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Volumn 4, Issue 3, 2008, Pages 116-133

Identification of new susceptibility genes for type 1 diabetes: An update

Author keywords

Genome wide association; Susceptibility; Type 1 diabetes

Indexed keywords


EID: 54749111086     PISSN: 15733955     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339508785160705     Document Type: Review
Times cited : (2)

References (169)
  • 1
    • 0036688819 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes mellitus
    • Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002; 3: 235-49.
    • (2002) Genes Immun , vol.3 , pp. 235-249
    • Pociot, F.1    McDermott, M.F.2
  • 2
    • 0034751376 scopus 로고    scopus 로고
    • EURODIAB ACE Study Group: Europe and diabetes: correlations between the incidence of childhood-onset type. I diabetes in Europe and HLA genotypes
    • Ronningen KS, Keiding N, Green A. EURODIAB ACE Study Group: Europe and diabetes: correlations between the incidence of childhood-onset type. I diabetes in Europe and HLA genotypes. Diabetologia 2001; 44 (Suppl 3): B51-9.
    • (2001) Diabetologia , vol.44 , Issue.SUPPL. 3
    • Ronningen, K.S.1    Keiding, N.2    Green, A.3
  • 4
    • 0041519032 scopus 로고    scopus 로고
    • Genetics of type 1A (immune mediated) diabetes
    • Melanitou E, Fain P, Eisenbarth GS. Genetics of type 1A (immune mediated) diabetes. J Autoimmun 2003; 21: 93-8.
    • (2003) J Autoimmun , vol.21 , pp. 93-98
    • Melanitou, E.1    Fain, P.2    Eisenbarth, G.S.3
  • 5
    • 0027944781 scopus 로고
    • Multiple DNA variant association analysis: Application to the insulin gene region in type I diabetes
    • Julier C, Lucassen A, Villedieu P, et al. Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes. Am J Hum Genet 1994: 55: 1247-54.
    • (1994) Am J Hum Genet , vol.55 , pp. 1247-1254
    • Julier, C.1    Lucassen, A.2    Villedieu, P.3
  • 6
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito, L, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506-11.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3
  • 7
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N, Musumeci L, Alonso A, et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 2004; 36: 337-8.
    • (2004) Nat Genet , vol.36 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3
  • 8
    • 33745592507 scopus 로고    scopus 로고
    • Statistical false positive or true disease pathway?
    • Todd JA. Statistical false positive or true disease pathway? Nat Genet 2006; 38: 731-3.
    • (2006) Nat Genet , vol.38 , pp. 731-733
    • Todd, J.A.1
  • 9
    • 79959503826 scopus 로고    scopus 로고
    • The international HapMap project
    • The International HapMap Consortium
    • The International HapMap Consortium. The international HapMap project. Nature 2003; 426: 789-96.
    • (2003) Nature , vol.426 , pp. 789-796
  • 10
    • 20244373351 scopus 로고    scopus 로고
    • Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    • Vella A, Cooper JD, Lowe CE, et al. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet 2005; 76: 773-9.
    • (2005) Am J Hum Genet , vol.76 , pp. 773-779
    • Vella, A.1    Cooper, J.D.2    Lowe, C.E.3
  • 11
    • 34047118563 scopus 로고    scopus 로고
    • Toward further mapping of the association between the IL2RA locus and type 1 diabetes
    • Qu HQ, Montpetit A, Ge B, Hudson TJ, Polychronakos C. Toward further mapping of the association between the IL2RA locus and type 1 diabetes. Diabetes 2007; 56: 1174-6.
    • (2007) Diabetes , vol.56 , pp. 1174-1176
    • Qu, H.Q.1    Montpetit, A.2    Ge, B.3    Hudson, T.J.4    Polychronakos, C.5
  • 12
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • Fehniger TA, Caligiuri MA. Interleukin 15: biology and relevance to human disease. Blood 2001; 97: 14-32.
    • (2001) Blood , vol.97 , pp. 14-32
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 13
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 39: 1074-82.
    • (2007) Nat Genet , vol.39 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3
  • 14
    • 0025490104 scopus 로고
    • The molecular basis for the generation of the human soluble interleukin 2 receptor
    • Rubin LA, Galli F, Greene WC, Nelson DL, Jay G. The molecular basis for the generation of the human soluble interleukin 2 receptor. Cytokine 1990; 2: 330-6.
    • (1990) Cytokine , vol.2 , pp. 330-336
    • Rubin, L.A.1    Galli, F.2    Greene, W.C.3    Nelson, D.L.4    Jay, G.5
  • 15
    • 33947274768 scopus 로고    scopus 로고
    • Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    • Brand OJ, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SCL. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol 2007; 66: 508-12.
    • (2007) Clin Endocrinol , vol.66 , pp. 508-512
    • Brand, O.J.1    Heward, J.M.2    Franklyn, J.A.3    Cooper, J.D.4    Todd, J.A.5    Gough, S.C.L.6
  • 16
    • 33750219508 scopus 로고    scopus 로고
    • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
    • Kim HP, Imbert J, Leonard WJ. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev 2006; 17: 349-66.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 349-366
    • Kim, H.P.1    Imbert, J.2    Leonard, W.J.3
  • 17
    • 0029360374 scopus 로고
    • Mapping of the diabetes polygene Idd3 on mouse chromosome 3 using novel congenic strains
    • Lord CJ, Bohlander SK, Hopes EA, et al. Mapping of the diabetes polygene Idd3 on mouse chromosome 3 using novel congenic strains. Mamm Genome 1995; 6: 563-70.
    • (1995) Mamm Genome , vol.6 , pp. 563-570
    • Lord, C.J.1    Bohlander, S.K.2    Hopes, E.A.3
  • 18
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857-64.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 19
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 20
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • The International HapMap Consortium
    • The International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437: 1299-1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 21
    • 36749054721 scopus 로고    scopus 로고
    • Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point a general risk locus for autoimmune diseases
    • Zhernakova A, Alizadeh BZ, Bevova M, et al. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point a general risk locus for autoimmune diseases. Am J Hum Genet 2007; 81: 1284-8
    • (2007) Am J Hum Genet , vol.81 , pp. 1284-1288
    • Zhernakova, A.1    Alizadeh, B.Z.2    Bevova, M.3
  • 22
    • 34347324029 scopus 로고    scopus 로고
    • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    • van Heel DA, Franke L, Hunt KA, et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007; 39: 827-9.
    • (2007) Nat Genet , vol.39 , pp. 827-829
    • van Heel, D.A.1    Franke, L.2    Hunt, K.A.3
  • 23
    • 34248677069 scopus 로고    scopus 로고
    • Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis
    • Mattuzzi S, Barbi S, Carletto A, Ravagnani V, et al. Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol 2007; 34: 997-1004.
    • (2007) J Rheumatol , vol.34 , pp. 997-1004
    • Mattuzzi, S.1    Barbi, S.2    Carletto, A.3    Ravagnani, V.4
  • 24
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005; 5: 688-98.
    • (2005) Nat Rev Immunol , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 25
    • 1942453326 scopus 로고    scopus 로고
    • Homeostatic expansion of T cell during immune unsufficiency generates autoimmunity
    • King C, Alic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cell during immune unsufficiency generates autoimmunity. Cell 2004; 117: 265-77.
