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Volumn 30, Issue , 1996, Pages 343-370

Human type 1 diabetes and the insulin gene: Principles of mapping polygenes

Author keywords

human insulin gene; IDDM2; minisatellite; multifactorial disease; VNTR

Indexed keywords

DNA MINISATELLITE; INSULIN;

EID: 0030444451     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.30.1.343     Document Type: Review
Times cited : (263)

References (100)
  • 1
    • 0024453932 scopus 로고
    • Polymorphism in the 5′-flanking region of the insulin gene and its potential relation to cardiovascular disease risk: Observations in a biracial community
    • Amos C, Cohen J, Srinivasan S, Freedman D, Elston R, Berensen G. 1989. Polymorphism in the 5′-flanking region of the insulin gene and its potential relation to cardiovascular disease risk: observations in a biracial community. Atherosclerosis 79:51-57
    • (1989) Atherosclerosis , vol.79 , pp. 51-57
    • Amos, C.1    Cohen, J.2    Srinivasan, S.3    Freedman, D.4    Elston, R.5    Berensen, G.6
  • 2
    • 0027971691 scopus 로고
    • MAZ-dependent termination between closely spaced human complement genes
    • Ashfield R, Patel AJ, Bossone SA, Brown H, Campbell RD, et al. 1994. MAZ-dependent termination between closely spaced human complement genes. EMBO J. 13:5656-67
    • (1994) EMBO J. , vol.13 , pp. 5656-5667
    • Ashfield, R.1    Patel, A.J.2    Bossone, S.A.3    Brown, H.4    Campbell, R.D.5
  • 3
    • 17644447822 scopus 로고
    • Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals
    • Bain SC, Prins JB, Hearne CM, Rodrigues NR, Rowe BR, et al. 1992. Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nat. Genet. 2:212-15
    • (1992) Nat. Genet. , vol.2 , pp. 212-215
    • Bain, S.C.1    Prins, J.B.2    Hearne, C.M.3    Rodrigues, N.R.4    Rowe, B.R.5
  • 4
    • 0029587022 scopus 로고
    • Gametic imprinting in mammals
    • Barlow DP. 1995. Gametic imprinting in mammals. Science 270:1610-13
    • (1995) Science , vol.270 , pp. 1610-1613
    • Barlow, D.P.1
  • 6
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. 1984. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33:176-83
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 7
    • 0345128844 scopus 로고
    • Polymorphic DNA region adjacent to the 5′ end of the human insulin gene
    • Bell GI, Karam JH, Rutter WJ. 1981. Polymorphic DNA region adjacent to the 5′ end of the human insulin gene. Proc. Natl. Acad. Sci. USA 78:5759-63
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 5759-5763
    • Bell, G.I.1    Karam, J.H.2    Rutter, W.J.3
  • 9
    • 0020080870 scopus 로고
    • The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
    • Bell GI, Selby MJ, Rutter WJ. 1982. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature 295:31-35
    • (1982) Nature , vol.295 , pp. 31-35
    • Bell, G.I.1    Selby, M.J.2    Rutter, W.J.3
  • 10
    • 0011936942 scopus 로고    scopus 로고
    • Fluorescence-based PCR for dissecting human disease genetics: Identification of insulin gene minisatellite alleles
    • ed. JF Burke, Oxford: BIOS Sci. Publ.
    • Bennett ST, Lucassen AM, Todd JA. 1996. Fluorescence-based PCR for dissecting human disease genetics: identification of insulin gene minisatellite alleles. In PCR: Essential Techniques, ed. JF Burke, pp. 31-33. Oxford: BIOS Sci. Publ.
