Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells

Diabetes

Volumn 55, Issue 1, 2006, Pages 158-170

  Harnaha, Jo ^a   Machen, Jennifer ^a   Wright, Marietta ^a   Lakomy, Robert ^a   Styche, Alexis ^a   Trucco, Massimo ^a   Makaroun, Sami ^a   Giannoukakis, Nick ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; INTERLEUKIN RECEPTOR; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BIOENGINEERING; CD4+ CD25+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; EX VIVO STUDY; FEMALE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; REGULATORY T LYMPHOCYTE; SCID MOUSE; SPLEEN CELL;

EID: 33644779794     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.55.01.06.db05-0340     Document Type: Article

References (73)

1. Thomson AW: Designer dendritic cells for transplant tolerance. Transplant Proc 34:2727-2728, 2002
2. Coates PT, Thomson AW: Dendritic cells, tolerance induction and transplant outcome. Am J Transplant 2:299-307, 2002
3. Morelli AE, Hackstein H, Thomson AW: Potential of tolerogenic dendritic cells for transplantation. Semin Immunol 13:323-335, 2001
4. Hackstein H, Morelli AE, Thomson AW: Designer dendritic cells for tolerance induction: guided not misguided missiles. Trends Immunol 22:437-442, 2001
5. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 392:245-252, 1998
6. Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DH, Thomson AW: Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 158:5676-5684, 1997
7. Coates PT, Colvin BL, Kaneko K, Taner T, Thomson AW: Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity. Transplantation 75:32S-36S, 2003
8. Mellor AL, Munn DH: IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762-774, 2004
9. Mellor AL, Chandler P, Baban B, Hansen AM, Marshall B, Pihkala J, Waldmann H, Cobbold S, Adams E, Munn DH: Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 16:1391-1401, 2004
10. Munn DH, Sharma MD, Hou D, Baban B, Lee JR, Antonia SJ, Messina JL, Chandler P, Koni PA, Mellor AL: Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest 114:280-290, 2004
11. Munn DH, Sharma MD, Mellor AL: Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 172:4100-4110, 2004
12. Mellor AL, Baban B, Chandler P, Marshall B, Jhaver K, Hansen A, Koni PA, Iwashima M, Munn DH: Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 171:1652-1655, 2003
13. Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, Marshall B, Chandler P, Antonia SJ, Burgess R, Slingluff CL Jr, Mellor AL: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297:1867-1870, 2002
14. Fallarino F, Vacca C, Orabona C, Belladonna ML, Bianchi R, Marshall B, Keskin DB, Mellor AL, Fioretti MC, Grohmann U, Puccetti P: Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. Int Immunol 14:65-68, 2002
15. Fan Z, Huang XL, Borowski L, Mellors JW, Rinaldo CR Jr: Restoration of anti-human immunodeficiency virus type 1 (HIV-1) responses in CD8+ T cells from late-stage patients on prolonged antiretroviral therapy by stimulation in vitro with HIV-1 protein-loaded dendritic cells. J Virol 75:4413-4419, 2001
16. Yamazaki S, Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, Steinman RM: Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 198:235-247, 2003
17. Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM: CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 199:1467-1477, 2004
18. Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT: Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol 173:7249-7258, 2004
19. Gad M, Kristensen NN, Kury E, Claesson MH: Characterization of T-regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen-reactive colitis-inducing T-cell responses in vitro and in vivo. Immunology 113:499-508, 2004
20. Moseman EA, Liang X, Dawson AJ, Panoskaltsis-Mortari A, Krieg AM, Liu YJ, Blazar BR, Chen W: Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol 173:4433-4442, 2004
