Nef proteins of distinct HIV-1 or -2 isolates differ in their binding properties for HCK: Isolation of a novel Nef binding factor with characteristics of an adaptor protein

Virology

Volumn 246, Issue 1, 1998, Pages 45-52

  Karn, Thomas ^a   Hock, Björn ^a   Holtrich, Uwe ^a   Adamski, Michalina ^b   Strebhardt, Klaus ^a   Rübsamen Waigmann, Helga ^b  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^b BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CELL PROTEIN; COMPLEMENTARY DNA; NEF PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0032551187     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9157     Document Type: Article

References (41)

1. Artenstein, A. W., Hegerich, P. A., Beyrer, C., Rungruengthanakit, K., Michael, N. L., and Natpratan, C. (1996). Sequences and phylogenetic analysis of the nef gene from thai subjects harboring subtype E HIV-1. Aids Res. Hum. Retroviruses 12, 557-560.
2. Aiken, C., and Trono, D. (1995). Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69, 5048-5056.
3. Barnett, S. W., Quiroga, M., Werner, A., Dina, D., and Levy, J. A. (1993). Distinguishing features of an infectious molecular clone of the highly divergent and noncytopathic human immunodeficiency virus type 2 UC1 strain. J. Virol. 67, 1006-1014.
4. Bartel, P. L., Chien, C.-T., Sternglanz, R., and Fields, S. (1993). "Cellular Interactions in Development: A Practical Approach" (D. A. Hartley, Ed.), pp. 153-179. Oxford Univ. Press, Oxford.
5. Baur, A. S., Sass, G., Laffert, B., Willbold, D., Cheng-Mayer, C., and Peterlin, B. M. (1997). The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6, 1-20.
6. Benichou, S., Bomsel, M., Bodéus, M., Durand, H., Douté, M., Letourneur, F., Camonis, J., and Benarous, R. (1994). Physical interaction of the HIV-1 Nef protein with β-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. J. Biol. Chem. 269, 30073-30076.
7. Chowers, M. Y., Spina, C. A., Kwoh, T. J., Fitch, N. J. S., Richman, D. D., and Guatelli, J. C. (1994). Optimal infectivity in vitro of HIV-1 requires an intact nef gene. J. Virol. 68, 2906-2914.
8. Deacon, N. J., Tsykin, A., Solomon, A., Smith, K., Ludford-Mentin, M., Hooker, D. J., McPhee, D. A., Greenway, A. L., Ellett, A., Chatfield, C., Lawson, V. A., Crowe, S., Maerz, A., Sonza, S., Learmont, J., Sullivan, J. S., Cunningham, A., Dwyer, D., Dowton, D., and Mills, J. (1995). Genomic structure of an attunuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270, 988-991.
9. Dietrich, U., Adamski, M., Kreutz, R., Seipp, A., Kühnel, H., and Rübsamen-Waigmann, H. (1989). A highly divergent HIV-2-related isolate. Nature 342, 948-950.
10. Goldsmith, M. A., Warmerdam, M. T., Atchison, R. E., Miller, M. D., and Greene, W. C. (1995). Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 nef. J. Virol. 69, 4112-4121.
11. Grzesiek, S., Bax, A., Clore, G. M., Gronenborn, A. M., Hu, J.-S., Kaufman, J., Palmer, I., Stahl, S. J., and Wingfield, P. T. (1996). The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nature Struct. Biol. 3, 340-345.
12. Hollenberg, S. M., Sternglanz, R., Cheng, P. F., and Weintraub, H. (1995). Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15, 3813-1822.
13. Karn, T., Holtrich, U., Bräuninger, A., Böhme, B., Wolf, G., Rübsamen-Waigmann, H., and Strebhardt, K. (1993). Structure expression and chromosomal mapping of TKT from man and mouse, a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene 8, 3433-3440.
14. Kestler, H. W., III, Ringler, D. J., Mori, K., Panicali, D. L., Sehgal, P. K., Daniel, M. D., and Desrosier, R. C. (1991). Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662.
15. Kirchhoff, F., Greenough, T. C., Brettler, D. B., Sullivan, J. L., and Desrosiers, R. C. (1995). Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332, 228-232.
16. ALT isolate extends the known range of variability within the primate immunodeficiency viruses. Aids Res. Hum. Retroviruses 8, 1619-1629.
