메뉴 건너뛰기




Volumn 163, Issue 6, 1999, Pages 2977-2981

Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; NEF PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2;

EID: 0033568211     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (50)

References (42)
  • 5
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchoff, T., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Derosiers. 1995. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332:228.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 228
    • Kirchoff, T.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Derosiers, R.C.5
  • 6
    • 0028302998 scopus 로고
    • Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene
    • Chowers, M. Y., C. A. Spina, T. J. Kwoh, N. J. Fitch, D. D. Richman, and J. C. Guatelli. 1994. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol. 68:2906.
    • (1994) J. Virol. , vol.68 , pp. 2906
    • Chowers, M.Y.1    Spina, C.A.2    Kwoh, T.J.3    Fitch, N.J.4    Richman, D.D.5    Guatelli, J.C.6
  • 7
    • 0028820530 scopus 로고
    • The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
    • Chowers, M. Y., M. W. Pandori, C. A. Spina, D. D. Richman, and J. C. Guatelli. 1995. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. Virology 212: 451.
    • (1995) Virology , vol.212 , pp. 451
    • Chowers, M.Y.1    Pandori, M.W.2    Spina, C.A.3    Richman, D.D.4    Guatelli, J.C.5
  • 8
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller, M. D., M. T. Warmerdam, I. Gaston, W. C. Greene, and M. B. Feinberg. 1994. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179:101.
    • (1994) J. Exp. Med. , vol.179 , pp. 101
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 9
    • 0028936207 scopus 로고
    • Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry
    • Miller, M. D., M. T. Warmerdam, K. A. Page, M. B. Feinberg, and W. C. Greene. 1995. Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. J. Virol. 69:579.
    • (1995) J. Virol. , vol.69 , pp. 579
    • Miller, M.D.1    Warmerdam, M.T.2    Page, K.A.3    Feinberg, M.B.4    Greene, W.C.5
  • 10
    • 0027158904 scopus 로고
    • Downregulation of cell surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection
    • Benson, R. E., A. Sanfridson, J. S. Ottinger, C. Doyle, and B. R. Cullen. 1993. Downregulation of cell surface CD4 expression by simian immunodeficiency virus nef prevents viral super infection. J. Exp. Med. 77:1561.
    • (1993) J. Exp. Med. , vol.77 , pp. 1561
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 11
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350:508.
    • (1991) Nature , vol.350 , pp. 508
    • Garcia, J.V.1    Miller, A.D.2
  • 13
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken, C., J. Konner, N. R. Landau, M. E. Lenburg, and D. Trono. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853.
    • (1994) Cell , vol.76 , pp. 853
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 14
    • 0027315870 scopus 로고
    • CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type I-infected individuals
    • Mariani, R., and J. Skowronski. 1993. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type I-infected individuals. Proc. Natl. Acad. Sci. USA 90:5549.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5549
    • Mariani, R.1    Skowronski, J.2
  • 15
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins, K. L., B. K. Chen, S. A. Kalams, B. D. Walker, and D. Baltimore. 1998. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397.
    • (1998) Nature , vol.391 , pp. 397
    • Collins, K.L.1    Chen, B.K.2    Kalams, S.A.3    Walker, B.D.4    Baltimore, D.5
  • 16
  • 17
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 nef protein
    • Schwartz, O., V. Marechal, S. Le Gall, F. Lemonnier, and J.-M. Heard. 1996. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 nef protein. Nat. Med. 2:338.
    • (1996) Nat. Med. , vol.2 , pp. 338
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.-M.5
  • 18
    • 0033013962 scopus 로고    scopus 로고
    • Nef-Induced CD4 and major histocompatibility complex class I (MHC-I down-regulation are governed by distinct determinants: N-terminal α helix and proline repeat of Nef selectively regulate MHC-I trafficking
    • Mangasarian, A., V. Piguet, J.-K. Wang, Y.-L. Chen, and D. Trono. 1999. Nef-Induced CD4 and major histocompatibility complex class I (MHC-I down-regulation are governed by distinct determinants: N-Terminal α helix and proline repeat of Nef selectively regulate MHC-I trafficking. J. Virol. 73:1964.
    • (1999) J. Virol. , vol.73 , pp. 1964
    • Mangasarian, A.1    Piguet, V.2    Wang, J.-K.3    Chen, Y.-L.4    Trono, D.5
  • 19
    • 0032488027 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    • Bresnahan, P. A., W. Yonemoto, S. Ferrell, D. Williams-Herman, R. Geleziunas, and W. C. Greene. 1998. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr. Biol. 8:1235.
