Human immunodeficiency virus type 1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway

Blood

Volumn 93, Issue 3, 1999, Pages 1000-1010

  Zauli, Giorgio ^a   Gibellini, Davide ^b   Secchiero, Paola ^b   Dutartre, Hélène ^b   Olive, Daniel ^b   Capitani, Silvano ^b   Collette, Yves ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; NEF PROTEIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL LINE; LYMPHOBLASTOID CELL LINE; LYMPHOCYTOPENIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

EID: 0032959989     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.3.1000     Document Type: Article

References (65)

1. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RP, Miedema F: Programmed cell death of T cells in HIV-1 infection. Science 257:217, 1992
2. Estaquier J, Idziorek T, de Bels F, Barré Sinoussi F, Hurtrel B, Auburtin AM, Venet A, Mehtali M, Muchmore E, Michel P: Programmed cell death and AIDS: Significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc Natl Acad Sci USA 91:9431, 1994
3. Finkel TH, Tudor Williams G, Banda NK, Cotton MF, Curiel T, Monks C, Baba TW, Ruprecht RM, Kupfer A: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1:1129, 1995
4. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029, 1995
5. + lymphocyte depletion and human immunodeficiency virus replication. Blood 89:1357, 1997
6. Gougeon ML, Lecoeur H, Boudet F, Ledru E, Marzabal S, Boullier S, Roué R, Nagata S, Heeney J: Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype. J Immunol 158:2964, 1997
7. Kesler HW, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Dersorsiers RC: Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651, 1991
8. Daniel MD, Kirchoff F, Czajak SC, Sehgal PK, Desrosiers RC: Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258:1938, 1992
9. Rud EW, Cranage M, Yon J, Quirk J, Ogilvie L, Cook N, Webster S, Dennis M, Clarke BE: Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants. J Gen Virol 75:529, 1994
10. Du Z, Lang SM, Sasseville VG, Lackner AA, Ilynskii PO, Daniel MD, Jung JU, Desrosiers RC: Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82:665, 1995
11. Jamieson BD, Aldrovandi GM, Planelles V, Jowett JBM, Gao L, Bloch LM, Chen ISY, Zack JA: Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol 68:3478, 1994
12. Kirchoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 332:228, 1995
13. Sinclair E, Barbosa P, Feinberg MB: The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeble. J Virol 71:3641, 1997
14. Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD: The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 179:115, 1994
15. Aldrovandi GM, Zack JA: Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol 70:1505, 1996
16. Lindemann D, Wilhelm R, Renard P, Althage A, Zinkernagel R, Mous J: Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3′-long terminal repeat transgene. J Exp Med 179:797, 1994
17. Cullen BR: The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology 205:1, 1994 (review)
18. Niederman TM, Hastings WR, Luria S, Bandres JC, Ratner L: Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells. J Virol 66:6213, 1992
19. Bandres JC, Ratner L: Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-κB and AP-1 in human T cells in vitro after T cell receptor stimulation. J Virol 68:3243, 1994
20. Collette Y, Chang HL, Cerdan C, Chambost H, Algarte M, Mawas C, Imbert J, Burny A, Olive D: Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 nef gene-induced expression. J Immunol 156:360, 1996
21. Collette Y, Dutartre H, Benziane A, Ramosmorales F, Benarous R, Harris M, Olive D: Physical and functional interaction of Nef with lck-HIV-1 Nef-induced T-cell signalling defects. J Biol Chem 271:6333, 1996
22. Sawai ET, Baur A, Struble H, Peterlin BM, Levy JA, Cheng-Mayer C: Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc Natl Acad Sci USA 91:1539, 1994
23. Greenway A, Azad A, McPhee D: Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J Virol 69:1842, 1995
24. Nunn MF, Marsh JW: Human immunodeficiency virus type 1 nef associates with a member of the p21-activated kinase family. J Virol 70:6157, 1996
25. Baur AS, Sass G, Laffert B, Willbold D, Cheng MC, Peterlin BM: The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6:283, 1997
26. Wiskerchen M, Cheng MC: HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology 224:292, 1996
27. Iafrate AJ, Bronson S, Skowronski J: Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J 16:673, 1997
28. Murphy KM, Sweet MT, Ross IL, Hume DA: Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages. J Virol 67:6959, 1993
29. Baur AS, Sawai ET, Dazin P, Fantl WJ, Cheng-Mayer C, Peterlin BM: HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1:373, 1994