    • (1996) PCR: Essential Techniques , pp. 31-33
    • Bennett, S.T.1    Lucassen, A.M.2    Todd, J.A.3
  • 12
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett ST, Lucassen AM, Gough SCL, Powell EE, Undlien DE, et al. 1995. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat. Genet. 9:284-92
    • (1995) Nat. Genet. , vol.9 , pp. 284-292
    • Bennett, S.T.1    Lucassen, A.M.2    Gough, S.C.L.3    Powell, E.E.4    Undlien, D.E.5
  • 13
    • 0001017310 scopus 로고    scopus 로고
    • IDDM2-VNTR-encoded susceptibility to type 1 diabetes: Dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus
    • Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, et al. 1996. IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus. J. Autoimmun. 9:415-21
    • (1996) J. Autoimmun. , vol.9 , pp. 415-421
    • Bennett, S.T.1    Wilson, A.J.2    Cucca, F.3    Nerup, J.4    Pociot, F.5
  • 14
    • 0024232010 scopus 로고
    • Polymorphism at the 5′ end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals
    • Coccoza S, Riccardi G, Monticelli A, Capaldo B, Genovese S, et al. 1988. Polymorphism at the 5′ end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals. Eur. J. Clin. Invest. 18:582-86
    • (1988) Eur. J. Clin. Invest. , vol.18 , pp. 582-586
    • Coccoza, S.1    Riccardi, G.2    Monticelli, A.3    Capaldo, B.4    Genovese, S.5
  • 15
    • 0028829170 scopus 로고
    • Multifactorial inheritance in type 1 diabetes
    • Cordell HJ, Todd JA. 1995. Multifactorial inheritance in type 1 diabetes. Trends Genet. 11:499-504
    • (1995) Trends Genet. , vol.11 , pp. 499-504
    • Cordell, H.J.1    Todd, J.A.2
  • 16
    • 0029112753 scopus 로고
    • Two-locus maximum lod score analysis of a multifactorial trait: Joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes
    • Cordell HJ, Todd JA, Bennett ST, Kawaguchi Y, Farrall M. 1995. Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. Am. J. Hum. Genet. 57:920-34
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 920-934
    • Cordell, H.J.1    Todd, J.A.2    Bennett, S.T.3    Kawaguchi, Y.4    Farrall, M.5
  • 17
    • 0023928708 scopus 로고
    • Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: No evidence for linkage
    • Cox NJ, Baker L. Spielman RS. 1988. Insulin-gene sharing in sib pairs with insulin-dependent diabetes mellitus: no evidence for linkage. Am. J. Hum. Genet. 42:167-72
    • (1988) Am. J. Hum. Genet. , vol.42 , pp. 167-172
    • Cox, N.J.1    Baker, L.2    Spielman, R.S.3
  • 18
    • 0024517006 scopus 로고
    • The insulin gene and susceptibility to IDDM
    • Cox NJ, Spielman RS. 1989. The insulin gene and susceptibility to IDDM. Genet. Epidemiol. 6:65-69
    • (1989) Genet. Epidemiol. , vol.6 , pp. 65-69
    • Cox, N.J.1    Spielman, R.S.2
  • 19
    • 0002189416 scopus 로고    scopus 로고
    • HLA susceptibility to type 1 diabetes: Methods and mechanisms
    • eds. MJ Browning, AJM McMichael, Oxford: BIOS Sci. Publ.
    • Cucca F, Todd JA. 1996. HLA susceptibility to type 1 diabetes: methods and mechanisms. In HLA/MHC: Genes, Molecules and Function, eds. MJ Browning, AJM McMichael, pp. 383-406. Oxford: BIOS Sci. Publ.
    • (1996) HLA/MHC: Genes, Molecules and Function , pp. 383-406
    • Cucca, F.1    Todd, J.A.2
  • 21
    • 13344259999 scopus 로고    scopus 로고
    • A comprehensive genetic map of the human genome based on 5264 microsatellites
    • Dib C, Faure S, Fizames C, Samson D, Drouot N, et al. 1996. A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 380:152-54
    • (1996) Nature , vol.380 , pp. 152-154
    • Dib, C.1    Faure, S.2    Fizames, C.3    Samson, D.4    Drouot, N.5
  • 22
    • 0022921742 scopus 로고
    • DNA polymorphic haplotypes on the short arm of chromosome 11 and the inheritance of type 1 diabetes mellitus
    • Ferns GAA, Hitman GA, Trembath R, Williams L, Tarn A, et al. 1986. DNA polymorphic haplotypes on the short arm of chromosome 11 and the inheritance of type 1 diabetes mellitus. J. Med. Genet. 23:210-16
