The role of the β-glucan receptor Dectin-1 in control of fungal infection

Journal of Leukocyte Biology

Volumn 82, Issue 2, 2007, Pages 253-258

  Dennehy, Kevin M ^a   Brown, Gordon D ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Aspergillus fumigatus; Candida albicans; Pneumocystis carinii; Toll like receptor

Indexed keywords

BETA GLUCAN; CHEMOKINE; CYTOKINE; CYTOPLASM PROTEIN; DECTIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CYTOKINE PRODUCTION; HUMAN; IMMUNE RESPONSE; INFECTION CONTROL; MYCOSIS; NONHUMAN; PHAGOCYTOSIS; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; FORECASTING; MEMBRANE PROTEINS; MICE; MODELS, IMMUNOLOGICAL; MYCOSES; NERVE TISSUE PROTEINS; RECEPTORS, IMMUNOLOGIC;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; MUS; PNEUMOCYSTIS CARINII;

EID: 34547797521     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1206753     Document Type: Review

References (34)

1. Saijo, S., Fujikado, N., Furuta, T., Chung, S. H., Kotaki, H., Seki, K., Sudo, K., Akira, S., Adachi, Y., Ohno, N., Kinjo, T., Nakamura, K., Kawakami, K., Iwakura, Y. (2007) Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 8, 39-46.
2. Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C., Botto, M., Gordon, S., Brown, G. D. (2007) Dectin-1 is required for β-glucan recognition and control of fungal infection. Nat. Immunol. 8, 31-38.
3. Brown, G. D. (2006) Dectin-1: a signaling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 6, 33-43.
4. Jouault, T., Ibata-Ombetta, S., Takeuchi, O., Trinel, P. A., Sacchetti, P., Lefebvre, P., Akira, S., Poulain, D. (2003) Candida albicans phospholipomannan is sensed through Toll-like receptors. J. Infect. Dis. 188, 165-172.
5. Netea, M. G., Gow, N. A., Munro, C. A., Bates, S., Collins, C., Ferwerda, G., Hobson, R. P., Bertram, G., Hughes, H. B., Jansen, T., Jacobs, L., Buurman, E. T., Gijzen, K., Williams, D. L., Torensma, R., McKinnon, A., MacCallum, D. M., Odds, F. C., Van der Meer, J. W., Brown, A. J., Kullberg, B. J. (2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J. Clin. Invest. 116, 1642-1650.
6. Ariizumi, K., Shen, G. L., Shikano, S., Xu, S., Ritter III, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R., Takashima, A. (2000) Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275, 20157-20167.
7. Brown, G. D., Gordon, S. (2001) Immune recognition. A new receptor for β-glucans. Nature 413, 36-37.
8. Palma, A. S., Feizi, T., Zhang, Y., Stoll, M. S., Lawson, A. M., Diaz-Rodriguez, E., Campanero-Rhodes, M. A., Costa, J., Gordon, S., Brown, G. D., Chai, W. (2006) Ligands for the β-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. J. Biol. Chem. 281, 5771-5779.
9. Gantner, B. N., Simmons, R. M., Underhill, D. M. (2005) Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J. 24, 1277-1286.
10. Gersuk, G. M., Underhill, D. M., Zhu, L., Marr, K. A. (2006) Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J. Immunol. 176, 3717-3724.
11. Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., Brown, G. D. (2005) The β-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 1, e42.
12. Taylor, P. R., Brown, G. D., Reid, D. M., Willment, J. A., Martinez-Pomares, L., Gordon, S., Wong, S. Y. (2002) The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 169, 3876-3882.
13. Willment, J. A., Marshall, A. S., Reid, D. M., Williams, D. L., Wong, S. Y., Gordon, S., Brown, G. D. (2005) The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. Eur. J. Immunol. 35, 1539-1547.
14. Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S., Gordon, S. (2003) Dectin-1 mediates the biological effects of β-glucans. J. Exp. Med. 197, 1119-1124.
15. Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., Underhill, D. M. (2003) Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197, 1107-1117.
16. Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L., Brown, G. D., Reis e Sousa, C. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22, 507-517.
17. Schulze-Luehrmann, J., Ghosh, S. (2006) Antigen-receptor signaling to nuclear factor κ B. Immunity 25, 701-715.
18. Hatada, M. H., Lu, X., Laird, E. R., Green, J., Morgenstern, J. P., Lou, M., Marr, C. S., Phillips, T. B., Ram, M. K., Theriault, K., et al. (1995) Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377, 32-38.
19. Futterer, K., Wong, J., Grucza, R. A., Chan, A. C., Waksman, G. (1998) Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J. Mol. Biol. 281, 523-537.
20. Herre, J., Marshall, A. S., Caron, E., Edwards, A. D., Williams, D. L., Schweighoffer, E., Tybulewicz, V., Reis e Sousa, C., Gordon, S., Brown, G. D. (2004) Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 104, 4038-4045.
21. Rawlings, D. J., Sommer, K., Moreno-Garcia, M. E. (2006) The CARMA1 signalosome links the signaling machinery of adaptive and innate immunity in lymphocytes. Nat. Rev. Immunol. 6, 799-812.
22. Gross, O., Gewies, A., Finger, K., Schafer, M., Sparwasser, T., Peschel, C., Forster, I., Ruland, J. (2006) Card9 controls a non-TLR signaling pathway for innate anti-fungal immunity. Nature 442, 651-656.
23. Underhill, D. M., Rossnagle, E., Lowell, C. A., Simmons, R. M. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106, 2543-2550.
24. Yoshitomi, H., Sakaguchi, N., Kobayashi, K., Brown, G. D., Tagami, T., Sakihama, T., Hirota, K., Tanaka, S., Nomura, T., Miki, I., Gordon, S., Akira, S., Nakamura, T., Sakaguchi, S. (2005) A role for fungal {β}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J. Exp. Med. 201, 949-960.
25. Davis, S. J., van der Merwe, P. A. (2006) The kinetic-segregation model: TCR triggering and beyond. Nat. Immunol. 7, 803-809.
26. Romani, L. (2004) Immunity to fungal infections. Nat. Rev. Immunol. 4, 1-23.
27. Rivera, A., Ro, G., Van Epps, H. L., Simpson, T., Leiner, I., Sant'Angelo, D. B., Pamer, E. G. (2006) Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 25, 665-675.
28. Steele, C., Marrero, L., Swain, S., Harmsen, A. G., Zheng, M., Brown, G. D., Gordon, S., Shellito, J. E., Kolls, J. K. (2003) Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 β-glucan receptor. J. Exp. Med. 198, 1677-1688.
29. Chaipan, C., Soilleux, E. J., Simpson, P., Hofmann, H., Gramberg, T., Marzi, A., Geier, M., Stewart, E. A., Eisemann, J., Steinkasserer, A., Suzuki-Inoue, K., Fuller, G. L., Pearce, A. C., Watson, S. P., Hoxie, J. A., Baribaud, F., Pohlmann, S. (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J. Virol. 80, 8951-8960.
30. Chen, C. H., Floyd, H., Olson, N. E., Magaletti, D., Li, C., Draves, K., Clark, E. A. (2006) Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. Blood 107, 1459-1467.
31. Pyz, E., Marshall, A. S., Gordon, S., Brown, G. D. (2006) C-type lectin-like receptors on myeloid cells. Ann. Med. 38, 242-251.
32. McGreal, E. P., Rosas, M., Brown, G. D., Zamze, S., Wong, S. Y., Gordon, S., Martinez-Pomares, L., Taylor, P. R. (2006) The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16, 422-430.
33. Sato, K., Yang, X. L., Yudate, T., Chung, J. S., Wu, J., Luby-Phelps, K., Kimberly, R. P., Underhill, D., Cruz Jr., P. D., Ariizumi, K. (2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses. J. Biol. Chem. 281, 38854-38866.
34. McCaw, S. E., Schneider, J., Liao, E. H., Zimmermann, W., Gray-Owen, S. D. (2003) Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. Mol. Microbiol. 49, 623-637.