-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
0030992349
-
A similarity between viral defense and gene silencing in plants
-
Ratcliff F, Harrison BD, Baulcombe DC. A similarity between viral defense and gene silencing in plants. Science 1997; 276: 1558-60.
-
(1997)
Science
, vol.276
, pp. 1558-1560
-
-
Ratcliff, F.1
Harrison, B.D.2
Baulcombe, D.C.3
-
3
-
-
3643145804
-
Initiation and maintenance of virus-induced gene silencing
-
Ruiz MT, Voinnet O, Baulcombe DC. Initiation and maintenance of virus-induced gene silencing. Plant Cell 1998; 10: 937-46.
-
(1998)
Plant Cell
, vol.10
, pp. 937-946
-
-
Ruiz, M.T.1
Voinnet, O.2
Baulcombe, D.C.3
-
4
-
-
0030927776
-
Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA
-
Angell SM, Baulcombe DC. Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA. EMBO J 1997; 16: 3675-84.
-
(1997)
EMBO J
, vol.16
, pp. 3675-3684
-
-
Angell, S.M.1
Baulcombe, D.C.2
-
5
-
-
0026441194
-
Quelling: Transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences
-
Romano N, Macino G. Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol 1992; 22: 3343-53.
-
(1992)
Mol Microbiol
, vol.22
, pp. 3343-3353
-
-
Romano, N.1
Macino, G.2
-
6
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001; 409: 363-6.
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
7
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 2000; 101: 25-33.
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
8
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 2001; 15: 188-200.
-
(2001)
Genes Dev
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
9
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond SM, Bernstein E, Beach D, Hannon GJ An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000; 404: 293-6.
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
10
-
-
0035798415
-
ATP requirements and small interfering RNA structure in the RNA interference pathway
-
Nykanen A, Haley B, Zamore PD. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 2001; 107: 309-21.
-
(2001)
Cell
, vol.107
, pp. 309-321
-
-
Nykanen, A.1
Haley, B.2
Zamore, P.D.3
-
11
-
-
0036752955
-
Evidence that RNAs function as guides, not primers, in the Drosophila and human RNAi pathway
-
Schwarz DS, Hutvagner G, Haley B, Zamore PD. Evidence that RNAs function as guides, not primers, in the Drosophila and human RNAi pathway. Mol Cell 2002; 10: 537-48.
-
(2002)
Mol Cell
, vol.10
, pp. 537-548
-
-
Schwarz, D.S.1
Hutvagner, G.2
Haley, B.3
Zamore, P.D.4
-
12
-
-
0030996469
-
Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation
-
Williams BR. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochem Soc Trans 1997; 25: 509-13.
-
(1997)
Biochem Soc Trans
, vol.25
, pp. 509-513
-
-
Williams, B.R.1
-
13
-
-
0344731406
-
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB
-
Gil J, Alcamf J, Esteban M. Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. Mol Cell Biol 1999; 19: 4653-63.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4653-4663
-
-
Gil, J.1
Alcamf, J.2
Esteban, M.3
-
14
-
-
0034084338
-
Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action
-
Gil J, Esteban M. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action. Apoptosis 2000; 5: 107-14.
-
(2000)
Apoptosis
, vol.5
, pp. 107-114
-
-
Gil, J.1
Esteban, M.2
-
15
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411: 494-8.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
16
-
-
0035859929
-
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
-
Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 2001; 98: 9742-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9742-9747
-
-
Caplen, N.J.1
Parrish, S.2
Imani, F.3
Fire, A.4
Morgan, R.A.5
-
17
-
-
0036847540
-
Ribonuclease activity and RNA binding of recombinant human Dicer
-
Provost P, Dishart D, Doucet J, Frendewey D, Samuelsson B, Rådmark O. Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J 2002; 21: 5864-74.
-
(2002)
EMBO J
, vol.21
, pp. 5864-5874
-
-
Provost, P.1
Dishart, D.2
Doucet, J.3
Frendewey, D.4
Samuelsson, B.5
Rådmark, O.6
-
18
-
-
18744407284
-
Purified Argonaute2 and an siRNA form recombinant human RISC
-
Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol 2005; 12: 340-9.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 340-349
-
-
Rivas, F.V.1
Tolia, N.H.2
Song, J.J.3
Aragon, J.P.4
Liu, J.5
Hannon, G.J.6
Joshua-Tor, L.7
-
19
-
-
0035955361
-
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
-
Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 2001; 294: 858-62.
