Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors

International Journal of Developmental Biology

Volumn 50, Issue 1, 2006, Pages 17-26

  Miralles, Francisco ^a   Lamotte, Luciane ^a   Couton, Dominique ^a   Joshi, Rajiv L ^a  

^a INSTITUT COCHIN   (France)

Author keywords

Differentiation; FGF10; Notch pathway; Pancreas development; Proliferation

Indexed keywords

AMYLASE; BETA CATENIN; FIBROBLAST GROWTH FACTOR 10; GAMMA SECRETASE INHIBITOR; NOTCH RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; EXPLANT; GENE; GENE EXPRESSION REGULATION; GENE TARGETING; HES1 GENE; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREAS ISLET CELL HYPERPLASIA; PANCREATIC PROGENITOR CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; EPITHELIAL CELLS; FIBROBLAST GROWTH FACTOR 10; GLYCOSYLTRANSFERASES; GROWTH INHIBITORS; LAMININ; MICE; ORGAN CULTURE TECHNIQUES; PANCREAS; PROTEOGLYCANS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS;

ANIMALIA; MUS MUSCULUS;

EID: 31344468846     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.052080fm     Document Type: Article

References (35)

1. APELQVIST, A., LI, H., SOMMER, L., BEATUS, P. ANDERSON, D.J., HONJO, T., HRABE DE ANGELIS, M., LENDAHL, U. and EDLUND, H. (1999). Notch signalling controls pancreatic cell differentiation. Nature 400: 877-81.
2. BEATUS, P. and LENDAHL, U. (1998). Notch and neurogenesis. J Neurosci Res 54: 125-36.
3. BHUSHAN, A., ITOH, N., KATO, S., THIERY, J.P., CZERNICHOW, P., BELLUSCI, S. and SCHARFMANN, R. (2001). Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128: 5109-17.
4. CELLI, G., LAROCHELLE, W.J., MACKEM, S., SHARP, R. and MERLINO, G. (1998). Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J 17: 1642-55.
5. DE STROOPER, B., ANNAERT, W., CUPERS, P., SAFTIG, P., CRAESSAERTS, K., MUMM, J.S., SCHROETER, E.H., SCHRIJVERS, V., WOLFE, M.S., RAY, W.J. et al. (1999). A presenilin-1-dependent gamma-secretase-like protease mediates release of notch intracellular domain. Nature 398: 518-22.
6. EDLUND, H. (2002). Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 3: 524-32.
7. ESNI, F., GHOSH, B., BIANKIN, A.V., LIN, J.W., ALBERT, M.A., YU, X., MACDONALD, R.J., CIVIN, C.I., REAL, F.X., PACK, M.A. et al. (2004). Notch inhibits ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Developmental 131: 4213-24.
8. FAUX, C.H., TURNLEY, A.M., EPA, R., CAPPAI, R. and BARTLETT, P.F. (2001). Interactions between fibroblast growth factors and notch regulate neuronal differentiation. J Neurosci 21: 5587-96.
9. FISHER, A. and CAUDY, M. (1998). The function of hairy-related bhlh repressor, proteins in cell fate decisions. Bioessays 20: 298-306.
10. GITTES, G. and GALANTE, P. (1993). A culture system for the study of pancreatic organogenesis. J Tiss Cult Meth 15: 23-28.
11. GITTES, G., GALANTE, P., HANAHAN, D., RUTTER, W. and DEBAS, H. (1996). Lineage specific morphogenesis in the developing pancreas: Role of mesenchymal factors. Development 122: 439-447.
12. GITTES, G. and RUTTER, W. (1992). Onset of cell-specific gene expression in the developing mouse pancreas. Proc Natl acad Sci USA 89: 1128-1132.
13. GOLOSOW, N. and GROBSTEIN, C. (1962). Epitheliomesenchymal interaction in pancreatic morphogenesis. Dev Biol 4: 242-255.
14. GRADWOHL, G., DIERICH, A., LEMEUR, M. and GUILLEMOT, F. (2000). Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97: 1607-11.
15. HALD, J., HJORTH, J.P., GERMAN, M.S., MADSEN, O.D., SERUP, P. and JENSEN, J. (2003). Activated notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 260: 426-37.
