-
1
-
-
0019085853
-
Lactam Restriction of Peptide Conformation in Cyclic Hexapeptides Which Alter Rumen Fermentation
-
Freidinger, R. M.; Veber, D. F.; Hirschmann, R.; Paege, L. M. Lactam Restriction of Peptide Conformation in Cyclic Hexapeptides Which Alter Rumen Fermentation. Int. J. Pept. Protein Res. 1980, 16, 464-470.
-
(1980)
Int. J. Pept. Protein Res.
, vol.16
, pp. 464-470
-
-
Freidinger, R.M.1
Veber, D.F.2
Hirschmann, R.3
Paege, L.M.4
-
2
-
-
0019305850
-
Three-Dimensional Molecular Modeling and Drug Design
-
Gund, P.; Andose, J. D.; Rhodes, J. B.; Smith, G. M. Three-Dimensional Molecular Modeling and Drug Design. Science 1980, 208, 1425-1431.
-
(1980)
Science
, vol.208
, pp. 1425-1431
-
-
Gund, P.1
Andose, J.D.2
Rhodes, J.B.3
Smith, G.M.4
-
3
-
-
0000378637
-
On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to Their Use in the Isolation of B. Influenze
-
Fleming, A. On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to Their Use in the Isolation of B. Influenze. Br. J. Exp. Pathol. 1929, 10, 226-236.
-
(1929)
Br. J. Exp. Pathol.
, vol.10
, pp. 226-236
-
-
Fleming, A.1
-
4
-
-
0242620142
-
The X-Ray Analysis of the Structure of Penicillin
-
Hodgkin, D. C. The X-Ray Analysis of the Structure of Penicillin. Adv. Sci. 1949, 6, 85-89.
-
(1949)
Adv. Sci.
, vol.6
, pp. 85-89
-
-
Hodgkin, D.C.1
-
5
-
-
0033788236
-
Argadin, a New Chitinase Inhibitor, Produced by Clonostachys sp. FO-7314
-
Arai, N.; Shiomi, K.; Yamaguchi, Y.; Masuma, R.; Iwai, Y.; Turberg, A.; Koelbl, H.; Omura, S. Argadin, a New Chitinase Inhibitor, Produced by Clonostachys sp. FO-7314. Chem. Pharm. Bull. 2000, 48, 1442-1446.
-
(2000)
Chem. Pharm. Bull.
, vol.48
, pp. 1442-1446
-
-
Arai, N.1
Shiomi, K.2
Yamaguchi, Y.3
Masuma, R.4
Iwai, Y.5
Turberg, A.6
Koelbl, H.7
Omura, S.8
-
6
-
-
0037047120
-
High-Resolution Structures of a Chitinase Complexed with Natural Product Cyclopentapeptide Inhibitors: Mimicry of Carbohydrate Substrate
-
Houston, D. R.; Shiomi, K.; Arai, N.; Omura, S.; Peter, M. G.; Turberg, A.; Synstad, B.; Eijsink, V. C. H.; van Aalten, D. M. F. High-Resolution Structures of a Chitinase Complexed with Natural Product Cyclopentapeptide Inhibitors: Mimicry of Carbohydrate Substrate. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 9127-9132.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 9127-9132
-
-
Houston, D.R.1
Shiomi, K.2
Arai, N.3
Omura, S.4
Peter, M.G.5
Turberg, A.6
Synstad, B.7
Eijsink, V.C.H.8
Van Aalten, D.M.F.9
-
7
-
-
0024379430
-
Antineoplastic Agent. 174. Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella Auricularia
-
Pettit, G. R.; Kamano, Y.; Herald, C. L.; Dufresne, C.; Cerny, R. L.; Herald, D. L.; Schmidt, J. M.; Kizu, H. Antineoplastic Agent. 174. Isolation and Structure of the Cytostatic Depsipeptide Dolastatin 13 from the Sea Hare Dolabella Auricularia. J. Am. Chem. Soc. 1989, 111, 5015-5017.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 5015-5017
-
-
Pettit, G.R.1
Kamano, Y.2
Herald, C.L.3
Dufresne, C.4
Cerny, R.L.5
Herald, D.L.6
Schmidt, J.M.7
Kizu, H.8
-
8
-
-
33845184916
-
Novel Sponge-Derived Amino Acids. 5. Structures, Stereochemistry, and Synthesis of Several New Heterocycles
-
Adamczeski, M.; Quiñoà, E.; Crews, P. Novel Sponge-Derived Amino Acids. 5. Structures, Stereochemistry, and Synthesis of Several New Heterocycles. J. Am. Chem. Soc. 1989, 111, 647-654.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 647-654
-
-
Adamczeski, M.1
Quiñoà, E.2
Crews, P.3
-
9
-
-
0038411479
-
Redox Regulation of Protein Tyrosine Phosphatase IB Involves a Sulphenyl-amide Intermediate
-
(a) Salmeen, A.; Andersen, J. N.; Myers, M. P.; Meng, T.-C.; Hinks, J. A.; Tonks, N. K.; Barford, D. Redox Regulation of Protein Tyrosine Phosphatase IB Involves a Sulphenyl-amide Intermediate. Nature 2003, 423, 769-773.
