Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells

Nature Immunology

Volumn 7, Issue 3, 2006, Pages 302-310

  Qiao, Xugang ^a   He, Bing ^a   Chiu, April ^a   Knowles, Daniel M ^a   Chadburn, Amy ^a   Cerutti, Andrea ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CYTOKINE; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; NEF PROTEIN; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; VIRUS PROTEIN; CD40 ANTIGEN; I KAPPA B KINASE;

ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA RECOMBINATION; FEEDBACK SYSTEM; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS CELL INTERACTION; BYSTANDER EFFECT; CELL CULTURE; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

ANTIGENS, CD40; B-LYMPHOCYTES; BYSTANDER EFFECT; CD40 LIGAND; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE PRODUCTS, NEF; HIV-1; HUMANS; I-KAPPA B KINASE; IMMUNOBLOTTING; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT TRANSCRIPTION FACTORS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES;

EID: 33645288761     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1302     Document Type: Article

References (50)

1. Pantaleo, G. & Fauci, A.S. New concepts in the immunopathogenesis of HIV infection. Annu. Rev. Immunol. 13, 487-512 (1995).
2. Lane, H.C. et al. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 309, 453-458 (1983).
3. Stavnezer, J. Antibody class switching. Adv. Immunol. 61, 79-146 (1996).
4. MacLennan, I.C. Germinal centers. Annu. Rev. Immunol. 12, 117-139 (1994).
5. Manis, J.P., Tian, M. & Alt, F.W. Mechanism and control of class-switch recombination. Trends Immunol. 23, 31-39 (2002).
6. Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular mechanism of class switch recombination: Linkage with somatic hypermutation. Annu. Rev. Immunol. 20, 165-196 (2002).
7. Pantaleo, G. et al. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 88, 9838-9842 (1991).
8. + T cell help in HIV-infected individuals. Proc. Natl. Acad. Sci. USA 100, 6057-6062 (2003).
9. Morris, L. et al. HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J. Exp. Med. 188, 233-245 (1998).
10. Moir, S. et al. B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells. J. Exp. Med. 192, 637-646 (2000).
11. Ravanel, K. et al. Measles virus nucleocapsid protein binds to FcγRII and inhibits human B cell antibody production. J. Exp. Med. 186, 269-278 (1997).
12. Guy, B. et al. HIV F/3′ ORF encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330, 266-269 (1987).
13. + T cells. FEBS Lett. 393, 93-96 (1996).
14. Cullen, B.R. HIV-1 auxiliary proteins: Making connections in a dying cell. Cell 93, 685-692 (1998).
15. Kestler, H.W., III et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662 (1991).
16. Deacon, N.J. et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270, 988-991 (1995).
17. Blagoveshchenskaya, A.D., Thomas, L., Feliciangeli, S.F., Hung, C.H. & Thomas, G. HIV-1 Net downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell 111, 853-866 (2002).
18. Collins, K.L., Chen, B.K., Kalams, S.A., Walker, B.D. & Baltimore, D. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401 (1998).
19. Garcia, J.V. & Miller, A.D. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350, 508-511 (1991).
20. Pope, M. et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 78, 389-398 (1994).
21. Swingler, S. et al. HIV-1 Net mediates lymphocyte chemotaxis and activation by infected macrophages. Nat. Med. 5, 997-1003 (1999).
22. Swingler, S. et al. HIV-1 Nef intersects the macrophage CD154 signalling pathway to promote resting-cell infection. Nature 424, 213-219 (2003).
23. Baur, A.S. et al. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1, 373-384 (1994).
24. Kuster, H. et al. Treatment-induced decline of human immunodeficiency virus-1 p24 and HIV-1 RNA in lymphoid tissue of patients with early human immunodeficiency virus-1 infection. Am. J. Pathol. 156, 1973-1986 (2000).
25. Brigino, E. et al. Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. Proc. Natl. Acad. Sci. USA 94, 3178-3182 (1997).
26. Federico, M. et al. HIV-1 Nef activates STAT1 in human monocytes/ macrophages through the release of soluble factors. Blood 98, 2752-2761 (2001).
27. + T cell activation. Exp. Cell Res. 275, 243-254 (2002).
28. Olivetta, E. et al. HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: Involvement of Nef endocytotic signals and NF-κB activation. J. Immunol. 170, 1716-1727 (2003).
29. Varin, A. et al. Exogenous Net protein activates NF-κB, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis. J. Biol. Chem. 278, 2219-2227 (2003).
30. + T cells for apoptosis by interacting with CXCR4 surface receptors. J. Virol. 78, 3099-3109 (2004).
31. Rubartelli, A., Poggi, A., Sitia, R. & Zocchi, M.R. HIV-I Tat: A polypeptide for all seasons. Immunol. Today 19, 543-545 (1998).
32. Lefevre, E.A., Krzysiek, R., Loret, E.P., Galanaud, P. & Richard, Y. Cutting edge: HIV-1 Tat protein differentially modulates the B cell response of naive, memory, and germinal center B cells. J. Immunol. 163, 1119-1122 (1999).
33. He, B., Qiao, X. & Cerutti, A. CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J. Immunol. 173, 4479-4491 (2004).
34. Peng, B. & Robert-Guroff, M. Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation. Immunol. Lett. 78, 195-200 (2001).
35. Geyer, M., Fackler, O.T. & Peterlin, B.M. Structure-function relationships in HIV-1 Nef. EMBO Rep. 2, 580-585 (2001).
36. Litinskiy, M.B. et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3, 822-829 (2002).
37. Stumptner-Cuvelette, P. et al. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc. Natl. Acad. Sci. USA 98, 12144-12149 (2001).
38. Chaudhry, A. et al. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J. Immunol. 175, 4566-4574 (2005).
39. Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109, S81-S96 (2002).
40. Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: The control of NF-κB activity. Annu. Rev. Immunol. 18, 621-663 (2000).
41. Lee, S.B., Park, J., Jung, J.U. & Chung, J. Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-κB-dependent immune responses in Drosophila. J. Cell Sci. 118, 1851-1859 (2005).
42. Geha, R.S., Jabara, H.H. & Brodeur, S.R. The regulation of immunoglobulin E class-switch recombination. Nat. Rev. Immunol. 3, 721-732 (2003).
43. Leonard, W.J. & O'Shea, J.J. Jaks and STATs: Biological implications. Annu. Rev. Immunol. 16, 293-322 (1998).
44. Alexander, W.S. & Hilton, D.J. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22, 503-529 (2004).
45. Burton, D.R. Antibodies, viruses and vaccines. Nat. Rev. Immunol. 2, 706-713 (2002).
46. Fagarasan, S. & Honjo, T. Intestinal IgA synthesis: Regulation of front-line body defences. Nat. Rev. Immunol. 3, 63-72 (2003).
47. Watkins, S.C. & Salter, R.D. Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity 23, 309-318 (2005).
48. Poudrier, J. et al. The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and autoantibodies and develops in the absence of IFN-γ and IL-6. Immunity 15, 173-185 (2001).
49. Hanada, T. et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19, 437-450 (2003).
50. Geyer, M. & Peterlin, B.M. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef. FEBS Lett. 496, 91-95 (2001).