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Volumn 27, Issue 11, 2006, Pages 525-532

Innate immune recognition of, and regulation by, DNA

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGODEOXYNUCLEOTIDE; TOLL LIKE RECEPTOR 9;

EID: 33749490571     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2006.09.002     Document Type: Review
Times cited : (200)

References (85)
  • 1
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., et al. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1
  • 2
    • 17644393549 scopus 로고    scopus 로고
    • DNA degradation in development and programmed cell death
    • Nagata S. DNA degradation in development and programmed cell death. Annu Rev. Immunol. 23 (2005) 853-875
    • (2005) Annu Rev. Immunol. , vol.23 , pp. 853-875
    • Nagata, S.1
  • 3
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 4
    • 2942679083 scopus 로고    scopus 로고
    • The immunobiology of the TLR9 subfamily
    • Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol. 25 (2004) 381-386
    • (2004) Trends Immunol. , vol.25 , pp. 381-386
    • Wagner, H.1
  • 5
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5 (2006) 471-484
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 6
    • 0033515098 scopus 로고    scopus 로고
    • Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
    • Suzuki K., et al. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 2285-2290
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 2285-2290
    • Suzuki, K.1
  • 7
    • 0035451081 scopus 로고    scopus 로고
    • Genomic DNA released by dying cells induces the maturation of APCs
    • Ishii K.J., et al. Genomic DNA released by dying cells induces the maturation of APCs. J. Immunol. 167 (2001) 2602-2607
    • (2001) J. Immunol. , vol.167 , pp. 2602-2607
    • Ishii, K.J.1
  • 8
    • 0037321024 scopus 로고    scopus 로고
    • Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
    • Kawane K., et al. Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol. 4 (2003) 138-144
    • (2003) Nat. Immunol. , vol.4 , pp. 138-144
    • Kawane, K.1
  • 9
    • 18644383289 scopus 로고    scopus 로고
    • Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
    • Yasuda K., et al. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 174 (2005) 6129-6136
    • (2005) J. Immunol. , vol.174 , pp. 6129-6136
    • Yasuda, K.1
  • 10
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y., et al. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J. Exp. Med. 202 (2005) 1333-1339
    • (2005) J. Exp. Med. , vol.202 , pp. 1333-1339
    • Okabe, Y.1
  • 11
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii K.J., et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7 (2006) 40-48
    • (2006) Nat. Immunol. , vol.7 , pp. 40-48
    • Ishii, K.J.1
  • 12
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 13
    • 33644889894 scopus 로고    scopus 로고
    • Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway
    • Martin D.A., and Elkon K.B. Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway. Arthritis Rheum. 54 (2006) 951-962
    • (2006) Arthritis Rheum. , vol.54 , pp. 951-962
    • Martin, D.A.1    Elkon, K.B.2
  • 14
    • 33745196222 scopus 로고    scopus 로고
    • Contribution of interferon-β to the immune activation induced by double-stranded DNA
    • Shirota H., et al. Contribution of interferon-β to the immune activation induced by double-stranded DNA. Immunology 118 (2006) 302-310
    • (2006) Immunology , vol.118 , pp. 302-310
    • Shirota, H.1
  • 15
    • 33744804308 scopus 로고    scopus 로고
    • TLR9-independent activation of B lymphocytes by bacterial DNA
    • Cortez-Gonzalez X., et al. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol. 25 (2006) 253-261
    • (2006) DNA Cell Biol. , vol.25 , pp. 253-261
    • Cortez-Gonzalez, X.1
  • 16
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72 (1984) 955-962
    • (1984) J. Natl. Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1
  • 17
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
    • Yamamoto S., et al. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. J. Immunol. 148 (1992) 4072-4076
    • (1992) J. Immunol. , vol.148 , pp. 4072-4076
    • Yamamoto, S.1
  • 18
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg A.M., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1
  • 19
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H., et al. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 20
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H., et al. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170 (2003) 3059-3064