-
(2003)
Nature
, vol.423
, pp. 769-773
-
-
Salmeen, A.1
Andersen, J.N.2
Myers, M.P.3
Meng, T.-C.4
Hinks, J.A.5
Tonks, N.K.6
Barford, D.7
-
10
-
-
0038749600
-
Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase IB
-
(b) van Montfort, R. L. M.; Congreve, M.; Tisi, D.; Carr, R.; Jhotl, H. Oxidation State of the Active-Site Cysteine in Protein Tyrosine Phosphatase IB. Nature 2003, 423, 773-777.
-
(2003)
Nature
, vol.423
, pp. 773-777
-
-
Van Montfort, R.L.M.1
Congreve, M.2
Tisi, D.3
Carr, R.4
Jhotl, H.5
-
11
-
-
33646825288
-
Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides
-
Freidinger, R. M.; Perlow, D. S.; Veber, D. F. Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides. J. Org. Chem. 1982, 47, 104-109.
-
(1982)
J. Org. Chem.
, vol.47
, pp. 104-109
-
-
Freidinger, R.M.1
Perlow, D.S.2
Veber, D.F.3
-
12
-
-
33845377006
-
Synthesis of γ-Lactam-Constrained Tryptophyllysine Derivatives
-
Freidinger, R. M. Synthesis of γ-Lactam-Constrained Tryptophyllysine Derivatives. J. Org. Chem. 1985, 50, 3631-3633.
-
(1985)
J. Org. Chem.
, vol.50
, pp. 3631-3633
-
-
Freidinger, R.M.1
-
13
-
-
0017128446
-
Conformational Energy Analysis of the Molecule, Luteinizing Hormone-Releasing Hormone. 1. Native Decapeptide
-
Momany, F. A. Conformational Energy Analysis of the Molecule, Luteinizing Hormone-Releasing Hormone. 1. Native Decapeptide. J. Am. Chem. Soc. 1976, 98, 2990-2996.
-
(1976)
J. Am. Chem. Soc.
, vol.98
, pp. 2990-2996
-
-
Momany, F.A.1
-
14
-
-
0019163001
-
Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog
-
Freidinger, R. M.; Veber, D. F.; Perlow, D. S.; Brooks, J. R.; Saperstein, R. Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog. Science 1980, 210, 656-658.
-
(1980)
Science
, vol.210
, pp. 656-658
-
-
Freidinger, R.M.1
Veber, D.F.2
Perlow, D.S.3
Brooks, J.R.4
Saperstein, R.5
-
15
-
-
0011809043
-
Peptide Backbone Folding in LHRH and Analogs
-
Rich, D. H., Gross, E., Eds.; Pierce Chemical Company: Rockford, IL
-
Kopple, K. D. Peptide Backbone Folding in LHRH and Analogs. In Peptides: Synthesis, Structure, Function: Proceedings of the Seventh American Peptide Symposium; Rich, D. H., Gross, E., Eds.; Pierce Chemical Company: Rockford, IL, 1981; pp 295-298.