    • (1986) J. Med. Genet. , vol.23 , pp. 210-216
    • Ferns, G.A.A.1    Hitman, G.A.2    Trembath, R.3    Williams, L.4    Tarn, A.5
  • 23
    • 0025830842 scopus 로고
    • Non-HLA region genes in insulin dependent diabetes mellitus
    • Field LL. 1991. Non-HLA region genes in insulin dependent diabetes mellitus. Bailliere's Clin. Endocrinol. Metab. 5:413-38
    • (1991) Bailliere's Clin. Endocrinol. Metab. , vol.5 , pp. 413-438
    • Field, L.L.1
  • 26
    • 0026562971 scopus 로고
    • Incidence of childhood-onset insulin-dependent diabetes mellitus: The EURODIAB ACE study
    • Green A, Gale EA, Patterson CC. 1992. Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE study. Lancet 339:905-9
    • (1992) Lancet , vol.339 , pp. 905-909
    • Green, A.1    Gale, E.A.2    Patterson, C.C.3
  • 27
    • 0019827947 scopus 로고
    • Localization of the human insulin gene to the distal end of the short arm of chromosome 11
    • Harper ME, Ullrich A, Saunders GF. 1981. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proc. Natl. Acad. Sci. USA 78:4458-60
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 4458-4460
    • Harper, M.E.1    Ullrich, A.2    Saunders, G.F.3
  • 28
    • 0028070552 scopus 로고
    • Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
    • Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, et al. 1994. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371:161-64
    • (1994) Nature , vol.371 , pp. 161-164
    • Hashimoto, L.1    Habita, C.2    Beressi, J.P.3    Delepine, M.4    Besse, C.5
  • 29
    • 0028587166 scopus 로고
    • The genetics of Wilms' tumor - A case of disrupted development
    • Hastie ND. 1994. The genetics of Wilms' tumor - a case of disrupted development. Annu. Rev. Genet. 28:523-58
    • (1994) Annu. Rev. Genet. , vol.28 , pp. 523-558
    • Hastie, N.D.1
  • 30
    • 0026780282 scopus 로고
    • Microsatellites for linkage analysis of genetic traits
    • Hearne CM, Ghosh S, Todd JA. 1992. Microsatellites for linkage analysis of genetic traits. Trends Genet. 8:288-94
    • (1992) Trends Genet. , vol.8 , pp. 288-294
    • Hearne, C.M.1    Ghosh, S.2    Todd, J.A.3
  • 31
  • 32
    • 0021847489 scopus 로고
    • Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11
    • Hitman GA, Tarn AC, Winter RM, Drummond V, Williams LG, et al. 1985. Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11. Diabetologia 28:218-22
    • (1985) Diabetologia , vol.28 , pp. 218-222
    • Hitman, G.A.1    Tarn, A.C.2    Winter, R.M.3    Drummond, V.4    Williams, L.G.5
  • 33
    • 8044233453 scopus 로고
    • Autoimmune diabetes assessed by ICA, anti-GAD and DR3/4 in population based cohort of patients with NIDDM
    • Abstr.
    • Horton V, Stratton I, Zimmet P, Mackay I, Bottazzo F, et al. 1995. Autoimmune diabetes assessed by ICA, anti-GAD and DR3/4 in population based cohort of patients with NIDDM. Diabetes 44:236A (Abstr.)
    • (1995) Diabetes , vol.44
    • Horton, V.1    Stratton, I.2    Zimmet, P.3    Mackay, I.4    Bottazzo, F.5
  • 34
    • 0028301977 scopus 로고
    • T-cell tolerance toward a transgenic β-cell antigen and transcription of the endogenous pancreatic genes in thymus
    • Jolicoeur C, Hanahan D, Smith KM. 1994. T-cell tolerance toward a transgenic β-cell antigen and transcription of the endogenous pancreatic genes in thymus. Proc. Natl. Acad. Sci. USA 91:6707-11
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6707-6711
    • Jolicoeur, C.1    Hanahan, D.2    Smith, K.M.3
  • 35
    • 0021220967 scopus 로고
    • Diabetic hypertriglyceridaemia and related 5′ flanking polymorphism of the human insulin gene
    • Jowett NI, Williams LG, Hitman GA, Galton DJ. 1984. Diabetic hypertriglyceridaemia and related 5′ flanking polymorphism of the human insulin gene. Br. Med. J. 288:96-99
    • (1984) Br. Med. J. , vol.288 , pp. 96-99
