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Volumn 70, Issue 10, 1996, Pages 6701-6708

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; VIRUS PROTEIN;

EID: 0029819124     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.10.6701-6708.1996     Document Type: Article
Times cited : (115)

References (57)
  • 1
    • 0023790222 scopus 로고
    • Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR
    • Ahmad, N., and S. Venkatesen. 1988. Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 241:1481-1485.
    • (1988) Science , vol.241 , pp. 1481-1485
    • Ahmad, N.1    Venkatesen, S.2
  • 3
    • 0028355604 scopus 로고
    • Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NFκB and AP-1 in human T cells in vitro after T-cell receptor stimulation
    • Bandres, J. C., and L. Ratner. 1994. Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NFκB and AP-1 in human T cells in vitro after T-cell receptor stimulation. J. Virol. 68:3243-3249.
    • (1994) J. Virol. , vol.68 , pp. 3243-3249
    • Bandres, J.C.1    Ratner, L.2
  • 4
    • 0027080147 scopus 로고
    • The src family of tyrosine protein kinases in hemopoietic signal transduction
    • Bolen, J. B., R. Rowley, C. Spana, and A. Y. Tsygankov. 1992. The src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 6:3403-3409.
    • (1992) FASEB J. , vol.6 , pp. 3403-3409
    • Bolen, J.B.1    Rowley, R.2    Spana, C.3    Tsygankov, A.Y.4
  • 6
    • 0026612694 scopus 로고
    • A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases
    • Cheng, H.-C., H. Nishio, O. Hatase, S. Ralph, and J. H. Wang. 1992. A synthetic peptide derived from p34cdc2 is a specific and efficient substrate of src-family tyrosine kinases. J. Biol. Chem. 267:9248-9256.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9248-9256
    • Cheng, H.-C.1    Nishio, H.2    Hatase, O.3    Ralph, S.4    Wang, J.H.5
  • 7
    • 0024829082 scopus 로고
    • Differential effects of nef on HIV replication. Implications for viral pathogenesis in the host
    • Cheng-Mayer, C., P. Iannello, K. Shaw, P. A. Luciw, and J. A. Levy. 1989. Differential effects of nef on HIV replication. Implications for viral pathogenesis in the host. Science 246:1629-1632.
    • (1989) Science , vol.246 , pp. 1629-1632
    • Cheng-Mayer, C.1    Iannello, P.2    Shaw, K.3    Luciw, P.A.4    Levy, J.A.5
  • 8
    • 0026743906 scopus 로고
    • Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho
    • Cicchetti, P., B. J. Mayer, G. Thiel, and D. Baltimore. 1992. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science 257:803-806.
    • (1992) Science , vol.257 , pp. 803-806
    • Cicchetti, P.1    Mayer, B.J.2    Thiel, G.3    Baltimore, D.4
  • 9
    • 0028895654 scopus 로고
    • Modular binding domains in signal transduction proteins
    • Cohen, G. B., R. Ren, and D. Baltimore. 1995. Modular binding domains in signal transduction proteins. Cell 80:237-248.
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 11
    • 0027300619 scopus 로고
    • The when and how of src regulation
    • Cooper, J. A., and B. Howell. 1993. The when and how of src regulation. Cell 73:1051-1054.
    • (1993) Cell , vol.73 , pp. 1051-1054
    • Cooper, J.A.1    Howell, B.2
  • 13
    • 0026754068 scopus 로고
    • Small deletion in v-src SH3 domain of a transformation defective mutant of Rous sarcoma virus restores wild type transforming properties
    • Dezelee, P., J. V. Barnier, A. Hampe, D. Lauier, M. Marx, F. Galibert, and G. Calothy. 1992. Small deletion in v-src SH3 domain of a transformation defective mutant of Rous sarcoma virus restores wild type transforming properties. Virology 189:556-567.
    • (1992) Virology , vol.189 , pp. 556-567
    • Dezelee, P.1    Barnier, J.V.2    Hampe, A.3    Lauier, D.4    Marx, M.5    Galibert, F.6    Calothy, G.7
  • 15
    • 0022860568 scopus 로고
    • Cytoplasmic localization of the HTLV-III 3′ orf protein in cultured T-cells
    • Franchini, G., M. Robert-Guroff, J. Ghrayeh, N. T. Chang, and F. Wong-Staal. 1986. Cytoplasmic localization of the HTLV-III 3′ orf protein in cultured T-cells. Virology 155:593-599.
