HIV-1 Nef binds the DOCK2-ELMO1 complex to activate Rac and inhibit lymphocyte chemotaxis

PLoS Biology

Volumn 2, Issue 1, 2004, Pages

  Janardhan, Ajit ^a,b   Swigut, Tomek ^a,c   Hill, Brian ^a,b,d   Myers, Michael P ^a   Skowronski, Jacek ^a,b  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; DOCKING PROTEIN; NEF PROTEIN; RAC PROTEIN; VIRULENCE FACTOR; CD28 ANTIGEN; CD3 ANTIGEN; DOCK2 PROTEIN, HUMAN; ELMO1 PROTEIN, HUMAN; EPITOPE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 2; RAC1 PROTEIN; RAC2 PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; CELL INTERACTION; CELL LINE; CELL MOTILITY; CHEMOTAXIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE SYSTEM; LENTIVIRINAE; LEUKEMIA CELL LINE; LYMPHOCYTE; LYMPHOCYTE FUNCTION; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN BINDING; PROTEIN FUNCTION; RETROVIRUS INFECTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRULENCE; VIRUS REPLICATION; BIOSYNTHESIS; CELL MOTION; CHEMISTRY; CYTOLOGY; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; PLASMID; PROTEOMICS; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; PRIMATES; UNIDENTIFIED RETROVIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD28; ANTIGENS, CD3; CELL MOVEMENT; CHEMOTAXIS; EPITOPES; GENE PRODUCTS, NEF; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HIV-1; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LENTIVIRUS; LYMPHOCYTES; MASS SPECTROMETRY; PLASMIDS; PROTEIN BINDING; PROTEOMICS; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 19344363916     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0020006     Document Type: Article

References (57)

