-
1
-
-
13144265739
-
Genome-wide association studies: Theoretical issues and practical concerns
-
WANG, W.Y.S., B.J. BARRATT, D.G. CLAYTON, et al. 2005. Genome-wide association studies: theoretical issues and practical concerns. Nat. Rev. Genet. 6: 109-118.
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 109-118
-
-
Wang, W.Y.S.1
Barratt, B.J.2
Clayton, D.G.3
-
2
-
-
0024510601
-
Identification of susceptibility loci for insulin-dependent diabetes by trans-racial gene mapping
-
TODD, J.A., C. MIJOVIC, J. FLETCHER, et al. 1989. Identification of susceptibility loci for insulin-dependent diabetes by trans-racial gene mapping. Nature 338: 587-589.
-
(1989)
Nature
, vol.338
, pp. 587-589
-
-
Todd, J.A.1
Mijovic, C.2
Fletcher, J.3
-
3
-
-
0025375542
-
Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping
-
JENKJNS, D., C. MIJOVIC, J. FLETCHER, et al. 1990. Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping. Diabetologia 33: 387-395.
-
(1990)
Diabetologia
, vol.33
, pp. 387-395
-
-
Jenkjns, D.1
Mijovic, C.2
Fletcher, J.3
-
4
-
-
0027933734
-
A genome-wide search for human type 1 diabetes susceptibility genes
-
DAVIES, J.L., Y. KAWAGUCHI, S.T. BENNETT, et al. 1994. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136.
-
(1994)
Nature
, vol.371
, pp. 130-136
-
-
Davies, J.L.1
Kawaguchi, Y.2
Bennett, S.T.3
-
5
-
-
0034821661
-
Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 7657 multiplex families
-
COX, N.J., B. WAPELHORST, V.A. MORRISON, et al. 2001 Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 7657 multiplex families. Am. J. Hum. Genet. 69: 820-830.
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 820-830
-
-
Cox, N.J.1
Wapelhorst, B.2
Morrison, V.A.3
-
6
-
-
25844441709
-
Type 1 diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1435 multiplex families
-
CONCANNON, P., H.A. ERLICH, C. JULIER, et al. 2005. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1435 multiplex families. Diabetes 54: 2995-3001.
-
(2005)
Diabetes
, vol.54
, pp. 2995-3001
-
-
Concannon, P.1
Erlich, H.A.2
Julier, C.3
-
7
-
-
0024270615
-
Genetic heterogeneity, mode of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus
-
THOMSON, G., W. ROBINSON, M. KUHNER, et al. 1988. Genetic heterogeneity, mode of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am. J. Hum. Genet. 43: 799-816.
-
(1988)
Am. J. Hum. Genet.
, vol.43
, pp. 799-816
-
-
Thomson, G.1
Robinson, W.2
Kuhner, M.3
-
8
-
-
0036068150
-
Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes
-
KAWABATA, Y., H. IKEGAMI, Y. KAWAGUCHI, et al. 2002. Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes. Diabetes 51: 545-551.
-
(2002)
Diabetes
, vol.51
, pp. 545-551
-
-
Kawabata, Y.1
Ikegami, H.2
Kawaguchi, Y.3
-
9
-
-
0025995836
-
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
-
JULIER, C., R.N. HYER, J. DAVIES, et al. 1991. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 354: 155-159.
-
(1991)
Nature
, vol.354
, pp. 155-159
-
-
Julier, C.1
Hyer, R.N.2
Davies, J.3
-
10
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
UEDA, H., J.M.M. HOWSON, L. ESPOSITO, et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511.
-
(2003)
Nature
, vol.423
, pp. 506-511
-
-
Ueda, H.1
Howson, J.M.M.2
Esposito, L.3
-
11
-
-
3543046736
-
A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes
-
GUO, D., M. LI, Y. ZHANG, et al. 2004. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat. Genet. 36: 837-841.
-
(2004)
Nat. Genet.
, vol.36
, pp. 837-841
-
-
Guo, D.1
Li, M.2
Zhang, Y.3
-
12
-
-
12144291502
-
A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes
-
MELONI, G.F., P. LUCARELLI, M. PELLECCHIA, et al. 2004. A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes. Nat. Genet. 36: 337-338.
-
(2004)
Nat. Genet.
, vol.36
, pp. 337-338
-
-
Meloni, G.F.1
Lucarelli, P.2
Pellecchia, M.3
-
13
-
-
0023135007
-
Assessing the role of HLA-linked and unlinked determinants of disease
-
RISH, N. 1987. Assessing the role of HLA-linked and unlinked determinants of disease. Am. J. Hum. Genet. 40: 1-14.
-
(1987)
Am. J. Hum. Genet.
, vol.40
, pp. 1-14
-
-
Rish, N.1
-
14
-
-
0033808399
-
Incidence of childhood type 1 diabetes worldwide
-
Diabetes Mondiale (DiaMond) Project Group
-
KARVONEN, M., M. VIIK-KAJANDER, E. MOLTCHANOVA, et al. 2000. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23: 1516-1526.
-
(2000)
Diabetes Care
, vol.23
, pp. 1516-1526
-
-
Karvonen, M.1
Viik-Kajander, M.2
Moltchanova, E.3
-
15
-
-
0030347743
-
Genetics of insulin-dependent diabetes mellitus
-
IKEGAMI, H. & T. OGIHARA. 1996. Genetics of insulin-dependent diabetes mellitus. Endocrine J. 43: 605-613.
-
(1996)
Endocrine J.
, vol.43
, pp. 605-613
-
-
Ikegami, H.1
Ogihara, T.2
-
16
-
-
18744366947
-
Prime role for an insulin epitope in the development of type I diabetes in NOD mice
-
NAKAYAMA, M., N. ABIRU, H. MIRIYAMA, et al. 2005. Prime role for an insulin epitope in the development of type I diabetes in NOD mice. Nature 435: 220-223.