    • (2004) Cell , vol.117 , pp. 265-277
    • King, C.1    Alic, A.2    Koelsch, K.3    Sarvetnick, N.4
  • 26
    • 33845711032 scopus 로고    scopus 로고
    • The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese
    • Asano K, Ikegami H, Fujisawa T, et al. The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese. Ann N Y Acad Sci 2006; 1079: 47-50.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 47-50
    • Asano, K.1    Ikegami, H.2    Fujisawa, T.3
  • 27
    • 34247186263 scopus 로고    scopus 로고
    • Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes
    • Asano K, Ikegami H, Fujisawa T, et al. Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. Hum Immunol 2007; 68: 384-91.
    • (2007) Hum Immunol , vol.68 , pp. 384-391
    • Asano, K.1    Ikegami, H.2    Fujisawa, T.3
  • 28
    • 15144356187 scopus 로고    scopus 로고
    • Mapping of the IDDM locus Idd3 to a 0.35 cM interval containing the Interleukin-2 gene
    • Denny P, Lord CJ, Hill NJ, et al. Mapping of the IDDM locus Idd3 to a 0.35 cM interval containing the Interleukin-2 gene. Diabetes 1997; 46: 695-700.
    • (1997) Diabetes , vol.46 , pp. 695-700
    • Denny, P.1    Lord, C.J.2    Hill, N.J.3
  • 29
    • 0034075807 scopus 로고    scopus 로고
    • Congenic mapping of the type 1 diabetes locus, region of mouse chromosome 3: Identification of a candidate, to a 780-kb Idd3 segment of ancestral DNA by haplotype mapping
    • Lyons PA, Armitage N, Argentina F, et al. Congenic mapping of the type 1 diabetes locus, region of mouse chromosome 3: identification of a candidate, to a 780-kb Idd3 segment of ancestral DNA by haplotype mapping. Genome Res 2000; 10: 446-53.
    • (2000) Genome Res , vol.10 , pp. 446-453
    • Lyons, P.A.1    Armitage, N.2    Argentina, F.3
  • 30
    • 0036272622 scopus 로고    scopus 로고
    • Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping
    • Ikegami H, Fujisawa T, Makino S, Ogihara T. Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping. Ann N Y Acad Sci 2002; 958: 325-8.
    • (2002) Ann N Y Acad Sci , vol.958 , pp. 325-328
    • Ikegami, H.1    Fujisawa, T.2    Makino, S.3    Ogihara, T.4
  • 31
    • 0033933070 scopus 로고    scopus 로고
    • Differential glycosylation of interleukin-2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
    • Podolin PL, Wilusz MB, Cubbon RM, et al. Differential glycosylation of interleukin-2, the molecular basis for the NOD Idd3 type 1 diabetes gene? Cytokine 2000; 12: 477-82.
    • (2000) Cytokine , vol.12 , pp. 477-482
    • Podolin, P.L.1    Wilusz, M.B.2    Cubbon, R.M.3
  • 32
    • 0033215132 scopus 로고    scopus 로고
    • Regulation of T cell homeostasis by heparan sulfate-bound IL-2
    • Wrenshall LE, Platt JL. Regulation of T cell homeostasis by heparan sulfate-bound IL-2. J Immunol 1999; 163: 3793-800.
    • (1999) J Immunol , vol.163 , pp. 3793-3800
    • Wrenshall, L.E.1    Platt, J.L.2
  • 33
    • 3242816153 scopus 로고    scopus 로고
    • Pearson T, Weiser P, Markees TG, et al. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes 2004; 53: 1972-8.
    • Pearson T, Weiser P, Markees TG, et al. Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3. Diabetes 2004; 53: 1972-8.
  • 34
    • 0002152913 scopus 로고    scopus 로고
    • The IL-2 deficiency syndrome. A lethal disease caused by abnormal lymphocyte survival
    • Durum SK, Muregge K, eds, Totowa, New Jersey, USA: Humana Press
    • Hunig T, Schimpl A. The IL-2 deficiency syndrome. A lethal disease caused by abnormal lymphocyte survival. In: Durum SK, Muregge K, eds. Cytokine knockouts. Totowa, New Jersey, USA: Humana Press, 1998:1-19.
    • (1998) Cytokine knockouts , pp. 1-19
    • Hunig, T.1    Schimpl, A.2
  • 35
  • 36
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi J, Rainbow D, Serra P, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 2007; 39: 329-37.
    • (2007) Nat Genet , vol.39 , pp. 329-337
    • Yamanouchi, J.1    Rainbow, D.2    Serra, P.3
  • 37
    • 0030027128 scopus 로고    scopus 로고
    • Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, colocalizes with I12, Fgfb and Idd3
    • Teuscher C, Wardell B, Lunceford J, Michael S, Tung K. Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, colocalizes with I12, Fgfb and Idd3. J Exp Med 1996; 183: 631-7.
    • (1996) J Exp Med , vol.183 , pp. 631-637
    • Teuscher, C.1    Wardell, B.2    Lunceford, J.3    Michael, S.4    Tung, K.5
  • 38
    • 0032947236 scopus 로고    scopus 로고
    • QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing I12
    • Encinas J, Wicker LS, Peterson LB, et al. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing I12. Nat Genet 1999; 21: 158-60.
    • (1999) Nat Genet , vol.21 , pp. 158-160
    • Encinas, J.1    Wicker, L.S.2    Peterson, L.B.3
  • 39
    • 25144452923 scopus 로고    scopus 로고
    • Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+ CD25+ regulatory T-cells in the regional lymph node
    • Samy E, Parker L, Sharp C, Tung K. Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+ CD25+ regulatory T-cells in the regional lymph node. J Exp Med 2005; 202: 771-81.
    • (2005) J Exp Med , vol.202 , pp. 771-781
    • Samy, E.1    Parker, L.2    Sharp, C.3    Tung, K.4
  • 40
    • 0029058037 scopus 로고
    • Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis
    • Simpson KJ, Jones AL, Forbes Howie A, Hayes PC. Soluble adhesion molecules and interleukin-2 receptor concentrations in patients with autoimmune chronic hepatitis. Eur J Gastroenterol Hepatol 1995; 7: 455-60.
    • (1995) Eur J Gastroenterol Hepatol , vol.7 , pp. 455-460
    • Simpson, K.J.1    Jones, A.L.2    Forbes Howie, A.3    Hayes, P.C.4
  • 41
    • 0028978458 scopus 로고
    • Circulating soluble interleukin-2 receptor alpha and beta chain in inflammatory bowel disease
    • Nielsen OH, Ciardelli T, Wu Z, Langholz E, Kirman I. Circulating soluble interleukin-2 receptor alpha and beta chain in inflammatory bowel disease. Am J Gastroenterol 1995; 90: 1301-6.
    • (1995) Am J Gastroenterol , vol.90 , pp. 1301-1306
    • Nielsen, O.H.1    Ciardelli, T.2    Wu, Z.3    Langholz, E.4    Kirman, I.5
  • 42
    • 0035401110 scopus 로고    scopus 로고
    • Serum soluble IL-2 receptor as a marker of lymphocyte activation in some autoimmune diseases. Effect of immunosuppressive therapy
    • Dejica D. Serum soluble IL-2 receptor as a marker of lymphocyte activation in some autoimmune diseases. Effect of immunosuppressive therapy. Roum Arch Microbiol Immunol 2001; 60: 183-201.
