Cellular ligands of activating NK receptors

Trends in Immunology

Volumn 26, Issue 4, 2005, Pages 221-226

  Bottino, Cristina ^a   Castriconi, Roberta ^a   Moretta, Lorenzo ^a,b   Moretta, Alessandro ^b  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNAM 1 RECEPTOR; HLA ANTIGEN CLASS 1; LIGAND; LYMPHOCYTE RECEPTOR; LYMPHOKINE; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER RECEPTOR; UNCLASSIFIED DRUG; CD226 ANTIGEN; IMMUNOGLOBULIN RECEPTOR; NATURAL KILLER CELL ACTIVATING RECEPTORS; T LYMPHOCYTE ANTIGEN;

CYTOLYSIS; CYTOTOXICITY; DOWN REGULATION; HUMAN; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; REVIEW; UPREGULATION; VIRUS INFECTION; BIOLOGICAL MODEL; IMMUNOLOGY; METABOLISM; NEOPLASM;

ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MODELS, IMMUNOLOGICAL; NEOPLASMS; RECEPTORS, IMMUNOLOGIC;

EID: 18844433996     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2005.02.007     Document Type: Review

References (73)

1. Biron, C.A. et al. (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189-220
2. Parham, P. (2003) Innate immunity: The unsung heroes. Nature 423, 20
3. Parham, P. (2003) Immunogenetics of killer-cell immunoglobulin-like receptors. Tissue Antigens 62, 194-200
4. Moretta, L. and Moretta, A. (2004) Killer immunoglobulin-like receptors. Curr. Opin. Immunol. 16, 626-633
5. Lopez-Botet, M. et al. (2000) NK cell recognition of non-classical HLA class I molecules. Semin. Immunol. 12, 109-119
6. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197-223
7. Lanier, L.L. (2003) Natural killer cell receptor signaling. Curr. Opin. Immunol. 15, 308-314
8. Bottino, C. et al. (2004) Learning how to discriminate between friends and enemies, a lesson from natural killer cells. Mol. Immunol. 41, 569-575
9. Algarra, I. et al. (2004) The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape. Cancer Immunol. Immunother. 53, 904-910
10. Alcami, A. and Koszinowski, U.H. (2000) Viral mechanisms of immune evasion. Immunol. Today 21, 447-455
11. Moretta, A. et al. (2000) Natural cytotoxicity receptors that trigger human NK-mediated cytolysis. Immunol. Today 21, 228-234
12. Sivori, S. et al. (1999) NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human natural killer cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur. J. Immunol. 29, 1656-1666
13. Pende, D. et al. (1999) Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 190, 1505-1516
14. Augugliaro, R. et al. (2003) Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. Eur. J. Immunol. 33, 1235-1241
15. Pende, D. et al. (2001) Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of non epithelial origin. Eur. J. Immunol. 31, 1076-1086
16. Sivori, S. et al. (2000) Involvement of natural cytotoxicity receptors in human natural killer cell mediated lysis of neuroblastoma and glyoblastoma cell lines. J. Neuroimmunol. 107, 220-225
17. Castriconi, R. et al. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAM-1/PVR interaction. Cancer Res. 64, 9180-9184
18. Pende, D. et al. (2004) Analysis of the receptor-ligand interactions in the NK-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias. Evidence for the involvement of the poliovirus receptor (CD155) and Nectin-2 (CD112). Blood. DOI: 10.1182/blood-2004-09-3548 (http://www.bloodjournal.org)
19. Parolini, S. et al. (2000) X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of NK cells to kill EBV-infected cells. J. Exp. Med. 192, 337-346
20. Bottino, C. et al. (2001) NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative diseases. J. Exp. Med. 194, 235-246
21. Bottino, C. et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198, 557-567
22. Biassoni, R. et al. (1999) The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity. Eur. J. Immunol. 29, 1014-1020
23. Falco, M. et al. (1999) Identification of the rat homologue of the human NKp46 triggering receptor. Immunol. Lett. 68, 411-414
24. De Maria, A. et al. (2001) Identification, molecular cloning and functional characterization of NKp46 and NKp30 natural cytotoxicity receptors in Macaca fascicularis (Macaca Rhesus) NK cells. Eur. J. Immunol. 31, 3546-3556
25. Velardi, A. et al. (2002) NK cells: a lesson from mismatched hematopoietic transplantation. Trends Immunol. 23, 438-444
26. Parham, P. and McQueen, K.L. (2003) Alloreactive killer cells: hindrance and help for haematopoietic transplants. Nat. Rev. Immunol. 3, 108-122
27. Ferlazzo, G. et al. (2002) Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195, 343-351
28. Della Chiesa, M. et al. (2003) The natural killer cell mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer IG-like receptors. Eur. J. Immunol. 33, 1657-1666
29. Castriconi, R. et al. (2003) TGFβ1 inhibits expression of the NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 100, 4120-4125
30. Lee, J.C. et al. (2004) Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J. Immunol. 172, 7335-7340
