Adjutant-enhanced antibody responses in the absence of toll-like receptor signaling

Science

Volumn 314, Issue 5807, 2006, Pages 1936-1938

  Gavin, Amanda L ^a   Hoebe, Kasper ^a   Duong, Bao ^a   Ota, Takayuki ^a   Martin, Christopher ^a   Beutler, Bruce ^a   Nemazee, Davrid ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS; RECEPTOR SIGNALING;

ANTIBODIES; ANTIGENS; ROBUSTNESS (CONTROL SYSTEMS); VACCINES;

SIGNALING;

ALUMINUM POTASSIUM SULFATE; CORD FACTOR; FREUND ADJUVANT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G2C; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; IMMUNOLOGICAL ADJUVANT; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYL LIPID A; T LYMPHOCYTE ANTIGEN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VACCINE; CELL WALL SKELETON; DRUG DERIVATIVE; HEMOCYANIN; IMMUNOGLOBULIN; LIGAND; LIPID A; LIPOPOLYSACCHARIDE; MYD88 PROTEIN, MOUSE; PICRIC ACID; RIBI ADJUVANT; THYMUS INDEPENDENT ANTIGEN; TICAM 1 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; TRINITROPHENYL KEYHOLE LIMPET HEMOCYANIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANTIBODY; ANTIGEN; IMMUNE RESPONSE; RODENT; SIGNALING; VACCINE;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG USE; IMMUNE DEFICIENCY; INNATE IMMUNITY; LIGAND BINDING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; ANTIBODY PRODUCTION; B LYMPHOCYTE; BLOOD; C57BL MOUSE; GENETICS; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; ANTIGENS, T-INDEPENDENT; B-LYMPHOCYTES; CELL WALL SKELETON; CORD FACTORS; FREUND'S ADJUVANT; HEMOCYANIN; IMMUNITY, NATURAL; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOGLOBULINS; LIGANDS; LIPID A; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; PICRATES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; VACCINES;

EID: 33845905223     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135299     Document Type: Article

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19. We thank D. Kono and A. Theofilopoulos for comments on the manuscript, A. Rolink for FGK4.5 antibody, and G. Nemerow and N. Sarvetnick for use of instruments. Supported by NIH grants RO1GM44809 to D.N., AI050241 to B.B., and T32AJ07606 to B.D.