β-methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity

Journal of Medicinal Chemistry

Volumn 40, Issue 17, 1997, Pages 2740-2749

  Haskell Luevano, Carrie ^a   Toth, Kate ^a   Boteju, Lakmal ^a   Job, Constatin ^b   Castrucci, Ana Maria De L ^c   Hadley, Mac E ^b   Hruby, Victor J ^a  

^a University of Arizona ^*  (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG CARRIER; INTERMEDIN; N METHYLTRYPTOPHAN; PHENYLALANINE; TRYPTOPHAN; HORMONE RECEPTOR; INTERMEDIN RECEPTOR; LIGAND;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; LIGAND BINDING; METHYLATION; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN PROTEIN INTERACTION; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; FROG; HUMAN; LIZARD; METABOLISM; STEREOISOMERISM;

ANIMALS; HUMANS; LIGANDS; LIZARDS; MELANOCYTE-STIMULATING HORMONES; METHYLATION; MODELS, CHEMICAL; MODELS, MOLECULAR; PHENYLALANINE; RANA PIPIENS; RECEPTORS, PITUITARY HORMONE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 0030610607     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970018t     Document Type: Article

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