-
(1981)
Peptides: Synthesis, Structure, Function: Proceedings of the Seventh American Peptide Symposium
, pp. 295-298
-
-
Kopple, K.D.1
-
16
-
-
0022654567
-
Conformationally Constrained Tachykinin Analogs Which Are Selective Ligands for the Eledoisin Binding Site
-
Cascieri, M. A.; Chicchi, G. G.; Freidinger, R. M.; Colton, C. D.; Perlow, D. S.; Williams, B.; Curtis, N. R.; McKnight, A. T.; Maguire, J. J.; Veber, D. F.; Liang, T. Conformationally Constrained Tachykinin Analogs Which Are Selective Ligands for the Eledoisin Binding Site. Mol. Pharmacol. 1986, 29, 34-38.
-
(1986)
Mol. Pharmacol.
, vol.29
, pp. 34-38
-
-
Cascieri, M.A.1
Chicchi, G.G.2
Freidinger, R.M.3
Colton, C.D.4
Perlow, D.S.5
Williams, B.6
Curtis, N.R.7
McKnight, A.T.8
Maguire, J.J.9
Veber, D.F.10
Liang, T.11
-
17
-
-
0021369749
-
Conformational Modifications of Cyclic Hexapeptide Somatostatin Analogs
-
Freidinger, R. M.; Perlow, D. S.; Randall, W. C.; Saperstein, R.; Arison B. H.; Veber D. F. Conformational Modifications of Cyclic Hexapeptide Somatostatin Analogs. Int. J. Pept. Protein Res. 1984, 23, 142-150.
-
(1984)
Int. J. Pept. Protein Res.
, vol.23
, pp. 142-150
-
-
Freidinger, R.M.1
Perlow, D.S.2
Randall, W.C.3
Saperstein, R.4
Arison, B.H.5
Veber, D.F.6
-
18
-
-
0020538232
-
Dipeptide Mimics. Conformationally Restricted Inhibitors of Angiotensin-Converting Enzyme
-
(a) Thorsett, E. D.; Harris, E. E.; Aster, S. D.; Peterson, E. R.; Taub, D.; Patchett, A. A. Dipeptide Mimics. Conformationally Restricted Inhibitors of Angiotensin-Converting Enzyme. Biochem. Biophys. Res. Commun. 1983, 111, 166-171.
-
(1983)
Biochem. Biophys. Res. Commun.
, vol.111
, pp. 166-171
-
-
Thorsett, E.D.1
Harris, E.E.2
Aster, S.D.3
Peterson, E.R.4
Taub, D.5
Patchett, A.A.6
-
19
-
-
0042711507
-
Conformationally Restricted Inhibitors of Angiotensin Converting Enzyme
-
Pierce Chemical Company: Rockford, IL
-
(b) Thorsett, E. D.; Harris, E. E.; Aster, S. D.; Peterson, E. R.; Tristram, E. W.; Snyder, J. P.; Springer, J. P.; Patchett, A. A. Conformationally Restricted Inhibitors of Angiotensin Converting Enzyme. In Peptides, Structure and Function: Proceedings of the Eighth American Peptide Symposium; Pierce Chemical Company: Rockford, IL, 1983; pp 555-558.
-
(1983)
Peptides, Structure and Function: Proceedings of the Eighth American Peptide Symposium
, pp. 555-558
-
-
Thorsett, E.D.1
Harris, E.E.2
Aster, S.D.3
Peterson, E.R.4
Tristram, E.W.5
Snyder, J.P.6
Springer, J.P.7
Patchett, A.A.8
-
20
-
-
0012046737
-
Bicyclic Inhibitors of Angiotensin-Converting Enzyme
-
Pierce Chemical Company: Rockford, IL
-
Wyvratt, M. J.; Tischler, M. H.; Ikeler, T. J.; Springer, J. P.; Tristram, E. W.; Patchett, A. A. Bicyclic Inhibitors of Angiotensin-Converting Enzyme. In Peptides, Structure and Function: Proceedings of the Eighth American Peptide Symposium; Pierce Chemical Company: Rockford, IL, 1983; pp 551-554.
-
(1983)
Peptides, Structure and Function: Proceedings of the Eighth American Peptide Symposium
, pp. 551-554
-
-
Wyvratt, M.J.1
Tischler, M.H.2
Ikeler, T.J.3
Springer, J.P.4
Tristram, E.W.5
Patchett, A.A.6
-
21
-
-
0000529234
-
Synthetic Routes to Lactam Peptidomimetics
-
JAI Press Inc.: Greenwich, CT
-
Aubé, J. Synthetic Routes to Lactam Peptidomimetics. In Advances in Amino Acid Mimetics and Peptidomimetics; JAI Press Inc.: Greenwich, CT, 1997; Vol. 1, pp 193-232.