21. Rutella S, Lemoli RM: Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications. Immunol Lett 94:11-26, 2004
22. Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB: In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104:453-461, 2004
23. Oldenhove G, de Heusch M, Urbain-Vansanten G, Urbain J, Maliszewski C, Leo O, Moser M: CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J Exp Med 198:259-266, 2003
24. Min WP, Zhou D, Ichim TE, Strejan GH, Xia X, Yang J, Huang X, Garcia B, White D, Dutartre P, Jevnikar AM, Zhong R: Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 170:1304-1312, 2003
25. Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N: Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 173:4331-4341, 2004
26. Fry TJ, Mackall CL: Interleukin-7: from bench to clinic. Blood 99:3892-3904, 2002
27. Fry TJ, Connick E, Falloon J, Lederman MM, Liewehr DJ, Spritzler J, Steinberg SM, Wood LV, Yarchoan R, Zuckerman J, Landay A, Mackall CL: A potential role for interleukin-7 in T-cell homeostasis. Blood 97:2983-2990, 2001
28. Fry TJ, Mackall CL: Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol 22:564-571, 2001
29. Jaleco S, Kinet S, Hassan J, Dardalhon V, Swainson L, Reen D, Taylor N: IL-7 and CD4+ T-cell proliferation. Blood 100:4676-4677 [author reply 4677-4678, 2002]
30. Geiselhart LA, Humphries CA, Gregorio TA, Mou S, Subleski J, Komschlies KL: IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation. J Immunol 166:3019-3027, 2001
31. Gringhuis SI, de Leij LF, Verschuren EW, Borger P, Vellenga E: Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Blood 90:2690-2700, 1997
32. Costello R, Brailly H, Mallet F, Mawas C, Olive D: Interleukin-7 is a potent co-stimulus of the adhesion pathway involving CD2 and CD28 molecules. Immunology 80:451-457, 1993
33. Chazen GD, Pereira GM, LeGros G, Gillis S, Shevach EM: Interleukin 7 is a T-cell growth factor. Proc Natl Acad Sci U S A 86:5923-5927, 1989
34. Borger P, Kauffman HF, Postma DS, Vellenga E: IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms. J Immunol 156:1333-1338, 1996
35. Mehrotra PT, Grant AJ, Siegel JP: Synergistic effects of IL-7 and IL-12 on human T cell activation. J Immunol 154:5093-5102, 1995
36. Schober SL, Kuo CT, Schluns KS, Lefrancois L, Leiden JM, Jameson SC: Expression of the transcription factor lung Kruppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. J Immunol 163:3662-3667, 1999
37. Lynch DH, Miller RE: Interleukin 7 promotes long-term in vitro growth of antitumor cytotoxic T lymphocytes with immunotherapeutic efficacy in vivo. J Exp Med 179:31-42, 1994
38. Ku CC, Murakami M, Sakamoto A, Kappler J, Marrack P: Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288:675-678, 2000
39. Fry TJ, Christensen BL, Komschlies KL, Gress RE, Mackall CL: Interleukin-7 restores immunity in athymic T-cell-depleted hosts. Blood 97:1525-1533, 2001
40. Boise LH, Minn AJ, June CH, Lindsten T, Thompson CB: Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division. Proc Natl Acad Sci U S A 92:5491-5495, 1995
41. Vella AT, Dow S, Potter TA, Kappler J, Marrack P: Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A 95:3810-3815, 1998
42. Furtado GC, Curotto de Lafaille MA, Kutchukhidze N, Lafaille JJ: Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med 196:851-857, 2002
43. Almeida AR, Legrand N, Papiernik M, Freitas AA: Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169:4850-4860, 2002
44. Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D: Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11:281-288, 1999
45. Nelson BH, Willerford DM: Biology of the interleukin-2 receptor. Adv Immunol 70:1-81, 1998
46. Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN: Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249-259, 1999
47. Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN: Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11:225-230, 1999
