-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S., et al. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
-
2
-
-
17644393549
-
DNA degradation in development and programmed cell death
-
Nagata S. DNA degradation in development and programmed cell death. Annu Rev. Immunol. 23 (2005) 853-875
-
(2005)
Annu Rev. Immunol.
, vol.23
, pp. 853-875
-
-
Nagata, S.1
-
3
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
4
-
-
2942679083
-
The immunobiology of the TLR9 subfamily
-
Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol. 25 (2004) 381-386
-
(2004)
Trends Immunol.
, vol.25
, pp. 381-386
-
-
Wagner, H.1
-
5
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg A.M. Therapeutic potential of Toll-like receptor 9 activation. Nat. Rev. Drug Discov. 5 (2006) 471-484
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
6
-
-
0033515098
-
Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
-
Suzuki K., et al. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 2285-2290
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 2285-2290
-
-
Suzuki, K.1
-
7
-
-
0035451081
-
Genomic DNA released by dying cells induces the maturation of APCs
-
Ishii K.J., et al. Genomic DNA released by dying cells induces the maturation of APCs. J. Immunol. 167 (2001) 2602-2607
-
(2001)
J. Immunol.
, vol.167
, pp. 2602-2607
-
-
Ishii, K.J.1
-
8
-
-
0037321024
-
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation
-
Kawane K., et al. Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat. Immunol. 4 (2003) 138-144
-
(2003)
Nat. Immunol.
, vol.4
, pp. 138-144
-
-
Kawane, K.1
-
9
-
-
18644383289
-
Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
-
Yasuda K., et al. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 174 (2005) 6129-6136
-
(2005)
J. Immunol.
, vol.174
, pp. 6129-6136
-
-
Yasuda, K.1
-
10
-
-
27944453599
-
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
-
Okabe Y., et al. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J. Exp. Med. 202 (2005) 1333-1339
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1333-1339
-
-
Okabe, Y.1
-
11
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii K.J., et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7 (2006) 40-48
-
(2006)
Nat. Immunol.
, vol.7
, pp. 40-48
-
-
Ishii, K.J.1
-
12
-
-
30444450839
-
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
-
Stetson D.B., and Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24 (2006) 93-103
-
(2006)
Immunity
, vol.24
, pp. 93-103
-
-
Stetson, D.B.1
Medzhitov, R.2
-
13
-
-
33644889894
-
Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway
-
Martin D.A., and Elkon K.B. Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll-like receptor 9-independent pathway. Arthritis Rheum. 54 (2006) 951-962
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 951-962
-
-
Martin, D.A.1
Elkon, K.B.2
-
14
-
-
33745196222
-
Contribution of interferon-β to the immune activation induced by double-stranded DNA
-
Shirota H., et al. Contribution of interferon-β to the immune activation induced by double-stranded DNA. Immunology 118 (2006) 302-310
-
(2006)
Immunology
, vol.118
, pp. 302-310
-
-
Shirota, H.1
-
15
-
-
33744804308
-
TLR9-independent activation of B lymphocytes by bacterial DNA
-
Cortez-Gonzalez X., et al. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol. 25 (2006) 253-261
-
(2006)
DNA Cell Biol.
, vol.25
, pp. 253-261
-
-
Cortez-Gonzalez, X.1
-
16
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
-
Tokunaga T., et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72 (1984) 955-962
-
(1984)
J. Natl. Cancer Inst.
, vol.72
, pp. 955-962
-
-
Tokunaga, T.1
-
17
-
-
0026625208
-
Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
-
Yamamoto S., et al. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. J. Immunol. 148 (1992) 4072-4076
-
(1992)
J. Immunol.
, vol.148
, pp. 4072-4076
-
-
Yamamoto, S.1
-
18
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg A.M., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
-
19
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H., et al. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
-
20
-
-
0037443644
-
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
-
Hemmi H., et al. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170 (2003) 3059-3064
-
(2003)
