Exploring Ramachandran and Chi space: Conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands

Current Medicinal Chemistry

Volumn 11, Issue 21, 2004, Pages 2785-2798

  Cowell, S M ^a   Lee, Y S ^a   Cain, J P ^a   Hruby, V J ^a  

^a University of Arizona   (United States)

Author keywords

Constrained amino acids; Constrained peptides; Drug design; Ligand receptor interactions

Indexed keywords

2 AMINO 1,2,3,4 TETRAHYDRONAPHTHALINE 1 CARBOXYLIC ACID; 2 AMINO 2 METHYLPROPIONIC ACID; 2',6' DIMETHYL BETA METHYLTYROSINE; 3 ACETYLAMINO 8 METHOXYCARBAMOYLAZOCAN 2 ONE; ALPHA AMINO ACID; AMINO ACID DERIVATIVE; AMINO ACID RECEPTOR; ARGININE DERIVATIVE; BETA ISOPROPYLPHENYLALANINE; BETA LACTAM DERIVATIVE; BETA METHYLTRYPTOPHAN; CALCITONIN DERIVATIVE; CYCLOBUTANE DERIVATIVE; CYCLOPENTANE DERIVATIVE; CYCLOPROPANE DERIVATIVE; CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; DELTORPHIN; INDOLE DERIVATIVE; LEVO OCTAHYDROINDOLE 2 CARBOXYLIC ACID; OXYTOCIN ANTAGONIST; OXYTOCIN DERIVATIVE; POLYPEPTIDE; PROLINE DERIVATIVE; TRIPEPTIDE DERIVATIVE; TRYPTOLINE; TRYPTOPHAN DERIVATIVE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; AMINO ACID SYNTHESIS; COVALENT BOND; DISULFIDE BOND; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PEPTIDE MAPPING; PHARMACOPHORE; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; RAT; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 5744233338     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043364270     Document Type: Review

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