Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses

Infection and Immunity

Volumn 72, Issue 5, 2004, Pages 2810-2816

  Cuadros, Camilo ^a   Lopez Hernandez, Francisco J ^a   Dominguez, Ana Lucia ^a   McClelland, Michael ^a   Lustgarten, Joseph ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CD4 ANTIGEN; DRUG CARRIER; FLAGELLIN; FLAGELLIN ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOLOGICAL ADJUVANT; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; FLAGELLIN; GREEN FLUORESCENT PROTEINS; INFLAMMATION; LUMINESCENT PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RECOMBINANT FUSION PROTEINS; VACCINES;

EID: 2142701465     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.5.2810-2816.2004     Document Type: Article

References (46)

1. Aderem, A., and R. J. Ulevitch. 2000. Toll-like receptors in the induction of the innate immune response. Nature 406:782-787.
2. Banchchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendram, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767-811.
3. Barton, G. M., and R. Medzhitov. 2002. Control of adaptive immune responses by Toll-like receptors. Curr. Opin. Immunol. 14:380-383.
4. Ben-Yedidia, T., and R. Arnon. 1998. Effect of pre-existing carrier immunity on the efficacy of synthetic influenza vaccine. Immunol. Lett. 64:9-15.
5. Chilcott, G. S., and K. T. Hughes. 2000. Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar Typhimurium and Escherichia coli. Microbiol. Mol. Biol. Rev. 64:694-708.
6. Cohen, J., and E. Marshall. 2001. Bioterrorism. Vaccines for biodefense: a system in distress. Science 204:498-501.
7. Curtiss, R., III. 2002. Bacterial infectious disease control by vaccine development. J. Clin. Investig. 110:1061-1066.
8. DeRosier, D. J. 1998. The turn of the screw: The bacterial flagellar motor. Cell 93:17-20.
9. Eaves-Pyles, T., K. Murthy, L. Liaudet, L. Virag, G. Ross, F. G. Soriano, C. Szabo, and A. L. Salzman. 2001. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J. Immunol. 166:1248-1260.
10. Eaves-Pyles, T. D., H. R. Wong, K. Odoms, and R. B. Pyles. 2001. Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J. Immunol. 167:7009-7016.
11. Gambotto, A., G. Dworacki, V. Cicinnati, T. Kenniston, J. Steitz, T. Tuting, P. D. Robbins, and A. B. DeLeo. 2000. Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope. Gene Ther. 7:2036-2040.
12. Gewirtz, A. T., P. O. Simon, Jr., C. K. Schmitt, L. J. Taylor, C. H. Hagedorn, A. D. O'Brien, A. S. Neish, and J. L. Madara. 2001. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J. Clin. Investig. 107:99-109.
13. Gewirtz, A. T., T. A. Navas, S. Lyons, P. J. Godowski, and J. L. Madara. 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167: 1882-1885.
14. Hayashi, F., K. D. Smith, A. Ozinsky, T. R. Hawn, E. C. Yi, D. R. Goodlett, J. K. Eng, S. Akira, D. M. Underhill, and A. Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-1103.
15. Heine, H., and E. Lien. 2003. Toll-like receptors and their function in innate and adaptive immunity. Int. Arch. Allergy Immunol. 130:180-192.
16. Homma, M., H. Fujita, S. Yamaguchi, and T. Iino. 1987. Regions of Salmonella typhimurium flagellin essential for its polymerization and excretion, J. Bacteriol. 169:291-296.
17. Huang, Q., D. Liu, P. Majewski, L. C. Schulte, J. M. Korn, R. A. Young, E. S. Lander, and N. Hacoben. 2001. The plasticity of dendritic cell responses to pathogens and their components. Science 294:870-875.
18. Hunter, R. L. 2002. Overview of vaccine adjuvants: present and future. Vaccine 20(Suppl. 3):S712-S12.
19. Imler, J. L., and J. A. Hoffmann. 2001. Toll receptors in innate immunity. Trends Cell Biol. 11:304-311.
20. Janeway, C. A., Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu. Rev. Immunol. 20:197-216.
21. Janeway, C. A., Jr. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1-13.