J. Immunol.
, vol.170
, pp. 3059-3064
-
-
Hemmi, H.1
-
21
-
-
20244367698
-
Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells
-
Kerkmann M., et al. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells. J. Biol. Chem. 280 (2005) 8086-8093
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8086-8093
-
-
Kerkmann, M.1
-
22
-
-
0037371208
-
Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner
-
Sano K., et al. Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner. J. Immunol. 170 (2003) 2367-2373
-
(2003)
J. Immunol.
, vol.170
, pp. 2367-2373
-
-
Sano, K.1
-
23
-
-
4744368053
-
Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation
-
Vollmer J., et al. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 113 (2004) 212-223
-
(2004)
Immunology
, vol.113
, pp. 212-223
-
-
Vollmer, J.1
-
24
-
-
11844290125
-
Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
-
Roberts T.L., et al. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J. Immunol. 174 (2005) 605-608
-
(2005)
J. Immunol.
, vol.174
, pp. 605-608
-
-
Roberts, T.L.1
-
25
-
-
21044444274
-
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
-
Kandimalla E.R., et al. Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6925-6930
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 6925-6930
-
-
Kandimalla, E.R.1
-
26
-
-
19944430901
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
-
Coban C., et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201 (2005) 19-25
-
(2005)
J. Exp. Med.
, vol.201
, pp. 19-25
-
-
Coban, C.1
-
27
-
-
23044445303
-
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
-
Choe J., et al. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 309 (2005) 581-585
-
(2005)
Science
, vol.309
, pp. 581-585
-
-
Choe, J.1
-
28
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz E., et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
-
29
-
-
2442450672
-
Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition
-
Cornelie S., et al. Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition. J. Biol. Chem. 279 (2004) 15124-15129
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15124-15129
-
-
Cornelie, S.1
-
30
-
-
4644330955
-
Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
-
Rutz M., et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 34 (2004) 2541-2550
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 2541-2550
-
-
Rutz, M.1
-
31
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
-
Ahmad-Nejad P., et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32 (2002) 1958-1968
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
-
32
-
-
3142697714
-
TLR9 is localized in the endoplasmic reticulum prior to stimulation
-
Leifer C.A., et al. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J. Immunol. 173 (2004) 1179-1183
-
(2004)
J. Immunol.
, vol.173
, pp. 1179-1183
-
-
Leifer, C.A.1
-
33
-
-
33645078650
-
Regulation of membrane traffic by phosphoinositide 3-kinases
-
Lindmo K., and Stenmark H. Regulation of membrane traffic by phosphoinositide 3-kinases. J. Cell Sci. 119 (2006) 605-614
-
(2006)
J. Cell Sci.
, vol.119
, pp. 605-614
-
-
Lindmo, K.1
Stenmark, H.2
-
34
-
-
0037099629
-
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
-
Ishii K.J., et al. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196 (2002) 269-274
-
(2002)
J. Exp. Med.
, vol.196
, pp. 269-274
-
-
Ishii, K.J.1
-
35
-
-
33646473522
-
Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway
-
Kuo C.C., et al. Class I and III phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway. J. Immunol. 176 (2006) 5943-5949
-
(2006)
J. Immunol.
, vol.176
, pp. 5943-5949
-
-
Kuo, C.C.1
-
36
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
Tabeta K., et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 (2006) 156-164
-
(2006)
Nat. Immunol.
, vol.7
, pp. 156-164
-
-
Tabeta, K.1
-
37
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda K., et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
-
38
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci C., et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203 (2006) 1999-2008
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
-
39
-
-
33644764063
-
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
-
Lakadamyali M., et al. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124 (2006) 997-1009
-
(2006)
Cell
, vol.124
, pp. 997-1009
-
-
Lakadamyali, M.1
-
40
-
-
29244450802
-
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
-
Barton G.M., et al. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7 (2006) 49-56
-
(2006)
Nat. Immunol.