    • (2001) Roum Arch Microbiol Immunol , vol.60 , pp. 183-201
    • Dejica, D.1
  • 43
    • 0028870119 scopus 로고
    • Soluble interleukin 2 receptor levels in children with type I insulin-dependent diabetes mellitus
    • Gartner LA, Pfeifer MC, Albini C, Francis GL. Soluble interleukin 2 receptor levels in children with type I insulin-dependent diabetes mellitus. Ann Clin Lab Sci 1995; 25: 44-51.
    • (1995) Ann Clin Lab Sci , vol.25 , pp. 44-51
    • Gartner, L.A.1    Pfeifer, M.C.2    Albini, C.3    Francis, G.L.4
  • 44
    • 0031065438 scopus 로고    scopus 로고
    • Increased soluble interleukin-2 receptor concentrations in patients with insulin-dependent diabetes mellitus
    • Netea MG, Nancu N. Increased soluble interleukin-2 receptor concentrations in patients with insulin-dependent diabetes mellitus. Diabet Med 1997; 14: 168-8.
    • (1997) Diabet Med , vol.14 , pp. 168-168
    • Netea, M.G.1    Nancu, N.2
  • 45
  • 46
    • 0024565494 scopus 로고
    • Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients
    • Giordano C, Panto F, Caruso C, et al. Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes, 1989;38:310-5.
    • (1989) Diabetes , vol.38 , pp. 310-315
    • Giordano, C.1    Panto, F.2    Caruso, C.3
  • 47
    • 0027479483 scopus 로고
    • Study of T-cell activation in type I diabetic patients and pre-type I diabetic subjects by cytometric analysis: Antigen expression defect in vitro
    • Giordano C, De Maria R, Todaro M, et al. Study of T-cell activation in type I diabetic patients and pre-type I diabetic subjects by cytometric analysis: antigen expression defect in vitro. J Clin Immunol 1993; 13: 68-78.
    • (1993) J Clin Immunol , vol.13 , pp. 68-78
    • Giordano, C.1    De Maria, R.2    Todaro, M.3
  • 48
    • 0033301697 scopus 로고    scopus 로고
    • In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects
    • Kretowski A, Mysliwiec J, Szelachowska M, Brzozowski C, Pietruczuk M, Kinalska I. In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects. Arch Immunol Ther Exp (Warsz) 1999; 47: 45-9.
    • (1999) Arch Immunol Ther Exp (Warsz) , vol.47 , pp. 45-49
    • Kretowski, A.1    Mysliwiec, J.2    Szelachowska, M.3    Brzozowski, C.4    Pietruczuk, M.5    Kinalska, I.6
  • 49
    • 33845691031 scopus 로고    scopus 로고
    • A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: Report of the Immunology of Diabetes Society T Cell Workshop
    • Tree TI, Roep BO, Peakman M. A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop. Ann N Y Acad Sci 2006; 1079: 9-18.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 9-18
    • Tree, T.I.1    Roep, B.O.2    Peakman, M.3
  • 50
    • 0035806289 scopus 로고    scopus 로고
    • Certified professionals: CD4+CD25+ suppressor T cells
    • Shevach EM. Certified professionals: CD4+CD25+ suppressor T cells. J Exp Med 2001; 193: F41-6.
    • (2001) J Exp Med , vol.193
    • Shevach, E.M.1
  • 51
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential fur the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, et al. B7/CD28 costimulation is essential fur the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 431-40.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 52
    • 32944456599 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells and their therapeutic potential
    • Randolph DA, Fathman CG. CD4+CD25+ regulatory T cells and their therapeutic potential. Annu Rev Med 2006; 57: 381-402.
    • (2006) Annu Rev Med , vol.57 , pp. 381-402
    • Randolph, D.A.1    Fathman, C.G.2
  • 53
    • 27644546712 scopus 로고    scopus 로고
    • Population structure, differential bias and genomic control in a large-scale, case-control association study
    • Clayton DG, Walker NM, Smyth DJ, et al. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet 2005; 37: 1243-6.
    • (2005) Nat Genet , vol.37 , pp. 1243-1246
    • Clayton, D.G.1    Walker, N.M.2    Smyth, D.J.3
  • 54
    • 33745240931 scopus 로고    scopus 로고
    • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth DJ, Cooper JD, Bailey R, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006; 38: 617-9.
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3
  • 55
    • 34547756980 scopus 로고    scopus 로고
    • Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility
    • Sutherland A, Davies J, Owen CJ, et al. Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility. J Clin Endocrinol Metab 2007; 92: 3338-41.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3338-3341
    • Sutherland, A.1    Davies, J.2    Owen, C.J.3
  • 56
    • 34248232526 scopus 로고    scopus 로고
    • The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis
    • Marinou I, Montgomery DS, Dickson MC, et al. The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. Arthritis Res Ther 2007; 9:.R40.
    • (2007) Arthritis Res Ther , vol.9
    • Marinou, I.1    Montgomery, D.S.2    Dickson, M.C.3
  • 57
    • 10344259136 scopus 로고    scopus 로고
    • The V proteins of paramyxoviruses bind the inducible RNA helicase, mda-5, and inhibit its activation of-the IFN-beta promoter
    • Andrejeva J, Childs KS, Young DF, et al. The V proteins of paramyxoviruses bind the inducible RNA helicase, mda-5, and inhibit its activation of-the IFN-beta promoter. Proc Natl Acad Sci USA 2004; 101: 17264-9.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17264-17269
    • Andrejeva, J.1    Childs, K.S.2    Young, D.F.3
  • 58
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    • Yoneyama M, Kikuchi M, Matsumoto K, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005; 175: 2851-8.
    • (2005) J Immunol , vol.175 , pp. 2851-2858
    • Yoneyama, M.1    Kikuchi, M.2    Matsumoto, K.3
  • 60
    • 0035076588 scopus 로고    scopus 로고
    • The role of viruses in type 1 diabetes: Two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals
    • Jun HS, Yoon JW. The role of viruses in type 1 diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals. Diabetologia 2001; 44: 271-85.
    • (2001) Diabetologia , vol.44 , pp. 271-285
    • Jun, H.S.1    Yoon, J.W.2
  • 61
    • 33845695056 scopus 로고    scopus 로고
    • Viruses induce type 1 diabetes in animals
    • Yoon JW, Jun HS. Viruses induce type 1 diabetes in animals. Ann N Y Acad Sci 2006; 1079: 138-46.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 138-146
    • Yoon, J.W.1    Jun, H.S.2
  • 62
    • 3543046736 scopus 로고    scopus 로고
    • A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
    • Guo D, Li M, Zhang Y, et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet 2004; 36: 837-41.
    • (2004) Nat Genet , vol.36 , pp. 837-841
    • Guo, D.1    Li, M.2    Zhang, Y.3
  • 63
    • 3042740794 scopus 로고    scopus 로고
    • A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to. type 1 diabetes
    • Owerbach D, Pina L, Gabbay KH. A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to. type 1 diabetes. Diabetes 2004; 53: 1890-93.