-
(1997)
Advances in Amino Acid Mimetics and Peptidomimetics
, vol.1
, pp. 193-232
-
-
Aubé, J.1
-
22
-
-
0034530960
-
Design, Synthesis, and Conformational Analysis of Azacycloalkane Amino Acids as Conformationally Constrained Probes for Mimicry of Peptide Secondary Structures
-
Halab, L.; Gosselin, F.; Lubell, W. D. Design, Synthesis, and Conformational Analysis of Azacycloalkane Amino Acids as Conformationally Constrained Probes for Mimicry of Peptide Secondary Structures. Biopolymers (Pept. Sci.) 2000, 55, 101-122.
-
(2000)
Biopolymers (Pept. Sci.)
, vol.55
, pp. 101-122
-
-
Halab, L.1
Gosselin, F.2
Lubell, W.D.3
-
23
-
-
0036132390
-
Conformationally Restricted TRH Analogues: Constraining the Pyroglutamate Region
-
Simpson, J. C.; Ho, C.; Shands, E. F. B.; Gershengorn, M. C.; Marshall, G. R.; Moeller, K. D. Conformationally Restricted TRH Analogues: Constraining the Pyroglutamate Region. Bioorg. Med. Chem. 2002, 10, 291-302.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 291-302
-
-
Simpson, J.C.1
Ho, C.2
Shands, E.F.B.3
Gershengorn, M.C.4
Marshall, G.R.5
Moeller, K.D.6
-
24
-
-
0037428001
-
A General Approach to Dehydro-Freidinger Lactams Ex-Chiral Pool Synthesis and Spectroscopic Evaluation as Potential Reverse Turn Inducers
-
Hoffmann, T.; Waibel, R.; Gmeiner, P. A General Approach to Dehydro-Freidinger Lactams: Ex-Chiral Pool Synthesis and Spectroscopic Evaluation as Potential Reverse Turn Inducers. J. Org. Chem. 2003, 68, 62-69.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 62-69
-
-
Hoffmann, T.1
Waibel, R.2
Gmeiner, P.3
-
25
-
-
0015914428
-
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
-
Brazeau, P.; Vale, W.; Burgus, R.; Ling, N.; Butcher, M.; Rivier, J.; Guillemin, R. Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone. Science 1973, 179, 77-79.
-
(1973)
Science
, vol.179
, pp. 77-79
-
-
Brazeau, P.1
Vale, W.2
Burgus, R.3
Ling, N.4
Butcher, M.5
Rivier, J.6
Guillemin, R.7
-
26
-
-
0001648081
-
Conformationally Restricted Bicyclic Analogs of Somatostatin
-
Veber, D. F.; Holly, F. W.; Paleveda, W. J.; Nutt, R. F.; Bergstrand, S. J.; Torchiana, M.; Glitzer, M. S.; Saperstein, R.; Hirschmann, R. Conformationally Restricted Bicyclic Analogs of Somatostatin. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 2636-2640.
-
(1978)
Proc. Natl. Acad. Sci. U.S.A.
, vol.75
, pp. 2636-2640
-
-
Veber, D.F.1
Holly, F.W.2
Paleveda, W.J.3
Nutt, R.F.4
Bergstrand, S.J.5
Torchiana, M.6
Glitzer, M.S.7
Saperstein, R.8
Hirschmann, R.9
-
27
-
-
0018770021
-
Highly Active Cyclic and Bicyclic Somatostatin Analogues of Reduced Ring Size
-
Veber, D. F.; Holly, F. W.; Nutt, R. F.; Bergstrand, S. J.; Brady, S. F. ; Hirschmann, R.; Glitzer, M. S.; Saperstein, R. Highly Active Cyclic and Bicyclic Somatostatin Analogues of Reduced Ring Size. Nature 1979, 280, 512-514.
