-
2
-
-
4544240500
-
HIV-1 virion fusion assay: Uncoating not required and no effect of Nef on fusion
-
Cavrois, M., J. Neidleman, W. Yonemoto, D. Fenard, and W. C. Greene. 2004. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology 328: 36-44.
-
(2004)
Virology
, vol.328
, pp. 36-44
-
-
Cavrois, M.1
Neidleman, J.2
Yonemoto, W.3
Fenard, D.4
Greene, W.C.5
-
3
-
-
0035848864
-
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
-
Geleziunas, R., W. Xu, K. Takeda, H. Ichijo, and W. C. Greene. 2001. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410: 834-838.
-
(2001)
Nature
, vol.410
, pp. 834-838
-
-
Geleziunas, R.1
Xu, W.2
Takeda, K.3
Ichijo, H.4
Greene, W.C.5
-
4
-
-
19344363916
-
HIV-1 Nef binds the DOCK2-ELMO1 complex to activate Rac and inhibit lymphocyte chemotaxis
-
Janardhan, A., T. Swigut, B. Hill, M. P. Myers, and J. Skowronski. 2004. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate Rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2: 65-76.
-
(2004)
PLoS Biol.
, vol.2
, pp. 65-76
-
-
Janardhan, A.1
Swigut, T.2
Hill, B.3
Myers, M.P.4
Skowronski, J.5
-
5
-
-
0026077650
-
Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA
-
Luria, S., I. Chambers, and P. Berg. 1991. Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proc. Natl. Acad. Sci. USA 88: 5326-5330.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 5326-5330
-
-
Luria, S.1
Chambers, I.2
Berg, P.3
-
6
-
-
0029789219
-
Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef. gene
-
Collette, Y., C. Mawas, and D. Olive. 1996. Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef. gene. Eur. J. Immunol. 26: 1788-1793.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 1788-1793
-
-
Collette, Y.1
Mawas, C.2
Olive, D.3
-
7
-
-
0042977420
-
Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells
-
Tuosto, L., B. Marinari, M. Andreotti, M. Federico, and E. Piccolella. 2003. Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells. Eur. J. Immunol. 33: 2186-2196.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 2186-2196
-
-
Tuosto, L.1
Marinari, B.2
Andreotti, M.3
Federico, M.4
Piccolella, E.5
-
8
-
-
0032538278
-
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
-
Hanna, Z., D. G. Kay, N. Rebai, A. Guimond, S. Jothy, and P. Jolicoeur. 1998. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95: 163-175.
-
(1998)
Cell
, vol.95
, pp. 163-175
-
-
Hanna, Z.1
Kay, D.G.2
Rebai, N.3
Guimond, A.4
Jothy, S.5
Jolicoeur, P.6
-
9
-
-
0033529258
-
HIV-1 Nef increases T cell activation in a stimulus-dependent manner
-
Schrager, J. A., and J. W. Marsh. 1999. HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc. Natl. Acad. Sci. USA 96: 8167-8172.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 8167-8172
-
-
Schrager, J.A.1
Marsh, J.W.2
-
10
-
-
0034602776
-
The Nef protein of HIV-1 associates with rafts and primes T cells for activation
-
Wang, J. K., E. Kiyokawa, E. Verdin, and D. Trono. 2000. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc. Natl. Acad. Sci. USA 97: 394-399.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 394-399
-
-
Wang, J.K.1
Kiyokawa, E.2
Verdin, E.3
Trono, D.4
-
11
-
-
0034948709
-
Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
-
Simmons, A., V. Aluvihare, and A. McMichael. 2001. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14: 763-777.
-
(2001)
Immunity
, vol.14
, pp. 763-777
-
-
Simmons, A.1
Aluvihare, V.2
McMichael, A.3
-
12
-
-
0035943355
-
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA
-
Wu, Y., and J. W. Marsh. 2001. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293: 1503-1506.
-
(2001)
Science
, vol.293
, pp. 1503-1506
-
-
Wu, Y.1
Marsh, J.W.2
-
13
-
-
2342569732
-
+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease
-
+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease. J. Virol. 78: 5244-5257.