    • (2004) Diabetes , vol.53 , pp. 1890-1893
    • Owerbach, D.1    Pina, L.2    Gabbay, K.H.3
  • 64
    • 33845693567 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes: Similarities and differences between Asian and Caucasian populations
    • Ikegami H, Fujisawa T, Kawabata Y, Noso S, Ogihara T. Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations. Ann N Y Acad Sci 2006; 1079: 51-9.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 51-59
    • Ikegami, H.1    Fujisawa, T.2    Kawabata, Y.3    Noso, S.4    Ogihara, T.5
  • 65
    • 33845689022 scopus 로고    scopus 로고
    • Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations
    • Noso S, Ikegami H, Fujisawa T, et al. Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations. Ann N Y Acad Sci 2006; 1079: 41-6.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 41-46
    • Noso, S.1    Ikegami, H.2    Fujisawa, T.3
  • 66
    • 33845696665 scopus 로고    scopus 로고
    • Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene
    • Wang C-Y, Podolsky R, She J-X. Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene. Ann N Y Acad Sci 2006; 1079: 257-67.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 257-267
    • Wang, C.-Y.1    Podolsky, R.2    She, J.-X.3
  • 67
    • 18444366769 scopus 로고    scopus 로고
    • Functional variants in SUMO4, TAB2, and NFkB and the risk of type 1 diabetes
    • Kosoy R, Concannon P. Functional variants in SUMO4, TAB2, and NFkB and the risk of type 1 diabetes. Genes Immun 2005; 6: 231-5.
    • (2005) Genes Immun , vol.6 , pp. 231-235
    • Kosoy, R.1    Concannon, P.2
  • 68
    • 13944254773 scopus 로고    scopus 로고
    • Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
    • Smyth DJ, Howson JMM, Lowe CE, et al. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 2005, 37. 110-1.
    • (2005) Nat Genet , vol.37 , pp. 110-111
    • Smyth, D.J.1    Howson, J.M.M.2    Lowe, C.E.3
  • 69
    • 33845700777 scopus 로고    scopus 로고
    • Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients
    • Sedimbi SK, Shastry A, Park Y, Rumba I, Sanjeevi CB. Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients. Ann N Y Acad Sci 2006; 1079: 273-7.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 273-277
    • Sedimbi, S.K.1    Shastry, A.2    Park, Y.3    Rumba, I.4    Sanjeevi, C.B.5
  • 70
    • 34250202180 scopus 로고    scopus 로고
    • No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3′ SIR and SUMO4 163 A/G polymorphism with autoimmune diabetes
    • Caputo M, Cerrone GE, Mazza C, Cedola N, Targovnik HM, Gustavo DF. No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3′ SIR and SUMO4 163 A/G polymorphism with autoimmune diabetes. Immunol Invest 2006; 36: 259-70.
    • (2006) Immunol Invest , vol.36 , pp. 259-270
    • Caputo, M.1    Cerrone, G.E.2    Mazza, C.3    Cedola, N.4    Targovnik, H.M.5    Gustavo, D.F.6
  • 71
    • 13944272309 scopus 로고    scopus 로고
    • Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
    • Wang CY, Yang P, She JX. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Gienet 2005; 37: 112-3.
    • (2005) Nat Gienet , vol.37 , pp. 112-113
    • Wang, C.Y.1    Yang, P.2    She, J.X.3
  • 72
    • 34548438102 scopus 로고    scopus 로고
    • SUMO4 M55V polymorphism affects susceptibility to type 1 diabetes in HLA DR3- and DR4-positive Swedish patients
    • Sedimbi SK, Luo XR, Sanjeevi CB, et al. SUMO4 M55V polymorphism affects susceptibility to type 1 diabetes in HLA DR3- and DR4-positive Swedish patients. Genes Immun 2007; 8: 518-521.
    • (2007) Genes Immun , vol.8 , pp. 518-521
    • Sedimbi, S.K.1    Luo, X.R.2    Sanjeevi, C.B.3
  • 73
    • 33644851944 scopus 로고    scopus 로고
    • Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase (PTPN22) gene: Association between promoter polymorphism and type 1 diabetes in Asian populations
    • Kawasaki E, Awata T, Ikegami H, et al. Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase (PTPN22) gene: Association between promoter polymorphism and type 1 diabetes in Asian populations. Am J Med Genet 2006; 140: 586-93.
    • (2006) Am J Med Genet , vol.140 , pp. 586-593
    • Kawasaki, E.1    Awata, T.2    Ikegami, H.3
  • 74
    • 33747648532 scopus 로고    scopus 로고
    • Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population
    • Tsurumaru M, Kawasaki E, Ida H, et al. Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population. J Clin Endocrinol Metab 2006; 91: 3138-43.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3138-3143
    • Tsurumaru, M.1    Kawasaki, E.2    Ida, H.3
  • 75
    • 27744597025 scopus 로고    scopus 로고
    • The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis
    • Gibbons LJ, Thomson W, Zeggini E, et al. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. Rheumatology 2005; 44; 1390-3.
    • (2005) Rheumatology , vol.44 , pp. 1390-1393
    • Gibbons, L.J.1    Thomson, W.2    Zeggini, E.3
  • 76
    • 33744753063 scopus 로고    scopus 로고
    • SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis
    • Costas J, Perez-Rampin E, Ferreidos-Vidal I, et al. SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis. J Rheumatol 2006; 33: 1048-51.
    • (2006) J Rheumatol , vol.33 , pp. 1048-1051
    • Costas, J.1    Perez-Rampin, E.2    Ferreidos-Vidal, I.3
  • 77
    • 33745798405 scopus 로고    scopus 로고
    • SLC22A4, RUNXI, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: A case-control study in a Spanish population
    • Orozco G, Sanchez E, Gonzalez-Gay MA, et al. SLC22A4, RUNXI, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population. J Rheumatol 2006; 33: 1235-9.
    • (2006) J Rheumatol , vol.33 , pp. 1235-1239
    • Orozco, G.1    Sanchez, E.2    Gonzalez-Gay, M.A.3
  • 78
    • 33744504186 scopus 로고    scopus 로고
    • Study of the role of functional variants of SLC22A4, RUNX1, and SUMO4 in systemic lupus erythematosus
    • Orozco G, Sanchez E, Gomez LM, et al. Study of the role of functional variants of SLC22A4, RUNX1, and SUMO4 in systemic lupus erythematosus. Ann Rheum Dis 2006; 65: 791-5.
    • (2006) Ann Rheum Dis , vol.65 , pp. 791-795
    • Orozco, G.1    Sanchez, E.2    Gomez, L.M.3
  • 79
    • 3042644131 scopus 로고    scopus 로고
    • A M55V polymorphism in a novel SUMO gene (SUMO4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus
    • Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D. A M55V polymorphism in a novel SUMO gene (SUMO4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem 2004; 279; 27233-8.
    • (2004) J Biol Chem , vol.279 , pp. 27233-27238
    • Bohren, K.M.1    Nadkarni, V.2    Song, J.H.3    Gabbay, K.H.4    Owerbach, D.5
  • 80
    • 34848892777 scopus 로고    scopus 로고
    • Emerging role of SUMO in pancreatic beta-cells
    • Ehninger A, Mziaut H, Solimena M. Emerging role of SUMO in pancreatic beta-cells. Horm Metab Res 2007; 39: 658-64.