-
(2001)
Science
, vol.294
, pp. 858-862
-
-
Lau, N.C.1
Lim, L.P.2
Weinstein, E.G.3
Bartel, D.P.4
-
20
-
-
0035955374
-
Identification of novel genes coding for small expressed RNAs
-
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001; 294: 853-8.
-
(2001)
Science
, vol.294
, pp. 853-858
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Lendeckel, W.3
Tuschl, T.4
-
21
-
-
0035955366
-
An extensive class of small RNAs in Caenorhabditis elegans
-
Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001; 294: 862-4.
-
(2001)
Science
, vol.294
, pp. 862-864
-
-
Lee, R.C.1
Ambros, V.2
-
22
-
-
0142173075
-
Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
-
Saxena S, Jónsson ZO, Dutta A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem 2003; 278: 44312-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 44312-44319
-
-
Saxena, S.1
Jónsson, Z.O.2
Dutta, A.3
-
23
-
-
0041691111
-
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
-
Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA 2003; 100: 9779-84.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9779-9784
-
-
Zeng, Y.1
Yi, R.2
Cullen, B.R.3
-
24
-
-
0034597777
-
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
-
Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000; 408: 86-9.
-
(2000)
Nature
, vol.408
, pp. 86-89
-
-
Pasquinelli, A.E.1
Reinhart, B.J.2
Slack, F.3
Martindale, M.Q.4
Kuroda, M.I.5
Maller, B.6
-
25
-
-
0034708122
-
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
-
Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403: 901-06.
-
(2000)
Nature
, vol.403
, pp. 901-906
-
-
Reinhart, B.J.1
Slack, F.J.2
Basson, M.3
Pasquinelli, A.E.4
Bettinger, J.C.5
Rougvie, A.E.6
-
26
-
-
0037418839
-
Bantamencodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hidin Drosophila
-
Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. Bantamencodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hidin Drosophila. Cell 2003; 113: 25-36.
-
(2003)
Cell
, vol.113
, pp. 25-36
-
-
Brennecke, J.1
Hipfner, D.R.2
Stark, A.3
Russell, R.B.4
Cohen, S.M.5
-
27
-
-
0037694970
-
The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism
-
Xu P, Vernooy SY, Guo M, Hay BA. The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol 2003; 13: 790-5.
-
(2003)
Curr Biol
, vol.13
, pp. 790-795
-
-
Xu, P.1
Vernooy, S.Y.2
Guo, M.3
Hay, B.A.4
-
28
-
-
0346727524
-
MicroRNAs modulate hematopoietic lineage differentiation
-
Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303: 83-6.
-
(2004)
Science
, vol.303
, pp. 83-86
-
-
Chen, C.Z.1
Li, L.2
Lodish, H.F.3
Bartel, D.P.4
-
29
-
-
0035800521
-
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
-
Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2000; 293: 834-8.
-
(2000)
Science
, vol.293
, pp. 834-838
-
-
Hutvágner, G.1
McLachlan, J.2
Pasquinelli, A.E.3
Bálint, E.4
Tuschl, T.5
Zamore, P.D.6
-
31
-
-
38149071979
-
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
-
Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC. Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res 2007; 12: 1850-64.
-
(2007)
Genome Res
, vol.12
, pp. 1850-1864
-
-
Ruby, J.G.1
Stark, A.2
Johnston, W.K.3
Kellis, M.4
Bartel, D.P.5
Lai, E.C.6
-
32
-
-
0038054470
-
Computational and experimental identification of C. elegans microRNAs
-
Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol Cell 2003; 11: 1253-63.
-
(2003)
Mol Cell
, vol.11
, pp. 1253-1263
-
-
Grad, Y.1
Aach, J.2
Hayes, G.D.3
Reinhart, B.J.4
Church, G.M.5
Ruvkun, G.6
Kim, J.7
-
33
-
-
38549150275
-
-
Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. miRBase: tools for microRNA genomics. Nucleic Acids Res 2008; 36(Database issue): D154-D158.
-
Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. miRBase: tools for microRNA genomics. Nucleic Acids Res 2008; 36(Database issue): D154-D158.
-
-
-
-
34
-
-
27344456287
-
microRNA target predictions across seven Drosophila species and comparison to mammalian targets
-
Grun D, Wang YL, Langenberger D, Gunsalus KC, Rajewsky N. microRNA target predictions across seven Drosophila species and comparison to mammalian targets. PLoS Comput Biol 2005; 1: e13.
-
(2005)
PLoS Comput Biol
, vol.1
-
-
Grun, D.1
Wang, Y.L.2
Langenberger, D.3
Gunsalus, K.C.4
Rajewsky, N.5
-
35
-
-
33744520104
-
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
-
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125: 887-901.
-
(2006)
Cell
, vol.125
, pp. 887-901
-
-
Han, J.1
Lee, Y.2
Yeom, K.H.3
Nam, J.W.4
Heo, I.5
Rhee, J.K.6
-
36
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415-9.
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
Ahn, C.2
Han, J.3
Choi, H.4
Kim, J.5
Yim, J.6
-
37
-
-
33744520104
-
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
-
Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125: 887-901.
-
(2006)
Cell
, vol.125
, pp. 887-901
-
-
Han, J.1
Lee, Y.2
Yeom, K.H.3
Nam, J.W.4
Heo, I.5
Rhee, J.K.6
-
38
-
-
0033572284
-
The lin-4 regulatory RNA controls developmental timing in C. elegans by blocking LIN-14 protein synthesis after the initiation of translation
-
Olsen PH, Ambros V. The lin-4 regulatory RNA controls developmental timing in C. elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol 1999; 2: 671-80.
-
(1999)
Dev Biol
, vol.2
, pp. 671-680
-
-
Olsen, P.H.1
Ambros, V.2
-
39
-
-
1642499415
-
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
-
Bohnsack MT, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004; 10: 185-91.
-
(2004)
RNA
, vol.10
, pp. 185-191
-
-
Bohnsack, M.T.1
Czaplinski, K.2
Gorlich, D.3
-
40
-
-
0346094457
-
Prediction of mammalian microRNA targets
-
Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003; 115: 787-98.
-
(2003)
Cell
, vol.115
, pp. 787-798
-
-
Lewis, B.P.1
Shih, I.H.2
Jones-Rhoades, M.W.3
Bartel, D.P.4
Burge, C.B.5
-
41
-
-
1642374097
-
Specificity of microRNA target selection in translational repression
-
Doench JG, Sharp PA Specificity of microRNA target selection in translational repression. Genes Dev 2004; 18: 504-11.
-
(2004)
Genes Dev
, vol.18
, pp. 504-511
-
-
Doench, J.G.1
Sharp, P.A.2
-
42
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
-
(2005)
Cell
, vol.120
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
43
-
-
33646522366
-
Recapitulation on Short RNA-Directed Translation Gene Silencing In Vitro
-
Wang B, Love TM, Call ME, Doench JG, Novina CD. Recapitulation on Short RNA-Directed Translation Gene Silencing In Vitro. Mol Cell 2006; 22: 553-60.
-
(2006)
Mol Cell
, vol.22
, pp. 553-560
-
-
Wang, B.1
Love, T.M.2
Call, M.E.3
Doench, J.G.4
Novina, C.D.5
-
44
-
-
24644480213
-
Inhibition of translational initiation by Let-7 MicroRNA in human cells
-
Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, et al. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 2005; 309: 1573-6.
-
(2005)
Science
, vol.309
, pp. 1573-1576
-
-
Pillai, R.S.1
Bhattacharyya, S.N.2
Artus, C.G.3
Zoller, T.4
Cougot, N.5
Basyuk, E.6
-
45
-
-
28044457883
-
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function
-
Humphreys DT, Westman BJ, Martin DI, Preiss T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci USA 2005; 102: 16961-6.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16961-16966
-
-
Humphreys, D.T.1
Westman, B.J.2
Martin, D.I.3
Preiss, T.4
-
46
-
-
23944514849
-
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
-
Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, Pasquinelli AE. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 2005; 122: 553-63.
-
(2005)
Cell
, vol.122
, pp. 553-563
-
-
Bagga, S.1
Bracht, J.2
Hunter, S.3
Massirer, K.4
Holtz, J.5
Eachus, R.6
Pasquinelli, A.E.7
-
48
-
-
44449164346
-
MicroRNA-repressed mRNAs contain 40S but not 60S components
-
Wang B, Yanez A, Novina CD. MicroRNA-repressed mRNAs contain 40S but not 60S components. Proc Natl Acad Sci 2008; 105: 5343-8.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 5343-5348
-
-
Wang, B.1
Yanez, A.2
Novina, C.D.3
-
49
-
-
22144478256
-
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
-
Liu J, et al. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biol 2005; 7: 719-23.
-
(2005)
Nature Cell Biol
, vol.7
, pp. 719-723
-
-
Liu, J.1
-
50
-
-
60149088848
-
Origins and Mechanisms of miRNAs and siRNAs
-
Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-55.
-
(2009)
Cell
, vol.136
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
51
-
-
34447107760
-
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila
-
Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 2007; 130(1): 89-100.
-
(2007)
Cell
, vol.130
, Issue.1
, pp. 89-100
-
-
Okamura, K.1
Hagen, J.W.2
Duan, H.3
Tyler, D.M.4
Lai, E.C.5
-
52
-
-
34447097693
-
Intronic microRNA precursors that bypass Drosha processing
-
Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing. Nature 2007; 448(7149): 83-6
-
(2007)
Nature
, vol.448
, Issue.7149
, pp. 83-86
-
-
Ruby, J.G.1
Jan, C.H.2
Bartel, D.P.3
-
53
-
-
54349104464
-
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
-
Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev 2008; 22: 2773-85.
-
(2008)
Genes Dev
, vol.22
, pp. 2773-2785
-
-
Babiarz, J.E.1
Ruby, J.G.2
Wang, Y.3
Bartel, D.P.4
Blelloch, R.5
-
54
-
-
44349084754
-
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs
-
Okamura K, Chung WJ, Ruby JG, Guo H, Bartel DP, Lai EC. The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature 2008; 453: 803-06.
-
(2008)
Nature
, vol.453
, pp. 803-806
-
-
Okamura, K.1
Chung, W.J.2
Ruby, J.G.3
Guo, H.4
Bartel, D.P.5
Lai, E.C.6
-
55
-
-
44349130233
-
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
-
Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, et al. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 2008; 453: 539-43.
-
(2008)
Nature
, vol.453
, pp. 539-543
-
-
Watanabe, T.1
Totoki, Y.2
Toyoda, A.3
Kaneda, M.4
Kuramochi-Miyagawa, S.5
Obata, Y.6
-
56
-
-
3242877996
-
Sfold web server for statistical folding and rational design of nucleic acids
-
Ding Y, Chan CY, Lawrence CE. Sfold web server for statistical folding and rational design of nucleic acids. Nucleic Acids Res 2004; 32. W135-W141.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Ding, Y.1
Chan, C.Y.2
Lawrence, C.E.3
-
57
-
-
17444368334
-
Highly specific and accurate selection of siRNAs for high-throughput functional assays
-
Santoyo J, Vaquerizas JM, Dopazo J. Highly specific and accurate selection of siRNAs for high-throughput functional assays. Bioinformatics 2005; 21: 1376-82.
-
(2005)
Bioinformatics
, vol.21
, pp. 1376-1382
-
-
Santoyo, J.1
Vaquerizas, J.M.2
Dopazo, J.3
-
58
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds A, et al. Rational siRNA design for RNA interference. Nat Biotechnol 2004; 22: 326-30.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
-
59
-
-
23444437819
-
Design of a genome-wide siRNA library using an artificial neural network
-
Huesken D, et al. Design of a genome-wide siRNA library using an artificial neural network. Nat Biotechnol 2005; 23: 995-1001.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 995-1001
-
-
Huesken, D.1
-
60
-
-
33748701701
-
Computational models with thermodynamic and composition features improve siRNA design
-
Shabalina SA, Spiridonov AN, Ogurtsov AY. Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics 2006; 7: 65-81.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 65-81
-
-
Shabalina, S.A.1
Spiridonov, A.N.2
Ogurtsov, A.Y.3
-
61
-
-
3542992506
-
An effective method for selecting siRNA target sequences in mammalian cells
-
Takasaki S, Kotani S, Konagaya A. An effective method for selecting siRNA target sequences in mammalian cells. Cell Cycle 2004; 3: 790-5.