-
(1979)
Nature
, vol.280
, pp. 512-514
-
-
Veber, D.F.1
Holly, F.W.2
Nutt, R.F.3
Bergstrand, S.J.4
Brady, S.F.5
Hirschmann, R.6
Glitzer, M.S.7
Saperstein, R.8
-
28
-
-
0019862208
-
A Potent Cyclic Hexapeptide Analogue of Somatostatin
-
Veber, D. F.; Freidinger, R. M.; Perlow, D. S.; Paleveda, W. J., Jr.; Holly, F. W.; Strachan, R. G.; Nutt, R. F.; Arison, B. H.; Homnick, C.; Randall, W. C.; Glitzer, M. S.; Saperstein, R.; Hirschmann, R. A Potent Cyclic Hexapeptide Analogue of Somatostatin. Nature 1981, 292, 55-58.
-
(1981)
Nature
, vol.292
, pp. 55-58
-
-
Veber, D.F.1
Freidinger, R.M.2
Perlow, D.S.3
Paleveda Jr., W.J.4
Holly, F.W.5
Strachan, R.G.6
Nutt, R.F.7
Arison, B.H.8
Homnick, C.9
Randall, W.C.10
Glitzer, M.S.11
Saperstein, R.12
Hirschmann, R.13
-
29
-
-
0021368050
-
A Super Active Cyclic Hexapeptide Analog of Somatostatin
-
Veber, D. F.; Saperstein, R.; Nutt, R. F.; Freidinger, R. M.; Brady, S. F.; Curley, P.; Perlow, D. S.; Paleveda, W. J.; Colton, C. D.; Zacchei, A. G.; Tocco, D. J.; Hoff, D. R.; Vandlen, R. L.; Gerich, J. E.; Hall, L.; Mandarino, L.; Cordes, E. H.; Anderson, P. S.; Hirschmann, R. A Super Active Cyclic Hexapeptide Analog of Somatostatin. Life Sci. 1984, 34, 1371-1378.
-
(1984)
Life Sci.
, vol.34
, pp. 1371-1378
-
-
Veber, D.F.1
Saperstein, R.2
Nutt, R.F.3
Freidinger, R.M.4
Brady, S.F.5
Curley, P.6
Perlow, D.S.7
Paleveda, W.J.8
Colton, C.D.9
Zacchei, A.G.10
Tocco, D.J.11
Hoff, D.R.12
Vandlen, R.L.13
Gerich, J.E.14
Hall, L.15
Mandarino, L.16
Cordes, E.H.17
Anderson, P.S.18
Hirschmann, R.19
-
30
-
-
33845560832
-
Practical Synthesis of Cyclic Peptides, with an Example of Dependence of Cyclization Yield upon Linear Sequence
-
Brady, S. F.; Varga, S. L.; Freidinger, R. M.; Schwenk, D. A.; Mendlowski, M.; Holly, F. W.; Veber, D. F. Practical Synthesis of Cyclic Peptides, with an Example of Dependence of Cyclization Yield upon Linear Sequence. J. Org. Chem. 1979, 44, 3101-3105.
-
(1979)
J. Org. Chem.
, vol.44
, pp. 3101-3105
-
-
Brady, S.F.1
Varga, S.L.2
Freidinger, R.M.3
Schwenk, D.A.4
Mendlowski, M.5
Holly, F.W.6
Veber, D.F.7
-
31
-
-
0023127588
-
Large-Scale Synthesis of a Cyclic Hexapeptide Analogue of Somatostatin
-
Brady, S. F.; Freidinger, R. M.; Paleveda, W. J.; Colton, C. D.; Homnick, C. F.; Whitter, W. L.; Curley, P.; Nutt, R. F.; Veber, D. F. Large-Scale Synthesis of a Cyclic Hexapeptide Analogue of Somatostatin. J. Org. Chem. 1987, 52, 764-769.
-
(1987)
J. Org. Chem.
, vol.52
, pp. 764-769
-
-
Brady, S.F.1
Freidinger, R.M.2
Paleveda, W.J.3
Colton, C.D.4
Homnick, C.F.5
Whitter, W.L.6
Curley, P.7
Nutt, R.F.8
Veber, D.F.9
-
32
-
-
0013614295
-
Design of Novel Cyclic Hexapeptide Somatostatin Analogs from a Model of the Bioactive Conformation
-
American Chemical Society: Washington, DC
-
Freidinger, R. M.; Veber, D. F. Design of Novel Cyclic Hexapeptide Somatostatin Analogs from a Model of the Bioactive Conformation. In Conformationally Directed Drug Design; American Chemical Society: Washington, DC, 1984; pp 169-187.
-
(1984)
Conformationally Directed Drug Design
, pp. 169-187
-
-
Freidinger, R.M.1
Veber, D.F.2
-
33
-
-
0002840747
-
Synthesis of 9-Fluorenylmethyloxycarbonyl-Protected N-Alkyl Amino Acids by Reduction of Oxazlidinones
-
Freidinger, R. M.; Hinkle, J. S.; Perlow, D. S.; Arison, B. H. Synthesis of 9-Fluorenylmethyloxycarbonyl-Protected N-Alkyl Amino Acids by Reduction of Oxazlidinones. J. Org. Chem. 1983, 48, 77-81.
-
(1983)
J. Org. Chem.
, vol.48
, pp. 77-81
-
-
Freidinger, R.M.1
Hinkle, J.S.2
Perlow, D.S.3
Arison, B.H.4
-
34
-
-
0037419344
-
An Efficient Synthesis of N-Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones
-
Aurelio, L.; Box, J. S.; Brownlee, R. T. C.; Hughes, A. B.; Sleebs, M. M. An Efficient Synthesis of N-Methyl Amino Acids by Way of Intermediate 5-Oxazolidinones. J. Org. Chem. 2003, 68, 2652-2667.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 2652-2667
-
-
Aurelio, L.1
Box, J.S.2
Brownlee, R.T.C.3
Hughes, A.B.4
Sleebs, M.M.5
-
35
-
-
0027256754
-
Approaches to Peptidomimetics Which Serve as Surrogates for the cis Amide Bond: Novel Disulfide-Constrained Bicyclic Hexapeptide Analogs of Somatostatin
-
Brady, S. F.; Paleveda, W. J., Jr.; Arison, B. H.; Saperstein, R.; Brady, E. J.; Raynor, K.; Reisine, T.; Veber, D. F.; Freidinger, R. M. Approaches to Peptidomimetics Which Serve as Surrogates for the cis Amide Bond: Novel Disulfide-Constrained Bicyclic Hexapeptide Analogs of Somatostatin. Tetrahedron 1993, 49, 3449-3466.
-
(1993)
Tetrahedron
, vol.49
, pp. 3449-3466
-
-
Brady, S.F.1
Paleveda Jr., W.J.2
Arison, B.H.3
Saperstein, R.4
Brady, E.J.5
Raynor, K.6
Reisine, T.7
Veber, D.F.8
Freidinger, R.M.9
-
36
-
-
0000891159
-
tert-Butyloxycarbonyl-L-cysteinyl-L-cysteine Disulfide Methyl Ester
-
Hata, Y.; Matsuura, Y.; Tanaka, N.; Ashida, T.; Kakudo, M. tert-Butyloxycarbonyl-L-cysteinyl-L-cysteine Disulfide Methyl Ester. Acta Crystallogr. 1977, B33, 3561-3564.
-
(1977)
Acta Crystallogr.
, vol.B33
, pp. 3561-3564
-
-
Hata, Y.1
Matsuura, Y.2
Tanaka, N.3
Ashida, T.4
Kakudo, M.5
-
37
-
-
33845560283
-
On the Concept of Linear Modified Retro-peptide Structures
-
Goodman, M.; Chorev, M. On the Concept of Linear Modified Retro-peptide Structures. Acc. Chem. Res. 1979, 12, 1-7.
-
(1979)
Acc. Chem. Res.
, vol.12
, pp. 1-7
-
-
Goodman, M.1
Chorev, M.2
-
38
-
-
0027857964
-
De Novo Design and Synthesis of Somatostatin Non-Peptide Peptidomimetics Utilzing β-D-Glucose as a Novel Scaffolding
-
Hirschmann, R.; Nicolaou, K. C.; Pietranico, S.; Leahy, E. M.; Salvino, J.; Arison, B.; Cichy, M. A.; Spoors, P. G.; Shakespeare, W. C.; Sprengeler, P. A.; Hamley, P.; Smith, A. B., III; Reisine, T.; Raynor, K.; Maechler, L.; Donaldson, C.; Vale, W.; Freidinger, R. M.; Cascieri, M. R.; Strader, C. D. De Novo Design and Synthesis of Somatostatin Non-Peptide Peptidomimetics Utilzing β-D-Glucose as a Novel Scaffolding. J. Am. Chem. Soc. 1993, 115, 12550-12568.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 12550-12568
-
-
Hirschmann, R.1
Nicolaou, K.C.2
Pietranico, S.3
Leahy, E.M.4
Salvino, J.5
Arison, B.6
Cichy, M.A.7
Spoors, P.G.8
Shakespeare, W.C.9
Sprengeler, P.A.10
Hamley, P.11
Smith III, A.B.12
Reisine, T.13
Raynor, K.14
Maechler, L.15
Donaldson, C.16
Vale, W.17
Freidinger, R.M.18
Cascieri, M.R.19
Strader, C.D.20
more..