1. Alexander L, Du Z, Rosenzweig M, Jung JU, Desrosiers RC (1994) A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation. J Virol 71: 6094-6099. Find this article online
2. Arora VK, Molina RP, Foster JL, Blakemore JL, Chernoff J, et al. (2000) Lentivirus Nef specifically activates Pak2. J Virol 74: 11081-11087. Find this article online
3. Baur AS, Sawai ET, Dazin P, Fantl WJ, Cheng-Mayer C (1994) HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1: 373-384. Find this article online
4. Baur AS, Sass G, Laffert B, Willbold D, Cheng-Mayer C, et al. (1997) The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6: 283-291. Find this article online
5. Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, et al. (2002) Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 4: 574-582. Find this article online
6. Bukrinsky MI, Stanwick TL, Dempsey MP, Stevenson M (1991) Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection. Science 254: 423-427. Find this article online
7. Burbelo PD, Drechsel D, Hall A (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 270: 29071-29074. Find this article online
8. Cohen GB, Rangan VS, Chen BK, Smith S, Baltimore D (2000) The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation. J Biol Chem 275: 23097-23105. Find this article online
9. Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D (1998) HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391: 397-401. Find this article online
10. Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, et al. (2002) Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol 80: 231-240. Find this article online
11. Delon J, Stoll S, Germain RN (2002) Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue. Immunol Rev 189: 51-63. Find this article online
12. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, et al. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661-666. Find this article online
13. + T cells. Nature 417: 95-98. Find this article online
14. Douek DC, Picker LJ, Koup RA (2003) T cell dynamics in HIV-1 infection. Annu Rev Immunol 21: 265-304. Find this article online
15. Du Z, Ilyinskii PO, Sasseville VG, Newstein M, Lackner AA, et al. (1996) Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus. J Virol 70: 4157-4161. Find this article online
16. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362: 359-362. Find this article online
17. Fackler OT, Luo W, Geyer M, Alberts AS, Peterlin BM (1999) Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol Cell 3: 729-739. Find this article online
18. Feng Y, Broder CC, Kennedy PE, Berger EA (1996) HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-877. Find this article online
19. Finzi D, Siliciano RF (1998) Viral dynamics in HIV-1 infection. Cell 93: 665-671. Find this article online
20. Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, et al. (2001) Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412: 826-831. Find this article online
21. Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, et al. (1998) Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281: 96-99. Find this article online
22. Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, et al. (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100: 587-597. Find this article online
23. Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, et al. (1997) Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J 16: 6964-6976. Find this article online
24. Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen TA (1998) A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 8: 1239-1242. Find this article online
25. Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, et al. (2001) CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107: 27-41. Find this article online
26. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514. Find this article online
27. Hanna Z, Kay DG, Rebai N, Guimond A, Jothy S, et al. (1998) Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95: 163-175. Find this article online
28. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, et al. (2002) Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Mol Cell Biol 22: 8044-8055. Find this article online
29. Kestler HW, Ringler DJ, Mori K, Panicali DL, Sehgal PK, et al. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662. Find this article online
30. Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, et al. (1998) Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 8: 483-495. Find this article online
31. Lock M, Greenberg ME, Iafrate AJ, Swigut T, Muench J, et al. (1999) Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J 18: 2722-2733. Find this article online
32. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D (2002) Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295: 868-872. Find this article online
33. Lu X, Wu X, Plemenitas A, Yu H, Sawai ET, et al. (1996) CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr Biol 6: 1677-1684. Find this article online
34. Manninen A, Saksela K (2002) HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J Exp Med 195: 1023-1032. Find this article online
35. Mariani R, Skowronski J (1993) CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc Natl Acad Sci U S A 90: 5549-5553. Find this article online
36. Mascola JR, Louder MK, Winter C, Prabhakara R, De Rosa SC, et al. (2002) Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells. J Virol 76: 4810-4821. Find this article online
37. Morgenstern JP, Land H (1990) Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18: 3587-3596. Find this article online
38. Piguet V, Chen YL, Mangasarian A, Foti M, Carpentier JL, et al. (1998) Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J 17: 2472-2481. Find this article online
39. Piguet V, Schwartz O, Le Gall S, Trono D (1999) The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors. Immunol Rev 168: 51-63. Find this article online
40. Reif K, Cyster J (2002) The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol 12: 368-373. Find this article online
41. Renkema GH, Saksela K (2000) Interactions of HIV-1 NEF with cellular signal transducing proteins. Front Biosci 5: D268-D283. Find this article online
42. Sanui T, Inayoshi A, Noda M, Iwata E, Oike M, et al. (2003a) DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells. Immunity 19: 119-129. Find this article online
43. Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, et al. (2003b) DOCK2 regulates Rac activation and cytoskeletal reorganization through the interaction with ELMO1. Blood 102: 2948-2950. Find this article online
44. Sawai ET, Baur AS, Peterlin BM, Levy JA, Cheng-Mayer CA (1995) A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J Biol Chem 270: 15307-15314. Find this article online
45. Schmitz AA, Govek EE, Bottner B, Van Aelst L (2000) Rho GTPases: Signaling, migration, and invasion. Exp Cell Res 261: 1-12. Find this article online
46. Schrager JA, Marsh JW (1999) HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci U S A 96: 8167-8172. Find this article online
47. Schwartz O, Marechal V, Le Gall S, Lemonnier F, Heard JM (1996) Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 2: 338-342. Find this article online
48. Simmons A, Aluvihare V, McMichael A (2001) Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14: 763-777. Find this article online
49. Skowronski J, Parks D, Mariani R (1993) Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J 12: 703-713. Find this article online
50. Stevenson M, Stanwick TL, Dempsey MP, Lamonica CA (1990) HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J 9: 1551-1560. Find this article online
51. Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, et al. (2003) Nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes. J Virol 77: 4169-4180. Find this article online
52. Swingler S, Mann A, Jacque J, Brichacek B, Sasseville VG, et al. (1999) HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat Med 5: 997-1103. Find this article online
53. Unutmaz D, Kewal-Ramani VN, Marmon S, Littman DR (1999) Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J Exp Med 189: 1735-1746. Find this article online
54. Vilhardt F, Plastre O, Sawada M, Suzuki K, Wiznerowicz M, et al. (2002) The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem 277: 42136-42143. Find this article online
55. Wang JK, Kiyokawa E, Verdin E, Trono D (2000) The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A 97: 394-399. Find this article online
56. Weissman D, Rabin RL, Arthos J, Rubbert A, Dybul M, et al. (1997) Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389: 981-985. Find this article online
57. Yu H, Leitenberg D, Li B, Flavell RA (2001) Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med 194: 915-926. Find this article online