Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

Immunity

Volumn 21, Issue 5, 2004, Pages 669-679

  Malherbe, Laurent ^a   Hausl, Christina ^a   Teyton, Luc ^a   McHeyzer Williams, Michael G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CELL SELECTION; CLONAL VARIATION; CLONE; CONTROLLED STUDY; GENE SEQUENCE; HELPER CELL; IMMUNE RESPONSE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEPTOR BINDING;

ANIMALS; CYTOCHROMES C; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 8444236620     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.09.008     Document Type: Article

References (43)

1. Alam S.M., Travers P.J., Wung J.L., Nasholds W., Redpath S., Jameson S.C., Gascoigne N.R.J. T-cell-receptor affinity and thymocyte positive selection. Nature. 381:1996;616-620
2. Baldwin K.K., Reay P.A., Wu L., Farr A., Davis M.M. A T cell receptor-specific blockade of positive selection. J. Exp. Med. 189:1999;13-23
3. Berg L.J., de St. Groth B.F., Pullen A.M., Davis M.M. Phenotypic differences between alpha-beta-T-cell versus beta-T-cell receptor transgenic mice undergoing negative selection. Nature. 340:1989;559-562
4. Bikah G., Pogue-Caley R.R., McHeyzer-Williams L.J., McHeyzer-Williams M.G. Regulating T helper cell immunity through antigen responsiveness and calcium entry. Nat. Immunol. 1:2000;402-412
5. Bitmansour A.D., Waldrop S.L., Pitcher C.J., Khatamzas E., Kern F., Maino V.C., Picker L.J. Clonotypic structure of the human CD4(+) memory T cell response to cytomegalovirus. J. Immunol. 167:2001;1151-1163
6. Bousso P., Levraud B.P., Kourilsky P., Abastado J.P. The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones. J. Exp. Med. 189:1999;1591-1600
7. Busch D.H., Pamer E.G. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:1999;701-709
8. Chen Z.W., Li Y.Y., Zeng X.J., Kuroda M.J., Schmitz J.E., Shen Y., Lai X.M., Shen L., Letvin N.L. The TCR repertoire of an immunodominant CD8(+) T lymphocyte population. J. Immunol. 166:2001;4525-4533
9. Correia-Neves M., Waltzinger C., Mathis D., Benoist C. The shaping of the T cell repertoire. Immunity. 14:2001;21-32
10. Fasso M., Anandasabapathy N., Crawford F., Kappler J., Fathman C.G., Ridgway W.M. T cell receptor (TCR)-mediated repertoire selection and loss of TCR V beta diversity during the initiation of a CD4(+) T cell response in vivo. J. Exp. Med. 192:2000;1719-1730
11. Fink P.J., Matis L.A., McElligott D.L., Bookman M., Hedrick S.M. Correlations between T-cell specificity and the structure of the antigen receptor. Nature. 321:1986;219-226
12. Gett A.V., Sallusto F., Lanzavecchia A., Geginat J. T cell fitness determined by signal strength. Nat. Immunol. 4:2003;355-360
13. Goldrath A.W., Bevan M.J. Selecting and maintaining a diverse T-cell repertoire. Nature. 402:1999;255-262
14. Hedrick S.M., Engel I., McElligott D.L., Fink P.J., Hsu M.L., Hansburg D., Matis L.A. Selection of amino-acid sequences in the beta chain of the T-cell antigen receptor. Science. 239:1988;1541-1544
15. Jameson S.C., Hogquist K.A., Bevan M.J. Positive selection of thymocytes. Annu. Rev. Immunol. 13:1995;93-126
16. Jorgensen J.L., Esser U., de St. Groth B.F., Reay P.A., Davis M.M. Mapping T-cell receptor peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:1992;224-230
17. Kaye J., Hsu M.L., Sauron M.E., Jameson S.C., Gascoigne N.R.J., Hedrick S.M. Selective development of CD4+ T-cells in transgenic mice expressing a class-II MHC-restricted antigen receptor. Nature. 341:1989;746-749
18. Kedl R.M., Rees K.A., Hildeman D.A., Schaefer B., Mitchell T., Kappler J., Marrack P. T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 192:2000;1105-1113
19. Kedl R.M., Schaefer B.C., Kappler J.W., Marrack P. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat. Immunol. 3:2002;27-32
20. Kedzierska K., Tuner S.J., Doherty P.C. Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope. Proc. Natl. Acad. Sci. USA. 101:2004;4942-4947