    • (2003) J. Immunol. , vol.170 , pp. 3059-3064
    • Hemmi, H.1
  • 21
    • 20244367698 scopus 로고    scopus 로고
    • Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells
    • Kerkmann M., et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells. J. Biol. Chem. 280 (2005) 8086-8093
    • (2005) J. Biol. Chem. , vol.280 , pp. 8086-8093
    • Kerkmann, M.1
  • 22
    • 0037371208 scopus 로고    scopus 로고
    • Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner
    • Sano K., et al. Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner. J. Immunol. 170 (2003) 2367-2373
    • (2003) J. Immunol. , vol.170 , pp. 2367-2373
    • Sano, K.1
  • 23
    • 4744368053 scopus 로고    scopus 로고
    • Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation
    • Vollmer J., et al. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113 (2004) 212-223
    • (2004) Immunology , vol.113 , pp. 212-223
    • Vollmer, J.1
  • 24
    • 11844290125 scopus 로고    scopus 로고
    • Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
    • Roberts T.L., et al. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J. Immunol. 174 (2005) 605-608
    • (2005) J. Immunol. , vol.174 , pp. 605-608
    • Roberts, T.L.1
  • 25
    • 21044444274 scopus 로고    scopus 로고
    • Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
    • Kandimalla E.R., et al. Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6925-6930
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 6925-6930
    • Kandimalla, E.R.1
  • 26
    • 19944430901 scopus 로고    scopus 로고
    • Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    • Coban C., et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201 (2005) 19-25
    • (2005) J. Exp. Med. , vol.201 , pp. 19-25
    • Coban, C.1
  • 27
    • 23044445303 scopus 로고    scopus 로고
    • Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • Choe J., et al. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 309 (2005) 581-585
    • (2005) Science , vol.309 , pp. 581-585
    • Choe, J.1
  • 28
    • 10744219675 scopus 로고    scopus 로고
    • TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    • Latz E., et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
    • (2004) Nat. Immunol. , vol.5 , pp. 190-198
    • Latz, E.1
  • 29
    • 2442450672 scopus 로고    scopus 로고
    • Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition
    • Cornelie S., et al. Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition. J. Biol. Chem. 279 (2004) 15124-15129
    • (2004) J. Biol. Chem. , vol.279 , pp. 15124-15129
    • Cornelie, S.1
  • 30
    • 4644330955 scopus 로고    scopus 로고
    • Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
    • Rutz M., et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 34 (2004) 2541-2550
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2541-2550
    • Rutz, M.1
  • 31
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P., et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32 (2002) 1958-1968
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1
  • 32
    • 3142697714 scopus 로고    scopus 로고
    • TLR9 is localized in the endoplasmic reticulum prior to stimulation
    • Leifer C.A., et al. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J. Immunol. 173 (2004) 1179-1183
    • (2004) J. Immunol. , vol.173 , pp. 1179-1183
    • Leifer, C.A.1
  • 33
    • 33645078650 scopus 로고    scopus 로고
    • Regulation of membrane traffic by phosphoinositide 3-kinases
    • Lindmo K., and Stenmark H. Regulation of membrane traffic by phosphoinositide 3-kinases. J. Cell Sci. 119 (2006) 605-614
    • (2006) J. Cell Sci. , vol.119 , pp. 605-614
    • Lindmo, K.1    Stenmark, H.2
  • 34
    • 0037099629 scopus 로고    scopus 로고
    • Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
    • Ishii K.J., et al. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196 (2002) 269-274
    • (2002) J. Exp. Med. , vol.196 , pp. 269-274
    • Ishii, K.J.1
  • 35
    • 33646473522 scopus 로고    scopus 로고
    • Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway
    • Kuo C.C., et al. Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway. J. Immunol. 176 (2006) 5943-5949
    • (2006) J. Immunol. , vol.176 , pp. 5943-5949
    • Kuo, C.C.1
  • 36
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • Tabeta K., et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 (2006) 156-164
    • (2006) Nat. Immunol. , vol.7 , pp. 156-164
    • Tabeta, K.1
  • 37
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K., et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1
  • 38
