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Volumn 79, Issue 9, 2005, Pages 5489-5498

Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DEATH RECEPTOR; ETOPOSIDE; FAS ANTIBODY; GREEN FLUORESCENT PROTEIN; NEF PROTEIN; RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VIRUS VECTOR;

EID: 17444413400     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.9.5489-5498.2005     Document Type: Article
Times cited : (60)

References (51)
  • 1
    • 0032473552 scopus 로고    scopus 로고
    • CD4 regulates susceptibility to Fas ligand- And tumor necrosis factor-mediated apoptosis
    • Algeciras, A., D. H. Dockrell, D. H., Lynch, and C. V. Paya. 1998. CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis. J. Exp. Med. 187:711-720.
    • (1998) J. Exp. Med. , vol.187 , pp. 711-720
    • Algeciras, A.1    Dockrell, D.H.2    Lynch, D.H.3    Paya, C.V.4
  • 2
    • 0037820578 scopus 로고    scopus 로고
    • Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
    • Alimonti, J. B., T. B. Ball, and K. R. Fowke. 2003. Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J. Gen. Virol. 84:1649-1661.
    • (2003) J. Gen. Virol. , vol.84 , pp. 1649-1661
    • Alimonti, J.B.1    Ball, T.B.2    Fowke, K.R.3
  • 4
    • 0026784923 scopus 로고
    • Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
    • Banda, N. K., J. Bernier, D. K. Kurahara, R. Kurrle, N. Haigwood, R. P. Sekaly, and T. H. Finkel. 1992. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. Exp. Med. 176:1099-1106.
    • (1992) J. Exp. Med. , vol.176 , pp. 1099-1106
    • Banda, N.K.1    Bernier, J.2    Kurahara, D.K.3    Kurrle, R.4    Haigwood, N.5    Sekaly, R.P.6    Finkel, T.H.7
  • 5
    • 0028485232 scopus 로고
    • HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
    • Baur, A. S., E. T. Sawai, P. Dazin, W. J. Fantl, C. Cheng-Mayer, and B. M. Peterlin. 1994. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1:373-384.
    • (1994) Immunity , vol.1 , pp. 373-384
    • Baur, A.S.1    Sawai, E.T.2    Dazin, P.3    Fantl, W.J.4    Cheng-Mayer, C.5    Peterlin, B.M.6
  • 6
    • 0033995168 scopus 로고    scopus 로고
    • Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques
    • Carl, S., A. J. Iafrate, S. M. Lang, N. Stolle, K. Matz-Rensing, D. Fuchs, C. Stahl-Hennig, J. Skowronski, and F. Kirchhoff. 2000. Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques. J. Virol. 74:4155-4164.
    • (2000) J. Virol. , vol.74 , pp. 4155-4164
    • Carl, S.1    Iafrate, A.J.2    Lang, S.M.3    Stolle, N.4    Matz-Rensing, K.5    Fuchs, D.6    Stahl-Hennig, C.7    Skowronski, J.8    Kirchhoff, F.9
  • 8
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins, K. L., B. K. Chen, S. A. Kalams, B. D. Walker, and D. Baltimore. 1998. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397-401.
    • (1998) Nature , vol.391 , pp. 397-401
    • Collins, K.L.1    Chen, B.K.2    Kalams, S.A.3    Walker, B.D.4    Baltimore, D.5
  • 12
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef
    • Garcia, J. V., and A. D. Miller. 1991. Serine phosphorylation-independent down-regulation of cell-surface CD4 by nef. Nature 350:508-511.
    • (1991) Nature , vol.350 , pp. 508-511
    • Garcia, J.V.1    Miller, A.D.2
  • 13
    • 0035848864 scopus 로고    scopus 로고
    • HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
    • Geleziunas, R., W. Xu, K. Takeda, H. Ichijo, and W. C. Greene. 2001. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410:834-838.