    • Jowett, N.I.1    Williams, L.G.2    Hitman, G.A.3    Galton, D.J.4
  • 36
    • 0025995836 scopus 로고
    • Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DA4-dependent diabetes susceptibility
    • Julier C, Hyer RN, Davies J, Merlin F, Soularu P, et al. 1991. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DA4-dependent diabetes susceptibility. Nature 354: 155-59
    • (1991) Nature , vol.354 , pp. 155-159
    • Julier, C.1    Hyer, R.N.2    Davies, J.3    Merlin, F.4    Soularu, P.5
  • 37
    • 0027944781 scopus 로고
    • Multiple DNA variant association analysis: Application to the insulin gene region in type 1 diabetes
    • Julier C, Lucassen A, Villedieu P, Delepine M, Levy-Marchal C, et al. 1994. Multiple DNA variant association analysis: application to the insulin gene region in type 1 diabetes. Am. J. Hum. Genet. 55:1247-54
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 1247-1254
    • Julier, C.1    Lucassen, A.2    Villedieu, P.3    Delepine, M.4    Levy-Marchal, C.5
  • 38
    • 0026352162 scopus 로고
    • Report of the committee on the genetic constitution of chromosome 11
    • Junien C, van Heyningen V. 1991. Report of the committee on the genetic constitution of chromosome 11. Cytogenet. Cell Genet. 58:459-54
    • (1991) Cytogenet. Cell Genet. , vol.58 , pp. 459-554
    • Junien, C.1    Van Heyningen, V.2
  • 40
    • 0027500910 scopus 로고
    • A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus
    • Karvonen M, Tuomilehto J, Libman I, La-Porte R. 1993. A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36:883-92
    • (1993) Diabetologia , vol.36 , pp. 883-892
    • Karvonen, M.1    Tuomilehto, J.2    Libman, I.3    La-Porte, R.4
  • 41
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
    • Kennedy CG, German MS, Rutter WJ. 1995. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat. Genet. 9:293-98
    • (1995) Nat. Genet. , vol.9 , pp. 293-298
    • Kennedy, C.G.1    German, M.S.2    Rutter, W.J.3
  • 42
    • 0029157488 scopus 로고
    • Minisatellites and human disease
    • Krontiris TG. 1995. Minisatellites and human disease. Science 269:1682-83
    • (1995) Science , vol.269 , pp. 1682-1683
    • Krontiris, T.G.1
  • 43
    • 0027214689 scopus 로고
    • An association between the risk of cancer and mutations in the HRAS1 minisatellite locus
    • Krontiris TG, Devlin B, Karp DD, Robert NJ, Risch N. 1993. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N. Engl. J. Med. 329:517-23
    • (1993) N. Engl. J. Med. , vol.329 , pp. 517-523
    • Krontiris, T.G.1    Devlin, B.2    Karp, D.D.3    Robert, N.J.4    Risch, N.5
  • 44
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241-47
    • (1995) Nat. Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 46
    • 0022473107 scopus 로고
    • High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients
    • Lidereau R, Escot C, Theillet C, Champeme M-H, Brunet M, et al. 1986. High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients. J. Natl. Cancer Inst. 77: 697-701
    • (1986) J. Natl. Cancer Inst. , vol.77 , pp. 697-701
    • Lidereau, R.1    Escot, C.2    Theillet, C.3    Champeme, M.-H.4    Brunet, M.5
  • 48
    • 0027200763 scopus 로고
    • Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
    • Lucassen AM, Julier C, Beressi J-P, Boitard C, Froguel P, et al. 1993. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat. Genet. 4:305-10
    • (1993) Nat. Genet. , vol.4 , pp. 305-310
    • Lucassen, A.M.1    Julier, C.2    Beressi, J.-P.3    Boitard, C.4    Froguel, P.5
  • 50
    • 0242580346 scopus 로고
    • Linkage of the insulin gene (INS) with insulin-dependent (IDD) in Caucasians suggest a maternal imprinting effect
    • Ma Bui M, Muir A, Maclaren N, She J-X. 1993. Linkage of the insulin gene (INS) with insulin-dependent (IDD) in Caucasians suggest a maternal imprinting effect. Diabetes 42 (Suppl. 1):63A
    • (1993) Diabetes , vol.42 , Issue.1 SUPPL.