    • (2007) Horm Metab Res , vol.39 , pp. 658-664
    • Ehninger, A.1    Mziaut, H.2    Solimena, M.3
  • 81
    • 23744460490 scopus 로고    scopus 로고
    • SUMO wrestling with type 1 diabetes
    • Li M, Guo D, Isales CM, et al. SUMO wrestling with type 1 diabetes. J Mol Med 2005; 83: 504-13.
    • (2005) J Mol Med , vol.83 , pp. 504-513
    • Li, M.1    Guo, D.2    Isales, C.M.3
  • 83
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death-the signal transduction of immune-mediated beta-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T. A choice of death-the signal transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44: 2115-33.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 84
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee CH, Olson P, Evans RM. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003; 144: 2201-7.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.H.1    Olson, P.2    Evans, R.M.3
  • 85
    • 33748349646 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor damma agonists: Their role as vasoprotective agents in diabetes
    • Blaschke F, Caglayan E, Hsueh WA. Peroxisome proliferator-activated receptor damma agonists: their role as vasoprotective agents in diabetes. Endocrinol Metab Clin North Am 2006; 35: 561-74.
    • (2006) Endocrinol Metab Clin North Am , vol.35 , pp. 561-574
    • Blaschke, F.1    Caglayan, E.2    Hsueh, W.A.3
  • 86
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits
    • Florez JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 2003; 4: 257-91.
    • (2003) Annu Rev Genomics Hum Genet , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.2    Altshuler, D.3
  • 87
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20; 284-287.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 88
    • 10744223678 scopus 로고    scopus 로고
    • Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes
    • Eftychi C, Howson JMM, Barratt BJ, et al. Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes. Diabetes 2004; 53: 870-3.
    • (2004) Diabetes , vol.53 , pp. 870-873
    • Eftychi, C.1    Howson, J.M.M.2    Barratt, B.J.3
  • 89
    • 33645988557 scopus 로고    scopus 로고
    • IRS1, KCNJ11, PPARγ2 and HNF-1α: Do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
    • Johansen A, Jensen DP, Bergholdt R, et al. IRS1, KCNJ11, PPARγ2 and HNF-1α: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes? Diabetes Obes Metab 2006; 8: 75-82.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 75-82
    • Johansen, A.1    Jensen, D.P.2    Bergholdt, R.3
  • 90
    • 34249913696 scopus 로고    scopus 로고
    • Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes. Effect of the PPARγ Pro12Ala polymorphism: The FinnDiane Study
    • Waden J, Thorn LM, Forsblom C, et al. Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes. Effect of the PPARγ Pro12Ala polymorphism: the FinnDiane Study. Diabetes Care 2007; 30: 1618-20.
    • (2007) Diabetes Care , vol.30 , pp. 1618-1620
    • Waden, J.1    Thorn, L.M.2    Forsblom, C.3
  • 91
    • 0030444451 scopus 로고    scopus 로고
    • Human type 1 diabetes and the insulin gene: Principles of mapping polygenes
    • Bennett ST, Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet 1996; 30: 343-70.
    • (1996) Annu Rev Genet , vol.30 , pp. 343-370
    • Bennett, S.T.1    Todd, J.A.2
  • 92
    • 0036255461 scopus 로고    scopus 로고
    • Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: Implications for human type 1 diabetes
    • Beales PE, Pozzilli P. Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes. Diabetes Metab Res Rev 2002; 18: 114-7.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 114-117
    • Beales, P.E.1    Pozzilli, P.2
  • 93
    • 23044440774 scopus 로고    scopus 로고
    • Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice
    • Botolin S, Faugere M-C, Malluche H, Orth M, Meyer R, McCabe LR. Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice. Endocrinology 2005; 146: 3622-31.
    • (2005) Endocrinology , vol.146 , pp. 3622-3631
    • Botolin, S.1    Faugere, M.-C.2    Malluche, H.3    Orth, M.4    Meyer, R.5    McCabe, L.R.6
  • 94
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma2 on thiazolidinedione-induced adipogenesis
    • Masugi J, Tamori Y, Mori H, Koike T, Kasuga M. Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 2000; 268: 178-82.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, H.3    Koike, T.4    Kasuga, M.5
  • 95
    • 0033626426 scopus 로고    scopus 로고
    • The PPARgamma2 polymorphism Pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients
    • Jacob S. The PPARgamma2 polymorphism Pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients. Horm Metab Res 2000; 32: 413-416.
    • (2000) Horm Metab Res , vol.32 , pp. 413-416
    • Jacob, S.1
  • 96
    • 17944362462 scopus 로고    scopus 로고
    • Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant Caucasians
    • Ek J. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant Caucasians. Diabetologia 2001;44: 1170-6.
    • (2001) Diabetologia , vol.44 , pp. 1170-1176
    • Ek, J.1
  • 97
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptorgamma is a negative regulator of macrophage activation
    • Ricot M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptorgamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricot, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 98
    • 0344088433 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells
    • Augstein P, Dunger A, Heinke P, et al. Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells. Biochem Biophys Res Commun 2003; 304: 378-84.
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 378-384
    • Augstein, P.1    Dunger, A.2    Heinke, P.3
  • 99
    • 17144452354 scopus 로고    scopus 로고
    • A search for type 1 diabetes susceptibility genes in famiiies from the United Kingdom
    • Mein CA, Esposito L, Dunn MG, et al. A search for type 1 diabetes susceptibility genes in famiiies from the United Kingdom. Nat Genet 1998; 19: 297-300.
    • (1998) Nat Genet , vol.19 , pp. 297-300
    • Mein, C.A.1    Esposito, L.2    Dunn, M.G.3
  • 100
    • 0034051537 scopus 로고    scopus 로고
    • Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism
    • Nishimura M, Obayashi H, Maruya E, et al. Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum Immunol 2000; 61, 507-10.
    • (2000) Hum Immunol , vol.61 , pp. 507-510
    • Nishimura, M.1    Obayashi, H.2    Maruya, E.3
  • 101
    • 0034433461 scopus 로고    scopus 로고
    • The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes
    • Kristiansen OP, Nolsoe RL, Holst H, et al. The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes. Immunogenetics 2000; 52: 107-11.
    • (2000) Immunogenetics , vol.52 , pp. 107-111
    • Kristiansen, O.P.1    Nolsoe, R.L.2    Holst, H.3
  • 102
    • 0034121252 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: No association with type 1 diabetes among Finns
    • Nejentsev S, Laine AP, Simell O, Ilonen J. Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns. Tiss Antigens 2000; 55: 568-70.
    • (2000) Tiss Antigens , vol.55 , pp. 568-570
    • Nejentsev, S.1    Laine, A.P.2    Simell, O.3    Ilonen, J.4
  • 103
    • 33748745009 scopus 로고    scopus 로고
    • Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of type 1 diabetes and diabetic nephropathy
    • Ma J, Mollsten A, Prazny M, Falhammar H, et al. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of type 1 diabetes and diabetic nephropathy. Diabet Med 2006; 23: 1093-9.
