Maintenance of serological memory by polyclonal activation of human memory B cells

Science

Volumn 298, Issue 5601, 2002, Pages 2199-2202

  Bernasconi, Nadia L ^a   Traggiai, Elisabetta ^a   Lanzavecchia, Antonio ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; CELLS; DNA;

HUMAN MEMORY CELLS;

NEUROLOGY;

ANTIBODY; DNA; MEMORY;

ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PLASMA CELL; POLYCLONAL ACTIVATION; PRIORITY JOURNAL;

ANTIBODIES; ANTIBODY FORMATION; ANTIGENS, CD; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; DINUCLEOSIDE PHOSPHATES; HUMANS; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULINS; IMMUNOLOGIC MEMORY; INTERLEUKIN-15; LYMPHOCYTE ACTIVATION; OLIGODEOXYRIBONUCLEOTIDES; PLASMA CELLS; T-LYMPHOCYTES, HELPER-INDUCER; TETANUS TOXOID; TIME FACTORS;

EID: 0037073930     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1076071     Document Type: Article

References (31)

1. K. Rajewsky, Nature 381, 751 (1996).
2. J. Banchereau et al., Annu. Rev. Immunol. 12, 881 (1994).
3. M. Maruyama, K. P. Lam. K. Rajewsky, Nature 407, 636 (2000).
4. R. A. Manz, A. Thiel, A. Radbruch, Nature 388, 133 (1997).
5. M. K. Slifka, R. Antia, J. K. Whitmire, R. Ahmed, Immunity 8, 363 (1998).
6. R. Ahmed, D. Gray, Science 272. 54 (1996).
7. R. A. Manz et al., Curr. Opin. Immunol. 14, 517 (2002).
8. R. M. Zinkernagel, Curr. Opin. Immunol. 14, 523 (2002).
9. A. F. Ochsenbein et al., Proc. Natl. Acad. Sci. U.S.A. 97, 13263 (2000).
10. A. Poltorak et al., Science 282, 20 (1998).
11. A. M. Krieg, Annu. Rev. Immunol. 20, 709 (2002).
12. A. Lanzavecchia, Eur. J. Immunol. 13, 820 (1983).
13. U. Klein, K. Rajewsky, R. Kuppers, J. Exp. Med. 188, 1679 (1998).
14. See supporting data on Science Online.
15. N. L Bernasconi, E. Traggiai, unpublished data.
16. K. M. Ansel et al., J. Exp. Med. 190, 1123 (1999).
17. M. Odendahl et al., J. Immunol. 165, 5970 (2000).
18. These observations may explain why a correlation between serum antibodies and antigen-binding memory B cells was not detected in a previous study where recently boosted individuals were analyzed (30).
19. A. Morell, W. D. Terry, T. A. Waldmann,J. Clin. Invest. 49. 673 (1970).
20. J. W. Uhr, G. Moller, Adv. Immunol. 8, 81 (1968).
21. R. A. Manz, A. Radbruch, Eur. J. Immunol. 32,923 (2002).
22. F. Celada, J. Exp. Med. 125, 199 (1967).
23. D. T. Fearon, P. Manders, S. D. Wagner. Science 293, 248 (2001).
24. S. Fagarasan, T. Honjo, Science 290, 89 (2000).
25. A. J. Macpherson et al., Science 288, 2222 (2000).
26. F. Martin, J. F. Kearney, Nature Rev. Immunol. 2, 323 (2002).
27. R. Kuppers, U. Klein, M. L Hansmann, K. Rajewsky, N. Engl. J. Med. 341, 1520 (1999).
28. E. Paramithiotis, M. D. Cooper, Proc. Natl. Acad. Sci. U.S.A. 94, 208 (1997).
29. B. P. O'Connor, M. Cascalho, R. J. Noelle, J. Exp. Med. 195, 737 (2002).
30. H. Leyendeckers et al., Eur. J. Immunol. 29, 1406 (1999).
31. We thank J. C. Howard, K. Karjalainen, G. Natoli, and F. Sallusto for critical reading of the manuscript. A.L is supported by the Helmut Horten Foundation and by the Swiss National Science Foundation (grant 31-6388S).