Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 325-328

  Ikegami, Hiroshi ^a   Fujisawa, Tomomi ^a   Makino, Susumu ^b   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

Idd3; IL2; NOD mouse; Susceptibility gene; Type 1 diabetes

Indexed keywords

GENE PRODUCT; INTERLEUKIN 2; PROTEIN IDD3; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; CHROMOSOME 3; CONFERENCE PAPER; CONGENIC STRAIN; CONTROLLED STUDY; DNA FLANKING REGION; GENE MAPPING; GENETIC RECOMBINATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; MARKER GENE; MOUSE; MOUSE STRAIN; NONHUMAN; ONSET AGE;

ANIMALIA;

EID: 0036272622     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02997.x     Document Type: Conference Paper

References (12)

1. Breeding of non-obese, diabetic strain of mice
2. The NOD mouse and its related strains
3. The NOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
4. Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse
5. Genetic analysis of autoimmune type 1 diabetes mellitus in mice
6. Polygenic control of autoimmune diabetes in nonobese diabetic mice
7. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
8. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1
9. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3
10. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse, chromosome 3: Identification of a candidate segment of ancestral DNA by haplotype mapping
11. The NSY mouse, a new animal model of spontaneous NIDDM with moderate obesity
12. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping