Large-scale asymmetric synthesis of novel sterically constrained 2′,6′-dimethyl- and α,2′,6′-trimethyltyrosine and -phenylalanine derivatives via alkylation of chiral equivalents of nucleophilic glycine and alanine

Tetrahedron

Volumn 57, Issue 30, 2001, Pages 6375-6382

  Soloshonok, Vadim A ^a   Tang, Xuejun ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

Author keywords

Alkylation reactions; Amino acids; Asymmetric synthesis; Nickel(II) complexes

Indexed keywords

2 [N (N BENZYLPROLYL)AMINO]BENZOPHENONE; 2',6' DIMETHYLBENZYLBROMIDE; 2',6' DIMETHYLPHENYLALANINE; 2',6' DIMETHYLTYROSINE; 4' BENZYLOXY 2',6' DIMETHYLBENZYL BROMIDE; ALANINE DERIVATIVE; ALPHA,2',6' TRIMETHYLPHENYLALANINE; ALPHA,2',6' TRIMETHYLTYROSINE; AMINO ACID DERIVATIVE; BENZOPHENONE DERIVATIVE; BROMINE DERIVATIVE; GLYCINE; NICKEL COMPLEX; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL REACTION; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; REACTION ANALYSIS; STOICHIOMETRY;

EID: 0035939193     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)00504-X     Document Type: Article

References (44)