    • (1986) Virology , vol.155 , pp. 593-599
    • Franchini, G.1    Robert-Guroff, M.2    Ghrayeh, J.3    Chang, N.T.4    Wong-Staal, F.5
  • 16
    • 0027450321 scopus 로고
    • The negative effect of human immunodeficiency virus type 1 nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4
    • Garcia, J. V., J. Alfono, and A. D. Miller. 1993. The negative effect of human immunodeficiency virus type 1 nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4. J. Virol. 65: 1511-1516.
    • (1993) J. Virol. , vol.65 , pp. 1511-1516
    • Garcia, J.V.1    Alfono, J.2    Miller, A.D.3
  • 17
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef
    • Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef. Nature (London) 350:508-511.
    • (1991) Nature (London) , vol.350 , pp. 508-511
    • Garcia, J.V.1    Miller, A.D.2
  • 18
    • 0028887886 scopus 로고
    • Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines
    • Greenway, A. L., A. Azad, and D. A. McPhee. 1995. Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines. J. Virol. 69:1842-1850.
    • (1995) J. Virol. , vol.69 , pp. 1842-1850
    • Greenway, A.L.1    Azad, A.2    McPhee, D.A.3
  • 19
    • 0028363597 scopus 로고
    • Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4-3 down-regulates surface CD4 and IL-2 R expression in peripheral blood mononuclear cells and transformed T cells
    • Greenway, A. L., D. A. McPhee, E. Grgacic, D. Hewish, A. Lucantoni, I. Macreadie, and A. Azad. 1994. Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4-3 down-regulates surface CD4 and IL-2 R expression in peripheral blood mononuclear cells and transformed T cells. Virology 198:245-256.
    • (1994) Virology , vol.198 , pp. 245-256
    • Greenway, A.L.1    McPhee, D.A.2    Grgacic, E.3    Hewish, D.4    Lucantoni, A.5    Macreadie, I.6    Azad, A.7
  • 20
    • 0024331985 scopus 로고
    • Nef protein of human immunodeficiency virus type 1: Evidence against its rule as a transcriptional inhibitor
    • Hammes, S. R., E. P. Dixon, M. H. Malim, B. R. Cullen, and W. C. Greene. 1989. Nef protein of human immunodeficiency virus type 1: evidence against its rule as a transcriptional inhibitor. Proc. Natl. Acad. Sci. USA 86:9549-9553.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9549-9553
    • Hammes, S.R.1    Dixon, E.P.2    Malim, M.H.3    Cullen, B.R.4    Greene, W.C.5
  • 24
    • 0026493503 scopus 로고
    • Expression and cellular localization of the Nef protein from human immunodeficiency virus-type 1 in stably transfected B-cells
    • Kienzle, N., M. Bachmann, W. E. G. Muller, and N. Muller-Lanztch. 1992. Expression and cellular localization of the Nef protein from human immunodeficiency virus-type 1 in stably transfected B-cells. Arch. Virol. 124:123-132.
    • (1992) Arch. Virol. , vol.124 , pp. 123-132
    • Kienzle, N.1    Bachmann, M.2    Muller, W.E.G.3    Muller-Lanztch, N.4
  • 25
    • 0024316873 scopus 로고
    • Lack of negative influence on viral growth by the nef gene of human immunodeficiency virus type 1
    • Kim, S., K. Ikeuchi, R. Byrn, J. Groopman, and D. Baltimore. 1989. Lack of negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:9544-9548.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9544-9548
    • Kim, S.1    Ikeuchi, K.2    Byrn, R.3    Groopman, J.4    Baltimore, D.5
  • 26
    • 0028835788 scopus 로고
    • Absence of intact nef sequences in a long-term survivor with non-progressive HIV-1 infection
    • Kirchoff, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Desrosiers. 1995. Absence of intact nef sequences in a long-term survivor with non-progressive HIV-1 infection. N. Engl. J. Med. 332:228-232.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 228-232
    • Kirchoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 27
    • 0025765803 scopus 로고
    • SH2 and SH3: Elements that control interactions of cytoplasmic signalling proteins
    • Koch, A. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3: elements that control interactions of cytoplasmic signalling proteins. Science 252:668-674.
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, A.A.1    Anderson, D.2    Moran, M.F.3    Ellis, C.4    Pawson, T.5
  • 29
    • 0028805516 scopus 로고
    • A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
    • Lee, C.-H., B. Leung, M. A. Lemmon, J. Zheng, D. Cowburn, J. Kuriyan, and K. Saksela. 1995. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J. 14:5006-5015.
