Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays

Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2000, Pages 569-580

  Bonner, G Gregg ^a   Davis, Peg ^a   Stropova, Dagmar ^a   Edsall, Sidney ^a   Yamamura, Henry I ^a   Porreca, Frank ^a   Hruby, Victor J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR ANTAGONIST; TRITIUM;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MALE; MOLECULAR MODEL; MOUSE; NONHUMAN; PAIN; PEPTIDE SYNTHESIS; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANALGESICS, OPIOID; ANIMALS; BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MODELS, MOLECULAR; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; PEPTIDES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0033997436     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9900218     Document Type: Article

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