Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 23, 2004, Pages 6107-6118

  Caron, Giulia ^a   Ermondi, Giuseppe ^a   Damiano, Alessandro ^a   Novaroli, Laura ^a   Tsinman, Oksana ^b   Ruell, Jeffrey A ^b   Avdeef, Alex ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b PION INC   (United States)

Author keywords

Anisotropic lipophilicity; ASA descriptors; Intramolecular effects; Isotropic lipophilicity; Molecular dynamics simulation; PAMPA; Permeability

Indexed keywords

AMLODIPINE; CALCIUM ANTAGONIST; NIFEDIPINE; NOVASC;

ARTICLE; CHEMICAL INTERACTION; DRUG PENETRATION; DRUG STRUCTURE; IONIZATION; LIPOPHILICITY; PROTON TRANSPORT; STRUCTURE ANALYSIS;

AMLODIPINE; CALCIUM CHANNEL BLOCKERS; COMPUTER SIMULATION; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; IONS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444246030     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.004     Document Type: Article

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