Central tolerance: Good but imperfect

Immunological Reviews

Volumn 209, Issue , 2006, Pages 290-296

  Gallegos, Alena M ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; OVALBUMIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; BINDING AFFINITY; CELL INTERACTION; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNIZATION; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THYMOCYTE;

AGE FACTORS; ANIMALS; AUTOANTIGENS; CELL COMMUNICATION; CLONAL DELETION; DENDRITIC CELLS; EPITHELIAL CELLS; MICE; SELF TOLERANCE; T-LYMPHOCYTES; THYMUS GLAND;

EID: 33645071052     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2006.00348.x     Document Type: Review

References (40)

1. Goldrath AW Bevan MJ Selecting and maintaining a diverse T-cell repertoire Nature 1999 402 255 262
2. Baldwin TA Sandau MM Jameson SC Hogquist KA The timing of TCRα expression critically influences T cell development and selection J Exp Med 2005 202 111 121
3. Kyewski B Derbinski J Self-representation in the thymus: an extended view Nat Rev Immunol 2004 4 688 698
4. Gallegos AM Bevan MJ Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation J Exp Med 2004 200 1039 1049
5. Smith KM Olson DC Hirose R Hanahan D Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance Int Immunol 1997 9 1355 1365
6. Derbinski J Schulte A Kyewski B Klein L Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self Nat Immunol 2001 2 1032 1039
7. Derbinski J et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels J Exp Med 2005 202 33 45
8. Klein L Klugmann M Nave KA Tuohy VK Kyewski B Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells Nat Med 2000 6 56 61
9. Pitkanen J Peterson P Autoimmune regulator: from loss of function to autoimmunity Genes Immun 2003 4 12 21
10. Anderson MS et al. Projection of an immunological self shadow within the thymus by the aire protein Science 2002 298 1395 1401
11. Liston A et al. Gene dosage - limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity J Exp Med 2004 200 1015 1026
12. Liston A Lesage S Wilson J Peltonen L Goodnow CC Aire regulates negative selection of organ-specific T cells Nat Immunol 2003 4 350 354
13. Klein L Roettinger B Kyewski B Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance Eur J Immunol 2001 31 2476 2486
14. Gao EK Lo D Sprent J Strong T cell tolerance in parent - F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy J Exp Med 1990 171 1101 1121
15. Sprent J Kosaka H Gao EK T cell tolerance after bone marrow transplantation in mice Bone Marrow Transplant 1992 10 5 9
16. Webb SR Sprent J Tolerogenicity of thymic epithelium Eur J Immunol 1990 20 2525 2528
17. van Meerwijk JP MacDonald HR In vivo T-lymphocyte tolerance in the absence of thymic clonal deletion mediated by hematopoietic cells Blood 1999 93 3856 3862
18. van Meerwijk JP Marguerat S Lees RK Germain RN Fowlkes BJ MacDonald HR Quantitative impact of thymic clonal deletion on the T cell repertoire J Exp Med 1997 185 377 383
19. Marrack P et al. The effect of thymus environment on T cell development and tolerance Cell 1988 53 627 634
20. Bonomo A Matzinger P Thymus epithelium induces tissue-specific tolerance J Exp Med 1993 177 1153 1164
21. Medzhitov R Toll-like receptors and innate immunity Nat Rev Immunol 2001 1 135 145
22. Pamer EG Immune responses to Listeria monocytogenes Nat Rev Immunol 2004 4 812 823
23. Buller RM Holmes KL Hugin A Frederickson TN Morse HC III. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells Nature 1987 328 77 79
24. Rahemtulla A et al. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4 Nature 1991 353 180 184
25. Pamer EG Wang CR Flaherty L Lindahl KF Bevan MJ H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes Cell 1992 70 215 223
26. Kurts C Kosaka H Carbone FR Miller JF Heath WR Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells J Exp Med 1997 186 239 245
27. Dillon SR Jameson SC Fink PJ V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition J Immunol 1994 152 1790 1801
28. Heath WR Carbone FR Cross-presentation in viral immunity and self-tolerance Nat Rev Immunol 2001 1 126 134
29. Belz GT et al. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens J Exp Med 2002 196 1099 1104
30. den Haan JM Lehar SM Bevan MJ CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo J Exp Med 2000 192 1685 1696
31. Wu L Shortman K Heterogeneity of thymic dendritic cells Semin Immunol 2005 17 304 312
32. Harshyne LA Zimmer MI Watkins SC Barratt-Boyes SM A role for class A scavenger receptor in dendritic cell nibbling from live cells J Immunol 2003 170 2302 2309
33. Morgan DJ Kreuwel HT Sherman LA Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens J Immunol 1999 163 723 727
34. Hoglund P Mintern J Waltzinger C Heath W Benoist C Mathis D Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes J Exp Med 1999 189 331 339
35. Morgan DJ Kurts C Kreuwel HT Holst KL Heath WR Sherman LA Ontogeny of T cell tolerance to peripherally expressed antigens Proc Natl Acad Sci USA 1999 96 3854 3858
36. Morgan DJ et al. CD8(+) T cell-mediated spontaneous diabetes in neonatal mice J Immunol 1996 157 978 983
37. Mintern JD Sutherland RM Lew AM Shortman K Carbone FR Heath WR Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice Eur J Immunol 2002 32 1044 1051
38. Fontenot JD Dooley JL Farr AG Rudensky AY Developmental regulation of Foxp3 expression during ontogery J Exp Med 2005 202 901 906
39. Scollay R Godfrey DI Thymic emigration: conveyor belts or lucky dips? Immunol Today 1995 16 268 273 (discussion 273-274).
40. Dakic A et al. Development of the dendritic cell system during mouse ontogeny J Immunol 2004 172 1018 1027