-
39
-
-
13144306065
-
Synthesis and Biological Activities of Potent Peptidomimetics Selective for Somatostatin Receptor Subtype 2
-
Yang, L.; Berk, S. C.; Rohrer, S. P.; Mosley, R. T.; Guo, L.; Underwood, D. J.; Arison, B. H.; Birzin, E. T.; Hayes, E. C.; Mitra, S. W.; Parmar, R. M.; Cheng, K.; Wu, T.-J.; Butler, B. S.; Foor, F.; Pasternak, A.; Pan, Y.; Silva, M.; Freidinger, R. M.; Smith, R. G.; Chapman, K. Synthesis and Biological Activities of Potent Peptidomimetics Selective for Somatostatin Receptor Subtype 2. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 10836-10841.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 10836-10841
-
-
Yang, L.1
Berk, S.C.2
Rohrer, S.P.3
Mosley, R.T.4
Guo, L.5
Underwood, D.J.6
Arison, B.H.7
Birzin, E.T.8
Hayes, E.C.9
Mitra, S.W.10
Parmar, R.M.11
Cheng, K.12
Wu, T.-J.13
Butler, B.S.14
Foor, F.15
Pasternak, A.16
Pan, Y.17
Silva, M.18
Freidinger, R.M.19
Smith, R.G.20
Chapman, K.21
more..
-
40
-
-
0347115743
-
An Approach to an Improved Antliinflammatory Steroid. The Synthesis of 11β, 17-Dihydroxy-3,20-dione-1,4-pregnadien-21-yl 2-Acetamido-2-deoxy-β-D-glucopyranoside
-
Hirschmann, R.; Strachan, R. G.; Buchschacher, P.; Sarett, L. H.; Steelman, S. L.; Silber, R. An Approach to an Improved Antliinflammatory Steroid. The Synthesis of 11β, 17-Dihydroxy-3,20-dione-1, 4-pregnadien-21-yl 2-Acetamido-2-deoxy-β-D-glucopyranoside. J. Am. Chem. Soc. 1964, 86, 3903-3904.
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 3903-3904
-
-
Hirschmann, R.1
Strachan, R.G.2
Buchschacher, P.3
Sarett, L.H.4
Steelman, S.L.5
Silber, R.6
-
41
-
-
0033678680
-
A Peptide-Doxorubicin "Prodrug" Activated by Prostate-Specific Antigen Selectively Kills Prostate Tumor Cells Positive for Prostate-Specific Antigen in Vivo
-
DeFeo-Jones, D.; Garsky, V. M.; Wong, B. K.; Feng, D.-M.; Bolyar, T.; Kaskell, K.; Kiefer, D. M.; Leander, K.; McAvoy, E.; Lumma, P.; Wai, J.; Senderak, E. T.; Motzel, S. L.; Keenan, K.; Van Zwieten, M.; Lin, J. H.; Freidinger, R.; Huff, J.; Oliff, A.; Jones R. E. A Peptide-Doxorubicin "Prodrug" Activated by Prostate-Specific Antigen Selectively Kills Prostate Tumor Cells Positive for Prostate-Specific Antigen in Vivo. Nat. Med. 2000, 11, 1248-1252.
-
(2000)
Nat. Med.
, vol.11
, pp. 1248-1252
-
-
DeFeo-Jones, D.1
Garsky, V.M.2
Wong, B.K.3
Feng, D.-M.4
Bolyar, T.5
Kaskell, K.6
Kiefer, D.M.7
Leander, K.8
McAvoy, E.9
Lumma, P.10
Wai, J.11
Senderak, E.T.12
Motzel, S.L.13
Keenan, K.14
Van Zwieten, M.15
Lin, J.H.16
Freidinger, R.17
Huff, J.18
Oliff, A.19
Jones, R.E.20
more..
