-
1
-
-
33751160381
-
Nef interference with HIV-1-specific CTL antiviral activity is epitope specific
-
Adnan S, Balamurugan A, Trocha A et al (2006) Nef interference with HIV-1-specific CTL antiviral activity is epitope specific. Blood 108:3414-3419
-
(2006)
Blood
, vol.108
, pp. 3414-3419
-
-
Adnan, S.1
Balamurugan, A.2
Trocha, A.3
-
2
-
-
33644778761
-
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2
-
Agopian K, Wei BL, Garcia JV et al (2006) A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol 80:3050-3061
-
(2006)
J Virol
, vol.80
, pp. 3050-3061
-
-
Agopian, K.1
Wei, B.L.2
Garcia, J.V.3
-
3
-
-
0029015330
-
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis
-
Aiken C, Trono D (1995) Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol 69:5048-5056
-
(1995)
J Virol
, vol.69
, pp. 5048-5056
-
-
Aiken, C.1
Trono, D.2
-
4
-
-
0028180868
-
Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
-
Aiken C, Konner J, Landau NR et al (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864
-
(1994)
Cell
, vol.76
, pp. 853-864
-
-
Aiken, C.1
Konner, J.2
Landau, N.R.3
-
5
-
-
0034001233
-
Nef-induced major histocompatibility complex class i down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
-
Akari H, Arold S, Fukumori T et al (2000) Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation. J Virol 74:2907-2912
-
(2000)
J Virol
, vol.74
, pp. 2907-2912
-
-
Akari, H.1
Arold, S.2
Fukumori, T.3
-
6
-
-
0034537667
-
T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: A possible mechanism of HIV T-tropic emergence in AIDS
-
Alessandrini L, Santarcangelo AC, Olivetta E et al (2000) T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS. J Gen Virol 81:2905-2917
-
(2000)
J Gen Virol
, vol.81
, pp. 2905-2917
-
-
Alessandrini, L.1
Santarcangelo, A.C.2
Olivetta, E.3
-
7
-
-
0035175924
-
HIV: Master of the host cell
-
Reviews1030
-
Arendt CW, Littman DR (2001) HIV: master of the host cell. Genome Biol 2:Reviews1030
-
(2001)
Genome Biol
, vol.2
-
-
Arendt, C.W.1
Littman, D.R.2
-
8
-
-
0141780822
-
Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
-
Arganaraz ER, Schindler M, Kirchhoff F et al (2003) Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem 278:33912-33919
-
(2003)
J Biol Chem
, vol.278
, pp. 33912-33919
-
-
Arganaraz, E.R.1
Schindler, M.2
Kirchhoff, F.3
-
9
-
-
44649173294
-
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class i (MHC-I) down-regulation: Analysis using short interfering RNA and knock-out mice
-
Atkins KM, Thomas L, Youker RT et al (2008) HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J Biol Chem 283:11772-11784
-
(2008)
J Biol Chem
, vol.283
, pp. 11772-11784
-
-
Atkins, K.M.1
Thomas, L.2
Youker, R.T.3
-
10
-
-
0030887932
-
The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
-
Baur AS, Sass G, Laffert B et al (1997) The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6:283-291
-
(1997)
Immunity
, vol.6
, pp. 283-291
-
-
Baur, A.S.1
Sass, G.2
Laffert, B.3
-
11
-
-
0028485232
-
HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
-
Baur AS, Sawai ET, Dazin P et al (1994) HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1:373-384
-
(1994)
Immunity
, vol.1
, pp. 373-384
-
-
Baur, A.S.1
Sawai, E.T.2
Dazin, P.3
-
12
-
-
0035946302
-
Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef
-
Bell I, Schaefer TM, Trible RP et al (2001) Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef. Virology 283:148-158
-
(2001)
Virology
, vol.283
, pp. 148-158
-
-
Bell, I.1
Schaefer, T.M.2
Trible, R.P.3
-
13
-
-
0031791917
-
Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation
-
Bell I, Ashman C, Maughan J et al (1998) Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation. J Gen Virol 79:2717-2727
-
(1998)
J Gen Virol
, vol.79
, pp. 2717-2727
-
-
Bell, I.1
Ashman, C.2
Maughan, J.3
-
14
-
-
0027158904
-
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
-
Benson RE, Sanfridson A, Ottinger JS et al (1993) Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J Exp Med 177:1561-1566
-
(1993)
J Exp Med
, vol.177
, pp. 1561-1566
-
-
Benson, R.E.1
Sanfridson, A.2
Ottinger, J.S.3
-
15
-
-
0029966857
-
The MHC class II-associated invariant chain: A molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells
-
Bertolino P, Rabourdin-Combe C (1996) The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells. Crit Rev Immunol 16:359-379
-
(1996)
Crit Rev Immunol
, vol.16
, pp. 359-379
-
-
Bertolino, P.1
Rabourdin-Combe, C.2
-
16
-
-
0037074008
-
HIV-1 Nef downregulates MHC-I by a PACS-1-and PI3K-regulated ARF6 endocytic pathway
-
Blagoveshchenskaya AD, Thomas L, Feliciangeli SF et al (2002) HIV-1 Nef downregulates MHC-I by a PACS-1-and PI3K-regulated ARF6 endocytic pathway. Cell 111:853-866
-
(2002)
Cell
, vol.111
, pp. 853-866
-
-
Blagoveshchenskaya, A.D.1
Thomas, L.2
Feliciangeli, S.F.3
-
17
-
-
0037423824
-
Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes
-
Bonaparte MI, Barker E (2003) Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes. AIDS 17:487-494
-
(2003)
AIDS
, vol.17
, pp. 487-494
-
-
Bonaparte, M.I.1
Barker, E.2
-
18
-
-
4644279778
-
Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class i molecules
-
Bonaparte MI, Barker E (2004) Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. Blood 104:2087-2094
-
(2004)
Blood
, vol.104
, pp. 2087-2094
-
-
Bonaparte, M.I.1
Barker, E.2
-
19
-
-
33845532053
-
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
-
Brenchley JM, Price DA, Schacker TW et al (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12:1365-1371
-
(2006)
Nat Med
, vol.12
, pp. 1365-1371
-
-
Brenchley, J.M.1
Price, D.A.2
Schacker, T.W.3
-
20
-
-
33646167689
-
Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques
-
Brenner M, Munch J, Schindler M et al (2006) Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. J Virol 80:4469-4481
-
(2006)
J Virol
, vol.80
, pp. 4469-4481
-
-
Brenner, M.1
Munch, J.2
Schindler, M.3
-
21
-
-
0033568211
-
Cutting edge: SIV Nef protein utilizes both leucine-and tyrosine-based protein sorting pathways for down-regulation of CD4
-
Bresnahan PA, Yonemoto W, Greene WC (1999) Cutting edge: SIV Nef protein utilizes both leucine-and tyrosine-based protein sorting pathways for down-regulation of CD4. J Immunol 163:2977-2981
-
(1999)
J Immunol
, vol.163
, pp. 2977-2981
-
-
Bresnahan, P.A.1
Yonemoto, W.2
Greene, W.C.3
-
22
-
-
2442707757
-
Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity
-
Campbell EM, Nunez R, Hope TJ (2004) Disruption of the actin cytoskeleton can complement the ability of Nef to enhance human immunodeficiency virus type 1 infectivity. J Virol 78:5745-5755
-
(2004)
J Virol
, vol.78
, pp. 5745-5755
-
-
Campbell, E.M.1
Nunez, R.2
Hope, T.J.3
-
23
-
-
0035082266
-
Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS
-
Carl S, Greenough TC, Krumbiegel M et al (2001) Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol 75:3657-3665
-
(2001)
J Virol
, vol.75
, pp. 3657-3665
-
-
Carl, S.1
Greenough, T.C.2
Krumbiegel, M.3
-
24
-
-
0142060865
-
CD4 and major histocompatibility complex class i downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression
-
Casartelli N, Di MG, Potesta M et al (2003) CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression. J Virol 77:11536-11545
-
(2003)
J Virol
, vol.77
, pp. 11536-11545
-
-
Casartelli, N.1
Di, M.G.2
Potesta, M.3
-
25
-
-
4544240500
-
HIV-1 virion fusion assay: Uncoating not required and no effect of Nef on fusion
-
Cavrois M, Neidleman J, Yonemoto W et al (2004) HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 328:36-44
-
(2004)
Virology
, vol.328
, pp. 36-44
-
-
Cavrois, M.1
Neidleman, J.2
Yonemoto, W.3
-
26
-
-
53849098555
-
HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi
-
Chaudhry A, Das SR, Jameel S et al (2008) HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi. Traffic 9:1925-1935
-
(2008)
Traffic
, vol.9
, pp. 1925-1935
-
-
Chaudhry, A.1
Das, S.R.2
Jameel, S.3
-
27
-
-
33947715044
-
A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86
-
Chaudhry A, Das SR, Jameel S et al (2007) A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86. Cell Host Microbe 1:37-49
-
(2007)
Cell Host Microbe
, vol.1
, pp. 37-49
-
-
Chaudhry, A.1
Das, S.R.2
Jameel, S.3
-
28
-
-
25444510358
-
The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs
-
Chaudhry A, Das SR, Hussain A et al (2005) The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol 175:4566-4574
-
(2005)
J Immunol
, vol.175
, pp. 4566-4574
-
-
Chaudhry, A.1
Das, S.R.2
Hussain, A.3
-
29
-
-
0035088135
-
Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity
-
Chazal N, Singer G, Aiken C et al (2001) Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity. J Virol 75:4014-4018
-
(2001)
J Virol
, vol.75
, pp. 4014-4018
-
-
Chazal, N.1
Singer, G.2
Aiken, C.3
-
30
-
-
0031901558
-
The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
-
Chen YL, Trono D, Camaur D (1998) The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity. J Virol 72:3178-3184
-
(1998)
J Virol
, vol.72
, pp. 3178-3184
-
-
Chen, Y.L.1
Trono, D.2
Camaur, D.3
-
32
-
-
0028820530
-
The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
-
Chowers MY, Pandori MW, Spina CA et al (1995) The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 212:451-457
-
(1995)
Virology
, vol.212
, pp. 451-457
-
-
Chowers, M.Y.1
Pandori, M.W.2
Spina, C.A.3
-
33
-
-
0028302998
-
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
-
Chowers MY, Spina CA, Kwoh TJ et al (1994) Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J Virol 68:2906-2914
-
(1994)
J Virol
, vol.68
, pp. 2906-2914
-
-
Chowers, M.Y.1
Spina, C.A.2
Kwoh, T.J.3
-
34
-
-
2942555187
-
A novel role for p21-activated protein kinase 2 in T cell activation
-
Chu PC, Wu J, Liao XC et al (2004) A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol 172:7324-7334
-
(2004)
J Immunol
, vol.172
, pp. 7324-7334
-
-
Chu, P.C.1
Wu, J.2
Liao, X.C.3
-
35
-
-
0033151621
-
The selective downregulation of class i major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
-
Cohen GB, Gandhi RT, Davis DM et al (1999) The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10:661-671
-
(1999)
Immunity
, vol.10
, pp. 661-671
-
-
Cohen, G.B.1
Gandhi, R.T.2
Davis, D.M.3
-
36
-
-
0029962938
-
Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects
-
Collette Y, Dutartre H, Benziane A et al (1996) Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects. J Biol Chem 271:6333-6341
-
(1996)
J Biol Chem
, vol.271
, pp. 6333-6341
-
-
Collette, Y.1
Dutartre, H.2
Benziane, A.3
-
37
-
-
0032556872
-
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
-
Collins KL, Chen BK, Kalams SA et al (1998) HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397-401
-
(1998)
Nature
, vol.391
, pp. 397-401
-
-
Collins, K.L.1
Chen, B.K.2
Kalams, S.A.3
-
38
-
-
0037127303
-
Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells
-
Cortes MJ, Wong-Staal F, Lama J (2002) Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J Biol Chem 277:1770-1779
-
(2002)
J Biol Chem
, vol.277
, pp. 1770-1779
-
-
Cortes, M.J.1
Wong-Staal, F.2
Lama, J.3
-
39
-
-
0032530773
-
Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
-
Craig HM, Pandori MW, Guatelli JC (1998) Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci \USA 95:11229-11234
-
(1998)
Proc Natl Acad Sci \USA
, vol.95
, pp. 11229-11234
-
-
Craig, H.M.1
Pandori, M.W.2
Guatelli, J.C.3
-
40
-
-
0033199655
-
P21-activated protein kinase: A crucial component of morphological signaling?
-
Daniels RH, Bokoch GM (1999) p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem Sci 24:350-355
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 350-355
-
-
Daniels, R.H.1
Bokoch, G.M.2
-
41
-
-
0028804160
-
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
-
Deacon NJ, Tsykin A, Solomon A et al (1995) Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270:988-991
-
(1995)
Science
, vol.270
, pp. 988-991
-
-
Deacon, N.J.1
Tsykin, A.2
Solomon, A.3
-
42
-
-
15844419153
-
Identification of a major co-receptor for primary isolates of HIV-1
-
Deng H, Liu R, Ellmeier W et al (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666
-
(1996)
Nature
, vol.381
, pp. 661-666
-
-
Deng, H.1
Liu, R.2
Ellmeier, W.3
-
43
-
-
2642557101
-
HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion
-
Djordjevic JT, Schibeci SD, Stewart GJ et al (2004) HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion. AIDS Res Hum Retroviruses 20:547-555
-
(2004)
AIDS Res Hum Retroviruses
, vol.20
, pp. 547-555
-
-
Djordjevic, J.T.1
Schibeci, S.D.2
Stewart, G.J.3
-
44
-
-
0029089406
-
Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys
-
Du Z, Lang SM, Sasseville VG et al (1995) Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665-674
-
(1995)
Cell
, vol.82
, pp. 665-674
-
-
Du, Z.1
Lang, S.M.2
Sasseville, V.G.3
-
45
-
-
21244444628
-
AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes
-
Dugast M, Toussaint H, Dousset C et al (2005) AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes. J Biol Chem 280:19656-19664
-
(2005)
J Biol Chem
, vol.280
, pp. 19656-19664
-
-
Dugast, M.1
Toussaint, H.2
Dousset, C.3
-
46
-
-
0032888972
-
Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1
-
Dyer WB, Ogg GS, Demoitie MA et al (1999) Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1. J Virol 73:436-443
-
(1999)
J Virol
, vol.73
, pp. 436-443
-
-
Dyer, W.B.1
Ogg, G.S.2
Demoitie, M.A.3
-
47
-
-
33947591273
-
Modulation of the immunological synapse: A key to HIV-1 pathogenesis?
-
Fackler OT, Alcover A, Schwartz O (2007) Modulation of the immunological synapse: a key to HIV-1 pathogenesis? Nat Rev Immunol 7:310-317
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 310-317
-
-
Fackler, O.T.1
Alcover, A.2
Schwartz, O.3
-
48
-
-
0036230879
-
Live and let die: Nef functions beyond HIV replication
-
Fackler OT, Baur AS (2002) Live and let die: Nef functions beyond HIV replication. Immunity 16:493-497
-
(2002)
Immunity
, vol.16
, pp. 493-497
-
-
Fackler, O.T.1
Baur, A.S.2
-
49
-
-
0034064726
-
P21-activated kinase 1 plays a critical role in cellular activation by Nef
-
Fackler OT, Lu X, Frost JA et al (2000) p21-activated kinase 1 plays a critical role in cellular activation by Nef. Mol Cell Biol 20:2619-2627
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2619-2627
-
-
Fackler, O.T.1
Lu, X.2
Frost, J.A.3
-
50
-
-
0033153464
-
Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
-
Fackler OT, Luo W, Geyer M et al (1999) Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 3:729-739
-
(1999)
Mol Cell
, vol.3
, pp. 729-739
-
-
Fackler, O.T.1
Luo, W.2
Geyer, M.3
-
51
-
-
34548134145
-
A whole-genome association study of major determinants for host control of HIV-1
-
Fellay J, Shianna KV, Ge D et al (2007) A whole-genome association study of major determinants for host control of HIV-1. Science 317:944-947
-
(2007)
Science
, vol.317
, pp. 944-947
-
-
Fellay, J.1
Shianna, K.V.2
Ge, D.3
-
52
-
-
27144505682
-
Nef is physically recruited into the immuno-logical synapse and potentiates T cell activation early after TCR engagement
-
Fenard D, Yonemoto W, de Noronha C et al (2005) Nef is physically recruited into the immuno-logical synapse and potentiates T cell activation early after TCR engagement. J Immunol 175:6050-6057
-
(2005)
J Immunol
, vol.175
, pp. 6050-6057
-
-
Fenard, D.1
Yonemoto, W.2
De Noronha, C.3
-
53
-
-
0030002637
-
HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
-
Feng Y, Broder CC, Kennedy PE et al (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877
-
(1996)
Science
, vol.272
, pp. 872-877
-
-
Feng, Y.1
Broder, C.C.2
Kennedy, P.E.3
-
54
-
-
4544288671
-
Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction
-
Fortin JF, Barat C, Beausejour Y et al (2004) Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction. J Biol Chem 279:39520-39531
-
(2004)
J Biol Chem
, vol.279
, pp. 39520-39531
-
-
Fortin, J.F.1
Barat, C.2
Beausejour, Y.3
-
55
-
-
0030858730
-
Nef-mediated clathrin-coated pit formation
-
Foti M, Mangasarian A, Piguet V et al (1997) Nef-mediated clathrin-coated pit formation. J Cell Biol 139:37-47
-
(1997)
J Cell Biol
, vol.139
, pp. 37-47
-
-
Foti, M.1
Mangasarian, A.2
Piguet, V.3
-
56
-
-
0030576919
-
Soluble Nef antigen of HIV-1 is cytotoxic for human CD4 + T cells
-
Fujii Y, Otake K, Tashiro M et al (1996) Soluble Nef antigen of HIV-1 is cytotoxic for human CD4 + T cells. FEBS Lett 393:93-96
-
(1996)
FEBS Lett
, vol.393
, pp. 93-96
-
-
Fujii, Y.1
Otake, K.2
Tashiro, M.3
-
57
-
-
0025733252
-
Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
-
Garcia JV, Miller AD (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350:508-511
-
(1991)
Nature
, vol.350
, pp. 508-511
-
-
Garcia, J.V.1
Miller, A.D.2
-
58
-
-
0034598905
-
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
-
Geijtenbeek TB, Kwon DS, Torensma R et al (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587-597
-
(2000)
Cell
, vol.100
, pp. 587-597
-
-
Geijtenbeek, T.B.1
Kwon, D.S.2
Torensma, R.3
-
59
-
-
0035848864
-
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
-
Geleziunas R, Xu W, Takeda K et al (2001) HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410:834-838
-
(2001)
Nature
, vol.410
, pp. 834-838
-
-
Geleziunas, R.1
Xu, W.2
Takeda, K.3
-
60
-
-
0034894379
-
Structure-function relationships in HIV-1 Nef
-
Geyer M, Fackler OT, Peterlin BM (2001) Structure-function relationships in HIV-1 Nef. EMBO Rep 2:580-585
-
(2001)
EMBO Rep
, vol.2
, pp. 580-585
-
-
Geyer, M.1
Fackler, O.T.2
Peterlin, B.M.3
-
61
-
-
0035844009
-
Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef
-
Geyer M, Peterlin BM (2001) Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef. FEBS Lett 496:91-95
-
(2001)
FEBS Lett
, vol.496
, pp. 91-95
-
-
Geyer, M.1
Peterlin, B.M.2
-
62
-
-
0034795885
-
CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo
-
Glushakova S, Munch J, Carl S et al (2001) CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. J Virol 75:10113-10117
-
(2001)
J Virol
, vol.75
, pp. 10113-10117
-
-
Glushakova, S.1
Munch, J.2
Carl, S.3
-
63
-
-
35448976736
-
Severe depletion of mucosal CD4+ T cells in AIDS-free SIV-infected sooty mangabeys
-
Gordon S, Klatt NR, Bosinger SE et al (2007) Severe depletion of mucosal CD4+ T cells in AIDS-free SIV-infected sooty mangabeys. J Immunol 179:3026-3034
-
(2007)
J Immunol
, vol.179
, pp. 3026-3034
-
-
Gordon, S.1
Klatt, N.R.2
Bosinger, S.E.3
-
64
-
-
0038725688
-
Apoptosis as an HIV strategy to escape immune attack
-
Gougeon ML (2003) Apoptosis as an HIV strategy to escape immune attack. Nat Rev Immunol 3:392-404
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 392-404
-
-
Gougeon, M.L.1
-
65
-
-
0030772239
-
Potential underestimation of HLA-C-restricted cytotoxic T-lymphocyte responses
-
Goulder PJ, Bunce M, Luzzi G et al (1997) Potential underestimation of HLA-C-restricted cytotoxic T-lymphocyte responses. AIDS 11:1884-1886
-
(1997)
AIDS
, vol.11
, pp. 1884-1886
-
-
Goulder, P.J.1
Bunce, M.2
Luzzi, G.3
-
66
-
-
0032955422
-
Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
-
Granelli-Piperno A, Finkel V, Delgado E et al (1999) Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells. Curr Biol 9:21-29
-
(1999)
Curr Biol
, vol.9
, pp. 21-29
-
-
Granelli-Piperno, A.1
Finkel, V.2
Delgado, E.3
-
67
-
-
0032525137
-
The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class i MHC complexes
-
Greenberg ME, Iafrate AJ, Skowronski J (1998a) The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J 17:2777-2789
-
(1998)
EMBO J
, vol.17
, pp. 2777-2789
-
-
Greenberg, M.E.1
Iafrate, A.J.2
Skowronski, J.3
-
68
-
-
0032488055
-
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
-
Greenberg M, DeTulleo L, Rapoport I et al (1998b) A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 8:1239-1242
-
(1998)
Curr Biol
, vol.8
, pp. 1239-1242
-
-
Greenberg, M.1
Detulleo, L.2
Rapoport, I.3
-
69
-
-
0037399363
-
HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication
-
Greenway AL, Holloway G, McPhee DA et al (2003) HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. J Biosci 28:323-335
-
(2003)
J Biosci
, vol.28
, pp. 323-335
-
-
Greenway, A.L.1
Holloway, G.2
McPhee, D.A.3
-
70
-
-
0029819124
-
Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
-
Greenway A, Azad A, Mills J et al (1996) Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. J Virol 70:6701-6708
-
(1996)
J Virol
, vol.70
, pp. 6701-6708
-
-
Greenway, A.1
Azad, A.2
Mills, J.3
-
71
-
-
0034723385
-
AIDS as a zoonosis: Scientific and public health implications
-
Hahn BH, Shaw GM, De Cock KM et al (2000) AIDS as a zoonosis: scientific and public health implications. Science 287:607-614
-
(2000)
Science
, vol.287
, pp. 607-614
-
-
Hahn, B.H.1
Shaw, G.M.2
De Cock, K.M.3
-
72
-
-
0032546958
-
Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein
-
Hodge DR, Dunn KJ, Pei GK et al (1998) Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein. J Biol Chem 273:15727-15733
-
(1998)
J Biol Chem
, vol.273
, pp. 15727-15733
-
-
Hodge, D.R.1
Dunn, K.J.2
Pei, G.K.3
-
73
-
-
0031774858
-
Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2
-
Howe AY, Jung JU, Desrosiers RC (1998) Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2. J Virol 72:9827-9834
-
(1998)
J Virol
, vol.72
, pp. 9827-9834
-
-
Howe, A.Y.1
Jung, J.U.2
Desrosiers, R.C.3
-
74
-
-
23244459907
-
Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1
-
Hrecka K, Swigut T, Schindler M et al (2005) Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. J Virol 79:10650-10659
-
(2005)
J Virol
, vol.79
, pp. 10650-10659
-
-
Hrecka, K.1
Swigut, T.2
Schindler, M.3
-
75
-
-
0030861249
-
Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4
-
Hua J, Cullen BR (1997) Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4. J Virol 71:6742-6748
-
(1997)
J Virol
, vol.71
, pp. 6742-6748
-
-
Hua, J.1
Cullen, B.R.2
-
76
-
-
34147169409
-
HIV-1 Nef assembles a Src family kinase-ZAP-70/ Syk-PI3K cascade to downregulate cell-surface MHC-I
-
Hung CH, Thomas L, Ruby CE et al (2007) HIV-1 Nef assembles a Src family kinase-ZAP-70/ Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe 1:121-133
-
(2007)
Cell Host Microbe
, vol.1
, pp. 121-133
-
-
Hung, C.H.1
Thomas, L.2
Ruby, C.E.3
-
77
-
-
0031039979
-
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
-
Iafrate AJ, Bronson S, Skowronski J (1997) Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J 16:673-684
-
(1997)
EMBO J
, vol.16
, pp. 673-684
-
-
Iafrate, A.J.1
Bronson, S.2
Skowronski, J.3
-
78
-
-
19344363916
-
HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis
-
Janardhan A, Swigut T, Hill B et al (2004) HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol 2:E6
-
(2004)
PLoS Biol
, vol.2
-
-
Janardhan, A.1
Swigut, T.2
Hill, B.3
-
79
-
-
67249114758
-
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
-
Jia B, Serra-Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana IB, Johnson WE, Westmoreland S, Evans DT (2009) Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog May; 5(5):e1000429
-
(2009)
PLoS Pathog May
, vol.5
, Issue.5
-
-
Jia, B.1
Serra-Moreno, R.2
Neidermyer, W.3
Rahmberg, A.4
MacKey, J.5
Fofana, I.B.6
Johnson, W.E.7
Westmoreland, S.8
Evans, D.T.9
-
80
-
-
50949130687
-
Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
-
Jin YJ, Cai CY, Zhang X et al (2008) Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation. J Immunol 180:7878-7886
-
(2008)
J Immunol
, vol.180
, pp. 7878-7886
-
-
Jin, Y.J.1
Cai, C.Y.2
Zhang, X.3
-
81
-
-
33645828833
-
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
-
Kärkkäinen S, Hiipakka M, Wang JH et al (2006) Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep 7:186-191
-
(2006)
EMBO Rep
, vol.7
, pp. 186-191
-
-
Kärkkäinen, S.1
Hiipakka, M.2
Wang, J.H.3
-
82
-
-
0032551187
-
Nef proteins of distinct HIV-1 or-2 isolates differ in their binding properties for HCK: Isolation of a novel Nef binding factor with characteristics of an adaptor protein
-
Karn T, Hock B, Holtrich U et al (1998) Nef proteins of distinct HIV-1 or-2 isolates differ in their binding properties for HCK: isolation of a novel Nef binding factor with characteristics of an adaptor protein. Virology 246:45-52
-
(1998)
Virology
, vol.246
, pp. 45-52
-
-
Karn, T.1
Hock, B.2
Holtrich, U.3
-
83
-
-
0037370728
-
Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells
-
Kasper MR, Collins KL (2003) Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. J Virol 77:3041-3049
-
(2003)
J Virol
, vol.77
, pp. 3041-3049
-
-
Kasper, M.R.1
Collins, K.L.2
-
85
-
-
0025743306
-
Importance of the nef gene for maintenance of high virus loads and for development of AIDS
-
Kestler HW, Ringler DJ, Mori K et al (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662
-
(1991)
Cell
, vol.65
, pp. 651-662
-
-
Kestler, H.W.1
Ringler, D.J.2
Mori, K.3
-
86
-
-
67349166158
-
Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?
-
Kirchhoff F (2009) Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution? Nat Rev Microbiol 7: 467-476
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 467-476
-
-
Kirchhoff, F.1
-
87
-
-
51349141354
-
Role of Nef in primate lentiviral immunopatho-genesis
-
Kirchhoff F, Schindler M, Specht A et al (2008) Role of Nef in primate lentiviral immunopatho-genesis. Cell Mol Life Sci 65:2621-2636
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 2621-2636
-
-
Kirchhoff, F.1
Schindler, M.2
Specht, A.3
-
88
-
-
0028835788
-
Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
-
Kirchhoff F, Greenough TC, Brettler DB et al (1995) Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 332:228-232
-
(1995)
N Engl J Med
, vol.332
, pp. 228-232
-
-
Kirchhoff, F.1
Greenough, T.C.2
Brettler, D.B.3
-
89
-
-
0346601814
-
The physiological relevance of CD4 receptor down-modulation during HIV infection
-
Lama J (2003) The physiological relevance of CD4 receptor down-modulation during HIV infection. Curr HIV Res 1:167-184
-
(2003)
Curr HIV Res
, vol.1
, pp. 167-184
-
-
Lama, J.1
-
90
-
-
0033578072
-
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner
-
Lama J, Mangasarian A, Trono D (1999) Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner. Curr Biol 9:622-631
-
(1999)
Curr Biol
, vol.9
, pp. 622-631
-
-
Lama, J.1
Mangasarian, A.2
Trono, D.3
-
91
-
-
0347990558
-
HIV Nef-mediated major histocompatibility complex class i down-modulation is independent of Arf6 activity
-
Larsen JE, Massol RH, Nieland TJ et al (2004) HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell 15:323-331
-
(2004)
Mol Biol Cell
, vol.15
, pp. 323-331
-
-
Larsen, J.E.1
Massol, R.H.2
Nieland, T.J.3
-
92
-
-
0033798906
-
Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class i down-regulation
-
Le Gall S, Buseyne F, Trocha A et al (2000) Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation. J Virol 74:9256-9266
-
(2000)
J Virol
, vol.74
, pp. 9256-9266
-
-
Le Gall, S.1
Buseyne, F.2
Trocha, A.3
-
93
-
-
0032055774
-
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC i molecules
-
Le Gall S, Erdtmann L, Benichou S et al (1998) Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 8:483-495
-
(1998)
Immunity
, vol.8
, pp. 483-495
-
-
Le Gall, S.1
Erdtmann, L.2
Benichou, S.3
-
94
-
-
44649089097
-
Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo
-
Lewis MJ, Balamurugan A, Ohno A et al (2008) Functional adaptation of Nef to the immune milieu of HIV-1 infection in vivo. J Immunol 180:4075-4081
-
(2008)
J Immunol
, vol.180
, pp. 4075-4081
-
-
Lewis, M.J.1
Balamurugan, A.2
Ohno, A.3
-
95
-
-
0036104855
-
Transient surface delivery of invariant chain-MHC II complexes via endosomes: A quantitative study
-
Lindner R (2002) Transient surface delivery of invariant chain-MHC II complexes via endosomes: a quantitative study. Traffic 3:133-146
-
(2002)
Traffic
, vol.3
, pp. 133-146
-
-
Lindner, R.1
-
96
-
-
38349109364
-
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
-
Lindwasser OW, Smith WJ, Chaudhuri R et al (2008) A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol 82:1166-1174
-
(2008)
J Virol
, vol.82
, pp. 1166-1174
-
-
Lindwasser, O.W.1
Smith, W.J.2
Chaudhuri, R.3
-
97
-
-
0036056929
-
Interaction between Nef and phosphatidylino-sitol-3-kinase leads to activation of p21-activated kinase and increased production of HIV
-
Linnemann T, Zheng YH, Mandic R et al (2002) Interaction between Nef and phosphatidylino-sitol-3-kinase leads to activation of p21-activated kinase and increased production of HIV. Virology 294:246-255
-
(2002)
Virology
, vol.294
, pp. 246-255
-
-
Linnemann, T.1
Zheng, Y.H.2
Mandic, R.3
-
98
-
-
0033577730
-
Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis
-
Lock M, Greenberg ME, Iafrate AJ et al (1999) Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J 18:2722-2733
-
(1999)
EMBO J
, vol.18
, pp. 2722-2733
-
-
Lock, M.1
Greenberg, M.E.2
Iafrate, A.J.3
-
99
-
-
0030475891
-
CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1
-
Lu X, Wu X, Plemenitas A et al (1996) CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr Biol 6:1677-1684
-
(1996)
Curr Biol
, vol.6
, pp. 1677-1684
-
-
Lu, X.1
Wu, X.2
Plemenitas, A.3
-
100
-
-
34548510349
-
HIV-1 Nef-induced down-regulation of MHC class i requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
-
Lubben NB, Sahlender DA, Motley AM et al (2007) HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell 18:3351-3365
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3351-3365
-
-
Lubben, N.B.1
Sahlender, D.A.2
Motley, A.M.3
-
101
-
-
0036231461
-
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
-
Lundquist CA, Tobiume M, Zhou J et al (2002) Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 76:4625-4633
-
(2002)
J Virol
, vol.76
, pp. 4625-4633
-
-
Lundquist, C.A.1
Tobiume, M.2
Zhou, J.3
-
102
-
-
20044362379
-
Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
-
Madrid R, Janvier K, Hitchin D et al (2005) Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem 280:5032-5044
-
(2005)
J Biol Chem
, vol.280
, pp. 5032-5044
-
-
Madrid, R.1
Janvier, K.2
Hitchin, D.3
-
103
-
-
44649139364
-
HIV-1 accessory proteins-ensuring viral survival in a hostile environment
-
Malim MH, Emerman M (2008) HIV-1 accessory proteins-ensuring viral survival in a hostile environment. Cell Host Microbe 3:388-398
-
(2008)
Cell Host Microbe
, vol.3
, pp. 388-398
-
-
Malim, M.H.1
Emerman, M.2
-
104
-
-
0033013962
-
Nef-induced CD4 and major histocompatibility complex class i (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
-
Mangasarian A, Piguet V, Wang JK et al (1999) Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking. J Virol 73:1964-1973
-
(1999)
J Virol
, vol.73
, pp. 1964-1973
-
-
Mangasarian, A.1
Piguet, V.2
Wang, J.K.3
-
105
-
-
33947390903
-
In vitro treatment of human monocytes/ macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon
-
Mangino G, Percario ZA, Fiorucci G et al (2007) In vitro treatment of human monocytes/ macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon. J Virol 81:2777-2791
-
(2007)
J Virol
, vol.81
, pp. 2777-2791
-
-
Mangino, G.1
Percario, Z.A.2
Fiorucci, G.3
-
106
-
-
0035123886
-
Activation of NFAT-dependent gene expression by Nef: Conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta
-
Manninen A, Huotari P, Hiipakka M et al (2001) Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta. J Virol 75:3034-3037
-
(2001)
J Virol
, vol.75
, pp. 3034-3037
-
-
Manninen, A.1
Huotari, P.2
Hiipakka, M.3
-
107
-
-
0034595806
-
Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
-
Manninen A, Renkema GH, Saksela K (2000) Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J Biol Chem 275:16513-16517
-
(2000)
J Biol Chem
, vol.275
, pp. 16513-16517
-
-
Manninen, A.1
Renkema, G.H.2
Saksela, K.3
-
108
-
-
0029912733
-
Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection
-
Marandin A, Katz A, Oksenhendler E et al (1996) Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection. Blood 88:4568-4578
-
(1996)
Blood
, vol.88
, pp. 4568-4578
-
-
Marandin, A.1
Katz, A.2
Oksenhendler, E.3
-
109
-
-
2142759185
-
Cytosolic Gag p24 as an index of productive entry of human immunodeficiency virus type 1
-
Marechal V, Clavel F, Heard JM et al (1998) Cytosolic Gag p24 as an index of productive entry of human immunodeficiency virus type 1. J Virol 72:2208-2212
-
(1998)
J Virol
, vol.72
, pp. 2208-2212
-
-
Marechal, V.1
Clavel, F.2
Heard, J.M.3
-
110
-
-
0029846223
-
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection
-
Mariani R, Kirchhoff F, Greenough TC et al (1996) High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol 70:7752-7764
-
(1996)
J Virol
, vol.70
, pp. 7752-7764
-
-
Mariani, R.1
Kirchhoff, F.2
Greenough, T.C.3
-
111
-
-
0032104461
-
The function of simian chemokine receptors in the replication of SIV
-
Marx PA, Chen Z (1998) The function of simian chemokine receptors in the replication of SIV. Semin Immunol 10:215-223
-
(1998)
Semin Immunol
, vol.10
, pp. 215-223
-
-
Marx, P.A.1
Chen, Z.2
-
112
-
-
10744222779
-
Natural killer cells in HIV-1 infection: Dichoto-mous effects of viremia on inhibitory and activating receptors and their functional correlates
-
Mavilio D, Benjamin J, Daucher M et al (2003) Natural killer cells in HIV-1 infection: dichoto-mous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci \USA 100:15011-15016
-
(2003)
Proc Natl Acad Sci \USA
, vol.100
, pp. 15011-15016
-
-
Mavilio, D.1
Benjamin, J.2
Daucher, M.3
-
113
-
-
0030816597
-
Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity
-
Miller MD, Warmerdam MT, Ferrell SS et al (1997) Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity. Virology 234:215-225
-
(1997)
Virology
, vol.234
, pp. 215-225
-
-
Miller, M.D.1
Warmerdam, M.T.2
Ferrell, S.S.3
-
114
-
-
0028936207
-
Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
-
Miller MD, Warmerdam MT, Page KA et al (1995) Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J Virol 69:579-584
-
(1995)
J Virol
, vol.69
, pp. 579-584
-
-
Miller, M.D.1
Warmerdam, M.T.2
Page, K.A.3
-
115
-
-
0028006247
-
The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
-
Miller MD, Warmerdam MT, Gaston I et al (1994) The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 179:101-113
-
(1994)
J Exp Med
, vol.179
, pp. 101-113
-
-
Miller, M.D.1
Warmerdam, M.T.2
Gaston, I.3
-
116
-
-
36048989674
-
Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host
-
Milush JM, Reeves JD, Gordon SN et al (2007) Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. J Immunol 179:3047-3056
-
(2007)
J Immunol
, vol.179
, pp. 3047-3056
-
-
Milush, J.M.1
Reeves, J.D.2
Gordon, S.N.3
-
117
-
-
49149110847
-
Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef
-
Mitchell RS, Chaudhuri R, Lindwasser OW et al (2008) Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef. J Virol 82:7758-7767
-
(2008)
J Virol
, vol.82
, pp. 7758-7767
-
-
Mitchell, R.S.1
Chaudhuri, R.2
Lindwasser, O.W.3
-
118
-
-
37049029214
-
Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses
-
Munch J, Rajan D, Schindler M et al (2007) Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J Virol 81:13852-13864
-
(2007)
J Virol
, vol.81
, pp. 13852-13864
-
-
Munch, J.1
Rajan, D.2
Schindler, M.3
-
119
-
-
0034796441
-
Efficient class i major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques
-
Munch J, Stolte N, Fuchs D et al (2001) Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J Virol 75:10532-10536
-
(2001)
J Virol
, vol.75
, pp. 10532-10536
-
-
Munch, J.1
Stolte, N.2
Fuchs, D.3
-
120
-
-
24744438912
-
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
-
Muthumani K, Choo AY, Hwang DS et al (2005) HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood 106:2059-2068
-
(2005)
Blood
, vol.106
, pp. 2059-2068
-
-
Muthumani, K.1
Choo, A.Y.2
Hwang, D.S.3
-
121
-
-
33748702282
-
Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion
-
Ndolo T, George M, Nguyen H et al (2006) Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion. Virology 353:374-387
-
(2006)
Virology
, vol.353
, pp. 374-387
-
-
Ndolo, T.1
George, M.2
Nguyen, H.3
-
122
-
-
38549095979
-
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
-
2008 Jan 24
-
Neil SJ, Zang T, Bieniasz PD (2008). Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature. 2008 Jan 24; 451(7177):425-430
-
(2008)
Nature
, vol.451
, Issue.7177
, pp. 425-430
-
-
Neil, S.J.1
Zang, T.2
Bieniasz, P.D.3
-
123
-
-
0036019511
-
CD4(+) T helper cells and the role they play in viral control
-
Norris PJ, Rosenberg ES (2002) CD4(+) T helper cells and the role they play in viral control. J Mol Med 80:397-405
-
(2002)
J Mol Med
, vol.80
, pp. 397-405
-
-
Norris, P.J.1
Rosenberg, E.S.2
-
124
-
-
38349127341
-
Cooperative binding of the class i major histocom-patibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit
-
Noviello CM, Benichou S, Guatelli JC (2008) Cooperative binding of the class I major histocom-patibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol 82:1249-1258
-
(2008)
J Virol
, vol.82
, pp. 1249-1258
-
-
Noviello, C.M.1
Benichou, S.2
Guatelli, J.C.3
-
125
-
-
0030768607
-
HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas)
-
Okada H, Takei R, Tashiro M (1997) HIV-1 Nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas). FEBS Lett 414:603-606
-
(1997)
FEBS Lett
, vol.414
, pp. 603-606
-
-
Okada, H.1
Takei, R.2
Tashiro, M.3
-
126
-
-
0037441996
-
HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: Involvement of Nef endocytotic signals and NF-kappa B activation
-
Olivetta E, Percario Z, Fiorucci G et al (2003) HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation. J Immunol 170:1716-1727
-
(2003)
J Immunol
, vol.170
, pp. 1716-1727
-
-
Olivetta, E.1
Percario, Z.2
Fiorucci, G.3
-
127
-
-
0030014162
-
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein
-
Pandori MW, Fitch NJ, Craig HM et al (1996) Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein. J Virol 70:4283-4290
-
(1996)
J Virol
, vol.70
, pp. 4283-4290
-
-
Pandori, M.W.1
Fitch, N.J.2
Craig, H.M.3
-
128
-
-
49849088558
-
Into the wild: Simian immunodeficiency virus (SIV) infection in natural hosts
-
Pandrea I, Sodora DL, Silvestri G et al (2008) Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts. Trends Immunol 29:419-428
-
(2008)
Trends Immunol
, vol.29
, pp. 419-428
-
-
Pandrea, I.1
Sodora, D.L.2
Silvestri, G.3
-
129
-
-
0036281905
-
Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class i major histocompatibility complex antigens
-
Patel PG, Yu Kimata MT, Biggins JE et al (2002) Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens. J Virol 76:6425-6434
-
(2002)
J Virol
, vol.76
, pp. 6425-6434
-
-
Patel, P.G.1
Yu Kimata, M.T.2
Biggins, J.E.3
-
130
-
-
0035919709
-
Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes
-
Petit C, Buseyne F, Boccaccio C et al (2001) Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes. Virology 286:225-236
-
(2001)
Virology
, vol.286
, pp. 225-236
-
-
Petit, C.1
Buseyne, F.2
Boccaccio, C.3
-
131
-
-
8644292571
-
Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes
-
Pham HM, Arganaraz ER, Groschel B et al (2004) Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes. J Virol 78:13072-13081
-
(2004)
J Virol
, vol.78
, pp. 13072-13081
-
-
Pham, H.M.1
Arganaraz, E.R.2
Groschel, B.3
-
132
-
-
0033776709
-
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class i major histocompatibility complexes
-
Piguet V, Wan L, Borel C et al (2000) HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol 2:163-167
-
(2000)
Nat Cell Biol
, vol.2
, pp. 163-167
-
-
Piguet, V.1
Wan, L.2
Borel, C.3
-
133
-
-
0032079665
-
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
-
Piguet V, Chen YL, Mangasarian A et al (1998) Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J 17:2472-2481
-
(1998)
EMBO J
, vol.17
, pp. 2472-2481
-
-
Piguet, V.1
Chen, Y.L.2
Mangasarian, A.3
-
134
-
-
55249115173
-
Nef can enhance the infectivity of receptor-pseudo-typed human immunodeficiency virus type 1 particles
-
Pizzato M, Popova E, Gottlinger HG (2008) Nef can enhance the infectivity of receptor-pseudo-typed human immunodeficiency virus type 1 particles. J Virol 82(21):10811-10810
-
(2008)
J Virol
, vol.82
, Issue.21
, pp. 10811-10810
-
-
Pizzato, M.1
Popova, E.2
Gottlinger, H.G.3
-
135
-
-
34249847836
-
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef
-
Pizzato M, Helander A, Popova E et al (2007) Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci \USA 104:6812-6817
-
(2007)
Proc Natl Acad Sci \USA
, vol.104
, pp. 6812-6817
-
-
Pizzato, M.1
Helander, A.2
Popova, E.3
-
136
-
-
43049118940
-
Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques
-
Prost S, Le DM, Auge S et al (2008) Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques. J Clin Invest 118:1765-1775
-
(2008)
J Clin Invest
, vol.118
, pp. 1765-1775
-
-
Prost, S.1
Le, D.M.2
Auge, S.3
-
137
-
-
33846474764
-
Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism
-
Qi M, Aiken C (2007) Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. J Virol 81:1534-1536
-
(2007)
J Virol
, vol.81
, pp. 1534-1536
-
-
Qi, M.1
Aiken, C.2
-
138
-
-
33645288761
-
Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells
-
Qiao X, He B, Chiu A et al (2006) Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol 7:302-310
-
(2006)
Nat Immunol
, vol.7
, pp. 302-310
-
-
Qiao, X.1
He, B.2
Chiu, A.3
-
139
-
-
34547816196
-
HIV-1 Nef impairs the dynamic of DC/NK crosstalk: Different outcome of CD56(dim) and CD56(bright) NK cell subsets
-
Quaranta MG, Napolitano A, Sanchez M et al (2007) HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets. FASEB J 21:2323-2334
-
(2007)
FASEB J
, vol.21
, pp. 2323-2334
-
-
Quaranta, M.G.1
Napolitano, A.2
Sanchez, M.3
-
140
-
-
0035163622
-
Apoptosis enhancement by the HIV-1 Nef protein
-
Rasola A, Gramaglia D, Boccaccio C et al (2001) Apoptosis enhancement by the HIV-1 Nef protein. J Immunol 166:81-88
-
(2001)
J Immunol
, vol.166
, pp. 81-88
-
-
Rasola, A.1
Gramaglia, D.2
Boccaccio, C.3
-
141
-
-
40149097137
-
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity
-
Rauch S, Pulkkinen K, Saksela K, Fackler OT (2008) Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity. J Virol 82:2918-2929
-
(2008)
J Virol
, vol.82
, pp. 2918-2929
-
-
Rauch, S.1
Pulkkinen, K.2
Saksela, K.3
Fackler, O.T.4
-
142
-
-
0034134113
-
Interactions of HIV-1 NEF with cellular signal transducing proteins
-
Renkema GH, Saksela K (2000) Interactions of HIV-1 NEF with cellular signal transducing proteins. Front Biosci 5:D268-D283
-
(2000)
Front Biosci
, vol.5
-
-
Renkema, G.H.1
Saksela, K.2
-
143
-
-
38049005960
-
MHC class II molecules on the move for successful antigen presentation
-
Rocha N, Neefjes J (2008) MHC class II molecules on the move for successful antigen presentation. EMBO J 27:1-5
-
(2008)
EMBO J
, vol.27
, pp. 1-5
-
-
Rocha, N.1
Neefjes, J.2
-
144
-
-
0027326548
-
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
-
Roche PA, Teletski CL, Stang E et al (1993) Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization. Proc Natl Acad Sci \USA 90:8581-8585
-
(1993)
Proc Natl Acad Sci \USA
, vol.90
, pp. 8581-8585
-
-
Roche, P.A.1
Teletski, C.L.2
Stang, E.3
-
145
-
-
0026708305
-
Stable surface expression of invariant chain prevents peptide presentation by HLA-DR
-
Roche PA, Teletski CL, Karp DR et al (1992) Stable surface expression of invariant chain prevents peptide presentation by HLA-DR. EMBO J 11:2841-2847
-
(1992)
EMBO J
, vol.11
, pp. 2841-2847
-
-
Roche, P.A.1
Teletski, C.L.2
Karp, D.R.3
-
146
-
-
33745122662
-
Human immunodeficiency virus type 1 Nef: Adapting to intracellular trafficking pathways
-
Roeth JF, Collins KL (2006) Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways. Microbiol Mol Biol Rev 70:548-563
-
(2006)
Microbiol Mol Biol Rev
, vol.70
, pp. 548-563
-
-
Roeth, J.F.1
Collins, K.L.2
-
147
-
-
10344258588
-
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
-
Roeth JF, Williams M, Kasper MR et al (2004) HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail. J Cell Biol 167:903-913
-
(2004)
J Cell Biol
, vol.167
, pp. 903-913
-
-
Roeth, J.F.1
Williams, M.2
Kasper, M.R.3
-
148
-
-
14844322164
-
CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms
-
Rose JJ, Janvier K, Chandrasekhar S et al (2005) CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms. J Biol Chem 280:7413-7426
-
(2005)
J Biol Chem
, vol.280
, pp. 7413-7426
-
-
Rose, J.J.1
Janvier, K.2
Chandrasekhar, S.3
-
149
-
-
0033578016
-
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
-
Ross TM, Oran AE, Cullen BR (1999) Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 9:613-621
-
(1999)
Curr Biol
, vol.9
, pp. 613-621
-
-
Ross, T.M.1
Oran, A.E.2
Cullen, B.R.3
-
150
-
-
0028878783
-
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+viruses but not for down-regulation of CD4