    • (1998) Curr. Biol. , vol.8 , pp. 1235
    • Bresnahan, P.A.1    Yonemoto, W.2    Ferrell, S.3    Williams-Herman, D.4    Geleziunas, R.5    Greene, W.C.6
  • 20
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 downregulation and optimal viral infectivity
    • Craig, H. M., M. W. Pandori, and J. C. Guatelli. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 downregulation and optimal viral infectivity. Proc. Natl. Acad. Sci. USA 95:11229.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11229
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 21
    • 0032488055 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    • Greenberg, M., L. De Tulleo, I. Rapoport, J. Skowronski, and T. Kirchhausen. 1998. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr. Biol. 8:1239.
    • (1998) Curr. Biol. , vol.8 , pp. 1239
    • Greenberg, M.1    De Tulleo, L.2    Rapoport, I.3    Skowronski, J.4    Kirchhausen, T.5
  • 22
    • 0029795040 scopus 로고    scopus 로고
    • The CD4 determinant for downregulation by HIV-1 nef directly binds to nef: Mapping of the nef binding surface by NMR
    • Grzesiek, S., S. J. Stahl, P. T. Wingfield, and A. Bax. 1996. The CD4 determinant for downregulation by HIV-1 nef directly binds to nef: mapping of the nef binding surface by NMR. Biochemistry 35:10256.
    • (1996) Biochemistry , vol.35 , pp. 10256
    • Grzesiek, S.1    Stahl, S.J.2    Wingfield, P.T.3    Bax, A.4
  • 23
    • 0030958508 scopus 로고    scopus 로고
    • Identification of regions in HIV-1 nef required for efficient downregulation of cell surface CD4
    • Hua, J., W. Blair, R. Truan, and B. R. Cullen. 1997. Identification of regions in HIV-1 nef required for efficient downregulation of cell surface CD4. Virology 231:231.
    • (1997) Virology , vol.231 , pp. 231
    • Hua, J.1    Blair, W.2    Truan, R.3    Cullen, B.R.4
  • 24
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
    • Piguet, V., F. Gu, M. Foti, N. Demaurex, J. Gruenberg, J.-L. Carpentier, and D. Trono. 1999. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes. Cell 97:63.
    • (1999) Cell , vol.97 , pp. 63
    • Piguet, V.1    Gu, F.2    Foti, M.3    Demaurex, N.4    Gruenberg, J.5    Carpentier, J.-L.6    Trono, D.7
  • 25
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg, M. E., A. J. Iafrate, and J. Skowronski. 1998. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17:2777.
    • (1998) EMBO J. , vol.17 , pp. 2777
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 26
    • 0031106614 scopus 로고    scopus 로고
    • Coats and vesicle budding
    • Robinson, M. S. 1997. Coats and vesicle budding. Trends Cell Biol. 7:99.
    • (1997) Trends Cell Biol. , vol.7 , pp. 99
    • Robinson, M.S.1
  • 27
    • 0030003317 scopus 로고    scopus 로고
    • Protein targeting by tyrosine- and di-leucine-based signals: Evidence for distinct saturable components
    • Marks, M. S., L. Woodruff, H. Ohno, and J. S. Bonifacino. 1996. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell Biol. 135:341.
    • (1996) J. Cell Biol. , vol.135 , pp. 341
    • Marks, M.S.1    Woodruff, L.2    Ohno, H.3    Bonifacino, J.S.4
  • 28
    • 0030003317 scopus 로고    scopus 로고
    • Protein targeting by tyrosine- and di-leucine-based signals: Evidence for distinct saturable components
    • Marks, M. S., L. Woodruff, H. Ohno, and J. S. Bonifacino. 1996. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell Biol. 135:341. Kirchhausen, T., J. S. Bonifacino, and H. Riezman. 1997. Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr. Opin. Cell Biol. 9:488.
    • (1996) J. Cell Biol. , vol.135 , pp. 341
    • Marks, M.S.1    Woodruff, L.2    Ohno, H.3    Bonifacino, J.S.4
  • 29
    • 0030794182 scopus 로고    scopus 로고
    • Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
    • Marks, M. S., L. Woodruff, H. Ohno, and J. S. Bonifacino. 1996. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell Biol. 135:341. Kirchhausen, T., J. S. Bonifacino, and H. Riezman. 1997. Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr. Opin. Cell Biol. 9:488.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 488
    • Kirchhausen, T.1    Bonifacino, J.S.2    Riezman, H.3
  • 30
    • 0032498792 scopus 로고    scopus 로고
    • A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway
    • Liu, S.-H., M. S. Marks, and F. M. Brodsky. 1998. A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway. J. Cell Biol. 140: 1023.