    • Ma Bui, M.1    Muir, A.2    Maclaren, N.3    She, J.-X.4
  • 52
    • 0028859447 scopus 로고
    • Insulin gene 5′ flanking polymorphism: Length of class I alleles in number of repeat units
    • McGinnis RE, Spielman RS. 1995. Insulin gene 5′ flanking polymorphism: length of class I alleles in number of repeat units. Diabetes 44:1296-302
    • (1995) Diabetes , vol.44 , pp. 1296-1302
    • McGinnis, R.E.1    Spielman, R.S.2
  • 54
    • 0025609150 scopus 로고
    • Allelic variants at insulin-receptor and insulin gene loci and susceptibility to NIDDM in Welsh population
    • Morgan R, Bishop A, Owens DR, Luzio SD, Peters JR, Rees A. 1990. Allelic variants at insulin-receptor and insulin gene loci and susceptibility to NIDDM in Welsh population. Diabetes 39:1479-84
    • (1990) Diabetes , vol.39 , pp. 1479-1484
    • Morgan, R.1    Bishop, A.2    Owens, D.R.3    Luzio, S.D.4    Peters, J.R.5    Rees, A.6
  • 55
    • 0020569338 scopus 로고
    • Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system
    • Morton NE, Green A, Dunsworth T, Svejgaard A, Barbosa J, et al. 1983. Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system. Am. J. Hum. Genet. 35:201-13
    • (1983) Am. J. Hum. Genet. , vol.35 , pp. 201-213
    • Morton, N.E.1    Green, A.2    Dunsworth, T.3    Svejgaard, A.4    Barbosa, J.5
  • 57
    • 0022515556 scopus 로고
    • High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes
    • Nomura M, Iwama N, Mukai M, Saito Y, Kawamori R, et al. 1986. High frequency of class 3 allele in the human insulin gene in Japanese type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes. Diabetologia 29:402-4
    • (1986) Diabetologia , vol.29 , pp. 402-404
    • Nomura, M.1    Iwama, N.2    Mukai, M.3    Saito, Y.4    Kawamori, R.5
  • 58
    • 0027285258 scopus 로고
    • Relaxation of insulin-like growth factor II gene imprinting in Wilms tumour
    • Ogawa O, Eccles MR, Szeto J, McNoe LA, Yun K, et al. 1993. Relaxation of insulin-like growth factor II gene imprinting in Wilms tumour. Nature 362: 749-51
    • (1993) Nature , vol.362 , pp. 749-751
    • Ogawa, O.1    Eccles, M.R.2    Szeto, J.3    McNoe, L.A.4    Yun, K.5
  • 59
    • 0021745142 scopus 로고
    • Analysis of a 1963-bp polymorphic region flanking the human insulin gene
    • Owerbach D, Aagaard L. 1984. Analysis of a 1963-bp polymorphic region flanking the human insulin gene. Gene 32:475-79
    • (1984) Gene , vol.32 , pp. 475-479
    • Owerbach, D.1    Aagaard, L.2
  • 60
    • 0019456804 scopus 로고
    • The insulin gene is located on the short arm of chromosome 11 in humans
    • Owerbach D, Bell GI, Rutter WJ, Brown JA, Shows TB. 1981. The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes 30:267-70
    • (1981) Diabetes , vol.30 , pp. 267-270
    • Owerbach, D.1    Bell, G.I.2    Rutter, W.J.3    Brown, J.A.4    Shows, T.B.5
  • 61
    • 0019222367 scopus 로고
    • The insulin gene is located on chromosome 11 in humans
    • Owerbach D, Bell GI, Rutter WJ, Shows TB. 1980. The insulin gene is located on chromosome 11 in humans. Nature 286:82-84
    • (1980) Nature , vol.286 , pp. 82-84
    • Owerbach, D.1    Bell, G.I.2    Rutter, W.J.3    Shows, T.B.4
  • 62
    • 0020027343 scopus 로고
    • DNA insertion sequences near the insulin gene affect glucose regulation
    • Owerbach D, Billesbolle P, Poulsen S, Nerup J. 1982. DNA insertion sequences near the insulin gene affect glucose regulation. Lancet 1:880-83
    • (1982) Lancet , vol.1 , pp. 880-883
    • Owerbach, D.1    Billesbolle, P.2    Poulsen, S.3    Nerup, J.4
  • 63
    • 0027333071 scopus 로고
    • Localization of a Type 1 diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene
    • Owerbach D, Gabbay KH. 1993. Localization of a Type 1 diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene. Diabetes 42:1708-14
    • (1993) Diabetes , vol.42 , pp. 1708-1714
    • Owerbach, D.1    Gabbay, K.H.2
  • 64
    • 0029987192 scopus 로고    scopus 로고
    • The search for IDDM susceptibility genes: The next generation
    • Owerbach D, Gabbay KH. 1996. The search for IDDM susceptibility genes: the next generation. Diabetes 45:544-51
    • (1996) Diabetes , vol.45 , pp. 544-551
    • Owerbach, D.1    Gabbay, K.H.2