    • (2001) Nature , vol.410 , pp. 834-838
    • Geleziunas, R.1    Xu, W.2    Takeda, K.3    Ichijo, H.4    Greene, W.C.5
  • 15
    • 0032897974 scopus 로고    scopus 로고
    • Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo
    • Glushakova, S., J. C. Grivel, K. Suryanarayana, P. Meylan, J. D. Lifson, R. Desrosiers, and L. Margolis. 1999. Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo. J. Virol. 73:3968-3974.
    • (1999) J. Virol. , vol.73 , pp. 3968-3974
    • Glushakova, S.1    Grivel, J.C.2    Suryanarayana, K.3    Meylan, P.4    Lifson, J.D.5    Desrosiers, R.6    Margolis, L.7
  • 16
    • 0038725688 scopus 로고    scopus 로고
    • Apoptosis as an HIV strategy to escape immune attack
    • Gougeon, M. L. 2003. Apoptosis as an HIV strategy to escape immune attack. Nat. Rev. Immunol. 3:392-404.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 392-404
    • Gougeon, M.L.1
  • 17
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg, M. E., A. J. Iafrate, and J. Skowronski. 1998. The SH3 domain binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17:2777-2789.
    • (1998) EMBO J. , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 18
    • 0036187980 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis
    • Greenway, A. L., D. A. McPhee, K. Allen, R. Johnstone, G. Holloway, J. Mills, A. Azad, S. Sankovich, and P. Lambert. 2002. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J. Virol. 76:2692-2702.
    • (2002) J. Virol. , vol.76 , pp. 2692-2702
    • Greenway, A.L.1    McPhee, D.A.2    Allen, K.3    Johnstone, R.4    Holloway, G.5    Mills, J.6    Azad, A.7    Sankovich, S.8    Lambert, P.9
  • 19
  • 20
    • 0031039979 scopus 로고    scopus 로고
    • Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
    • Iafrate, A. J., S. Bronson, and J. Skowronski. 1997. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J. 16:673-684.
    • (1997) EMBO J. , vol.16 , pp. 673-684
    • Iafrate, A.J.1    Bronson, S.2    Skowronski, J.3
  • 21
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of Nef required for down regulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • Iafrate, A. J., S. Carl, S. Bronson, C. Stahl Hennig, T. Swigut, J. Skowronski, and F. Kirchhoff. 2000. Disrupting surfaces of Nef required for down regulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J. Virol. 74:9836-9844.
    • (2000) J. Virol. , vol.74 , pp. 9836-9844
    • Iafrate, A.J.1    Carl, S.2    Bronson, S.3    Stahl Hennig, C.4    Swigut, T.5    Skowronski, J.6    Kirchhoff, F.7
  • 22
    • 0031974417 scopus 로고    scopus 로고
    • TRAIL/Apo-2-ligand-induced apoptosis in human T cells
    • Jeremias, I., I. Herr, T. Boehler, and K. M. Debatin. 1998. TRAIL/Apo-2-ligand-induced apoptosis in human T cells. Eur. J. Immunol. 28:143-152.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 143-152
    • Jeremias, I.1    Herr, I.2    Boehler, T.3    Debatin, K.M.4
  • 23
    • 0029018855 scopus 로고
    • T cell apoptosis triggered via the CD3/T cell receptor complex and alternative activation pathways
    • Kabelitz, D., T. Pohl, and K. Pechhold. 1995. T cell apoptosis triggered via the CD3/T cell receptor complex and alternative activation pathways. Curr. Top Microbiol. Immunol. 200:1-14.
    • (1995) Curr. Top Microbiol. Immunol. , vol.200 , pp. 1-14
    • Kabelitz, D.1    Pohl, T.2    Pechhold, K.3
  • 24
    • 0037053298 scopus 로고    scopus 로고
    • The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c
    • Karpinich, N. O., M. Tafani, R. J. Rothman, M. A. Russo, and J. L. Farber. 2002. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J. Biol. Chem. 277:16547-16552.