48. Snow JW, Abraham N, Ma MC, Herndier BG, Pastuszak AW, Goldsmith MA: Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J Immunol 171:5042-5050, 2003
49. Burchill MA, Goetz CA, Prlic M, O'Neil JJ, Harmon IR, Bensinger SJ, Turka LA, Brennan P, Jameson SC, Farrar MA: Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol 171:5853-5864, 2003
50. Goetz CA, Harmon IR, O'Neil JJ, Burchill MA, Farrar MA: STAT5 activation underlies IL7 receptor-dependent B cell development. J Immunol 172:4770-4778, 2004
51. Stanton ML, Brodeur PH: Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene. J Immunol 174:3164-3168, 2005
52. Xue HH, Kovanen PE, Pise-Masison CA, Berg M, Radovich MF, Brady JN, Leonard WJ: IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci U S A 99:13759-13764, 2002
53. Ye SK, Agata Y, Lee HC, Kurooka H, Kitamura T, Shimizu A, Honjo T, Ikuta K: The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. Immunity 15:813-823, 2001
54. Sato AK, Yanai N, Okubo T, Mori KJ, Obinata M: Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells. Cell Struct Funct 26:95-101, 2001
55. Leonard WJ, Imada K, Nakajima H, Puel A, Soldaini E, John S: Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus. Cold Spring Harb Symp Quant Biol 64:417-424, 1999
56. Rosenthal LA, Winestock KD, Finbloom DS: IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts. Cell Immunol 181:172-181, 1997
57. Foxwell BM, Beadling C, Guschin D, Kerr I, Cantrell D: Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells. Eur J Immunol 25:3041-3046, 1995
58. Giannoukakis N, Bonham CA, Qian S, Zhou Z, Peng L, Harnaha J, Li W, Thomson AW, Fung JJ, Robbins PD, Lu L: Prolongation of cardiac allograft survival using dendritic cells treated with NF-kappaB decoy oligodeoxyribonucleotides. Mol Ther 1:430-437, 2000
59. Yeoman H, Clark DR, DeLuca D: Development of CD4 and CD8 single positive T cells in human thymus organ culture: IL-7 promotes human T cell production by supporting immature T cells. Dev Comp Immunol 20:241-263, 1996
60. Hassan J, Reen DJ: IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur J Immunol 28:3057-3065, 1998
61. Li J, Huston G, Swain SL: IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med 198:1807-1815, 2003
62. Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H: Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proc Natl Acad Sci U S A 93:3613-3618, 1996
63. Kroncke R, Loppnow H, Flad HD, Gerdes J: Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol 26:2541-2544, 1996
64. Sorg RV, McLellan AD, Hock BD, Fearnley DB, Hart DN: Human dendritic cells express functional interleukin-7. Immunobiology 198:514-526, 1998
65. Varas A, Vicente A, Sacedon R, Zapata AG: Interleukin-7 influences the development of thymic dendritic cells. Blood 92:93-100, 1998
66. Li L, Masucci MG, Levitsky V: Effect of interleukin-7 on the in vitro development and maturation of monocyte derived human dendritic cells. Scand J Immunol 51:361-371, 2000
67. Gombert JM, Herbelin A, Tancrede-Bohin E, Dy M, Carnaud C, Bach JF: Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse. Eur J Immunol 26:2989-2998, 1996
68. Herbelin A, Gombert JM, Lepault F, Bach JF, Chatenoud L: Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J Immunol 161:2620-2628, 1998
69. Lin CH, Hunig T: Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol 33:626-638, 2003
70. Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M: Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 104:895-903, 2004
71. Huber S, Schramm C, Lehr HA, Mann A, Schmitt S, Becker C, Protschka M, Galle PR, Neurath MF, Blessing M: Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol 173:6526-6531, 2004
72. Fu S, Zhang N, Yopp AC, Chen D, Mao M, Zhang H, Ding Y, Bromberg JS: TGF-beta induces Foxp3+ T-regulatory cells from CD4+ CD25- precursors. Am J Transplant 4:1614-1627, 2004
73. Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA: In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199:1455-1465, 2004