31. Costello, R.J. et al. (2002) Defective expression and function of natural killer cell triggering receptors in patients with acute myeloid leukemia. Blood 99, 3661-3667
32. Mavilio, D. et al. (2003) Natural killer cell in HIV-1 infections: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc. Natl. Acad. Sci. U. S. A. 100, 15011-15016
33. De Maria, A. et al. (2003) The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur. J. Immunol. 33, 2410-2418
34. Arnon, T.I. et al. (2004) The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. Blood 103, 664-672
35. Cerwenka, A. and Lanier, L.L. (2003) NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. Tissue Antigens 61, 335-343
36. Raulet, D.H. (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781-790
37. Diefenbach, A. et al. (2002) Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3, 1142-1149
38. Zompi, S. et al. (2003) NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat. Immunol. 4, 565-572
39. Andre, P. et al. (2004) Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors. Eur. J. Immunol. 34, 961-971
40. Pende, D. et al. (2002) Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 62, 6178-6186
41. Berking, C. et al. (2001) Transforming growth factor-β1 increases survival of human melanoma through stroma remodeling. Cancer Res. 61, 8306-8316
42. Pasche, B. (2001) Role of transforming growth factor β in cancer. J. Cell. Physiol. 186, 153-168
43. Groh, V. et al. (2002) Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734-738
44. Raffaghello, L. et al. (2004) Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma. Neoplasia 6, 558-568
45. Reddehase, M.J. et al. (2004) Stalemating a clever opportunist: lessons from murine cytomegalovirus. Hum. Immunol. 65, 446-455
46. Lopez-Botet, M. et al. (2004) Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection. Tissue Antigens 63, 195-203
47. Tomasec, P. et al. (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287, 1031-1033
48. Ulbrecht, M. et al. (2000) Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J. Immunol. 164, 5019-5022
49. Dunn, C. et al. (2003) Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J. Exp. Med. 197, 1427-1439
50. Lodoen, M. et al. (2003) NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 197, 1245-1253
51. Lodoen, M.B. et al. (2004) The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J. Exp. Med. 200, 1075-1081
52. Krmpotic, A. et al. (2005) NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145. J. Exp. Med. 201, 211-220
53. Burns, G.F. et al. (1985) TLiSA1, a human T lineage-specific activation antigen involved in the differentiation of cytotoxic T lymphocytes and anomalous killer cells from their precursors. J. Exp. Med. 161, 1063-1078
54. Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4, 573-581
55. Fuchs, A. et al. (2004) CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172, 3994-3998
56. Reymond, N. et al. (2004) DNAM-1 and PVR regulate monocyte migration through endothelial junctions. J. Exp. Med. 199, 1331-1341
57. Tomasec, P. et al. (2005) Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nat. Immunol. 6, 181-188
58. Sun, M. et al. (2002) Characterization of mouse and human B7-H3 genes. J. Immunol. 168, 6294-6297
59. Steinberger, P. et al. (2004) Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol. 172, 2352-2359
60. Carreno, B.M. and Collins, M. (2002) The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20, 29-53
61. Chen, L. (2004) Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4, 336-347
62. Moretta, A. and Bottino, C. (2004) Commentary: regulated equilibrium between opposite signals: a general paradigm for T cell function? Eur. J. Immunol. 34, 2084-2088
63. Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U. S. A. 101, 12640-12645
64. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human natural killer cell activation. Eur. J. Immunol. 30, 787-793
65. Vitale, M. et al. (2001) Identification of NKp80, a novel triggering molecule expressed by human natural killer cells. Eur. J. Immunol. 31, 233-242
66. Marcenaro, E. et al. (2003) CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotocicity. Eur. J. Immunol. 33, 3367-3376
67. Nakajima, H. et al. (1999) Activating interactions in human NK cell recognition: the role of 2B4-CD48. Eur. J. Immunol. 29, 1676-1683
68. Falco, M. et al. (2004) Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells. Eur. J. Immunol. 34, 1663-1672
69. Poggi, A. et al. (1996) Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. Eur. J. Immunol. 26, 967-975
70. Barber, D.F. et al. (2004) LFA-1 contributes an early signal for NK cell cytotoxicity. J. Immunol. 173, 3653-3659
71. Schmidt, K.N. et al. (2004) APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol. 172, 138-143
72. Sivori, S. et al. (2004) CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 101, 10116-10121
73. Moretta, A. (2002) Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat. Rev. Immunol. 2, 957-964