    • (1995) EMBO J. , vol.14 , pp. 5006-5015
    • Lee, C.-H.1    Leung, B.2    Lemmon, M.A.3    Zheng, J.4    Cowburn, D.5    Kuriyan, J.6    Saksela, K.7
  • 30
    • 0009524520 scopus 로고
    • Mutational analysis of the human deficiency virus: The ORF-B region down regulates virus replication
    • Luciw, P. A., C. Cheng-Mayer, and J. A. Levy. 1987. Mutational analysis of the human deficiency virus: the ORF-B region down regulates virus replication. Proc. Natl. Acad. Sci. USA 84:1434-1438.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1434-1438
    • Luciw, P.A.1    Cheng-Mayer, C.2    Levy, J.A.3
  • 31
    • 0026077650 scopus 로고
    • Expression of the type 1 human immunodeficiency virus nef protein in T-cells prevents antigen receptor-mediated induction of IL-2 mRNA
    • Luria, S., I. Chambers, and P. Berg. 1991. Expression of the type 1 human immunodeficiency virus nef protein in T-cells prevents antigen receptor-mediated induction of IL-2 mRNA. Proc. Natl. Acad. Sci. USA 88:5326-5330.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5326-5330
    • Luria, S.1    Chambers, I.2    Berg, P.3
  • 32
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1-nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller, M. D., M. T. Warmerdam, I. Gaston, W. C. Greene, and M. B. Feinberg. 1994. The human immunodeficiency virus-1-nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med. 179:101-113.
    • (1994) J. Exp. Med. , vol.179 , pp. 101-113
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 34
    • 0026674005 scopus 로고
    • Human immunodeficiency virus type 1 Nef protein inhibits NFκB induction in human T cells
    • Niederman, T. M., J. V. Garcia, R. W. Hastings, S. Luria, and L. Ratner. 1992. Human immunodeficiency virus type 1 Nef protein inhibits NFκB induction in human T cells. J. Virol. 66:6213-6219.
    • (1992) J. Virol. , vol.66 , pp. 6213-6219
    • Niederman, T.M.1    Garcia, J.V.2    Hastings, R.W.3    Luria, S.4    Ratner, L.5
  • 35
    • 0027496255 scopus 로고
    • Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix
    • Niederman, T. M., W. Randall, and L. Rainer. 1993. Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix. Virology 197:420-425.
    • (1993) Virology , vol.197 , pp. 420-425
    • Niederman, T.M.1    Randall, W.2    Rainer, L.3
  • 36
    • 9544234383 scopus 로고
    • Human immunodeficiency virus type 1 negative factor is a transcriptional silencer
    • Niederman, T. M., B. J. Thielan, and L. Ratner. 1989. Human immunodeficiency virus type 1 negative factor is a transcriptional silencer. Proc. Natl. Acad. Sci. USA 90:5549-5553.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5549-5553
    • Niederman, T.M.1    Thielan, B.J.2    Ratner, L.3
  • 37
    • 0028605565 scopus 로고
    • Control of T-cell development by non-receptor protein tyrosine kinases
    • Perlmutter, R. M. 1995. Control of T-cell development by non-receptor protein tyrosine kinases. Cancer Surv. 22:85-95.
    • (1995) Cancer Surv. , vol.22 , pp. 85-95
    • Perlmutter, R.M.1
  • 38
    • 0024165855 scopus 로고
    • Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95
    • Potts, W. M., A. B. Reynolds, T. J. Lansing, and J. T. Parsons. 1988. Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95. Oncogene Res. 3:343-355.
    • (1988) Oncogene Res. , vol.3 , pp. 343-355
    • Potts, W.M.1    Reynolds, A.B.2    Lansing, T.J.3    Parsons, J.T.4
  • 39
    • 0027494083 scopus 로고
    • Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity
    • Purcell, D. F. J., and M. M. Martin. 1993. Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J. Virol. 67:6365-6378.
    • (1993) J. Virol. , vol.67 , pp. 6365-6378
    • Purcell, D.F.J.1    Martin, M.M.2
  • 40
    • 0027408247 scopus 로고
    • Identification of a ten-amino acid proline-rich SH3 binding site
    • Ren, R., B. J. Mayer, P. Cicchetti, and D. Baltimore. 1993. Identification of a ten-amino acid proline-rich SH3 binding site. Science 259:1157-1161.
    • (1993) Science , vol.259 , pp. 1157-1161
    • Ren, R.1    Mayer, B.J.2    Cicchetti, P.3    Baltimore, D.4
  • 41
    • 0028181873 scopus 로고
    • Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites
    • Ren, R., Z.-S. Ye, and D. Baltimore. 1994. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 8:783-795.
