Unexpectedly Fast Cis/Trans Isomerization of Xaa-Pro Peptide Bonds in Disulfide-Constrained Cyclic Peptides

Journal of the American Chemical Society

Volumn 126, Issue 3, 2004, Pages 790-796

  Shi, Tiesheng ^a   Spain, Stephen M ^a   Rabenstein, Dallas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; CATALYSIS; HYDROGEN BONDS; ISOMERIZATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RATE CONSTANTS; STEREOCHEMISTRY; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL); THERMAL EFFECTS;

PEPTIDES;

ORGANIC COMPOUNDS;

ACETYLALANYLGLYCYLPROLYLALANINAMIDE; ACETYLCYSTEINYLGLYCYLPROLYLCYSTEINAMIDE; ACETYLCYSTEINYLPROLYLGLYCYLCYSTEINAMIDE; ACETYLCYSTEINYLPROLYLHISTIDYLCYSTEINAMIDE; ACETYLCYSTEINYLPROLYLPHENYLALANYLCYSTEINAMIDE; ACETYLCYSTEINYLPROLYLTHREONYLCYSTEINAMIDE; ACETYLCYSTEINYLPROLYLTYROSYLCYSTEINAMIDE; CYSTEINE; DISULFIDE; DITHIOL DERIVATIVE; GLYCINE; NITROGEN; OXIDOREDUCTASE; PEPTIDE; PEPTIDE DERIVATIVE; PROLINE; PROTON; THIOREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL BOND; CIS ISOMER; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME METABOLISM; EQUILIBRIUM CONSTANT; HYDROGEN BOND; ISOMERIZATION; MAGNETISM; MASS SPECTROMETRY; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMETER; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; TECHNIQUE; TEMPERATURE DEPENDENCE; TRANS ISOMER;

CYSTEINE; DISULFIDES; ISOMERISM; KINETICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROLINE; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 1642535352     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja030311k     Document Type: Article

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