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Miriyama, H.3
-
17
-
-
0027200763
-
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1kb segment of DNA spanning the insulin gene and associated with VNTR
-
LUCASSEN, A.M., C. JULIER, J.-P. BERESSI, et al. 1993. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1kb segment of DNA spanning the insulin gene and associated with VNTR. Nat. Genet. 4: 305-310.
-
(1993)
Nat. Genet.
, vol.4
, pp. 305-310
-
-
Lucassen, A.M.1
Julier, C.2
Beressi, J.-P.3
-
18
-
-
0028871202
-
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
-
BENNETT, S.T., A.M. LUCASSEN, S.C.L. GOUGH, et al. 1995. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat. Genet. 9: 284-292.
-
(1995)
Nat. Genet.
, vol.9
, pp. 284-292
-
-
Bennett, S.T.1
Lucassen, A.M.2
Gough, S.C.L.3
-
19
-
-
0031557662
-
Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese
-
KAWAGUCHI, Y., H. IKEGAMI, G.-Q. SHEN, et al. 1997. Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese. Biochem. Biophys. Res. Commun. 233: 283-287.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.233
, pp. 283-287
-
-
Kawaguchi, Y.1
Ikegami, H.2
Shen, G.-Q.3
-
20
-
-
33845707890
-
-
manuscript in preparation
-
AWATA, T. et al. manuscript in preparation.
-
-
-
Awata, T.1
-
21
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
VAFIADIA, P., S.T. BENNETT, J.A. TODD, et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15: 289-292.
-
(1997)
Nat. Genet.
, vol.15
, pp. 289-292
-
-
Vafiadia, P.1
Bennett, S.T.2
Todd, J.A.3
-
22
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
PUGLIESE, A., M. ZELLER, A. FERNANDEZ, et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat .Genet. 15: 293-296.
-
(1997)
Nat.Genet.
, vol.15
, pp. 293-296
-
-
Pugliese, A.1
Zeller, M.2
Fernandez, A.3
-
23
-
-
33644828029
-
The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: A multi-center collaborative study in Japan
-
IKEGAMI, H., T. AWATA, E. KAWASAKI, et al. 2006. The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multi-center collaborative study in Japan. J. Clin. Endocrino Metab. 91: 1087-1092.
-
(2006)
J. Clin. Endocrino Metab.
, vol.91
, pp. 1087-1092
-
-
Ikegami, H.1
Awata, T.2
Kawasaki, E.3
-
24
-
-
12144291502
-
A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes
-
BOTTINI, N., L. MUSUMECI, A. ALONSO, et al. 2004. A functional variant of lymphoid tyrosine phosphatase is associated with type 1 diabetes. Nat. Genet. 36: 337-338.
-
(2004)
Nat. Genet.
, vol.36
, pp. 337-338
-
-
Bottini, N.1
Musumeci, L.2
Alonso, A.3
-
25
-
-
33644851944
-
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase (PTPN22) gene: Association between promoter polymorphism and type 1 diabetes in Asian populations
-
KAWASAKI, E., T. AWATA, H. IKEGAMI, et al. 2006. Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase (PTPN22) gene: Association between promoter polymorphism and type 1 diabetes in Asian populations. Am. J. Med. Genet. 140: 586-593.
-
(2006)
Am. J. Med. Genet.
, vol.140
, pp. 586-593
-
-
Kawasaki, E.1
Awata, T.2
Ikegami, H.3
-
26
-
-
3042740794
-
A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes
-
OWERBACH, D., L. PINA & K.H. GABBAY. 2004. A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. Diabetes 53: 1890-1893.
-
(2004)
Diabetes
, vol.53
, pp. 1890-1893
-
-
Owerbach, D.1
Pina, L.2
Gabbay, K.H.3
-
27
-
-
3042644131
-
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type 1 diabetes mellitus
-
BOHREN, K.M., V. NADKARNI, J.H. SONG, et al. 2004. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type 1 diabetes mellitus. J. Biol. Chem. 279: 27233-27238.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 27233-27238
-
-
Bohren, K.M.1
Nadkarni, V.2
Song, J.H.3
-
28
-
-
13944254773
-
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
-
SMYTH, D.J., J.M.M. HOWSON, C.E. LOWE, et al. 2005. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat. Genet. 37: 110-111.
-
(2005)
Nat. Genet.
, vol.37
, pp. 110-111
-
-
Smyth, D.J.1
Howson, J.M.M.2
Lowe, C.E.3
-
29
-
-
13944272690
-
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
-
QU, H., B. BHARAJ, X.-Q. LIU, et al. 2005. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat. Genet. 37: 111-112.
-
(2005)
Nat. Genet.
, vol.37
, pp. 111-112
-
-
Qu, H.1
Bharaj, B.2
Liu, X.-Q.3
-
30
-
-
13944272309
-
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes
-
PARK, Y., S. PARK, J. KANG, et al. 2005. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat. Genet. 37: 112.
-
(2005)
Nat. Genet.
, vol.37
, pp. 112
-
-
Park, Y.1
Park, S.2
Kang, J.3
-
31
-
-
33644693805
-
Genetic heterogeneity in association of SUMO4 M55V variant with susceptibility to type 1 diabetes
-
NOSO, S., H. IKEGAMI, T. FUJISAWA, et al. 2005. Genetic heterogeneity in association of SUMO4 M55V variant with susceptibility to type 1 diabetes. Diabetes. 54: 3582-3586.
-
(2005)
Diabetes
, vol.54
, pp. 3582-3586
-
-
Noso, S.1
Ikegami, H.2
Fujisawa, T.3
|