22. Jeon, S. H., and R. Arnon. 2002. Immunization with influenza virus hemagglutinin globular region containing the receptor-binding pocket. Viral Immunol. 15:165-176.
23. Kalsho, T., and S. Akira. 2002. Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta 1589:I-13.
24. Lee, L. H., E. Burg III, S. Baqar, A. L. Bourgeois, D. H. Burr, C. P. Ewing, T. J. Trust, and P. Guerry. 1999. Evaluation of a truncated recombinant flagellin subunit vaccine against Campylobacter jejuni. Infect. Immun. 67: 5799-5805.
25. Lee, S. F., S. A. Halperin, D. F. Salloum, A. MacMillan, and A. Morris. 2003. Mucosal immunization with a genetically engineered pertussis toxin SI fragment-cholera toxin subunit B chimeric protein. Infect. Immun. 71:2272-2275.
26. Madrazo, D. R., S. L. Tranguch, and I. Marriott. 2003. Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts. Infect. Immun. 71:5418-5421.
27. McSorley, S. J., B. D. Ehst, Y. Yu, and A. T. Gewirtz. 2002. Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J. Immunol. 169:3914-3919.
28. Means, T. K., D. T. Golenbock, and M. J. Fenton. 2000. Structure and function of Toll-like receptor proteins. Life Sci. 68:241-258.
29. Means, T. K., D. T. Golenbock, and M. J. Fenton. 2000. The biology of Toll-like receptors. Cytokine Growth Factor Rev. 11:219-232.
30. Means, T. K., F. Hayashi, K. D. Smith, A. Aderem, and A. D. Luster. 2003. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170:5165-5175.
31. Medzhitov, R., and C. Janeway, Jr. 2000. Innate immunity. N. Engl. J. Med. 343:338-344.
32. Morse, M. A., and H. K. Lyerly. 2000. Clinical applications of dendritic cell vaccines. Curr. Opin. Mol. Ther. 2:20-28.
33. Murtaugh, M. P., and D. L. Foss. 2002. Inflammatory cytokines and antigen presenting cell activation. Vet. Immunol. Immunopathol. 87:109-121.
34. Newton, S. M., C. O. Jacob, and B. A. Stocker. 1989. Immune response to cholera toxin epitope inserted in Salmonella flagellin. Science 244:70-72.
35. Newton, S. M., T. M. Joys, S. A. Anderson, R. C. Kennedy, M. E. Hovi, and B. A. Stocker. 1995. Expression and immunogenicity of an 18-residue epitope of HIV1 gp41 inserted in the flagellar protein of a Salmonella live vaccine. Res. Microbiol. 146:203-216.
36. Renshaw, M., J. Rockwell, C. Engleman, A. Gewirtz, J. Katz, and S. Sambhara. 2002. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol. 169:4697-4701.
37. Schijns, V. E. 2001. Induction and direction of immune responses by vaccine adjuvants. Crit. Rev. Immunol. 21:75-85.
38. Sebastiani, G., G. Leveque, L. Lariviere, L. Laroche, E. Skamene, P. Gros, and D. Malo. 2000. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics 64:230-240.
39. Sparwasser, T., R. M. Vabulas, B. Villmow, G. B. Lipford, and H. Wagner. 2000. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur. J. Immunol. 30:3591-3597.
40. Stocker, B. A., and S. M. Newton. 1994. Immune responses to epitopes inserted in Salmonella flagellin. Int. Rev. Immunol. 11:167-178.
41. Stripecke, R., M. Carmen Villacres, D. Skelton, N. Satake, S. Halene, and D. Kohn. 1999. Immune response to green fluorescent protein: implications for gene therapy. Gene Ther. 6:1305-1312.
42. Takeda, K., and S. Akira. 2003. Toll receptors and pathogen resistance. Cell Microbiol. 5:143-153.
43. Takeuchi, O., and S. Akira. 2002. MyD88 as a bottle neck in Toll/IL-1 signaling. Curr. Top. Microbiol. Immunol. 270:155-167.
44. Verma, N. K., H. K. Ziegler, B. A. Stocker, and G. K. Schoolnik. 1995. Induction of a cellular immune response to a defined T-cell epitope as an insert in the flagellin of a live vaccine strain of Salmonella. Vaccine 13:235-244.
45. Verthelyl, D., R. T. Kenney, R. A. Seder, A. A. Gam, B. Friedag, and D. M. Klinman. 2002. CpG oligodeoxynucleotides as vaccine adjuvants in primates. J. Immunol. 168:1659-1663.
46. Wyant, T. L., M. K. Tanner, and M. B. Sztein. 1999. Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cells. Infect. Immun. 67:1338-1346.