  • 65
    • 0025650585 scopus 로고
    • Multigenic basis for type 1 diabetes: Association of HRAS1 polymorphism with HLA-DA3, DQw2/DR4, DQw8
    • Owerbach D, Gunn S, Gabbay KH. 1990. Multigenic basis for type 1 diabetes: association of HRAS1 polymorphism with HLA-DA3, DQw2/DR4, DQw8. Diabetes 39:1504-9
    • (1990) Diabetes , vol.39 , pp. 1504-1509
    • Owerbach, D.1    Gunn, S.2    Gabbay, K.H.3
  • 66
    • 0020073179 scopus 로고
    • Restriction fragment length polymorphism of the insulin gene in diabetes mellitus
    • Owerbach D, Nerup J. 1982. Restriction fragment length polymorphism of the insulin gene in diabetes mellitus. Diabetes 31:275-77
    • (1982) Diabetes , vol.31 , pp. 275-277
    • Owerbach, D.1    Nerup, J.2
  • 67
    • 0021943651 scopus 로고
    • Islet β-cell function and polymorphism in the 5′-flanking region of the human insulin gene
    • Permutt MA, Rotwein P, Andreone T, Ward WK, Porte D. 1985. Islet β-cell function and polymorphism in the 5′-flanking region of the human insulin gene. Diabetes 34:311-14
    • (1985) Diabetes , vol.34 , pp. 311-314
    • Permutt, M.A.1    Rotwein, P.2    Andreone, T.3    Ward, W.K.4    Porte, D.5
  • 68
    • 13344268996 scopus 로고    scopus 로고
    • Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus
    • Phelan CM, Rebbeck TR, Weber BL, Devilee P, Ruttledge MH, et al. 1996. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nat. Genet. 12:309-11
    • (1996) Nat. Genet. , vol.12 , pp. 309-311
    • Phelan, C.M.1    Rebbeck, T.R.2    Weber, B.L.3    Devilee, P.4    Ruttledge, M.H.5
  • 69
    • 13344261391 scopus 로고    scopus 로고
    • Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
    • Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, et al. 1996. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat. Genet. 12:241-47
    • (1996) Nat. Genet. , vol.12 , pp. 241-247
    • Pilia, G.1    Hughes-Benzie, R.M.2    MacKenzie, A.3    Baybayan, P.4    Chen, E.Y.5
  • 70
    • 0028868872 scopus 로고
    • Imprinting of IGF2, insulin-dependent diabetes, immune function, and apoptosis: A hypothesis
    • Polychronakos C, Giannoukakis N, Deal CL. 1995. Imprinting of IGF2, insulin-dependent diabetes, immune function, and apoptosis: a hypothesis. Dev. Genet. 17:253-62
    • (1995) Dev. Genet. , vol.17 , pp. 253-262
    • Polychronakos, C.1    Giannoukakis, N.2    Deal, C.L.3
  • 71
    • 0029074963 scopus 로고
    • Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus
    • Polychronakos C, Kukuvitis A, Giannoukakis N, Colle E. 1995. Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus. Diabetologia 38:715-19
    • (1995) Diabetologia , vol.38 , pp. 715-719
    • Polychronakos, C.1    Kukuvitis, A.2    Giannoukakis, N.3    Colle, E.4
  • 72
    • 0028151268 scopus 로고
    • The paternally inherited insulin gene B allele (1,428 Fokl site) confers protection from insulin-dependent diabetes in families
    • Pugliese A, Awdeh ZL, Alper CA, Jackson RA, Eisenbarth GS. 1994. The paternally inherited insulin gene B allele (1,428 Fokl site) confers protection from insulin-dependent diabetes in families. J. Autoimmun. 7:687-94
    • (1994) J. Autoimmun. , vol.7 , pp. 687-694
    • Pugliese, A.1    Awdeh, Z.L.2    Alper, C.A.3    Jackson, R.A.4    Eisenbarth, G.S.5
  • 73
    • 0029584717 scopus 로고
    • The INS B allele (1,428 FokI) is associated with reduced IDDM incidence in autoantibody-positive first degree relatives despite the presence of autoantibodies and high-risk HLA alleles
    • Pugliese A, Awdeh ZL, Alper CA, Jackson RA, Eisenbarth GS. 1995. The INS B allele (1,428 FokI) is associated with reduced IDDM incidence in autoantibody-positive first degree relatives despite the presence of autoantibodies and high-risk HLA alleles. Transplant. Proc. 27:3392
    • (1995) Transplant. Proc. , vol.27 , pp. 3392
    • Pugliese, A.1    Awdeh, Z.L.2    Alper, C.A.3    Jackson, R.A.4    Eisenbarth, G.S.5
  • 74
    • 0012003525 scopus 로고
    • Monoallelic expression of the insulin gene message in the human thymus provides additional evidence for parental imprinting
    • Pugliese A, Fernandez A, Bartlett RJ, Eisenbarth GS, Ricordi C, et al. 1995. Monoallelic expression of the insulin gene message in the human thymus provides additional evidence for parental imprinting. Autoimmunity 21:15