-
(2004)
J. Virol.
, vol.78
, pp. 5244-5257
-
-
Weng, X.1
Priceputu, E.2
Chrobak, P.3
Poudrier, J.4
Kay, D.G.5
Hanna, Z.6
Mak, T.W.7
Jolicoeur, P.8
-
14
-
-
0034595806
-
Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
-
Manninen, A., G. H. Renkema, and K. Saksela. 2000. Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J. Biol. Chem. 275: 16513-16517.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16513-16517
-
-
Manninen, A.1
Renkema, G.H.2
Saksela, K.3
-
15
-
-
0037089651
-
HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells
-
Manninen, A., and K. Saksela. 2002. HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J. Exp. Med. 195: 1023-1032.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1023-1032
-
-
Manninen, A.1
Saksela, K.2
-
16
-
-
0030887932
-
The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
-
Baur, A. S., G. Sass, B. Laffert, D. Willbold, C. Cheng-Mayer, and B. M. Peterlin. 1997. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6: 283-291.
-
(1997)
Immunity
, vol.6
, pp. 283-291
-
-
Baur, A.S.1
Sass, G.2
Laffert, B.3
Willbold, D.4
Cheng-Mayer, C.5
Peterlin, B.M.6
-
17
-
-
0028805516
-
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
-
Lee, C. H., B. Leung, M. A. Lemmon, J. Zheng, D. Cowbura, J. Kuriyan, and K. Saksela. 1995. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14: 5006-5015.
-
(1995)
EMBO J.
, vol.14
, pp. 5006-5015
-
-
Lee, C.H.1
Leung, B.2
Lemmon, M.A.3
Zheng, J.4
Cowbura, D.5
Kuriyan, J.6
Saksela, K.7
-
18
-
-
0034843329
-
The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck
-
Hanna, Z., X. Weng, D. G. Kay, J. Poudrier, C. Lowell, and P. Joucoeur. 2001. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J. Virol. 75: 9378-9392.
-
(2001)
J. Virol.
, vol.75
, pp. 9378-9392
-
-
Hanna, Z.1
Weng, X.2
Kay, D.G.3
Poudrier, J.4
Lowell, C.5
Joucoeur, P.6
-
19
-
-
0033153464
-
Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
-
Fackler, O. T., W. Luo, M. Geyer, A. S. Alberts, and B. M. Peterlin. 1999. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol. Cell. 3: 729-739.
-
(1999)
Mol. Cell.
, vol.3
, pp. 729-739
-
-
Fackler, O.T.1
Luo, W.2
Geyer, M.3
Alberts, A.S.4
Peterlin, B.M.5
-
20
-
-
0034469146
-
Lentivirus Nef specifically activates Pak2
-
Arora, V. K., R. P. Molina, J. L. Foster, J. L. Blakemore, J. Chernoff, B. L. Fredericksen, and J. V. Garcia. 2000. Lentivirus Nef specifically activates Pak2. J. Virol. 74: 11081-11087.
-
(2000)
J. Virol.
, vol.74
, pp. 11081-11087
-
-
Arora, V.K.1
Molina, R.P.2
Foster, J.L.3
Blakemore, J.L.4
Chernoff, J.5
Fredericksen, B.L.6
Garcia, J.V.7
-
21
-
-
0033518291
-
Identification of the Nef-associated kinase as p21-activated kinase 2
-
Renkema, G. H., A. Manninen, D. A. Mann, M. Harris, and K. Saksela. 1999. Identification of the Nef-associated kinase as p21-activated kinase 2. Curr. Biol. 9: 1407-1410.
-
(1999)
Curr. Biol.
, vol.9
, pp. 1407-1410
-
-
Renkema, G.H.1
Manninen, A.2
Mann, D.A.3
Harris, M.4
Saksela, K.5
-
22
-
-
0032566903
-
SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase
-
Manninen, A., M. Hiipakka, M. Vihinen, W. Lu, B. J. Mayer, and K. Saksela. 1998. SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 250: 273-282.
-
(1998)
Virology
, vol.250
, pp. 273-282
-
-
Manninen, A.1
Hiipakka, M.2
Vihinen, M.3
Lu, W.4
Mayer, B.J.5
Saksela, K.6
-
23
-
-
0038554077
-
Biology of the p21-activated kinases
-
Bokoch, G. M. 2003. Biology of the p21-activated kinases. Annu. Rev. Biochem. 72: 743-781.
-
(2003)
Annu. Rev. Biochem.
, vol.72
, pp. 743-781
-
-
Bokoch, G.M.1
-
24
-
-
2942555187
-
A novel role for p21-activated protein kinase 2 in T cell activation
-
Chu, P. C., J. Wu, X. C. Liao, J. Pardo, H. Zhao, C. Li, M. K. Mendenhall, E. Pali, M. Shen, S. Yu, et al. 2004. A novel role for p21-activated protein kinase 2 in T cell activation. J. Immunol. 172: 7324-7334.
