In vitro secretion of interleukin 2 and expression of IL-2 receptor in peripheral blood lymphocytes in high risk of insulin-dependent diabetes mellitus subjects

Archivum Immunologiae et Therapiae Experimentalis

Volumn 47, Issue 1, 1999, Pages 45-49

  Kretowski, Adam ^a   Myśliwiec, Janusz ^a   Szelachowska, Małgorzata ^a   Brzozowski, Cezary ^a   Pietruczuk, Mirosława ^a   Kinalska, Ida ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Cd25 antigen; Diabetes mellitus type 1; Etiopathogenesis; Interleukin 2

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PANCREAS ISLET CELL ANTIBODY; RECEPTORS, INTERLEUKIN 2;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CHILD; FEMALE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE; MALE; METABOLISM; RISK;

ADOLESCENT; ADULT; AUTOANTIBODIES; CHILD; DIABETES MELLITUS, INSULIN-DEPENDENT; FEMALE; HUMAN; INTERLEUKIN-2; LYMPHOCYTES; MALE; RECEPTORS, INTERLEUKIN-2; RISK;

EID: 0033301697     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. BAKER J. W. (1990): An innovate lymphocyte preparation system for flow cytometry. Am. J. Clin. Pathol., 93, 263-266.
2. CAVALLO M. G., POZZILLI P., BIRD C., WADHWA M., MEAGER A., VISALLI N., GEARING A. J. H., ANDREANI D. and THORPE R. (1991): Cytokines in sera from insulin-dependent diabetic patients at diagnosis. Clin. Exp. Immunol., 86, 256-259.
3. GIORDANO C., DEMARIA R., TODARO M., STASSI G., MATTINA A., RICHIUSA P. and GALLUZZO A. (1993): Study of T-cell activation in type 1 diabetic patients and pre-type 1 diabetic subjects by cytometric analysis: antigen expression defect in vitro. J. Clin. Immunol., 13, 68-78.
4. HANNET I., ERKELLER-YUKSEL F., LYDYARD P., DENEYS V. and DE BRUYERE M. (1992): Developmental and maturational changes in human blood lymphocyte subpopulations. Immunol. Today, 13, 215-218.
5. HONEYMAN M., WASSERFALL C., NERUP J. and ROSSINI A. (1997): Prediction and prevention of IDDM. Diabetologia, 40, B58-B61.
6. HUSSAIN M. J., PEAKMAN M., GALLATI H., LO S. S., VIBERTI G. C., WATKINS P. J. and VERGANI D. (1996): Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia, 39, 60-69.
7. KALLMANN B. A., HUTHER M., TUBES M., FELDKAMP J., BERTRAMS J., GRIES F. A., LAMPETER E. F. and KOLB H. (1997): Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves' disease. Diabetes, 46, 237-243.
8. KRETOWSKI A., SZELACHOWSKA M., PIETRUCZUK M. and KINALSKA I. (1996): The changes of the memory T cells and NK cells populations in peripheral blood of high risk diabetes type 1 subjects. Diabetologia, 39 (suppl. 1), A95.
9. LOKEN M. R., BROSNAN J. M., BACH B. A. and AULT K. A. (1990): Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry. Cytometry, 11, 453-459.
10. MCHUGH S., DEIGHTON J., RIFKIN I., and EWAN P. (1996): Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur. J. Immunol, 26, 1260-1265.
11. MOSMANN T. R. and SUBASH S. (1996): The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today, 17, 138-146.
12. NOORCHASHM H., KWOK W., RABINOVITCH A. and HARRISON L. C. (1997): Immunology of IDDM. Diabetologia, 40, B50-B57.
13. + T-cells characterizes prediabetic twins. Diabetes Care, 19, 1177-1184.
14. RABINOVITCH A. (1994): Immunoregulatory and cytokine imbalance in the pathogenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes, 43, 613-621.
15. REINHOLD D., ANSORGE S. and SCHLEICHER E. D. (1996): Elevated glucose levels stimulate transforming growth factor-beta 1 (TGF-beta 1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Horm. Metab. Res., 28, 267-270.
16. SIGŃORE A., CHIANELLI M., PICARELLI A., FERRETTI E., MULTARI M. and POZZILLI P. (1995): In vivo detection of pancreatic T-lymphocytes: a new tool for IDDM prediction? Autoimmunity, 21, 64.
17. SIGNORE A., CHIANELLI M., FERRETTI E., TOSCANO A., BRITTON K. E., ANDREANI D., GALE E. A. and POZZILLI P. (1994): New approach for in vivo detection of insulitis in type 1 diabetes: activated lymphocyte targeting with I-123-labelled interleukin 2. Eur. J. Endocrinol., 131, 431-437.
18. SONI N., MEROPOL N. J., PORTER M. and CALIGIURI M. A. (1996): Diabetes mellitus induced by low-dose interleukin-2. Cancer Immunol. Immunother., 43, 59-62.
19. TOMODA T., KURASHIGE T. and TANIGUCHI T. (1994): Imbalance of the interleukin 2 system in children with IDDM. Diabetologia, 37, 476-482.
20. WAGNER R., BONIFACIO E., BINGLEY P. J., GENOVESE S., REINWEIN D. and BOTAZZO G. F. (1994): Low interleukin receptor levels in serum of patients with insulin-dependent diabetes. Clin. Invest., 72, 494-498.
21. ZIELASEK J., BURKART V., NAYLOR P., KIESEL U. and KOLB H. (1990): Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats. Immunology, 69, 209-214.
22. ZIER K. S., LEO M. M., SPIELMAN R. S. and BAKER L. (1984): Decreased synthesis of interleukin-2 in insulin-dependent diabetes mellitus. Diabetes, 33, 552-555.