-
Saksela K, Cheng G, Baltimore D (1995) Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+viruses but not for down-regulation of CD4. EMBO J 14:484-491
-
(1995)
EMBO J
, vol.14
, pp. 484-491
-
-
Saksela, K.1
Cheng, G.2
Baltimore, D.3
-
151
-
-
0031979771
-
Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor
-
Salvi R, Garbuglia AR, Di CA et al (1998) Grossly defective nef gene sequences in a human immunodeficiency virus type 1-seropositive long-term nonprogressor. J Virol 72:3646-3657
-
(1998)
J Virol
, vol.72
, pp. 3646-3657
-
-
Salvi, R.1
Garbuglia, A.R.2
Di, C.A.3
-
152
-
-
0027958148
-
Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes
-
Sawai ET, Baur A, Struble H et al (1994) Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc Natl Acad Sci \USA 91:1539-1543
-
(1994)
Proc Natl Acad Sci \USA
, vol.91
, pp. 1539-1543
-
-
Sawai, E.T.1
Baur, A.2
Struble, H.3
-
153
-
-
50849129910
-
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
-
Schaefer MR, Wonderlich ER, Roeth JF et al (2008) HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog 4: e1000131
-
(2008)
PLoS Pathog
, vol.4
-
-
Schaefer, M.R.1
Wonderlich, E.R.2
Roeth, J.F.3
-
154
-
-
0036435652
-
The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs
-
Schaefer TM, Bell I, Pfeifer ME et al (2002) The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs. Virology 302:106-122
-
(2002)
Virology
, vol.302
, pp. 106-122
-
-
Schaefer, T.M.1
Bell, I.2
Pfeifer, M.E.3
-
155
-
-
0035120461
-
Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
-
Schaeffer E, Geleziunas R, Greene WC (2001) Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions. J Virol 75:2993-3000
-
(2001)
J Virol
, vol.75
, pp. 2993-3000
-
-
Schaeffer, E.1
Geleziunas, R.2
Greene, W.C.3
-
156
-
-
0024429664
-
Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection
-
Scheppler JA, Nicholson JK, Swan DC et al (1989) Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection. J Immunol 143:2858-2866
-
(1989)
J Immunol
, vol.143
, pp. 2858-2866
-
-
Scheppler, J.A.1
Nicholson, J.K.2
Swan, D.C.3
-
157
-
-
48249157009
-
Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection
-
Schindler M, Schmokel J, Specht A et al (2008) Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection. PLoS Pathog 4: e1000107
-
(2008)
PLoS Pathog
, vol.4
-
-
Schindler, M.1
Schmokel, J.2
Specht, A.3
-
158
-
-
34248572102
-
Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progres-sors
-
Schindler M, Wildum S, Casartelli N et al (2007a) Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II expression more efficiently than those from rapid progres-sors. AIDS 21:1103-1107
-
(2007)
AIDS
, vol.21
, pp. 1103-1107
-
-
Schindler, M.1
Wildum, S.2
Casartelli, N.3
-
159
-
-
36349022028
-
Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue
-
Schindler M, Rajan D, Specht A et al (2007b) Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue. J Virol 81:13005-13014
-
(2007)
J Virol
, vol.81
, pp. 13005-13014
-
-
Schindler, M.1
Rajan, D.2
Specht, A.3
-
160
-
-
33745070227
-
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
-
Schindler M, Munch J, Kutsch O et al (2006) Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 125:1055-1067
-
(2006)
Cell
, vol.125
, pp. 1055-1067
-
-
Schindler, M.1
Munch, J.2
Kutsch, O.3
-
161
-
-
17444413400
-
Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism
-
Schindler M, Munch J, Kirchhoff F (2005) Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism. J Virol 79:5489-5498
-
(2005)
J Virol
, vol.79
, pp. 5489-5498
-
-
Schindler, M.1
Munch, J.2
Kirchhoff, F.3
-
162
-
-
0141521574
-
Down-modulation of mature major histo-compatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
-
Schindler M, Wurfl S, Benaroch P et al (2003) Down-modulation of mature major histo-compatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol 77:10548-10556
-
(2003)
J Virol
, vol.77
, pp. 10548-10556
-
-
Schindler, M.1
Wurfl, S.2
Benaroch, P.3
-
163
-
-
0033529258
-
HIV-1 Nef increases T cell activation in a stimulus-dependent manner
-
Schrager JA, Marsh JW (1999) HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci \USA 96:8167-8172
-
(1999)
Proc Natl Acad Sci \USA
, vol.96
, pp. 8167-8172
-
-
Schrager, J.A.1
Marsh, J.W.2
-
164
-
-
0029875421
-
Endocytosis of major histocompatibility complex class i molecules is induced by the HIV-1 Nef protein
-
Schwartz O, Marechal V, Le Gall S et al (1996) Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 2:338-342
-
(1996)
Nat Med
, vol.2
, pp. 338-342
-
-
Schwartz, O.1
Marechal, V.2
Le Gall, S.3
-
165
-
-
0029045360
-
Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell
-
Schwartz O, Marechal V, Danos O et al (1995) Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell. J Virol 69:4053-4059
-
(1995)
J Virol
, vol.69
, pp. 4053-4059
-
-
Schwartz, O.1
Marechal, V.2
Danos, O.3
-
166
-
-
0036162160
-
Effects of HIV-1 Nef on cellular gene expression profiles
-
Shaheduzzaman S, Krishnan V, Petrovic A et al (2002) Effects of HIV-1 Nef on cellular gene expression profiles. J Biomed Sci 9:82-96
-
(2002)
J Biomed Sci
, vol.9
, pp. 82-96
-
-
Shaheduzzaman, S.1
Krishnan, V.2
Petrovic, A.3
-
167
-
-
0034948709
-
Nef triggers atranscriptional programinTcells imitating single-signal T cell activation and inducing HIV virulence mediators
-
SimmonsA,AluvihareV,McMichaelA (2001) Nef triggers atranscriptional programinTcells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14:763-777
-
(2001)
Immunity
, vol.14
, pp. 763-777
-
-
Simmons, A.1
Aluvihare, V.2
McMichael, A.3
-
168
-
-
0027533215
-
Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
-
Skowronski J, Parks D, Mariani R (1993) Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J 12:703-713
-
(1993)
EMBO J
, vol.12
, pp. 703-713
-
-
Skowronski, J.1
Parks, D.2
Mariani, R.3
-
169
-
-
0030859776
-
Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients
-
Sloand EM, Young NS, Sato T et al (1997) Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients. AIDS 11:1547-1553
-
(1997)
AIDS
, vol.11
, pp. 1547-1553
-
-
Sloand, E.M.1
Young, N.S.2
Sato, T.3
-
170
-
-
0029953176
-
The HIV nef protein associates with protein kinase C theta
-
Smith BL, Krushelnycky BW, Mochly-Rosen D et al (1996) The HIV nef protein associates with protein kinase C theta. J Biol Chem 271:16753-16757
-
(1996)
J Biol Chem
, vol.271
, pp. 16753-16757
-
-
Smith, B.L.1
Krushelnycky, B.W.2
Mochly-Rosen, D.3
-
171
-
-
0036169006
-
HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread
-
Sol-Foulon N, Moris A, Nobile C et al (2002) HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 16:145-155
-
(2002)
Immunity
, vol.16
, pp. 145-155
-
-
Sol-Foulon, N.1
Moris, A.2
Nobile, C.3
-
172
-
-
40649109097
-
Selective downmodulation of HLA-A and-B by Nef alleles from different groups of primate lentiviruses
-
Specht A, DeGottardi MQ, Schindler M et al (2008) Selective downmodulation of HLA-A and-B by Nef alleles from different groups of primate lentiviruses. Virology 373:229-237
-
(2008)
Virology
, vol.373
, pp. 229-237
-
-
Specht, A.1
De Gottardi, M.Q.2
Schindler, M.3
-
173
-
-
0038299654
-
HIV-1 pathogenesis
-
Stevenson M (2003) HIV-1 pathogenesis. Nat Med 9:853-860
-
(2003)
Nat Med
, vol.9
, pp. 853-860
-
-
Stevenson, M.1
-
174
-
-
0344875506
-
Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocom-patibility complex class II complexes: Potential role of phosphatidylinositol 3-kinase
-
Stumptner-Cuvelette P, Jouve M, Helft J et al (2003) Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocom-patibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol Biol Cell 14:4857-4870
-
(2003)
Mol Biol Cell
, vol.14
, pp. 4857-4870
-
-
Stumptner-Cuvelette, P.1
Jouve, M.2
Helft, J.3
-
175
-
-
0035834141
-
HIV-1 Nef impairs MHC class II antigen presentation and surface expression
-