    • (2006) Diabet Med , vol.23 , pp. 1093-1099
    • Ma, J.1    Mollsten, A.2    Prazny, M.3    Falhammar, H.4
  • 104
    • 0004048999 scopus 로고    scopus 로고
    • Increased transmission of intracellular adhesion molecule 1 469E allele in type 1 Romanian diabetic families
    • Guja C, Todd JA, Welsh A, Marshall S, Ionescu-Tirgoviste C. Increased transmission of intracellular adhesion molecule 1 469E allele in type 1 Romanian diabetic families. Diabetologia 1999; 42(Suppl. 1): 327.
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1 , pp. 327
    • Guja, C.1    Todd, J.A.2    Welsh, A.3    Marshall, S.4    Ionescu-Tirgoviste, C.5
  • 105
    • 10744233878 scopus 로고    scopus 로고
    • The ARG241 allele of the intercellular adhesion molecule-1 is associated with a reduced risk of type 1 diabetes
    • Nejentsev S, Guja C, McCormack R, et al. The ARG241 allele of the intercellular adhesion molecule-1 is associated with a reduced risk of type 1 diabetes. Lancet 2003; 362: 1723-4.
    • (2003) Lancet , vol.362 , pp. 1723-1724
    • Nejentsev, S.1    Guja, C.2    McCormack, R.3
  • 106
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39: 857-64.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 107
    • 0028239569 scopus 로고
    • Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster
    • Vora DK, Rosenbloom CL, Beaudet AL, Cottingham RW. Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. Genomics 1994; 21: 473-7.
    • (1994) Genomics , vol.21 , pp. 473-477
    • Vora, D.K.1    Rosenbloom, C.L.2    Beaudet, A.L.3    Cottingham, R.W.4
  • 108
    • 0028575926 scopus 로고
    • Domain 5 of the intercellular adhesion molecule-1(ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells
    • Joling P, Boom S, Johnson J, et al. Domain 5 of the intercellular adhesion molecule-1(ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells. Adv Exp Med Biol 1994; 355: 131-5.
    • (1994) Adv Exp Med Biol , vol.355 , pp. 131-135
    • Joling, P.1    Boom, S.2    Johnson, J.3
  • 109
    • 0025774796 scopus 로고
    • Generation of recombinant, carbohydrate-free intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 fragments in Escherichia coli and mapping of epitopes recognized by- anti-ICAM-1 monoclonal antibodies
    • Molgg M, Schwaeble W, Johnson JP, Dierich MP. Generation of recombinant, carbohydrate-free intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 fragments in Escherichia coli and mapping of epitopes recognized by- anti-ICAM-1 monoclonal antibodies. Immunol Lett 1991; 28: 237-43.
    • (1991) Immunol Lett , vol.28 , pp. 237-243
    • Molgg, M.1    Schwaeble, W.2    Johnson, J.P.3    Dierich, M.P.4
  • 110
    • 1842740224 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism 1548G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis
    • Iwao M, Morisaki H, Morisaki T. Single-nucleotide polymorphism 1548G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis. Biochem Biophys Res Commun 2004; 7: 729-35.
    • (2004) Biochem Biophys Res Commun , vol.7 , pp. 729-735
    • Iwao, M.1    Morisaki, H.2    Morisaki, T.3
  • 111
    • 0032516060 scopus 로고    scopus 로고
    • A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1
    • Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA. A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc Natl Acad Sci USA 1998; 95: 4134-9.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4134-4139
    • Casasnovas, J.M.1    Stehle, T.2    Liu, J.H.3    Wang, J.H.4    Springer, T.A.5
  • 112
    • 0029150433 scopus 로고
    • Intercellular adhesion molecule 1 gene associations with immunologic subset of inflammatory bowel disease
    • Yang H, Vora DK, Targan SR, Toyodam H, Beaudet AL, Rotter JI. Intercellular adhesion molecule 1 gene associations with immunologic subset of inflammatory bowel disease. Gastroenterology 1995; 109: 440-8.
    • (1995) Gastroenterology , vol.109 , pp. 440-448
    • Yang, H.1    Vora, D.K.2    Targan, S.R.3    Toyodam, H.4    Beaudet, A.L.5    Rotter, J.I.6
  • 114
    • 0027425476 scopus 로고
    • Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM
    • Hanninen A, Salmi M, Simell O, Jalkanen S. Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM. Diabetes 1993; 42: 1556-42.
    • (1993) Diabetes , vol.42 , pp. 1556-1642
    • Hanninen, A.1    Salmi, M.2    Simell, O.3    Jalkanen, S.4
  • 115
    • 0027362474 scopus 로고
    • Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium
    • Hanninen A, Taylor C, Streeter PR, et al. Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest 1993; 92: 2509-15.
    • (1993) J Clin Invest , vol.92 , pp. 2509-2515
    • Hanninen, A.1    Taylor, C.2    Streeter, P.R.3
  • 116
    • 0029162631 scopus 로고
    • Expression of intercellular adhesion molecule 1 on pancreatic β-cells accelerates β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes
    • Yagi N, Yokono K, Amano K, et al. Expression of intercellular adhesion molecule 1 on pancreatic β-cells accelerates β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 1995; 44: 744-52.
    • (1995) Diabetes , vol.44 , pp. 744-752
    • Yagi, N.1    Yokono, K.2    Amano, K.3
  • 117
    • 0027991221 scopus 로고
    • Prevention of autoimmune diabetes by treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies
    • Herold KC, Vezys V, Gage A, Montag AG. Prevention of autoimmune diabetes by treatment with anti-LFA-1 and anti-ICAM-1 monoclonal antibodies. Cell Immunol 1994; 157: 489-500.
    • (1994) Cell Immunol , vol.157 , pp. 489-500
    • Herold, K.C.1    Vezys, V.2    Gage, A.3    Montag, A.G.4
  • 118
    • 0030272634 scopus 로고    scopus 로고
    • Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1 and Th2-type infiltrates
    • Martin S, Hibino T, Faust A, Kleeman R, Kolb H. Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1 and Th2-type infiltrates. J Autoimmun 1996; 9: 637-43.
    • (1996) J Autoimmun , vol.9 , pp. 637-643
    • Martin, S.1    Hibino, T.2    Faust, A.3    Kleeman, R.4    Kolb, H.5
  • 119
    • 0031465079 scopus 로고    scopus 로고
    • Soluble adhesion molecules in type 1 diabetes mellitus
    • Martin S. Soluble adhesion molecules in type 1 diabetes mellitus. Horm Metab Res 1997; 29: 639-42.
    • (1997) Horm Metab Res , vol.29 , pp. 639-642
    • Martin, S.1
  • 120
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007; 39: 830-2.
    • (2007) Nat Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 122
    • 0028783629 scopus 로고
    • COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus
    • Lorenzen JA, Dadabay CY, Fischer EH. COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. J Cell Biol 1995; 131: 631-43.
    • (1995) J Cell Biol , vol.131 , pp. 631-643
    • Lorenzen, J.A.1    Dadabay, C.Y.2    Fischer, E.H.3
  • 123
    • 0030769147 scopus 로고    scopus 로고
    • Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice
    • You-Ten KE, Muise ES, Itie A, et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med 1997; 186: 683-93.
    • (1997) J Exp Med , vol.186 , pp. 683-693
    • You-Ten, K.E.1    Muise, E.S.2    Itie, A.3
  • 124
    • 1942489307 scopus 로고    scopus 로고
    • T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease
    • Heinonen KM, Nestal FP, Newell EW, et al. T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood 2004; 103: 3457-64.