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci C., et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203 (2006) 1999-2008
    • (2006) J. Exp. Med. , vol.203 , pp. 1999-2008
    • Guiducci, C.1
  • 39
    • 33644764063 scopus 로고    scopus 로고
    • Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    • Lakadamyali M., et al. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124 (2006) 997-1009
    • (2006) Cell , vol.124 , pp. 997-1009
    • Lakadamyali, M.1
  • 40
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton G.M., et al. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7 (2006) 49-56
    • (2006) Nat. Immunol. , vol.7 , pp. 49-56
    • Barton, G.M.1
  • 41
    • 29444441343 scopus 로고    scopus 로고
    • Manifold mechanisms of toll-like receptor-ligand recognition
    • Ishii K.J., et al. Manifold mechanisms of toll-like receptor-ligand recognition. J. Clin. Immunol. 25 (2005) 511-521
    • (2005) J. Clin. Immunol. , vol.25 , pp. 511-521
    • Ishii, K.J.1
  • 42
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule M.W., et al. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199 (2004) 1631-1640
    • (2004) J. Exp. Med. , vol.199 , pp. 1631-1640
    • Boule, M.W.1
  • 43
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • Means T.K., et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115 (2005) 407-417
    • (2005) J. Clin. Invest. , vol.115 , pp. 407-417
    • Means, T.K.1
  • 44
    • 32944462310 scopus 로고    scopus 로고
    • CpG motif-independent activation of TLR9 upon endosomal translocation of 'natural' phosphodiester DNA
    • Yasuda K., et al. CpG motif-independent activation of TLR9 upon endosomal translocation of 'natural' phosphodiester DNA. Eur. J. Immunol. 36 (2006) 431-436
    • (2006) Eur. J. Immunol. , vol.36 , pp. 431-436
    • Yasuda, K.1
  • 45
    • 33746214827 scopus 로고    scopus 로고
    • CXCL16 influences the nature and specificity of CpG-induced immune activation
    • Gursel M., et al. CXCL16 influences the nature and specificity of CpG-induced immune activation. J. Immunol. 177 (2006) 1575-1580
    • (2006) J. Immunol. , vol.177 , pp. 1575-1580
    • Gursel, M.1
  • 46
    • 29144434113 scopus 로고    scopus 로고
    • TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
    • Bafica A., et al. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J. Exp. Med. 202 (2005) 1715-1724
    • (2005) J. Exp. Med. , vol.202 , pp. 1715-1724
    • Bafica, A.1
  • 47
    • 24744456326 scopus 로고    scopus 로고
    • Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9
    • Huang L.Y., et al. Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J. Immunol. 175 (2005) 3964-3970
    • (2005) J. Immunol. , vol.175 , pp. 3964-3970
    • Huang, L.Y.1
  • 48
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta K., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3516-3521
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3516-3521
    • Tabeta, K.1
  • 49
    • 0041832267 scopus 로고    scopus 로고
    • FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG
    • Bave U., et al. FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171 (2003) 3296-3302
    • (2003) J. Immunol. , vol.171 , pp. 3296-3302
    • Bave, U.1
  • 50
    • 33744909412 scopus 로고    scopus 로고
    • Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H
    • Blasius A.L., and Colonna M. Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H. Trends Immunol. 27 (2006) 255-260
    • (2006) Trends Immunol. , vol.27 , pp. 255-260
    • Blasius, A.L.1    Colonna, M.2
  • 51
    • 4043064293 scopus 로고    scopus 로고
    • Transcriptional regulation of the human TLR9 gene
    • Takeshita F., et al. Transcriptional regulation of the human TLR9 gene. J. Immunol. 173 (2004) 2552-2561
    • (2004) J. Immunol. , vol.173 , pp. 2552-2561
    • Takeshita, F.1
  • 52
    • 28244458932 scopus 로고    scopus 로고
    • A distal regulatory region is required for constitutive and IFN-β-induced expression of murine TLR9 gene
    • Guo Z., et al. A distal regulatory region is required for constitutive and IFN-β-induced expression of murine TLR9 gene. J. Immunol. 175 (2005) 7407-7418
    • (2005) J. Immunol. , vol.175 , pp. 7407-7418
    • Guo, Z.1
  • 53
    • 33746238512 scopus 로고    scopus 로고
    • Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice
    • Brummel R., et al. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur. J. Immunol. 36 (2006) 1951-1962
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1951-1962
    • Brummel, R.1
  • 54
    • 13144259663 scopus 로고    scopus 로고