    • (1994) Genes Dev. , vol.8 , pp. 783-795
    • Ren, R.1    Ye, Z.-S.2    Baltimore, D.3
  • 42
    • 0025281329 scopus 로고
    • Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages
    • Robert-Guroff, M., M. Popovic, S. Gartner, P. Markham, R. C. Gallo, and M. S. Reitz. 1990. Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages. J. Virol. 64:3391-3398.
    • (1990) J. Virol. , vol.64 , pp. 3391-3398
    • Robert-Guroff, M.1    Popovic, M.2    Gartner, S.3    Markham, P.4    Gallo, R.C.5    Reitz, M.S.6
  • 43
    • 0024040125 scopus 로고
    • The CD4 receptor is complexed in detergent lysates to a protein tyrosine kinase (pp58) from human T-lymphocytes
    • Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 receptor is complexed in detergent lysates to a protein tyrosine kinase (pp58) from human T-lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190-5194.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5190-5194
    • Rudd, C.E.1    Trevillyan, J.M.2    Dasgupta, J.D.3    Wong, L.L.4    Schlossman, S.F.5
  • 44
    • 0028878783 scopus 로고
    • Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of src kinases and are required for the enhanced growth of Nef viruses but not for down-regulation of CD4
    • Saksela, K., G. Cheng, and D. Baltimore. 1995. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of src kinases and are required for the enhanced growth of Nef viruses but not for down-regulation of CD4. EMBO J. 14:484-491.
    • (1995) EMBO J. , vol.14 , pp. 484-491
    • Saksela, K.1    Cheng, G.2    Baltimore, D.3
  • 45
    • 0025325392 scopus 로고
    • Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor
    • Samelson, L. E., A. F. Phillips, E. T. Luong, and R. D. Klausner. 1990. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:4348-4362.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4348-4362
    • Samelson, L.E.1    Phillips, A.F.2    Luong, E.T.3    Klausner, R.D.4
  • 46
  • 47
    • 0026572318 scopus 로고
    • Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src
    • Seidel-Dugan, C., B. E. Meyer, S. M. Thomas, and J. S. Brugge. 1992. Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol. Cell. Biol. 12:1835-1845.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1835-1845
    • Seidel-Dugan, C.1    Meyer, B.E.2    Thomas, S.M.3    Brugge, J.S.4
  • 49
    • 0024425159 scopus 로고
    • The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
    • Shaw, A. S., K. E. Amrein, C. Hammond, D. F. Stern, B. M. Sefton, and J. K. Rose. 1989. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59:627-636.
    • (1989) Cell , vol.59 , pp. 627-636
    • Shaw, A.S.1    Amrein, K.E.2    Hammond, C.3    Stern, D.F.4    Sefton, B.M.5    Rose, J.K.6
  • 52
    • 0027533215 scopus 로고
    • Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
    • Skowronski, J., D. Parks, and R. Mariani. 1993. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J. 12:703-713.
    • (1993) EMBO J. , vol.12 , pp. 703-713
    • Skowronski, J.1    Parks, D.2    Mariani, R.3
  • 53
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • Spina, C. A., T. J. Kwoh, M. Y. Chowers, J. C. Guatelli, and D. D. Richman. 1994. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med. 179:115-123.
    • (1994) J. Exp. Med. , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3    Guatelli, J.C.4    Richman, D.D.5
  • 54
    • 0023025035 scopus 로고
    • Effects of mutations within the 3′ open reading frame region down-regulates virus replication
    • Terwilliger, E. F., J. G. Sodroski, C. A. Rosen, and W. A. Haseltine. 1986. Effects of mutations within the 3′ open reading frame region down-regulates virus replication. J. Virol. 60:754-760.
    • (1986) J. Virol. , vol.60 , pp. 754-760
    • Terwilliger, E.F.1    Sodroski, J.G.2    Rosen, C.A.3    Haseltine, W.A.4
  • 57
    • 0013484134 scopus 로고
    • Structural basis for the binding of proline-rich peptides to SH3 domains
    • Yu, H., J. K. Chen, S. Feng, D. C. Dalgarno, A. W. Brauer, and S. L. Schreiber. 1994. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 76:933-945.
    • (1994) Cell , vol.76 , pp. 933-945
    • Yu, H.1    Chen, J.K.2    Feng, S.3    Dalgarno, D.C.4    Brauer, A.W.5    Schreiber, S.L.6


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