    • (2004) Blood , vol.103 , pp. 3457-3464
    • Heinonen, K.M.1    Nestal, F.P.2    Newell, E.W.3
  • 125
    • 0037769202 scopus 로고    scopus 로고
    • + myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism
    • + myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism. J Immunol 2003; 171: 726-32.
    • (2003) J Immunol , vol.171 , pp. 726-732
    • Dupuis, M.1    De2    Jesus Ibarra-Sanchez, M.3    Tremblay, M.L.4    Duplay, P.5
  • 126
    • 0036006288 scopus 로고    scopus 로고
    • The T cell protein phosphatase is a negative regulator of Janus family kinases 1 and 3
    • Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ. The T cell protein phosphatase is a negative regulator of Janus family kinases 1 and 3. Curr Biol 2002; 12: 446-53.
    • (2002) Curr Biol , vol.12 , pp. 446-453
    • Simoncic, P.D.1    Lee-Loy, A.2    Barber, D.L.3    Tremblay, M.L.4    McGlade, C.J.5
  • 127
    • 0036318564 scopus 로고    scopus 로고
    • Identification of a nuclear Stat1 protein tyrosine phosphatase
    • ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, et al. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol 2002; 22: 5662-5668
    • (2002) Mol Cell Biol , vol.22 , pp. 5662-5668
    • ten Hoeve, J.1    de Jesus2    Ibarra-Sanchez, M.3    Fu, Y.4
  • 128
    • 0037184022 scopus 로고    scopus 로고
    • Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase
    • Zhu W, Mustelin T, and David M. Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem 2002; 277: 35787-90.
    • (2002) J Biol Chem , vol.277 , pp. 35787-35790
    • Zhu, W.1    Mustelin, T.2    David, M.3
  • 129
    • 54749094106 scopus 로고    scopus 로고
    • Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase gene
    • Van Vliet C, Bukczynska PE, Puryer MA, et al. Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase gene. Gene 2005; 237: 351-60.
    • (2005) Gene , vol.237 , pp. 351-360
    • Van Vliet, C.1    Bukczynska, P.E.2    Puryer, M.A.3
  • 130
    • 0036138705 scopus 로고    scopus 로고
    • A nuclear protein-tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducerand activator of transcription 5a and 5b by TC-PTP in nucleus
    • Aoki N, Matsuda T. A nuclear protein-tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducerand activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol 2002; 16: 58-69.
    • (2002) Mol Endocrinol , vol.16 , pp. 58-69
    • Aoki, N.1    Matsuda, T.2
  • 131
    • 0036033161 scopus 로고    scopus 로고
    • The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
    • Yamamoto T, Sekine Y, Kashima K, et al. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun 2002; 297: 811-7.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 811-817
    • Yamamoto, T.1    Sekine, Y.2    Kashima, K.3
  • 132
    • 35748978843 scopus 로고    scopus 로고
    • Interleukin-6 - a key mediator of systemic and local symptoms in rheumatoid arthritis
    • Cronstein BN. Interleukin-6 - a key mediator of systemic and local symptoms in rheumatoid arthritis. Bull NYU Hosp Jt Dis 2007; 65(Suppl.1): S11-5.
    • (2007) Bull NYU Hosp Jt Dis , vol.65 , Issue.SUPPL.1
    • Cronstein, B.N.1
  • 133
    • 34548323860 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase PTPN22 in human autoimmunity
    • Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity 2007; 40: 453-61.
    • (2007) Autoimmunity , vol.40 , pp. 453-461
    • Vang, T.1    Miletic, A.V.2    Bottini, N.3    Mustelin, T.4
  • 134
    • 15844375309 scopus 로고    scopus 로고
    • DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
    • Shibuya A, Campbell D, Hannum C, et al. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 1996; 4: 573-81.
    • (1996) Immunity , vol.4 , pp. 573-581
    • Shibuya, A.1    Campbell, D.2    Hannum, C.3
  • 135
    • 9144273834 scopus 로고    scopus 로고
    • CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation
    • Shibuya K, Shirakawa J, Kameyama T, et al. CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med 2003; 198: 1829-39.
    • (2003) J Exp Med , vol.198 , pp. 1829-1839
    • Shibuya, K.1    Shirakawa, J.2    Kameyama, T.3
  • 137
    • 0033229832 scopus 로고    scopus 로고
    • Physical and functional association of LFA-1 with DNAM-1 adhesion molecule
    • Shibuya K, Lanier LL, Phillips JH, et al. Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 1999; 11: 615-23.
    • (1999) Immunity , vol.11 , pp. 615-623
    • Shibuya, K.1    Lanier, L.L.2    Phillips, J.H.3
  • 139
    • 0030764335 scopus 로고    scopus 로고
    • TliSA (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the regulation of expression
    • Sherrington PD, Scott JL, Jin B, et al. TliSA (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the regulation of expression. J Biol Chem 1997; 272: 21735-44.
    • (1997) J Biol Chem , vol.272 , pp. 21735-21744
    • Sherrington, P.D.1    Scott, J.L.2    Jin, B.3
  • 140
    • 12444304178 scopus 로고    scopus 로고
    • CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus
    • Tao D, Shangwu L, Qun W, et al. CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus. J Immunol 2005; 174: 1281-90.
    • (2005) J Immunol , vol.174 , pp. 1281-1290
    • Tao, D.1    Shangwu, L.2    Qun, W.3
  • 141
    • 33645337913 scopus 로고    scopus 로고
    • A nalysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    • Smyth DJ, Howson JMM, Payne F, et al. A nalysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet 2006; 7: 20.
    • (2006) BMC Med Genet , vol.7 , pp. 20
    • Smyth, D.J.1    Howson, J.M.M.2    Payne, F.3
  • 143
    • 34548354646 scopus 로고    scopus 로고
    • Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene
    • Del Mastro RG, Turenne L, Giese H, et al. Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene. BMC Medl Genet 2007; 8: 46.
    • (2007) BMC Medl Genet , vol.8 , pp. 46
    • Del Mastro, R.G.1    Turenne, L.2    Giese, H.3
  • 144
    • 40449098551 scopus 로고    scopus 로고
    • ADAM33, a new candidate for psoriasis susceptibility
    • Lesueur F, Oudot T, Heath S, et al. ADAM33, a new candidate for psoriasis susceptibility. PLos ONE 2007; 2: e906.
    • (2007) PLos ONE , vol.2
    • Lesueur, F.1    Oudot, T.2    Heath, S.3
  • 145
    • 34248549989 scopus 로고    scopus 로고
    • Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in French families
    • Lesueur F, Lefevre C, Has C, et al. Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in French families. J Invest Dermatol 2007; 127: 1403-9.
    • (2007) J Invest Dermatol , vol.127 , pp. 1403-1409
    • Lesueur, F.1    Lefevre, C.2    Has, C.3
  • 146
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418: 426-30.
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1    Little, R.D.2    Dupuis, J.3
  • 149
    • 12144290186 scopus 로고    scopus 로고
    • Catalytic activity of human ADAM33
    • Zou J, Zhu F, Liu J, et al, Catalytic activity of human ADAM33. J Biol Chem 2004; 279: 9818-30.