, vol.7
, pp. 49-56
-
-
Barton, G.M.1
-
41
-
-
29444441343
-
Manifold mechanisms of toll-like receptor-ligand recognition
-
Ishii K.J., et al. Manifold mechanisms of toll-like receptor-ligand recognition. J. Clin. Immunol. 25 (2005) 511-521
-
(2005)
J. Clin. Immunol.
, vol.25
, pp. 511-521
-
-
Ishii, K.J.1
-
42
-
-
3042548183
-
Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
-
Boule M.W., et al. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199 (2004) 1631-1640
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1631-1640
-
-
Boule, M.W.1
-
43
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means T.K., et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115 (2005) 407-417
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 407-417
-
-
Means, T.K.1
-
44
-
-
32944462310
-
CpG motif-independent activation of TLR9 upon endosomal translocation of 'natural' phosphodiester DNA
-
Yasuda K., et al. CpG motif-independent activation of TLR9 upon endosomal translocation of 'natural' phosphodiester DNA. Eur. J. Immunol. 36 (2006) 431-436
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 431-436
-
-
Yasuda, K.1
-
45
-
-
33746214827
-
CXCL16 influences the nature and specificity of CpG-induced immune activation
-
Gursel M., et al. CXCL16 influences the nature and specificity of CpG-induced immune activation. J. Immunol. 177 (2006) 1575-1580
-
(2006)
J. Immunol.
, vol.177
, pp. 1575-1580
-
-
Gursel, M.1
-
46
-
-
29144434113
-
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
-
Bafica A., et al. TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis. J. Exp. Med. 202 (2005) 1715-1724
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1715-1724
-
-
Bafica, A.1
-
47
-
-
24744456326
-
Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9
-
Huang L.Y., et al. Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J. Immunol. 175 (2005) 3964-3970
-
(2005)
J. Immunol.
, vol.175
, pp. 3964-3970
-
-
Huang, L.Y.1
-
48
-
-
12144286763
-
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
-
Tabeta K., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3516-3521
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 3516-3521
-
-
Tabeta, K.1
-
49
-
-
0041832267
-
FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG
-
Bave U., et al. FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171 (2003) 3296-3302
-
(2003)
J. Immunol.
, vol.171
, pp. 3296-3302
-
-
Bave, U.1
-
50
-
-
33744909412
-
Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H
-
Blasius A.L., and Colonna M. Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H. Trends Immunol. 27 (2006) 255-260
-
(2006)
Trends Immunol.
, vol.27
, pp. 255-260
-
-
Blasius, A.L.1
Colonna, M.2
-
51
-
-
4043064293
-
Transcriptional regulation of the human TLR9 gene
-
Takeshita F., et al. Transcriptional regulation of the human TLR9 gene. J. Immunol. 173 (2004) 2552-2561
-
(2004)
J. Immunol.
, vol.173
, pp. 2552-2561
-
-
Takeshita, F.1
-
52
-
-
28244458932
-
A distal regulatory region is required for constitutive and IFN-β-induced expression of murine TLR9 gene
-
Guo Z., et al. A distal regulatory region is required for constitutive and IFN-β-induced expression of murine TLR9 gene. J. Immunol. 175 (2005) 7407-7418
-
(2005)
J. Immunol.
, vol.175
, pp. 7407-7418
-
-
Guo, Z.1
-
53
-
-
33746238512
-
Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice
-
Brummel R., et al. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur. J. Immunol. 36 (2006) 1951-1962
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 1951-1962
-
-
Brummel, R.1
-
54
-
-
13144259663
-
IFN-γ overcomes low responsiveness of myeloid dendritic cells to CpG DNA
-
Uchijima M., et al. IFN-γ overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Immunol. Cell Biol. 83 (2005) 92-95
-
(2005)
Immunol. Cell Biol.