    • (1995) Autoimmunity , vol.21 , pp. 15
    • Pugliese, A.1    Fernandez, A.2    Bartlett, R.J.3    Eisenbarth, G.S.4    Ricordi, C.5
  • 76
    • 0028240980 scopus 로고
    • Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping
    • Reed PW, Davies JL, Copeman JB, Bennett ST, Palmer SM, et al. 1994. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nat. Genet. 7:390-95
    • (1994) Nat. Genet. , vol.7 , pp. 390-395
    • Reed, P.W.1    Davies, J.L.2    Copeman, J.B.3    Bennett, S.T.4    Palmer, S.M.5
  • 77
    • 0023135007 scopus 로고
    • Assessing the role of HLA-linked and unlinked determinants of disease
    • Risch N. 1987. Assessing the role of HLA-linked and unlinked determinants of disease. Am. J. Hum. Genet. 40:1-14
    • (1987) Am. J. Hum. Genet. , vol.40 , pp. 1-14
    • Risch, N.1
  • 78
    • 37049186659 scopus 로고
    • Polymorphism in the 5′-flanking region of the human insulin gene and its possible relation to type 2 diabetes
    • Rotwein P, Chyn R, Chirgwin J, Cordell B, Goodman HM, Permutt MA. 1981. Polymorphism in the 5′-flanking region of the human insulin gene and its possible relation to type 2 diabetes. Science 213:1117-20
    • (1981) Science , vol.213 , pp. 1117-1120
    • Rotwein, P.1    Chyn, R.2    Chirgwin, J.3    Cordell, B.4    Goodman, H.M.5    Permutt, M.A.6
  • 79
    • 0022968867 scopus 로고
    • Genetic analysis of the hypervariable region flanking the human insulin gene
    • Rotwein P, Yokoyama S, Didier DK, Chirgwin JM. 1986. Genetic analysis of the hypervariable region flanking the human insulin gene. Hum. Genet. 39:291-99
    • (1986) Hum. Genet. , vol.39 , pp. 291-299
    • Rotwein, P.1    Yokoyama, S.2    Didier, D.K.3    Chirgwin, J.M.4
  • 80
    • 0020664519 scopus 로고
    • Polymorphism in the 5′ flanking region of the human insulin gene: A genetic marker for non-insulin-dependent diabetes
    • Rotwein PS, Chirgwin J, Province M, Knowler WC, Pettitt DJ, et al. 1983. Polymorphism in the 5′ flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes. N. Engl. J. Med. 308:65-71
    • (1983) N. Engl. J. Med. , vol.308 , pp. 65-71
    • Rotwein, P.S.1    Chirgwin, J.2    Province, M.3    Knowler, W.C.4    Pettitt, D.J.5
  • 81
    • 0026605981 scopus 로고
    • Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys
    • Seino S, Bell GI, Li W-H. 1992. Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Mol. Biol. Evol. 9:193-203
    • (1992) Mol. Biol. Evol. , vol.9 , pp. 193-203
    • Seino, S.1    Bell, G.I.2    Li, W.-H.3
  • 82
    • 0023443205 scopus 로고
    • Sequence of a New World primate insulin having low biological potency and immunoreactivity
    • Seino S, Steiner DI, Bell GI. 1987. Sequence of a New World primate insulin having low biological potency and immunoreactivity. Proc. Natl. Acad. Sci. USA 84:7423-27
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7423-7427
    • Seino, S.1    Steiner, D.I.2    Bell, G.I.3
  • 83
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:506-16
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 84
    • 0028356544 scopus 로고
    • Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour
    • Steenman MJ, Rainier S, Dobry CJ, Grundy P, Horon IL, Feinberg AP. 1994. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour. Nat. Genet. 7:433-39
    • (1994) Nat. Genet. , vol.7 , pp. 433-439
    • Steenman, M.J.1    Rainier, S.2    Dobry, C.J.3    Grundy, P.4    Horon, I.L.5    Feinberg, A.P.6
  • 85
    • 0027529973 scopus 로고
    • DNA polymorphisms in the human tyrosine hydroxylase/insulin/insulin-like growth factor II region in relation to glucose and insulin responses
    • Sten-Linder M, Wedell A, Iselius L, Efendic S, Luft R, Luthman H. 1993. DNA polymorphisms in the human tyrosine hydroxylase/insulin/insulin-like growth factor II region in relation to glucose and insulin responses. Diabetologia 36:25-32
    • (1993) Diabetologia , vol.36 , pp. 25-32
    • Sten-Linder, M.1    Wedell, A.2    Iselius, L.3    Efendic, S.4    Luft, R.5    Luthman, H.6
  • 87
    • 0025787852 scopus 로고
    • A protective role of the environment in the development of type 1 diabetes?