    • IFN-γ overcomes low responsiveness of myeloid dendritic cells to CpG DNA
    • Uchijima M., et al. IFN-γ overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Immunol. Cell Biol. 83 (2005) 92-95
    • (2005) Immunol. Cell Biol. , vol.83 , pp. 92-95
    • Uchijima, M.1
  • 55
    • 33645758475 scopus 로고    scopus 로고
    • IFN-γ primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking
    • Adachi Y., et al. IFN-γ primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking. J. Immunol. 176 (2006) 5033-5040
    • (2006) J. Immunol. , vol.176 , pp. 5033-5040
    • Adachi, Y.1
  • 56
    • 10344228773 scopus 로고    scopus 로고
    • Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells
    • Saikh K.U., et al. Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells. J. Immunol. 173 (2004) 7426-7434
    • (2004) J. Immunol. , vol.173 , pp. 7426-7434
    • Saikh, K.U.1
  • 57
    • 0141705297 scopus 로고    scopus 로고
    • Toll-like receptors stimulate human neutrophil function
    • Hayashi F., et al. Toll-like receptors stimulate human neutrophil function. Blood 102 (2003) 2660-2669
    • (2003) Blood , vol.102 , pp. 2660-2669
    • Hayashi, F.1
  • 58
    • 30744437150 scopus 로고    scopus 로고
    • Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils
    • Jozsef L., et al. Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. J. Immunol. 176 (2006) 1195-1202
    • (2006) J. Immunol. , vol.176 , pp. 1195-1202
    • Jozsef, L.1
  • 59
    • 20844445114 scopus 로고    scopus 로고
    • TGF-α regulates TLR expression and function on epidermal keratinocytes
    • Miller L.S., et al. TGF-α regulates TLR expression and function on epidermal keratinocytes. J. Immunol. 174 (2005) 6137-6143
    • (2005) J. Immunol. , vol.174 , pp. 6137-6143
    • Miller, L.S.1
  • 60
    • 23844553873 scopus 로고    scopus 로고
    • + dendritic cells protect against lethal Listeria monocytogenes infection
    • + dendritic cells protect against lethal Listeria monocytogenes infection. Eur. J. Immunol. 35 (2005) 2397-2405
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2397-2405
    • Ishii, K.J.1
  • 61
    • 33745214259 scopus 로고    scopus 로고
    • Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    • Kuwajima S., et al. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol. 7 (2006) 740-746
    • (2006) Nat. Immunol. , vol.7 , pp. 740-746
    • Kuwajima, S.1
  • 62
    • 32244448339 scopus 로고    scopus 로고
    • Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
    • Chan C.W., et al. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat. Med. 12 (2006) 207-213
    • (2006) Nat. Med. , vol.12 , pp. 207-213
    • Chan, C.W.1
  • 63
    • 14044269485 scopus 로고    scopus 로고
    • Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-γ via autocrine IL-12
    • Pillarisetty V.G., et al. Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-γ via autocrine IL-12. J. Immunology 174 (2005) 2612-2618
    • (2005) J. Immunology , vol.174 , pp. 2612-2618
    • Pillarisetty, V.G.1
  • 64
    • 33746671960 scopus 로고    scopus 로고
    • A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide
    • Shen H., and Iwasaki A. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J. Clin. Invest. 116 (2006) 2237-2243
    • (2006) J. Clin. Invest. , vol.116 , pp. 2237-2243
    • Shen, H.1    Iwasaki, A.2
  • 65
    • 0001311171 scopus 로고
    • Inhibition of virus multiplication by foreign nucleic acid
    • Rotem Z., et al. Inhibition of virus multiplication by foreign nucleic acid. Nature 197 (1963) 564-566
    • (1963) Nature , vol.197 , pp. 564-566
    • Rotem, Z.1
  • 66
    • 0000970577 scopus 로고
    • Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds
    • Jensen K.E., et al. Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds. Nature 200 (1963) 433-434
    • (1963) Nature , vol.200 , pp. 433-434
    • Jensen, K.E.1
  • 67
    • 0034114882 scopus 로고    scopus 로고
    • Features of systemic lupus erythematosus in Dnase1-deficient mice
    • Napirei M., et al. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat. Genet. 25 (2000) 177-181
    • (2000) Nat. Genet. , vol.25 , pp. 177-181
    • Napirei, M.1
  • 68
    • 0034939627 scopus 로고    scopus 로고
    • Mutation of DNASE1 in people with systemic lupus erythematosus
    • Yasutomo K., et al. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat. Genet. 28 (2001) 313-314
    • (2001) Nat. Genet. , vol.28 , pp. 313-314
    • Yasutomo, K.1
  • 69
    • 3242672339 scopus 로고    scopus 로고
    • Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis
    • Morita M., et al. Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis. Mol. Cell. Biol. 24 (2004) 6719-6727
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 6719-6727
    • Morita, M.1
  • 70
    • 14644387513 scopus 로고    scopus 로고
    • Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways
    • Yasuda K., et al. Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways. J. Leukoc. Biol. 77 (2005) 71-79
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 71-79
    • Yasuda, K.1
  • 71
    • 16244376480 scopus 로고    scopus 로고
    • Toll-like receptors, endogenous ligands, and systemic autoimmune disease
    • Rifkin I.R., et al. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol. Rev. 204 (2005) 27-42
    • (2005) Immunol. Rev. , vol.204 , pp. 27-42
    • Rifkin, I.R.1
  • 72
    • 27544434183 scopus 로고    scopus 로고
    • Essential function for the kinase TAK1 in innate and adaptive immune responses
    • Sato S., et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6 (2005) 1087-1095
    • (2005) Nat. Immunol. , vol.6 , pp. 1087-1095
    • Sato, S.1
  • 73
    • 33747615237 scopus 로고    scopus 로고
    • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
    • Yamamoto M., et al. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 7 (2006) 962-970
    • (2006) Nat. Immunol. , vol.7 , pp. 962-970
    • Yamamoto, M.1
  • 74
    • 23744506255 scopus 로고    scopus 로고
    • Negative regulation of cytokine and TLR signalings by SOCS and others
    • Naka T., et al. Negative regulation of cytokine and TLR signalings by SOCS and others. Adv. Immunol. 87 (2005) 61-122
    • (2005) Adv. Immunol. , vol.87 , pp. 61-122
    • Naka, T.1
  • 75
    • 27644548945 scopus 로고    scopus 로고
    • Negative regulation of Toll-like-receptor signaling by IRF-4
    • Negishi H., et al. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 15989-15994
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 15989-15994
    • Negishi, H.1
  • 76
    • 23844461233 scopus 로고    scopus 로고
    • TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
    • Takeshita F., et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur. J. Immunol. 35 (2005) 2477-2485
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2477-2485
    • Takeshita, F.1
  • 77
    • 9644301015 scopus 로고    scopus 로고
    • A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
    • Sugimoto K., et al. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J. Clin. Invest. 114 (2004) 857-866
    • (2004) J. Clin. Invest. , vol.114 , pp. 857-866
    • Sugimoto, K.1
  • 78
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai T., and Akira S. Innate immune recognition of viral infection. Nat. Immunol. 7 (2006) 131-137
    • (2006) Nat. Immunol. , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 79
    • 30544447047 scopus 로고    scopus 로고
    • Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    • Oganesyan G., et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439 (2006) 208-211
    • (2006) Nature , vol.439 , pp. 208-211
    • Oganesyan, G.1
  • 80
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • Hacker H., et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207
    • (2006) Nature , vol.439 , pp. 204-207
    • Hacker, H.1
  • 81
    • 33645841633 scopus 로고    scopus 로고
    • IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
    • Hoshino K., et al. IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature 440 (2006) 949-953
    • (2006) Nature , vol.440 , pp. 949-953
    • Hoshino, K.1
  • 82
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H., et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441 (2006) 101-105
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1
  • 83
    • 33646592188 scopus 로고    scopus 로고
    • The specific and essential role of MAVS in antiviral innate immune responses
    • Sun Q., et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24 (2006) 633-642
    • (2006) Immunity , vol.24 , pp. 633-642
    • Sun, Q.1
  • 84
    • 33745814424 scopus 로고    scopus 로고
    • Essential role of IPS-1 in innate immune responses against RNA viruses
    • Kumar H., et al. Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med. 203 (2006) 1795-1803
    • (2006) J. Exp. Med. , vol.203 , pp. 1795-1803
    • Kumar, H.1
  • 85
    • 31444432184 scopus 로고    scopus 로고
    • Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification
    • Igoucheva O., et al. Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene Ther. 13 (2006) 266-275
    • (2006) Gene Ther. , vol.13 , pp. 266-275
    • Igoucheva, O.1


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