    • (2004) J Biol Chem , vol.279 , pp. 9818-9830
    • Zou, J.1    Zhu, F.2    Liu, J.3
  • 150
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    • Hakonarson H, Grant SFA, Bradfield JP, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 2007; 448: 591-4.
    • (2007) Nature , vol.448 , pp. 591-594
    • Hakonarson, H.1    Grant, S.F.A.2    Bradfield, J.P.3
  • 151
    • 20544436120 scopus 로고    scopus 로고
    • Levels of complexity in pathogen recognition by C-type lectins
    • Cambi A, Figdor CG. Levels of complexity in pathogen recognition by C-type lectins. Curr Opin Immunol 2005; 17: 345-51.
    • (2005) Curr Opin Immunol , vol.17 , pp. 345-351
    • Cambi, A.1    Figdor, C.G.2
  • 152
    • 33846307747 scopus 로고    scopus 로고
    • Robinson MJ, Sancho D, Slack EC, Leibundgut-Landmann S, Reis e Sousa C. Myeloid C-type lectins in innate immunity. Nat Immunol 2006; 7: 1258-65.
    • Robinson MJ, Sancho D, Slack EC, Leibundgut-Landmann S, Reis e Sousa C. Myeloid C-type lectins in innate immunity. Nat Immunol 2006; 7: 1258-65.
  • 153
    • 33846252426 scopus 로고    scopus 로고
    • Dendritic cell immunoreceptors: C-type lectin receptors for pattern recognition and signaling on antigen-presenting cells
    • Kanazawa N. Dendritic cell immunoreceptors: C-type lectin receptors for pattern recognition and signaling on antigen-presenting cells. J Dermatol Sci 2007; 45: 77-86.
    • (2007) J Dermatol Sci , vol.45 , pp. 77-86
    • Kanazawa, N.1
  • 154
    • 0029987320 scopus 로고    scopus 로고
    • The c-erB3/HER3 receptor in human cancer
    • Gullick WJ. The c-erB3/HER3 receptor in human cancer. Cancer Surv 1996; 27: 339-49.
    • (1996) Cancer Surv , vol.27 , pp. 339-349
    • Gullick, W.J.1
  • 155
    • 0035360262 scopus 로고    scopus 로고
    • A naturally occurring secreted human ErB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4
    • Lee H, Alita RW, Sliwkowski MX, Maihle NJ. A naturally occurring secreted human ErB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4. Cancer Res 2001; 61: 4467-73.
    • (2001) Cancer Res , vol.61 , pp. 4467-4473
    • Lee, H.1    Alita, R.W.2    Sliwkowski, M.X.3    Maihle, N.J.4
  • 156
    • 0030684122 scopus 로고    scopus 로고
    • Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors
    • Carver RS, Mathew PM, Russell WE. Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors. Endocrinology 1997; 38: 5195-201.
    • (1997) Endocrinology , vol.38 , pp. 5195-5201
    • Carver, R.S.1    Mathew, P.M.2    Russell, W.E.3
  • 157
    • 36549026427 scopus 로고    scopus 로고
    • Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: Implications for erectile dysfunction
    • Soh J, Katsuyama M, Ushijima S, et al. Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: implications for erectile dysfunction. Urology 2007; 70: 1019-23:
    • (2007) Urology , vol.70 , pp. 1019-1023
    • Soh, J.1    Katsuyama, M.2    Ushijima, S.3
  • 158
    • 34247863773 scopus 로고    scopus 로고
    • The neuregulin-I/Erb signaling system in development and disease
    • Britsch S. The neuregulin-I/Erb signaling system in development and disease. Ådv Anat Embriol Cell Biol 2007; 190: 1-65.
    • (2007) Ådv Anat Embriol Cell Biol , vol.190 , pp. 1-65
    • Britsch, S.1
  • 159
    • 0031731919 scopus 로고    scopus 로고
    • Calcium-binding protein calcyphosine in dog central astrocytes and ependymal cells and in peripheral neurons
    • Halleux P, Schurmans S, Schiffman SN, et al. Calcium-binding protein calcyphosine in dog central astrocytes and ependymal cells and in peripheral neurons. J Chem Neuroanat 1998; 15: 239-50.
    • (1998) J Chem Neuroanat , vol.15 , pp. 239-250
    • Halleux, P.1    Schurmans, S.2    Schiffman, S.N.3
  • 160
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory SG, Schmidt S, Seth P, et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007; 39: 1083-91.
    • (2007) Nat Genet , vol.39 , pp. 1083-1091
    • Gregory, S.G.1    Schmidt, S.2    Seth, P.3
  • 161
    • 26044433609 scopus 로고    scopus 로고
    • Gene expression and genotyping studies implicate the interleukin 7 receptor gene in the pathogenesis of primary progressive multiple sclerosis
    • Booth DR, Arthur AT, Teutsch SM, et al. Gene expression and genotyping studies implicate the interleukin 7 receptor gene in the pathogenesis of primary progressive multiple sclerosis. J Mol Med 2005; 83: 822-30.
    • (2005) J Mol Med , vol.83 , pp. 822-830
    • Booth, D.R.1    Arthur, A.T.2    Teutsch, S.M.3
  • 162
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • Hafler DA, Compston A, Sawcer S, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851-62.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3
  • 163
    • 34548368541 scopus 로고    scopus 로고
    • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    • Lundmark F, Duveleft K, Iacobaeus E, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007; 39: 1108-13.
    • (2007) Nat Genet , vol.39 , pp. 1108-1113
    • Lundmark, F.1    Duveleft, K.2    Iacobaeus, E.3
  • 164
    • 34548833894 scopus 로고    scopus 로고
    • Interlinking interleukin-7
    • Kittipatarin C, Khaled A. Interlinking interleukin-7. Cytokine 2007; 39: 75-83.
    • (2007) Cytokine , vol.39 , pp. 75-83
    • Kittipatarin, C.1    Khaled, A.2
  • 165
    • 0027751556 scopus 로고
    • Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor
    • Noguchi M, Nakamura Y, Russell SM, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993; 262: 1877-80.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1    Nakamura, Y.2    Russell, S.M.3
  • 167
    • 0034667634 scopus 로고    scopus 로고
    • A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
    • Roifman CM, Zhang J, Chitayat D, Sharfe N. A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood 2000; 96: 2803-07.
    • (2000) Blood , vol.96 , pp. 2803-2807
    • Roifman, C.M.1    Zhang, J.2    Chitayat, D.3    Sharfe, N.4
  • 168
    • 33644779794 scopus 로고    scopus 로고
    • Interleukin-7 is a survival factor for CD4+CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells
    • Hamaha J, Machen J, Wright M, et al. Interleukin-7 is a survival factor for CD4+CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes 2006; 55: 158-170.
    • (2006) Diabetes , vol.55 , pp. 158-170
    • Hamaha, J.1    Machen, J.2    Wright, M.3
  • 169
    • 34447574943 scopus 로고    scopus 로고
    • The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro
    • Yates J, Rovis F, Mitchell P, et al. The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol 2007; 19: 785-99.
    • (2007) Int Immunol , vol.19 , pp. 785-799
    • Yates, J.1    Rovis, F.2    Mitchell, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.