    • Todd JA. 1991. A protective role of the environment in the development of type 1 diabetes? Diabet. Med. 8:906-10
    • (1991) Diabet. Med. , vol.8 , pp. 906-910
    • Todd, J.A.1
  • 88
    • 0028009661 scopus 로고
    • The emperor's new genes: 1993 RD Lawrence lecture
    • Todd JA. 1994. The emperor's new genes: 1993 RD Lawrence lecture. Diabet. Med. 11:6-16
    • (1994) Diabet. Med. , vol.11 , pp. 6-16
    • Todd, J.A.1
  • 89
    • 0029022917 scopus 로고
    • Genetic analysis of type 1 diabetes using whole genome approaches
    • Todd JA. 1995. Genetic analysis of type 1 diabetes using whole genome approaches. Proc. Natl. Acad. Sci. USA 92:8560-65
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8560-8565
    • Todd, J.A.1
  • 90
    • 0025777873 scopus 로고
    • Genetic analysis of autoimmune type 1 diabetes mellitus in mice
    • Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JRS, et al. 1991. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351:542-47
    • (1991) Nature , vol.351 , pp. 542-547
    • Todd, J.A.1    Aitman, T.J.2    Cornall, R.J.3    Ghosh, S.4    Hall, J.R.S.5
  • 92
    • 0020478874 scopus 로고
    • Variation in the sequence and modification state of the human insulin gene flanking regions
    • Ullrich A, Dull TJ, Gray A, Philips JA, Peter S. 1982. Variation in the sequence and modification state of the human insulin gene flanking regions. Nucleic Acids Res. 10:2225-40
    • (1982) Nucleic Acids Res. , vol.10 , pp. 2225-2240
    • Ullrich, A.1    Dull, T.J.2    Gray, A.3    Philips, J.A.4    Peter, S.5
  • 93
    • 0028999853 scopus 로고
    • Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene
    • Undlien DE, Bennett ST, Todd JA, Akselsen HE, Ikaheimo I, et al. 1995. Insulin gene region-encoded susceptibility to IDDM maps upstream of the insulin gene. Diabetes 44:620-25
    • (1995) Diabetes , vol.44 , pp. 620-625
    • Undlien, D.E.1    Bennett, S.T.2    Todd, J.A.3    Akselsen, H.E.4    Ikaheimo, I.5
  • 94
  • 95
    • 0029144870 scopus 로고
    • Genetic susceptibility for insulin-dependent diabetes mellitus in caucasians revisted: The importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk
    • Van Der Auwera B, Schutt F, Lyaruu I, Falorni A, Svanholm S, et al. 1995. Genetic susceptibility for insulin-dependent diabetes mellitus in caucasians revisted: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. J. Clin. Endocrinol. Metab. 80:2567-73
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 2567-2573
    • Van Der Auwera, B.1    Schutt, F.2    Lyaruu, I.3    Falorni, A.4    Svanholm, S.5
  • 96
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse TJ, Todd JA. 1996. Genetic analysis of autoimmune disease. Cell 85:311-18
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 97
    • 0021249781 scopus 로고
    • Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers
    • Warram JH, Krolewski AS, Gottlieb MS, Kayn CR. 1984. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N. Engl. J. Med. 311:149-52
    • (1984) N. Engl. J. Med. , vol.311 , pp. 149-152
    • Warram, J.H.1    Krolewski, A.S.2    Gottlieb, M.S.3    Kayn, C.R.4
  • 98
    • 0026568387 scopus 로고
    • Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′ flanking region of the human insulin gene
    • Weaver JU, Kopelman PG, Hitman GA. 1992. Central obesity and hyperinsulinaemia in women are associated with polymorphism in the 5′ flanking region of the human insulin gene. Eur. J. Clin. Invest. 22:265-70
    • (1992) Eur. J. Clin. Invest. , vol.22 , pp. 265-270
    • Weaver, J.U.1    Kopelman, P.G.2    Hitman, G.A.3
  • 100
    • 0027080297 scopus 로고
    • Application of automated DNA sizing technology for genotyping microsatellite loci
    • Ziegle JS, Su Y, Corcoran KP, Nie L, Mayrand PE, et al. 1992. Application of automated DNA sizing technology for genotyping microsatellite loci. Genomics 14:1026-31
    • (1992) Genomics , vol.14 , pp. 1026-1031
    • Ziegle, J.S.1    Su, Y.2    Corcoran, K.P.3    Nie, L.4    Mayrand, P.E.5


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