Novel, potent ORL-1 receptor agonist peptides containing α-helix-promoting conformational constraints

Journal of Medicinal Chemistry

Volumn 45, Issue 24, 2002, Pages 5280-5286

  Zhang, Chongwu ^a   Miller, Wendy ^a   Valenzano, Kenneth J ^a   Kyle, Donald J ^a  

^a PURDUE PHARMA L P   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ALANINE; AMINO ACID DERIVATIVE; N METHYLALANINE; NOCICEPTIN; OPIATE AGONIST; OPIOID RECEPTOR 1; PEPTIDE; PHENYLALANYLGLYCYLGLYCYLPHENYLALANYLTHREONYLGLYCYLALANYLARGINYLLYSYLSERYLAL ANYLARGINYLLYSYLLEUCYLALANYLASPARAGINYLGLUTAMINE; RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN CONFORMATION; PROTEIN MODIFICATION;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CELL LINE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPIOID PEPTIDES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037153197     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0202021     Document Type: Article

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