17. Kühnel, H., von Briesen, H., Dietrich, U., Adamski, M., Mix, D., Biesert, L., Kreutz, R., Immelmann, A., Henco, K., Meichsner, C., Andreesen, R., Gelderblom, H., and Rübsamen-Waigmann, H. (1989). Molecular cloning of two west African human immunodeficiency virus type 2 isolates that replicate well in macrophages: A Gambian isolate, from a patient with neurologic acquired immunodeficiency syndrome, and a highly divergent Ghanian isolate. Proc. Natl. Acad. Sci. USA 86, 2383-2387.
18. Lang, S. M., Iafrate, A. J., Stahl-Hennig, C., Kuhn, E. M., Nisslein, T., Kaup, F.-J., Haupt, M., Hunsmann, G., Skowronski, J., and Kirchhoff, F. (1997). Association of simian immunodeficiency virus nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nature Med. 3, 860-865.
19. Lee, C.-H., Leung, B., Lemmon, M. A., Zheng, J., Cowburn, D., Kuriyan, J., and Saksela, K. (1995). A single amino acid in the SH3 domain of HCK determines its high affinity and specifity in binding to HIV-1 Nef protein. EMBO J. 14, 5006-5015.
20. Lee, C.-H., Saksela, K., Mirza, U. A., Chait, B. T., and Kuriyan, J. (1996). Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85, 931-942.
21. Luo, T., and Garcia, J. V. (1996). The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent. J. Virol. 70, 6493-6496.
22. Lupas, A., Van Dyke, M., and Stock, J. (1991). Predicting coiled coils from protein sequences. Science 252, 1162-1164.
23. Mariani, R., and Skowronski, J. (1993). CD4 down-regulation by nef alleles isolated from human immunodeficiency type 1-infected individuals. Proc. Natl. Acad. Sci. USA 90, 5549-5553.
24. Michael, N. L., Chang, G., D'Arcy, L. A., Tseng, C. J., Birx, D. L., and Sheppard, H. W. (1995). Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression. J. Virol. 69, 6758-6769.
25. Miller, M. D., Warmerdam, M. T., Gaston, I., Greene, W. C., and Feinberg, M. B. (1994). The HIV-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179, 101-113.
26. Miller, M. D., Warmerdam, M. T., Page, K. A., Feinberg, M. B., and Greene, W. C. (1995). Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J. Virol. 69, 579-584.
27. Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 385, 650-653.
28. Noble, M. E. M., Musacchio, A., Saraste, M., Courtneidge, S. A., and Wierenga, R. K. (1993). Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. EMBO J. 12, 2617-2624.
29. Nunn, M. F., and Marsh, J. W. (1996). Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J. Virol. 70, 6157-6161.
30. Pearson, W. R., and Lipman, D. J. (1988). Improved tools for biological sequence analysis. Proc. Natl. Acad. Sci. USA 85, 2444-2448.
31. Ruppach, H., Knechten, H., Jäger, H., Rübsamen-Waigmann, H., and Dietrich, U. (1996). Risk of HIV transmission in infected US military personnel. Lancet 347, 697-698.
32. + viruses but not for down-regulation of CD4. EMBO J. 14, 484-491.
33. lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc. Natl. Acad. Sci. USA 92, 349-353.
34. Sawai, E. T., Baur, A. S., Struble, H., Peterlin, B. M., Levy, J. A., and Cheng-Mayer, C. (1994). Human immunodeficiency virus type 1 associates with a cellular serine kinase in T lymphocytes. Proc. Natl. Acad. Sci. USA 91, 1539-1543.
35. Sawai, E. T., Baur, A. S., Peterlin, B. M., Levy, J. A., and Cheng-Mayer, C. (1995). A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270, 15307-15314.
36. Sawai, E. T., Khan, I. H., Montbriand, P. M., Peterlin, B. M., Cheng-Mayer, C., and Luciw, P. A. (1996). Activation of PAK by HIV and SIV Nef: Importance for AIDS in rhesus macaques. Curr. Biol. 6, 1519-1527.
37. Schwartz, O., Maréchal, V., Danos, O., and Heard, J.-M. (1995). Human immunodeficiency virus type 1 nef increases the efficiency of reverse transcription in the infected cell. J. Virol. 69, 4053-4059.
38. Sicheri, F., Moarefi, I., and Kuriyan, J. (1997). Crystal structure of the Src family tyrosine kinase Hck. Nature 385, 602-609.
39. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994). CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680.
40. Trono, D. (1995). HIV accessory proteins: Leading roles for the supporting cast. Cell 82, 189-192.
41. Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A. (1993). Mammalian ras interacts directly with the serine/threonine kinase raf. Cell 74, 205-214.