Separable effector T cell populations specialized for B cell help or tissue inflammation

Nature Immunology

Volumn 2, Issue 9, 2001, Pages 876-881

  Campbell, Daniel J ^a   Kim, Chang H ^a   Butcher, Eugene C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIBODY; CD4 ANTIGEN; CD40 LIGAND; CELL ADHESION MOLECULE; CHEMOATTRACTANT; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; CYTOKINE; L SELECTIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; CELL POPULATION; CELL SEPARATION; CONTROLLED STUDY; CYTOKINE RELEASE; EFFECTOR CELL; HELPER CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; PRECURSOR; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; CD40 LIGAND; CELLS, CULTURED; CYTOKINES; HYPERSENSITIVITY, DELAYED; INFLAMMATION; L-SELECTIN; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED BALB C; OVALBUMIN; RECEPTORS, LYMPHOCYTE HOMING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0035554935     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0901-876     Document Type: Article

References (50)

1. Lymphocyte homing and homeostasis
2. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
3. Molecular mechanisms of lymphocyte homing to peripheral lymph nodes
4. In vivo-activated CD4T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
5. A putative chemokine receptor, BLRI, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
6. Monocyte chemoattractant protein I acts as a T-lymphocyte chemoattractant
7. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
8. + T cells migrate into inflamed skin only if they express ligands for E- and P- selection
9. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
10. A cell-surface molecule involved in organ-specific homing of lymphocytes
11. P- and E-selectin mediate recruitment of T-helper-I but not T-helper-2 cells into inflammed tissues
12. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
13. The C-X-C chemokine Mig is highly expressed in the papillae of psoriatic lesions
14. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium
15. Expression of IFN-inducible protein-10 in chronic hepatitis
16. H2 cell localization and delivery of B cell help in vivo
17. The molecular cell biology of interferon-γ and its receptor
18. Lymphokine control of in vivo immunoglobulin isotype selection
19. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity
20. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
21. CD40 and CD154 in cell-mediated immunity
22. H2 cells: Different patterns of lymphokine secretion lead to different functional properties
23. Lymphocyte trafficking and regional immunity
24. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
25. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites
26. A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-I and correlation with β 7 integrins and memory differentiation
27. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
28. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an in regional immunity
29. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
30. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
31. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
32. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
33. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
34. +) T cells
35. ICOS co-stimulatory receptor is essential for T-cell activation and function
36. + T cells or B cells
37. + T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo
38. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
39. Lack of correlation between chemokine receptor and T(h)1/T(h)2 cytokine expression by individual memory T cells
40. Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns
41. Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations
42. + T cell phenotype development
43. Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones
44. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis
45. Subtypes of helper cells. Non-inflammatory type 1 helper T cells
46. Cytokines induce the development of functionally heterogeneous T helper cell subsets
47. C-C chemokine receptor 4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential
48. + memory T cell differentiation
49. α(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts
50. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7