30. Cooke SJ, Coates K, Barton CH, Biggs TE, Barrett SJ, Cochrane A, Oliver K, McKeating JA, Harris MPG, Mann DA: Regulated expression vectors demonstrate cell-type-specific sensitivity to human immunodeficiency virus type 1 Nef-induced cytostasis. J Gen Virol 78:381, 1997
31. Xu XN, Screaton GR, Gotch FM, Dong T, Tan R, Almond N, Walker B, Stebbings R, Kent P, Nagata S, Stott JE, McMichael AJ: Evasion of cytotoxic T lymphocyte (CTL) responses by Nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J Exp Med 186:7, 1997
32. Dittmer U, Nisslein T, Bodemer W, Petry H, Sauermann U, Stahlhennig C, Hunsmann G: Cellular immune response of rhesus monkeys infected with a partially attenuated nef deletion mutant of the simian immunodeficiency virus. Virology 212:392, 1995
33. Hunninghake GW, Monick MM, Liu B, Stinski MF: The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements. J Virol 63:3026, 1989
34. + T lymphocytes. J Immunol 157:2216, 1996
35. Zauli G, Vitale M, Re MC, Furlini G, Zamai L, Falcieri E, Gibellini D, Visani G, Davis BR, Capitani S, La Placa M: In vitro exposure to human immunodeficiency virus type-1 (HIV-1) induces apoptotic cell death of the factor-dependent TF-1 hematopoietic cell line. Blood 83:167, 1994
36. Collette Y, Mawas C, Olive D: Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef gene. Eur J Immunol 26:1788, 1996
37. Gehri R, Hahn S, Rothen M, Steuerwald M, Nuesch R, Erb P: The Fas receptor in HIV infection: Expression on peripheral blood lymphocytes and role in the depletion of T cells. AIDS 10:9, 1996
38. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233, 1991
39. Tanaka M, Suda T, Takahashi T, Nagata S: Expression of the functional soluble form of human fas ligand in activated lymphocytes. EMBO J 14:1129, 1995
40. Sawai ET, Khan IH, Montbriand PM, Peterlin BM, Cheng-Mayer C, Luciw PA: Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques. Curr Biol 6:1519, 1996
41. Lu X, Wu X, Plemenitas A, Yu H, Sawai ET, Abo A, Peterlin BM: CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1. Curr Biol 6:1677, 1996
42. + T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease. Ann Intern Med 113:438, 1990
43. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123, 1995
44. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117, 1995
45. Shen Y, Shenk T: Viruses and apoptosis. Curr Opin Genet Dev 5:105, 1995
46. Woloschak GE, Schireck S, Panozzo J, Chang-Liu CM, Libertin CR: HIV expression is induced in dying cells. Biochim Biophys Acta 1351:105, 1997
47. Collins KL, Chen BK, Kafarns SA, Walker BD, Baltimore D: HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397, 1998
48. Ovod V, Lagerstedt A, Ranki A, Gombert FO, Spohn R, Tahtinen M, Jung G, Krohn KJE: Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies. AIDS 6:25, 1992
49. Okada H, Takei R, Tashiro M: HIV-1 nef protein-induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95 (Fas). FEBS Lett 414:603, 1997
50. Okada H, Takei R, Tashiro M: Nef protein of HIV-1 induces apoptotic cytolysis of murine lymphoid cells independently of CD95 (Fas) and its suppression by serine/threonine protein kinase inhibitors. FEBS Lett 417:61, 1997
51. Okada H, Takei R, Tashiro M: Inhibition of HIV-1 Nef-induced apoptosis of uninfected human blood cells by serine/threonine protein kinase inhibitors, fasudil hydrochloride and M3. FEBS Lett 422:363, 1998
52. Nagata S, Golstein P: The Fas death factor. Science 267:1449, 1995
53. Alderson MR, Tough TW, Davis Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 181:71, 1995
54. Nagata S: Fas ligand and immune evasion. Nat Med 2:1306, 1996
55. Dickie P: HIV type 1 Nef perturbs eye lens development in transgenic mice. AIDS Res Hum Retroviruses 12:177, 1996
56. Badley AD, McElhinny JA, Leibson PJ, Lynch DH, Alderson MR, Paya CV: Upregulation of Fas ligand expression by human immunodefiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 70:199, 1996
57. Briggs SD, Sharkey M, Stevenson M, Smithgall TE: SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. J Biol Chem 272:17899, 1997
58. Anel A, Buferne M, Boyer C, Schitt VA, Golstein P: T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur J Immunol 24:2469, 1994
59. Chung CD, Lewis LA, Miceli MC: T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities. J Immunol 159:1758, 1997
60. Gonzales GA, Leonardo E, Merida I, Martinez AC, Carrera AC: Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J Immunol 158:4104, 1997
61. Latinis KM, Carr LL, Peterson EJ, Norian LA, Eliason SL, Koretzky GA: Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J Immunol 158:4602, 1997
62. Van AL, D'Souza SC: Rho GTPases and signaling networks. Genes Dev 11:2295, 1997
63. Sieg S, Huang Y, Kaplan D: The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable. J Virol 71:3641, 1997
64. Latinis KM, Koretzky GA: Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood 87:871, 1996
65. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497, 1995