N-methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity

Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2001, Pages 1416-1421

  Rajeswaran, W G ^a   Hocart, S J ^a   Murphy, W A ^a   Taylor, J E ^b   Coy, D H ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Biomeasure Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OCTAPEPTIDE; RECEPTOR SUBTYPE; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN OCTAPEPTIDE AGONIST; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; DRUG POTENCY; ENZYME SPECIFICITY; HYDROGEN BOND; METHYLATION; MOLECULAR CLONING; NEUROMODULATION; NONHUMAN; RECEPTOR AFFINITY;

ANIMALS; CHO CELLS; CRICETINAE; GROWTH HORMONE; HUMANS; MALE; METHYLATION; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PITUITARY GLAND, ANTERIOR; RADIOLIGAND ASSAY; RATS; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035953312     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000361p     Document Type: Article

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