21. Kersh G.J., Kersh E.N., Fremont D.H., Allen P.M. High- and low-potency ligands with similar affinities for the TCR. the importance of kinetics in TCR signaling Immunity. 9:1998;817-826
22. Lanzavecchia A., Sallusto F. Progressive differentiation and selection of the fittest in the immune response. Nat. Rev. Immunol. 2:2002;982-987
23. Liu C.P., Parker D., Kappler J., Marrack P. Selection of antigen-specific T cells by a single IEk peptide combination. J. Exp. Med. 186:1997;1441-1450
24. Lyons D.S., Lieberman S.A., Hampl J., Boniface J.J., Chien Y.H., Berg L.J., Davis M.M. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 5:1996;53-61
25. Malherbe L., Filippi C., Julia V., Foucras G., Moro M., Appel H., Wucherpfennig K., Guery J.C., Glaichenhaus N. Selective activation and expansion of high-affinity CD4(+) T cells in resistant mice upon infection with Leishmania major. Immunity. 13:2000;771-782
26. Matsui K., Boniface J.J., Steffner P., Reay P.A., Davis M.M. Kinetics of T-cell receptor-binding to peptide I-E(K) complexes - correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA. 91:1994;12862-12866
27. McHeyzer-Williams M.G., Nossal G.J.V., Lalor P.A. Molecular characterization of single memory B-cells. Nature. 350:1991;502-505
28. McHeyzer-Williams M.G., McLean M.J., Lalor P.A., Nossal G.J.V. Antigen-driven B-cell differentiation in vivo. J. Exp. Med. 178:1993;295-307
29. McHeyzer-Williams M.G., Davis M.M. Antigen-specific development of primary and memory T-cells in vivo. Science. 268:1995;106-111
30. McHeyzer-Williams L.J., Panus J.F., Mikszta J.A., McHeyzer-Williams M.G. Evolution of antigen-specific T cell receptors in vivo. preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs J. Exp. Med. 189:1999;1823-1837
31. McHeyzer-Williams M.G., McHeyzer-Williams L.J., Panus J.F., Bikah G., Pogue-Caley R.R., Driver D.J., Eisenbraun M.D. Antigen-specific immunity. Th cell-dependent a cell responses. Immunol. Res. 22:2000;223-236
32. McHeyzer-Williams L.J., Malherbe L., Eisenbraun M., Driver D., McHeyzer-Williams M. Development of antigen-specific helper T cell responses in vivo. antigen-specific Th cell subsets Adv. Exp. Med. Biol. 512:2002;11-20
33. Nakano N., Rooke R., Benoist C., Mathis D. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science. 275:1997;678-683
34. Panus J.F., McHeyzer-Williams L.J., McHeyzer-Williams M.G. Antigen-specific T helper cell function. differential cytokine expression in primary and memory responses J. Exp. Med. 192:2000;1301-1316
35. Rees W., Bender J., Teague T.K., Kedl R.M., Crawford F., Marrack P., Kappler J. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc. Natl. Acad. Sci. USA. 96:1999;9781-9786
36. Sant'Angelo D.B., Waterbury P.G., Cohen B.E., Martin W.D., VanKaer L., Hayday A.C., Janeway C.A. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity. 7:1997;517-524
37. Savage P.A., Davis M.M. A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity. 14:2001;243-252
38. Savage P.A., Boniface J.J., Davis M.M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity. 10:1999;485-492
39. Schatz P.J. Use of peptide libraries to map the substrate-specificity of a peptide-modifying enzyme - a 13 residue consensus peptide specifies biotinylation in Escherichia coli. Biotechnology. 11:1993;1138-1143
40. Scott C.A., Garcia K.C., Carbone F.R., Wilson I.A., Teyton L. Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules. J. Exp. Med. 183:1996;2087-2095
41. Sebzda E., Mariathasan S., Ohteki T., Jones R., Bachmann M.F., Ohashi P.S. Selection of the T cell repertoire. Annu. Rev. Immunol. 17:1999;829-874
42. Stratmann T., Apostolopoulos V., Mallet-Designe V., Corper A.L., Scott C.A., Wilson I.A., Kang A.S., Teyton L. The I-A(g7) MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. J. Immunol. 165:2000;3214-3225
43. Winoto A., Urban J.L., Lan N.C., Goverman J., Hood L., Hansburg D. Predominant use of a V-alpha-gene segment in mouse T-cell receptors for cytochrome-C. Nature. 324:1986;679-682