-
(2004)
J. Immunol.
, vol.172
, pp. 7324-7334
-
-
Chu, P.C.1
Wu, J.2
Liao, X.C.3
Pardo, J.4
Zhao, H.5
Li, C.6
Mendenhall, M.K.7
Pali, E.8
Shen, M.9
Yu, S.10
-
25
-
-
0030292953
-
Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques
-
Sawai, E. T., I. H. Khan, P. M. Montbriand, B. M. Peterlin, C. Cheng-Mayer, and P. A. Luciw. 1996. Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques. Curr. Biol. 6: 1519-1527.
-
(1996)
Curr. Biol.
, vol.6
, pp. 1519-1527
-
-
Sawai, E.T.1
Khan, I.H.2
Montbriand, P.M.3
Peterlin, B.M.4
Cheng-Mayer, C.5
Luciw, P.A.6
-
26
-
-
0034064726
-
p21-activated kinase 1 plays a critical role in cellular activation by Nef
-
Fackler, O. T., X. Lu, J. A. Frost, M. Geyer, B. Jiang, W. Luo, A. Abo, A. S. Alberts, and B. M. Peterlin. 2000. p21-activated kinase 1 plays a critical role in cellular activation by Nef. Mol. Cell. Biol. 20: 2619-2627.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2619-2627
-
-
Fackler, O.T.1
Lu, X.2
Frost, J.A.3
Geyer, M.4
Jiang, B.5
Luo, W.6
Abo, A.7
Alberts, A.S.8
Peterlin, B.M.9
-
27
-
-
0035128420
-
Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or β-PIX
-
Renkema, G. H., A. Manninen, and K. Saksela. 2001. Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or β-PIX. J. Virol. 75: 2154-2160.
-
(2001)
J. Virol.
, vol.75
, pp. 2154-2160
-
-
Renkema, G.H.1
Manninen, A.2
Saksela, K.3
-
28
-
-
0035173735
-
HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
-
Wolf, D., V. Witte, B. Laffert, K. Blume, E. Stromer, S. Trapp, P. d'Aloja, A. Schurmann, and A. S. Baur. 2001. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals. Nat. Med. 7: 1217-1224.
-
(2001)
Nat. Med.
, vol.7
, pp. 1217-1224
-
-
Wolf, D.1
Witte, V.2
Laffert, B.3
Blume, K.4
Stromer, E.5
Trapp, S.6
D'Aloja, P.7
Schurmann, A.8
Baur, A.S.9
-
29
-
-
0036056929
-
Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV
-
Linnemann, T., Y. H. Zheng, R. Mandic, and B. M. Peterlin. 2002. Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV. Virology 294: 246-255.
-
(2002)
Virology
, vol.294
, pp. 246-255
-
-
Linnemann, T.1
Zheng, Y.H.2
Mandic, R.3
Peterlin, B.M.4
-
30
-
-
12144291075
-
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts
-
Krautkramer, E., S. I. Giese, J. E. Gasteier, W. Muranyi, and O. T. Fackler. 2004. Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J. Virol. 78: 4085-4097.
-
(2004)
J. Virol.
, vol.78
, pp. 4085-4097
-
-
Krautkramer, E.1
Giese, S.I.2
Gasteier, J.E.3
Muranyi, W.4
Fackler, O.T.5
-
31
-
-
8644224930
-
Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts
-
Pulkkinen, K., G. H. Renkema, F. Kirchhoff, and K. Saksela. 2004. Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. J. Virol. 78: 12773-12780.
-
(2004)
J. Virol.
, vol.78
, pp. 12773-12780
-
-
Pulkkinen, K.1
Renkema, G.H.2
Kirchhoff, F.3
Saksela, K.4
-
32
-
-
4644324248
-
Diversity in immune-cell interactions: States and functions of the immunological synapse
-
Friedl, P., and J. Storim. 2004. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell. Biol. 14: 557-567.
-
(2004)
Trends Cell. Biol.
, vol.14
, pp. 557-567
-
-
Friedl, P.1
Storim, J.2
-
33
-
-
13744259226
-
Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor nef
-
Keppler, O. T., I. Allespach, L. Schuller, D. Fenard, W. C. Greene, and O. T. Fackler. 2005. Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor nef. J. Virol. 79: 1655-1665.