-
43
-
-
0035935668
-
The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy
-
Garsky, V. M.; Lumma, P. K.; Feng, D.-M.; Wai, J.; Ramjit, H. G.; Sardana, M. K.; Oliff, A.; Jones, R. E.; DeFeo-Jones, D.; Freidinger, R. M. The Synthesis of a Prodrug of Doxorubicin Designed To Provide Reduced Systemic Toxicity and Greater Target Efficacy. J. Med. Chem. 2001, 44, 4216-4224.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 4216-4224
-
-
Garsky, V.M.1
Lumma, P.K.2
Feng, D.-M.3
Wai, J.4
Ramjit, H.G.5
Sardana, M.K.6
Oliff, A.7
Jones, R.E.8
DeFeo-Jones, D.9
Freidinger, R.M.10
-
44
-
-
0005941124
-
Phase I and Pharmacokinetic Study of L377202, a Novel Peptide Doxorubicin Conjugate, in Patients with Advanced Prostate Cancer
-
DiPaola, R. S.; Ebbinghaus, S.; Nemunaitis, J.; McCullough, J.; Ciardella, M.; Adams, N.; Williams, A.; Garsky, V.; Wong, B, K.; Defeo-Jones, D.; Jones, R.; Schwartz, M.; Winchell, G.; Arena, C.; Deutsch, P.; Yao, S. Phase I and Pharmacokinetic Study of L377202, a Novel Peptide Doxorubicin Conjugate, in Patients with Advanced Prostate Cancer. Proc. Am. Soc. Clin. Oncol. 2000, 19, 348.
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
, pp. 348
-
-
DiPaola, R.S.1
Ebbinghaus, S.2
Nemunaitis, J.3
McCullough, J.4
Ciardella, M.5
Adams, N.6
Williams, A.7
Garsky, V.8
Wong, B.K.9
Defeo-Jones, D.10
Jones, R.11
Schwartz, M.12
Winchell, G.13
Arena, C.14
Deutsch, P.15
Yao, S.16
-
45
-
-
0037057580
-
Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity
-
Brady, S. F.; Pawluczyk, J. M.; Lumma, P. K.; Feng, D.-M.; Wai, J. M.; Jones, R.; DeFeo-Jones, D.; Wong, B. K.; Miller-Stein, C.; Lin, J. H.; Oliff, A.; Freidinger, R. M.; Garsky, V. M. Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity. J. Med. Chem. 2002, 45, 4706-4715.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 4706-4715
-
-
Brady, S.F.1
Pawluczyk, J.M.2
Lumma, P.K.3
Feng, D.-M.4
Wai, J.M.5
Jones, R.6
DeFeo-Jones, D.7
Wong, B.K.8
Miller-Stein, C.9
Lin, J.H.10
Oliff, A.11
Freidinger, R.M.12
Garsky, V.M.13
-
46
-
-
18844470751
-
A prostate specific antigen (PSA) activated vinblastine prodrug selectively kills PSA secreting cells in vivo
-
DeFeo-Jones, D.; Brady, S. F.; Feng, D.-M.; Wong, B. K.; Bolyar, T.; Haskell, K.; Kiefer, D. M.; Leander, K.; McAvoy, E.; Lumma, P.; Pawluczyk, J. M.; Wai, J.; Motzel, S. L.; Keenan, K.; Van Zwieten, M.; Lin, J. H.; Garsky, V. M.; Freidinger, R.; Oliff, A.; Jones, R. E. A prostate specific antigen (PSA) activated vinblastine prodrug selectively kills PSA secreting cells in vivo. Mol. Cancer Ther. 2002, 1, 451-459.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 451-459
-
-
DeFeo-Jones, D.1
Brady, S.F.2
Feng, D.-M.3
Wong, B.K.4
Bolyar, T.5
Haskell, K.6
Kiefer, D.M.7
Leander, K.8
McAvoy, E.9
Lumma, P.10
Pawluczyk, J.M.11
Wai, J.12
Motzel, S.L.13
Keenan, K.14
Van Zwieten, M.15
Lin, J.H.16
Garsky, V.M.17
Freidinger, R.18
Oliff, A.19
Jones, R.E.20
more..
|