    • (2002) J. Biol. Chem. , vol.277 , pp. 16547-16552
    • Karpinich, N.O.1    Tafani, M.2    Rothman, R.J.3    Russo, M.A.4    Farber, J.L.5
  • 27
    • 0031777959 scopus 로고    scopus 로고
    • Role of the SH3-Ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques
    • Khan, I. H., E. T. Sawai, E. Antonio, C. J. Weber, C. P. Mandell, P. Montbriand, and P. A. Luciw. 1998. Role of the SH3-Ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. J. Virol. 72:5820-5830.
    • (1998) J. Virol. , vol.72 , pp. 5820-5830
    • Khan, I.H.1    Sawai, E.T.2    Antonio, E.3    Weber, C.J.4    Mandell, C.P.5    Montbriand, P.6    Luciw, P.A.7
  • 28
  • 29
    • 0030836543 scopus 로고    scopus 로고
    • Association of simian immunodeficiency virus nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques
    • Lang, S. M., A. J. Iafrate, C. Stahl-Hennig, E. M. Kuhn, T. Nißlein, M. Haupt, G. Hunsmann, J. Skowronski, and F. Kirchhoff. 1997. Association of simian immunodeficiency virus nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nat. Med. 3:860-865.
    • (1997) Nat. Med. , vol.3 , pp. 860-865
    • Lang, S.M.1    Iafrate, A.J.2    Stahl-Hennig, C.3    Kuhn, E.M.4    Nißlein, T.5    Haupt, M.6    Hunsmann, G.7    Skowronski, J.8    Kirchhoff, F.9
  • 30
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu, X., and D. P. Lane. 1993. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75:765-778.
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 32
    • 0035912232 scopus 로고    scopus 로고
    • The dynamics of CD4+ T-cell depletion in HIV disease
    • McCune, J. M. 2001. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 410:974-979.
    • (2001) Nature , vol.410 , pp. 974-979
    • McCune, J.M.1
  • 33
    • 0034796441 scopus 로고    scopus 로고
    • Efficient class I MHC down regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques
    • Munch, J., N. Stolte, D. Fuchs, C. Stahl Hennig, and F. Kirchhoff. 2001. Efficient class I MHC down regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J. Virol. 75:10532-10536.
    • (2001) J. Virol. , vol.75 , pp. 10532-10536
    • Munch, J.1    Stolte, N.2    Fuchs, D.3    Stahl Hennig, C.4    Kirchhoff, F.5
  • 34
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139: 271-279.
    • (1991) J. Immunol. Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 35
    • 0028939951 scopus 로고
    • Apoptosis in HIV infection
    • Pantaleo, G., and A. S. Fauci. 1995. Apoptosis in HIV infection. Nat. Med. 1:118-120.
    • (1995) Nat. Med. , vol.1 , pp. 118-120
    • Pantaleo, G.1    Fauci, A.S.2
  • 36
    • 0036281905 scopus 로고    scopus 로고
    • Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens
    • Patel, P. G., M. T. Yu Kimata, J. E. Biggins, J. M. Wilson, and J. T. Kimata. 2002. Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens. J. Virol. 76:6425-6434.
    • (2002) J. Virol. , vol.76 , pp. 6425-6434
    • Patel, P.G.1    Yu Kimata, M.T.2    Biggins, J.E.3    Wilson, J.M.4    Kimata, J.T.5
  • 38
    • 8644224930 scopus 로고    scopus 로고
    • Nef associates with PAK2 in a p21-GTPase-dependent dynamic activation complex with lipid rafts
    • Pulkkinen, K., G. H. Renkema, F. Kirchhoff, and K. Saksela. 2004. Nef associates with PAK2 in a p21-GTPase-dependent dynamic activation complex with lipid rafts. J. Virol. 78:12773-12780.
    • (2004) J. Virol. , vol.78 , pp. 12773-12780
    • Pulkkinen, K.1    Renkema, G.H.2    Kirchhoff, F.3    Saksela, K.4
  • 40
    • 0029860936 scopus 로고    scopus 로고
    • Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factors and cytokine receptors
    • Rosette, C., and M. Karin. 1996. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factors and cytokine receptors. Science 274:1194-1197.