16. HART, A., PAPADOPOULOU, S. and EDLUND, H. (2003). Fgf10 maintains notch activation, stimulates proliferation and blocks differentiation of pancreatic epithelial cells. Dev Dyn 228: 185-93.
17. HART, A.W., BAEZA, N., APELQVIST, A. and EDLUND, H. (2000). Attenuation of fgf signalling in mouse beta-cells leads to diabetes. Nature 408: 864-8.
18. JENSEN, J. (2004). Gene regulatory factors in pancreatic development. Dev Dyn 229: 176-200.
19. JENSEN, J., PEDERSEN, E.E., GALANTE, P., HALD, J., HELLER, R.S., ISHIBASHI, M., KAGEYAMA, R., GUILLEMOT, F., SERUP, P. and MADSEN, O.D. (2000). Control of endodermal endocrine development by hes-1. Nat Genet 24: 36-44.
20. KIM, S.K. and MACDONALD, R.J. (2002). Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 12: 540-7.
21. KURODA, K., TANI, S., TAMURA, K., MINOGUCHI, S., KUROOKA, H. and HONJO, T. (1999). Delta-induced notch signaling mediated by rbp-j inhibits myod expression and myogenesis. J Biol Chem 274: 7238-44.
22. LEE, J.C., SMITH, S.B., WATADA, H., LIN, J., SCHEEL, D., WANG, J., MIRMIRA, R.G. and GERMAN, M.S. (2001). Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50: 928-36.
23. MIRALLES, F., CZERNICHOW, P., OZAKI, K., ITOH, N. and SCHARFMANN, R. (1999). Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 96: 6267-72.
24. MIRALLES, F., CZERNICHOW, P. and SCHARFMANN, R. (1998). Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125: 1017-24.
25. MITSIADIS, T.A., HENRIQUE, D., THESLEFF, I. and LENDAHL, U. (1997). Mouse serrate-1 (jagged-1): Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4. Development 124: 1473-83.
26. MIYAMOTO, Y., MAITRA, A., GHOSH, B., ZECHNER, U., ARGANI, P., IACOBUZIO-DONAHUE, C.A., SRIURANPONG, V., ISO, T., MESZOELY, I.M., WOLFE, M.S. et al. (2003). Notch mediates tgf alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3: 565-76.
27. MURTAUGH, L.C., STANGER, B.Z., KWAN, K.M. and MELTON, D.A. (2003). Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A 100: 14920-5.
28. MUSTONEN, T., TUMMERS, M., MIKAMI, T., ITOH, N., ZHANG, N., GRIDLEY, T. and THESLEFF, I. (2002). Lunatic fringe, fgf and bmp regulate the notch pathway during epithelial morphogenesis of teeth. Dev Biol 248: 281-93.
29. NORGAARD, G.A., JENSEN, J.N. and JENSEN, J. (2003). Fgf10 signaling maintains the pancreatic progenitor cell state revealing a novel role of notch in organ development. Dev Biol 264: 323-38.
30. POWERS, C.J., MCLESKEY, S.W. and WELLSTEIN, A. (2000). Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer 7: 165-97.
31. PULKKINEN, M.A., SPENCER-DENE, B., DICKSON, C. and OTONKOSKI, T. (2003). The iiib isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells. Mech Dev 120: 167-75.
32. REVEST, J.M., SPENCER-DENE, B., KERR, K., DE MOERLOOZE, L., ROSEWELL, I. and DICKSON, C. (2001). Fibroblast growth factor receptor 2-iiib acts upstream of shh and fgf4 and is required for limb bud maintenance but not for the induction of fgf8, fgf10, msx1, or bmp4. Dev Biol 231: 47-62.
33. RUTTER, W., PICTET, R., HARDING, J., CHIRGWIN, J., MACDONALD, R. and PRZYBYLA, A. (1978). An analysis of pancreattic development: Role of mesenchymal factor and other extracellular factors. Symp Soc Dev Biol 35: 205-227.
34. WESSELS, N. and COHEN, J. (1967). Early pancreas organogenesis: Morphogenesis, tissue interactions and mass effects. Dev Biol 15: 237-270.
35. WOLFE, M.S., XIA, W., MOORE, C.L., LEATHERWOOD, D.D., OSTASZEWSKI, B., RAHMATI, T., DONKOR, I.O. and SELKOE, D.J. (1999). Peptidomimetic probes and molecular modeling suggest that alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 38: 4720-7.