Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs

Journal of Experimental Medicine

Volumn 189, Issue 11, 1999, Pages 1823-1837

  McHeyzer Williams, Louise J ^a   Panus, Joanne Fanelli ^a   Mikszta, John A ^a   McHeyzer Williams, Michael G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antigen specific immunity; Clonal maturation; Helper T cells; Immunologic memory; T cell receptor

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; GERMINAL CENTER; HELPER CELL; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; COLUMBIDAE; COMPLEMENTARITY DETERMINING REGIONS; CYTOCHROME C GROUP; DNA PRIMERS; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; IMMUNOGLOBULIN ALPHA-CHAINS; IMMUNOLOGIC MEMORY; MALE; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; SELECTION (GENETICS); T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0033532540     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.11.1823     Document Type: Article

References (50)

1. Davis, M.M. 1990. T cell receptor gene diversity and selection. Annu. Rev. Biochem. 59:475-496.
2. Bevan, M.J. 1977. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature. 269:417-418.
3. Zinkernagel, R.M., G.N. Callahan, A. Althage, S. Cooper, P.A. Klein, and J. Klein. 1978. On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J. Exp. Med. 147:882-896.
4. Zinkernagel, R.M., and P.C. Doherty. 1974. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature. 248:701-702.
5. Fink, P.J., and M.J. Bevan. 1978. H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148:766-775.
6. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science. 272:54-60.
7. McHeyzer-Williams, M.G., J.D. Altman, and M.M. Davis. 1996. Enumeration and characterization of memory cells in the TH compartment. Immunol. Rev. 150:5-21.
8. Dutton, R.W., L.M. Bradley, and S.L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201-223.
9. Schwartz, R.H. 1985. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3:237-261.
10. Winoto, A., J.L. Urban, N.C. Lan, J. Goverman, L. Hood, and D. Hansburg. 1986. Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature. 324:679-682.
11. Hedrick, S.M., I. Engel, D.L. McElligott, P.J. Fink, M.L. Hsu, D. Hansburg, and L.A. Matis. 1988. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science. 239:1541-1544.
12. Cochet, M., C. Pannetier, A. Regnault, S. Darche, C. Leclerc, and P. Kourilsky. 1992. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 22:2639-2647.
13. McHeyzer-Williams, M.G., and M.M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science. 268:106-111.
14. Jorgensen, J.L., U. Esser, B. Fazekas de St Groth, P.A. Reay, and M.M. Davis. 1992. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:224-230.
15. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84:521-529.
16. Ignatowicz, L., W. Rees, R. Pacholczyk, H. Ignatowicz, E. Kushnir, J. Kappler, and P. Marrack. 1997. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity. 7:179-186.
17. k peptide combination. J. Exp. Med. 186:1441-1450.
18. Zheng, B., S. Han, Q. Zhu, R. Goldsby, and G. Kelsoe. 1996. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature. 384:263-266.
19. Maryanski, J.L., C.V. Jongeneel, P. Bucher, J.L. Casanova, and P.R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity. 4:47-55.
20. Busch, D.H., I.M. Pilip, S. Vijh, and E.G. Pamer. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity. 8:353-362.
21. Busch, D.H., and E.G. Pamer. 1998. MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL. J. Immuuol. 160: 4441-4448.
22. Busch, D.H., I. Pilip, and E.G. Pamer. 1998. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188:61-70.
23. Sourdive, D.J., K. Murali-Krishna, J.D. Altman, A.J. Zajac, J.K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71-82.
24. Kearney, E.R., K.A. Pape, D.Y. Loh, and M.K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
25. Khoruts, A., A. Mondino, K.A. Pape, S.L. Reiner, and M.K. Jenkins. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187:225-236.
26. Garside, P., E. Ingulli, R.R. Merrica, J.G. Johnson, R.J. Noelle, and M.K. Jenkins. 1998. Visualization of specific B and T lymphocyte interactions in the lymph node. Science. 281:96-99.
27. + T cells. J. Exp. Med. 185:2133-2141.
28. Gulbranson-Judge, A., and I. MacLennan. 1996. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur. J. Immunol. 26:1830-1837.
29. Arden, B., S.P. Clark, D. Kabelitz, and T.W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics. 42:501-530.
30. Zheng, B., W. Xue, and G. Kelsoe. 1994. Locus-specific somatic hypermutation in germinal centre T cells. Nature. 372: 556-559.
31. Cheynier, R., S. Henrichwark, and S. Wain-Hobson. 1998. Somatic hypermutation of the T cell receptor Vβ gene in microdissected splenic white pulps from HIV-1-positive patients. Eur. J. Immunol. 28:1604-1610.
32. Nakano, N., R. Rooke, C. Benoist, and D. Mathis. 1997. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science. 275:678-683.
33. Liu, C.-P., F. Crawford, J. Kappler, and P. Marrack. 1998. T cell positive selection by a high density, low affinity ligand. Proc. Natl. Acad. Sci. USA. 95:4522-4526.
34. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature. 375:148-151.
35. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science. 273:104-106.
36. Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity. 8:675-682.
37. k complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA. 91:12862-12866.
38. Davis, M.M., J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y.-H. Chien. 1998. Ligand recognition by αβ T Cell receptors. Annu. Rev. Immunol. 16:523-544.
39. Altman, J.D., P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
40. Murali-Krishna, K., J.D. Altman, M. Suresh, D.J. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
41. + T cells in primary and secondary influenza pneumonia. Immunity. 8:683-691.
42. Gallimore, A., A. Glithero, A. Godkin, A.C. Tissot, A. Pluckthun, T. Elliott, H. Hengartner, and R. Zinkernagel. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med. 187:1383-1393.
43. Bousso, P., A. Casrouge, J.D. Altman, M. Haury, J. Kanellopoulos, J.-P. Abastado, and P. Kourilsky. 1998. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires. Immunity. 9:169-178.
44. Gutgemann, I., A.M. Fahrer, J.D. Altman, M.M. Davis, and Y.-H. Chien. 1998. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity. 8:667-673.
45. Valitutti, S., S. Muller, M. Salio, and A. Lanzavecchia. 1997. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185:1859-1864.
46. + T cells during an acute virus infection. Immunity. 8:167-175.
47. Burnet, F.M. 1959. The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge, UK.
48. Han, S., K. Hathcock, B. Zheng, T.B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interactions in germinal centers: roles for CD40 ligand and B7-2 in establishing germinal centers. J. Immunol. 155:556-567.
49. van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature. 378:620-623.
50. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341:746-749.