    • (1998) J. Cell Biol. , vol.140 , pp. 1023
    • Liu, S.-H.1    Marks, M.S.2    Brodsky, F.M.3
  • 31
    • 0032079665 scopus 로고    scopus 로고
    • Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes
    • Piguet, V., Y.-L. Chen, A. Mangasarian, M. Foti, J.-L. Carpentier, and D. Trono. 1998. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes. EMBO J. 17:2472.
    • (1998) EMBO J. , vol.17 , pp. 2472
    • Piguet, V.1    Chen, Y.-L.2    Mangasarian, A.3    Foti, M.4    Carpentier, J.-L.5    Trono, D.6
  • 32
    • 0028485232 scopus 로고
    • HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
    • Baur, A. S., E. T. Sawai, P. Dazin, W. J. Fanti, C. Cheng-Mayer, and B. M. Peterlin, 1994. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1:373.
    • (1994) Immunity , vol.1 , pp. 373
    • Baur, A.S.1    Sawai, E.T.2    Dazin, P.3    Fanti, W.J.4    Cheng-Mayer, C.5    Peterlin, B.M.6
  • 34
    • 0030614819 scopus 로고    scopus 로고
    • The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
    • Mangasarian, A., M. Foti, C. Aiken, D. Chin, J.-L. Carpentier, and D. Trono. 1997. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Immunity 6:66.
    • (1997) Immunity , vol.6 , pp. 66
    • Mangasarian, A.1    Foti, M.2    Aiken, C.3    Chin, D.4    Carpentier, J.-L.5    Trono, D.6
  • 35
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    • Lu, X., H. Yu, S.-H. Liu, F. M. Brodsky, and B. M. Peterlin. 1998. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8:647.
    • (1998) Immunity , vol.8 , pp. 647
    • Lu, X.1    Yu, H.2    Liu, S.-H.3    Brodsky, F.M.4    Peterlin, B.M.5
  • 37
    • 0031106781 scopus 로고    scopus 로고
    • Protein sorting by tyrosine-based signals: Adapting to the Ys and wherefores
    • Marks, M. S., H. Ohno, T. Kirchhausen, and J. S. Bonifacino. 1997. Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores. Trends Cell Biol. 7:124.
    • (1997) Trends Cell Biol. , vol.7 , pp. 124
    • Marks, M.S.1    Ohno, H.2    Kirchhausen, T.3    Bonifacino, J.S.4
  • 38
    • 0027249993 scopus 로고
    • Interaction of activated EGF receptors with coated pit adapting
    • Sorkin, A., and G. Carpenter. 1993. Interaction of activated EGF receptors with coated pit adapting. Science 261:612.
    • (1993) Science , vol.261 , pp. 612
    • Sorkin, A.1    Carpenter, G.2
  • 40
    • 0027203952 scopus 로고
    • Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors
    • Chang, C. P., C. S. Lazar, B. J. Walsh, M. Komuro, J. F. Collawn, L. A. Kuhn, J. A. Tainer, I. S. Trowbridge, M. G. Farquhar, and M. G. Rosenfeld. 1993. Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. J. Biol. Chem. 268:19312.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19312
    • Chang, C.P.1    Lazar, C.S.2    Walsh, B.J.3    Komuro, M.4    Collawn, J.F.5    Kuhn, L.A.6    Tainer, J.A.7    Trowbridge, I.S.8    Farquhar, M.G.9    Rosenfeld, M.G.10
  • 41
    • 0026757062 scopus 로고
    • The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi
    • Johnson, K. F., and S. Kornfeld. 1992. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi. J. Cell Biol. 119:249.
    • (1992) J. Cell Biol. , vol.119 , pp. 249
    • Johnson, K.F.1    Kornfeld, S.2
  • 42
    • 0029099399 scopus 로고
    • Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment
    • Verhey, K. J., J. I. Yeh, and M. J. Birnbaum. 1995. Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment. J. Cell Biol. 130:1071.
    • (1995) J. Cell Biol. , vol.130 , pp. 1071
    • Verhey, K.J.1    Yeh, J.I.2    Birnbaum, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.