-
(2004)
Cell Cycle
, vol.3
, pp. 790-795
-
-
Takasaki, S.1
Kotani, S.2
Konagaya, A.3
-
62
-
-
1642273831
-
An algorithm for selection of functional siRNA sequences
-
Amarzguioui M, Prydz H. An algorithm for selection of functional siRNA sequences. Biochem Biophys Res Commun 2004; 316: 1050-8.
-
(2004)
Biochem Biophys Res Commun
, vol.316
, pp. 1050-1058
-
-
Amarzguioui, M.1
Prydz, H.2
-
63
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge AD, et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol 2005; 23: 457-62.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
-
64
-
-
20144389695
-
Sequence-specific potent induction of interferon-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung V, et al. Sequence-specific potent induction of interferon-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 2005; 11: 263-70.
-
(2005)
Nat Med
, vol.11
, pp. 263-270
-
-
Hornung, V.1
-
65
-
-
0038606999
-
Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells
-
Czauderna F, et al. Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res 2003; 31: 2705-16.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 2705-2716
-
-
Czauderna, F.1
-
66
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey DV, et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnol 2005; 23: 1002-7.
-
(2005)
Nature Biotechnol
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
-
67
-
-
0037069417
-
Retroviral delivery of small interfering RNA into primary cells
-
Barton GM, Medzhitov R. Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci USA 2002; 99: 14943-5.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14943-14945
-
-
Barton, G.M.1
Medzhitov, R.2
-
69
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-7.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Blömer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
-
70
-
-
0025279872
-
Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
-
Miller DG, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 1990; 10: 4239-42.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 4239-4242
-
-
Miller, D.G.1
Adam, M.A.2
Miller, A.D.3
-
71
-
-
39149084389
-
Silencing of mammalian genes by tetracycline-inducible shRNA expression
-
Kappel S, Mattess Y, Kaufman M, Strebhardt K. Silencing of mammalian genes by tetracycline-inducible shRNA expression. Nature Protocols 2007; 2: 3257-60.
-
(2007)
Nature Protocols
, vol.2
, pp. 3257-3260
-
-
Kappel, S.1
Mattess, Y.2
Kaufman, M.3
Strebhardt, K.4
-
72
-
-
33747778686
-
Tuning silence: Conditional systems for RNA interference
-
Wiznerowicz M, Szulc J, Trono D. Tuning silence: conditional systems for RNA interference. Nat Methods 2006; 3: 682-8.
-
(2006)
Nat Methods
, vol.3
, pp. 682-688
-
-
Wiznerowicz, M.1
Szulc, J.2
Trono, D.3
-
73
-
-
13444262170
-
Inhibition of respiratory viruses by nasally administered siRNA
-
Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005; 11: 50-5.
-
(2005)
Nat Med
, vol.11
, pp. 50-55
-
-
Bitko, V.1
Musiyenko, A.2
Shulyayeva, O.3
Barik, S.4
-
74
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 2006; 439: 89-94.
-
(2006)
Nature
, vol.439
, pp. 89-94
-
-
Palliser, D.1
Chowdhury, D.2
Wang, Q.Y.3
Lee, S.J.4
Bronson, R.T.5
Knipe, D.M.6
Lieberman, J.7
-
75
-
-
31444440290
-
Suppression of ocular neovascularization with siRNA targeting VEGF receptor
-
Shen J, et al. Suppression of ocular neovascularization with siRNA targeting VEGF receptor. Gene Ther 2006; 13: 225-34.
-
(2006)
Gene Ther
, vol.13
, pp. 225-234
-
-
Shen, J.1
-
76
-
-
1242297011
-
Intravitreal injection of VEGF small interfering RNA inhibits growth and leakage in a nonhuman primate laser-induced model of chroidal neovascularization
-
Tolentino MJ, et al. Intravitreal injection of VEGF small interfering RNA inhibits growth and leakage in a nonhuman primate laser-induced model of chroidal neovascularization. Retina 2004; 24: 132-8.
-
(2004)
Retina
, vol.24
, pp. 132-138
-
-
Tolentino, M.J.1
-
77
-
-
17644383664
-
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
-
Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, et al. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 2005; 11: 423-8.
-
(2005)
Nat Med
, vol.11
, pp. 423-428
-
-
Raoul, C.1
Abbas-Terki, T.2
Bensadoun, J.C.3
Guillot, S.4
Haase, G.5
Szulc, J.6
-
78
-
-
4043057946
-
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia
-
Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, et al. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med 2004; 10: 816-20.