-
(2005)
J. Virol.
, vol.79
, pp. 1655-1665
-
-
Keppler, O.T.1
Allespach, I.2
Schuller, L.3
Fenard, D.4
Greene, W.C.5
Fackler, O.T.6
-
34
-
-
0035794535
-
Mechanism for down-regulation of CD28 by Nef
-
Swigut, T., N. Shohdy, and J. Skowronski. 2001. Mechanism for down-regulation of CD28 by Nef. EMBO J. 20: 1593-1604.
-
(2001)
EMBO J.
, vol.20
, pp. 1593-1604
-
-
Swigut, T.1
Shohdy, N.2
Skowronski, J.3
-
35
-
-
0030684068
-
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
-
Greenberg, M. E., S. Bronson, M. Lock, M. Neumann, G. N. Pavlakis, and J. Skowronski. 1997. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J. 16: 6964-6976.
-
(1997)
EMBO J.
, vol.16
, pp. 6964-6976
-
-
Greenberg, M.E.1
Bronson, S.2
Lock, M.3
Neumann, M.4
Pavlakis, G.N.5
Skowronski, J.6
-
36
-
-
0034713437
-
Interactions of HIV-1 nef with the μ subunits of adaptor protein complexes 1, 2, and 3: Role of the dileucine-based sorting motif
-
Craig, H. M., T. R. Reddy, N. L. Riggs, P. P. Dao, and J. C. Guatelli. 2000. Interactions of HIV-1 nef with the μ subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology 271: 9-17.
-
(2000)
Virology
, vol.271
, pp. 9-17
-
-
Craig, H.M.1
Reddy, T.R.2
Riggs, N.L.3
Dao, P.P.4
Guatelli, J.C.5
-
37
-
-
0033613826
-
T lymphocyte costimulation mediated by reorganization of membrane microdomains
-
Viola, A., S. Schroeder, Y. Sakakibara, and A. Lanzavecchia. 1999. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283: 680-682.
-
(1999)
Science
, vol.283
, pp. 680-682
-
-
Viola, A.1
Schroeder, S.2
Sakakibara, Y.3
Lanzavecchia, A.4
-
38
-
-
0035811040
-
Nef increases infectivity of HIV via lipid rafts
-
Zheng, Y. H., A. Plemenitas, T. Linnemann, O. T. Fackler, and B. M. Peterlin. 2001. Nef increases infectivity of HIV via lipid rafts. Curr. Biol. 11: 875-879.
-
(2001)
Curr. Biol.
, vol.11
, pp. 875-879
-
-
Zheng, Y.H.1
Plemenitas, A.2
Linnemann, T.3
Fackler, O.T.4
Peterlin, B.M.5
-
39
-
-
0038153856
-
Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions
-
Zheng, Y. H., A. Plemenitas, C. J. Fielding, and B. M. Peterlin. 2003. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc. Natl. Acad. Sci. USA 100: 8460-8465.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8460-8465
-
-
Zheng, Y.H.1
Plemenitas, A.2
Fielding, C.J.3
Peterlin, B.M.4
-
40
-
-
0035123886
-
Activation of NFAT-dependent gene expression by Nef: Conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-θ
-
Manninen, A., P. Huotari, M. Hiipakka, G. H. Renkema, and K. Saksela. 2001. Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-θ. J. Virol. 75: 3034-3037.
-
(2001)
J. Virol.
, vol.75
, pp. 3034-3037
-
-
Manninen, A.1
Huotari, P.2
Hiipakka, M.3
Renkema, G.H.4
Saksela, K.5
-
41
-
-
0037105477
-
Cutting edge: Quantitative imaging of raft accumulation in the immunological synapse
-
Burack, W. R., K. H. Lee, A. D. Holdorf, M. L. Dustin, and A. S. Shaw. 2002. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J. Immunol. 169: 2837-2841.
-
(2002)
J. Immunol.
, vol.169
, pp. 2837-2841
-
-
Burack, W.R.1
Lee, K.H.2
Holdorf, A.D.3
Dustin, M.L.4
Shaw, A.S.5
-
42
-
-
2642557101
-
HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion
-
Djordjevic, J. T., S. D. Schibeci, G. J. Stewart, and P. Williamson. 2004. HIV type 1 Nef increases the association of T cell receptor (TCR)-signaling molecules with T cell rafts and promotes activation-induced raft fusion. AIDS Res. Hum. Retroviruses 20: 547-555.
-
(2004)
AIDS Res. Hum. Retroviruses
, vol.20
, pp. 547-555
-
-
Djordjevic, J.T.1
Schibeci, S.D.2
Stewart, G.J.3
Williamson, P.4
|