, vol.83
, pp. 92-95
-
-
Uchijima, M.1
-
55
-
-
33645758475
-
IFN-γ primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking
-
Adachi Y., et al. IFN-γ primes RAW264 macrophages and human monocytes for enhanced oxidant production in response to CpG DNA via metabolic signaling: roles of TLR9 and myeloperoxidase trafficking. J. Immunol. 176 (2006) 5033-5040
-
(2006)
J. Immunol.
, vol.176
, pp. 5033-5040
-
-
Adachi, Y.1
-
56
-
-
10344228773
-
Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells
-
Saikh K.U., et al. Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells. J. Immunol. 173 (2004) 7426-7434
-
(2004)
J. Immunol.
, vol.173
, pp. 7426-7434
-
-
Saikh, K.U.1
-
57
-
-
0141705297
-
Toll-like receptors stimulate human neutrophil function
-
Hayashi F., et al. Toll-like receptors stimulate human neutrophil function. Blood 102 (2003) 2660-2669
-
(2003)
Blood
, vol.102
, pp. 2660-2669
-
-
Hayashi, F.1
-
58
-
-
30744437150
-
Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils
-
Jozsef L., et al. Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. J. Immunol. 176 (2006) 1195-1202
-
(2006)
J. Immunol.
, vol.176
, pp. 1195-1202
-
-
Jozsef, L.1
-
59
-
-
20844445114
-
TGF-α regulates TLR expression and function on epidermal keratinocytes
-
Miller L.S., et al. TGF-α regulates TLR expression and function on epidermal keratinocytes. J. Immunol. 174 (2005) 6137-6143
-
(2005)
J. Immunol.
, vol.174
, pp. 6137-6143
-
-
Miller, L.S.1
-
60
-
-
23844553873
-
+ dendritic cells protect against lethal Listeria monocytogenes infection
-
+ dendritic cells protect against lethal Listeria monocytogenes infection. Eur. J. Immunol. 35 (2005) 2397-2405
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2397-2405
-
-
Ishii, K.J.1
-
61
-
-
33745214259
-
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
-
Kuwajima S., et al. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat. Immunol. 7 (2006) 740-746
-
(2006)
Nat. Immunol.
, vol.7
, pp. 740-746
-
-
Kuwajima, S.1
-
62
-
-
32244448339
-
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
-
Chan C.W., et al. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat. Med. 12 (2006) 207-213
-
(2006)
Nat. Med.
, vol.12
, pp. 207-213
-
-
Chan, C.W.1
-
63
-
-
14044269485
-
Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-γ via autocrine IL-12
-
Pillarisetty V.G., et al. Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-γ via autocrine IL-12. J. Immunology 174 (2005) 2612-2618
-
(2005)
J. Immunology
, vol.174
, pp. 2612-2618
-
-
Pillarisetty, V.G.1
-
64
-
-
33746671960
-
A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide
-
Shen H., and Iwasaki A. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J. Clin. Invest. 116 (2006) 2237-2243
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2237-2243
-
-
Shen, H.1
Iwasaki, A.2
-
65
-
-
0001311171
-
Inhibition of virus multiplication by foreign nucleic acid
-
Rotem Z., et al. Inhibition of virus multiplication by foreign nucleic acid. Nature 197 (1963) 564-566
-
(1963)
Nature
, vol.197
, pp. 564-566
-
-
Rotem, Z.1
-
66
-
-
0000970577
-
Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds
-
Jensen K.E., et al. Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds. Nature 200 (1963) 433-434
-
(1963)
Nature
, vol.200
, pp. 433-434
-
-
Jensen, K.E.1
-
67
-
-
0034114882
-
Features of systemic lupus erythematosus in Dnase1-deficient mice
-
Napirei M., et al. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat. Genet. 25 (2000) 177-181
-
(2000)
Nat. Genet.
, vol.25
, pp. 177-181
-
-
Napirei, M.1
-
68
-
-
0034939627
-
Mutation of DNASE1 in people with systemic lupus erythematosus
-
Yasutomo K., et al. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat. Genet. 28 (2001) 313-314
-
(2001)
Nat. Genet.