-
(2004)
Nat Med
, vol.10
, pp. 816-820
-
-
Xia, H.1
Mao, Q.2
Eliason, S.L.3
Harper, S.Q.4
Martins, I.H.5
Orr, H.T.6
-
79
-
-
23044506285
-
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
-
Landen CN Jr, Chavez-Reyes A, Bucana C, Schmandt R, Deavers MT, Lopez-Berestein G, Sood AK. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 2005; 65: 6910-8.
-
(2005)
Cancer Res
, vol.65
, pp. 6910-6918
-
-
Landen Jr, C.N.1
Chavez-Reyes, A.2
Bucana, C.3
Schmandt, R.4
Deavers, M.T.5
Lopez-Berestein, G.6
Sood, A.K.7
-
80
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLIl by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLIl by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005; 65: 8984-92.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
81
-
-
49549117077
-
T Cell-Specific siRNA Delivery suppresses HIV-1 Infection in Humanized Mice
-
Kumar P, et al. T Cell-Specific siRNA Delivery suppresses HIV-1 Infection in Humanized Mice. Cell 2009; 134: 577-86.
-
(2009)
Cell
, vol.134
, pp. 577-586
-
-
Kumar, P.1
-
82
-
-
34548108038
-
2′-O-Methyl-modified RNAs act as TLR7 anatgonist
-
Robbins M, et al. 2′-O-Methyl-modified RNAs act as TLR7 anatgonist. Mol Ther 2007; 15: 1663-9.
-
(2007)
Mol Ther
, vol.15
, pp. 1663-1669
-
-
Robbins, M.1
-
83
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grim D, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006; 441: 537-41.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grim, D.1
-
84
-
-
33748438866
-
Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors
-
An DS, et al. Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther 2006; 14: 494-505.
-
(2006)
Mol Ther
, vol.14
, pp. 494-505
-
-
An, D.S.1
-
85
-
-
13444262170
-
Inhibition of respiratory viruses by nasally administered siRNA
-
Bitko V, et al. Inhibition of respiratory viruses by nasally administered siRNA. Nature Med 2005; 11: 50-5.
-
(2005)
Nature Med
, vol.11
, pp. 50-55
-
-
Bitko, V.1
-
86
-
-
9144247189
-
Therapeutic silencing o fan endogenous gene by systemic administration of modified siRNAs
-
Soutschek J, et al. Therapeutic silencing o fan endogenous gene by systemic administration of modified siRNAs. Nature 2004; 432: 173-8.
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
87
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, et al. RNAi-mediated gene silencing in non-human primates. Nature 2006; 441: 111-14.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
-
88
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastactic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastactic Ewing's sarcoma. Cancer Res 2005; 65: 8984-92.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
89
-
-
23844474160
-
Antibody mediated in vivo delivery of siRNA via cell-surface receptors
-
Song E, et al. Antibody mediated in vivo delivery of siRNA via cell-surface receptors. Nature Biotechnol 2005; 23: 709-17.
-
(2005)
Nature Biotechnol
, vol.23
, pp. 709-717
-
-
Song, E.1
-
90
-
-
33747031960
-
Cell type-specific delivery of siRNA with aptamer-siRNA chimeras
-
McNamara JO, et al. Cell type-specific delivery of siRNA with aptamer-siRNA chimeras. Nature Biotechnol 2006; 24: 1005-15.
-
(2006)
Nature Biotechnol
, vol.24
, pp. 1005-1015
-
-
McNamara, J.O.1
-
91
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, non-viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005; 65: 8984-92.
-
(2005)
Cancer Res
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
92
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002; 2: 243-7.
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
93
-
-
34248146697
-
High-capacity adenoviral vector-mediated reduction of Huntington aggregate load in vitro and in vivo
-
Huang B, Schiefer J, Sass C, Landwehrmeyer GB, Kosinski CM, Kochanek S. High-capacity adenoviral vector-mediated reduction of Huntington aggregate load in vitro and in vivo. Hum Gene Ther 2007; 18: 303-11.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 303-311
-
-
Huang, B.1
Schiefer, J.2
Sass, C.3
Landwehrmeyer, G.B.4
Kosinski, C.M.5
Kochanek, S.6
|