analogs of thymidine
    • Wright, L. L., Painter, G. R. (1992) Rule of desolvation energy in the nonfacilitated membrane permeability of dideoxyribose analogs of thymidine. Mol. Pharmacol. 41: 957-962
    • (1992) Mol. Pharmacol. , vol.41 , pp. 957-962
    • Wright, L.L.1    Painter, G.R.2
  • 216
    • 0028272183 scopus 로고
    • The relationship between permeant size and permeability in lipid bilayer membranes
    • Xiang, T. X., Anderson, B. D. (1994) The relationship between permeant size and permeability in lipid bilayer membranes. J. Membr. Biol. 140: 111-122
    • (1994) J. Membr. Biol. , vol.140 , pp. 111-122
    • Xiang, T.X.1    Anderson, B.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.