Stumptner-Cuvelette P, Morchoisne S, Dugast M et al (2001) HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci \USA 98:12144-12149
-
(2001)
Proc Natl Acad Sci \USA
, vol.98
, pp. 12144-12149
-
-
Stumptner-Cuvelette, P.1
Morchoisne, S.2
Dugast, M.3
-
176
-
-
0035836367
-
HIV-1 Nef blocks transport of MHC class i molecules to the cell surface via a PI 3-kinase-dependent pathway
-
Swann SA, Williams M, Story CM et al (2001) HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Virology 282:267-277
-
(2001)
Virology
, vol.282
, pp. 267-277
-
-
Swann, S.A.1
Williams, M.2
Story, C.M.3
-
177
-
-
8644289282
-
Impact of Nef-mediated downregulation of major histocompatibility complex class i on immune response to simian immunodeficiency virus
-
Swigut T, Alexander L, Morgan J et al (2004) Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus. J Virol 78:13335-13344
-
(2004)
J Virol
, vol.78
, pp. 13335-13344
-
-
Swigut, T.1
Alexander, L.2
Morgan, J.3
-
178
-
-
0038758782
-
Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and
-
Swigut T, Greenberg M, Skowronski J (2003) Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis. J Virol 77:8116-8126
-
(2003)
J Virol
, vol.77
, pp. 8116-8126
-
-
Swigut, T.1
Greenberg, M.2
Skowronski, J.3
-
179
-
-
0035794535
-
Mechanism for down-regulation of CD28 by Nef
-
Swigut T, Shohdy N, Skowronski J (2001) Mechanism for down-regulation of CD28 by Nef. EMBO J 20:1593-1604
-
(2001)
EMBO J
, vol.20
, pp. 1593-1604
-
-
Swigut, T.1
Shohdy, N.2
Skowronski, J.3
-
180
-
-
0034034278
-
Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class i major histocompatibility complex antigen expression
-
Swigut T, Iafrate AJ, Muench J et al (2000) Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression. J Virol 74:5691-5701
-
(2000)
J Virol
, vol.74
, pp. 5691-5701
-
-
Swigut, T.1
Iafrate, A.J.2
Muench, J.3
-
181
-
-
0038342442
-
HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
-
Swingler S, Brichacek B, Jacque JM et al (2003) HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 424:213-219
-
(2003)
Nature
, vol.424
, pp. 213-219
-
-
Swingler, S.1
Brichacek, B.2
Jacque, J.M.3
-
182
-
-
0032845027
-
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
-
Swingler S, Mann A, Jacque J et al (1999) HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med 5:997-103
-
(1999)
Nat Med
, vol.5
, pp. 997-103
-
-
Swingler, S.1
Mann, A.2
Jacque, J.3
-
183
-
-
46949095793
-
Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
-
Swingler S, Zhou J, Swingler C et al (2008) Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe 17:63-76
-
(2008)
Cell Host Microbe
, vol.17
, pp. 63-76
-
-
Swingler, S.1
Zhou, J.2
Swingler, C.3
-
184
-
-
0141744628
-
Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells
-
Tobiume M, Lineberger JE, Lundquist CA et al (2003) Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. J Virol 77:10645-10650
-
(2003)
J Virol
, vol.77
, pp. 10645-10650
-
-
Tobiume, M.1
Lineberger, J.E.2
Lundquist, C.A.3
-
185
-
-
50149094043
-
Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain
-
Toussaint H, Gobert FX, Schindler M et al (2008) Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain. J Virol 82:8373-8382
-
(2008)
J Virol
, vol.82
, pp. 8373-8382
-
-
Toussaint, H.1
Gobert, F.X.2
Schindler, M.3
-
186
-
-
33748751555
-
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction
-
Trible RP, Emert-Sedlak L, Smithgall TE (2006) HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J Biol Chem 281:27029-27038
-
(2006)
J Biol Chem
, vol.281
, pp. 27029-27038
-
-
Trible, R.P.1
Emert-Sedlak, L.2
Smithgall, T.E.3
-
187
-
-
0037462825
-
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis
-
Varin A, Manna SK, Quivy V et al (2003) Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis. J Biol Chem 278:2219-2227
-
(2003)
J Biol Chem
, vol.278
, pp. 2219-2227
-
-
Varin, A.1
Manna, S.K.2
Quivy, V.3
-
188
-
-
33750716106
-
Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection
-
Venzke S, Michel N, Allespach I et al (2006) Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection. J Virol 80:11141-11152
-
(2006)
J Virol
, vol.80
, pp. 11141-11152
-
-
Venzke, S.1
Michel, N.2
Allespach, I.3
-
189
-
-
33847237613
-
CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1
-
Wang JH, Janas AM, Olson WJ et al (2007) CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. J Virol 81:2497-2507
-
(2007)
J Virol
, vol.81
, pp. 2497-2507
-
-
Wang, J.H.1
Janas, A.M.2
Olson, W.J.3
-
190
-
-
0034602776
-
The Nef protein of HIV-1 associates with rafts and primes T cells for activation
-
Wang JK, Kiyokawa E, Verdin E et al (2000) The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci \USA 97:394-399
-
(2000)
Proc Natl Acad Sci \USA
, vol.97
, pp. 394-399
-
-
Wang, J.K.1
Kiyokawa, E.2
Verdin, E.3
-
191
-
-
0029975546
-
Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
-
Welker R, Kottler H, Kalbitzer HR et al (1996) Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219:228-236
-
(1996)
Virology
, vol.219
, pp. 228-236
-
-
Welker, R.1
Kottler, H.2
Kalbitzer, H.R.3
-
192
-
-
33746799703
-
Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection
-
Wildum S, Schindler M, Munch J et al (2006) Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. J Virol 80:8047-8059
-
(2006)
J Virol
, vol.80
, pp. 8047-8059
-
-
Wildum, S.1
Schindler, M.2
Munch, J.3
-
193
-
-
0036889125
-
Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class i (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
-
Williams M, Roeth JF, Kasper MR et al (2002) Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking. J Virol 76:12173-12184
-
(2002)
J Virol
, vol.76
, pp. 12173-12184
-
-
Williams, M.1
Roeth, J.F.2
Kasper, M.R.3
-
194
-
-
0030273317
-
HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
-
Wiskerchen M, Cheng-Mayer C (1996) HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology 224:292-301
-
(1996)
Virology
, vol.224
, pp. 292-301
-
-
Wiskerchen, M.1
Cheng-Mayer, C.2
-
195
-
-
0035173735
-
HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
-
Wolf D, Witte V, Laffert B et al (2001) HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat Med 7:1217-1224
-
(2001)
Nat Med
, vol.7
, pp. 1217-1224
-
-
Wolf, D.1
Witte, V.2
Laffert, B.3
-
196
-
-
0035943355
-
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA
-
Wu Y, Marsh JW (2001) Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293:1503-1506
-
(2001)
Science
, vol.293
, pp. 1503-1506
-
-
Wu, Y.1
Marsh, J.W.2
-
197
-
-
0033519235
-
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain
-
Xu XN, Laffert B, Screaton GR et al (1999) Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain. J Exp Med 189:1489-1496
-
(1999)
J Exp Med
, vol.189
, pp. 1489-1496
-
-
Xu, X.N.1
Laffert, B.2
Screaton, G.R.3
-
198
-
-
0032974805
-
Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway
-
Yang X, Gabuzda D (1999) Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway. J Virol 73:3460-3466
-
(1999)
J Virol
, vol.73
, pp. 3460-3466
-
-
Yang, X.1
Gabuzda, D.2
-
199
-
-
0032959989
-
Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway
-
Zauli G, Gibellini D, Secchiero P et al (1999) Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93:1000-1010
-
(1999)
Blood
, vol.93
, pp. 1000-1010
-
-
Zauli, G.1
Gibellini, D.2
Secchiero, P.3
-
200
-
-
67651111833
-
Nef proteins from simian immunodeficiency viruses are tetherin antagonists
-
2009 Jun 3. [Epub ahead of print]
-
Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T (2009) Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists. Cell Host Microbe 2009 Jun 3. [Epub ahead of print] 177
-
(2009)
Cell Host Microbe
, pp. 177
-
-
Zhang, F.1
Wilson, S.J.2
Landford, W.C.3
Virgen, B.4
Gregory, D.5
Johnson, M.C.6
Munch, J.7
Kirchhoff, F.8
Bieniasz, P.D.9
Hatziioannou, T.10
|