    • (1996) Science , vol.274 , pp. 1194-1197
    • Rosette, C.1    Karin, M.2
  • 41
    • 7644220888 scopus 로고    scopus 로고
    • Vpr and Vpu are important for efficient HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo
    • Rucker, E., J. Munch, J. C. Grivel, F. Kirchhoff, F., and L. Margolis. 2004. Vpr and Vpu are important for efficient HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo. J. Virol. 78:12689-12693.
    • (2004) J. Virol. , vol.78 , pp. 12689-12693
    • Rucker, E.1    Munch, J.2    Grivel, J.C.3    Kirchhoff, F.4    Margolis, L.5
  • 42
    • 0141521574 scopus 로고    scopus 로고
    • Down-modulation of mature MHC class II and up-regulation of invariant chain cell surface expression are well conserved functions of human and simian immunodeficiency virus nef alleles
    • Schindler, M., S. Wuerfl, P. Benaroch, T. C. Greenough, R. Daniels, P. Easterbrook, M. Brenner, J. Münch, and F. Kirchhoff. 2003. Down-modulation of mature MHC class II and up-regulation of invariant chain cell surface expression are well conserved functions of human and simian immunodeficiency virus nef alleles. J. Virol. 77:10548-10556.
    • (2003) J. Virol. , vol.77 , pp. 10548-10556
    • Schindler, M.1    Wuerfl, S.2    Benaroch, P.3    Greenough, T.C.4    Daniels, R.5    Easterbrook, P.6    Brenner, M.7    Münch, J.8    Kirchhoff, F.9
  • 43
    • 4544337312 scopus 로고    scopus 로고
    • Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques
    • Schindler, M., J. Münch, C. Stahl-Hennig, J. Skowronski, and F. Kirchhoff. 2004. Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques. J. Virol. 78:10588-10597.
    • (2004) J. Virol. , vol.78 , pp. 10588-10597
    • Schindler, M.1    Münch, J.2    Stahl-Hennig, C.3    Skowronski, J.4    Kirchhoff, F.5
  • 44
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    • Schwartz, O., V. Marechal, S. Le Gall, F. Lemonnier, and J. M. Heard. 1996. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 2:338-342.
    • (1996) Nat. Med. , vol.2 , pp. 338-342
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.M.5
  • 45
    • 0034948709 scopus 로고    scopus 로고
    • Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators
    • Simmons, A., V. Aluvihare, and A. McMichael. 2001. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14:763-777.
    • (2001) Immunity , vol.14 , pp. 763-777
    • Simmons, A.1    Aluvihare, V.2    McMichael, A.3
  • 47
    • 0035794535 scopus 로고    scopus 로고
    • Mechanism for down regulation of CD28 by Nef
    • Swigut, T., N. Shody, and J. Skowronski. 2001. Mechanism for down regulation of CD28 by Nef. EMBO J. 20:1593-1604.
    • (2001) EMBO J. , vol.20 , pp. 1593-1604
    • Swigut, T.1    Shody, N.2    Skowronski, J.3
  • 48
    • 0035173735 scopus 로고    scopus 로고
    • HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce antiapoptotic signals
    • Wolf, D., V. Witte, B. Laffert, K. Blume, E. Stromer, S. Trapp, P. d'Aloja, A. Schurmann, and A. S. Baur. 2001. HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce antiapoptotic signals. Nat. Med. 7:1217-1224.
    • (2001) Nat. Med. , vol.7 , pp. 1217-1224
    • Wolf, D.1    Witte, V.2    Laffert, B.3    Blume, K.4    Stromer, E.5    Trapp, S.6    D'Aloja, P.7    Schurmann, A.8    Baur, A.S.9
  • 51
    • 0032959989 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway
    • Zauli, G., D. Gibellini, P. Secchiero, H. Dutartre, D. Olive, S. Capitani, and Y. Collette. 1999. Human immunodeficiency virus type 1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93:1000-1010.
    • (1999) Blood , vol.93 , pp. 1000-1010
    • Zauli, G.1    Gibellini, D.2    Secchiero, P.3    Dutartre, H.4    Olive, D.5    Capitani, S.6    Collette, Y.7


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