, vol.28
, pp. 313-314
-
-
Yasutomo, K.1
-
69
-
-
3242672339
-
Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis
-
Morita M., et al. Gene-targeted mice lacking the Trex1 (DNase III) 3′ → 5′ DNA exonuclease develop inflammatory myocarditis. Mol. Cell. Biol. 24 (2004) 6719-6727
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6719-6727
-
-
Morita, M.1
-
70
-
-
14644387513
-
Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways
-
Yasuda K., et al. Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways. J. Leukoc. Biol. 77 (2005) 71-79
-
(2005)
J. Leukoc. Biol.
, vol.77
, pp. 71-79
-
-
Yasuda, K.1
-
71
-
-
16244376480
-
Toll-like receptors, endogenous ligands, and systemic autoimmune disease
-
Rifkin I.R., et al. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol. Rev. 204 (2005) 27-42
-
(2005)
Immunol. Rev.
, vol.204
, pp. 27-42
-
-
Rifkin, I.R.1
-
72
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S., et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6 (2005) 1087-1095
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
-
73
-
-
33747615237
-
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
-
Yamamoto M., et al. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 7 (2006) 962-970
-
(2006)
Nat. Immunol.
, vol.7
, pp. 962-970
-
-
Yamamoto, M.1
-
74
-
-
23744506255
-
Negative regulation of cytokine and TLR signalings by SOCS and others
-
Naka T., et al. Negative regulation of cytokine and TLR signalings by SOCS and others. Adv. Immunol. 87 (2005) 61-122
-
(2005)
Adv. Immunol.
, vol.87
, pp. 61-122
-
-
Naka, T.1
-
75
-
-
27644548945
-
Negative regulation of Toll-like-receptor signaling by IRF-4
-
Negishi H., et al. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 15989-15994
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 15989-15994
-
-
Negishi, H.1
-
76
-
-
23844461233
-
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
-
Takeshita F., et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur. J. Immunol. 35 (2005) 2477-2485
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2477-2485
-
-
Takeshita, F.1
-
77
-
-
9644301015
-
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation
-
Sugimoto K., et al. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J. Clin. Invest. 114 (2004) 857-866
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 857-866
-
-
Sugimoto, K.1
-
78
-
-
31344461659
-
Innate immune recognition of viral infection
-
Kawai T., and Akira S. Innate immune recognition of viral infection. Nat. Immunol. 7 (2006) 131-137
-
(2006)
Nat. Immunol.
, vol.7
, pp. 131-137
-
-
Kawai, T.1
Akira, S.2
-
79
-
-
30544447047
-
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
-
Oganesyan G., et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 439 (2006) 208-211
-
(2006)
Nature
, vol.439
, pp. 208-211
-
-
Oganesyan, G.1
-
80
-
-
30544451546
-
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
-
Hacker H., et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207
-
(2006)
Nature
, vol.439
, pp. 204-207
-
-
Hacker, H.1
-
81
-
-
33645841633
-
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
-
Hoshino K., et al. IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature 440 (2006) 949-953
-
(2006)
Nature
, vol.440
, pp. 949-953
-
-
Hoshino, K.1
-
82
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato H., et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441 (2006) 101-105
-
(2006)
Nature
, vol.441
, pp. 101-105
-
-
Kato, H.1
-
83
-
-
33646592188
-
The specific and essential role of MAVS in antiviral innate immune responses
-
Sun Q., et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24 (2006) 633-642
-
(2006)
Immunity
, vol.24
, pp. 633-642
-
-
Sun, Q.1
-
84
-
-
33745814424
-
Essential role of IPS-1 in innate immune responses against RNA viruses
-
Kumar H., et al. Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med. 203 (2006) 1795-1803
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1795-1803
-
-
Kumar, H.1
-
85
-
-
31444432184
-
Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification
-
Igoucheva O., et al. Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene Ther. 13 (2006) 266-275
-
(2006)
Gene Ther.
, vol.13
, pp. 266-275
-
-
Igoucheva, O.1
|