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Volumn 5, Issue 10, 2004, Pages 805-815

Connecting proliferation and apoptosis in development and disease

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN BCL 2;

EID: 5044232018     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1491     Document Type: Review
Times cited : (182)

References (136)
  • 1
    • 0035805201 scopus 로고    scopus 로고
    • Endoreplication cell cycles: More for less
    • Edgar, B. A. & Orr-Weaver, T. L. Endoreplication cell cycles: more for less. Cell 106, 297-306 (2001).
    • (2001) Cell , vol.106 , pp. 297-306
    • Edgar, B.A.1    Orr-Weaver, T.L.2
  • 2
    • 0016613341 scopus 로고
    • Minutes: Mutants of Drosophila autonomously affecting cell division rate
    • Morata, G. & Ripoll, P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42, 211-221 (1975).
    • (1975) Dev. Biol. , vol.42 , pp. 211-221
    • Morata, G.1    Ripoll, P.2
  • 4
    • 0036781812 scopus 로고    scopus 로고
    • c-MYC: More than just a matter of life and death
    • Pelengaris, S., Khan, M. & Evan, G. c-MYC: more than just a matter of life and death. Nature Rev. Cancer 2, 764-776 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 5
    • 0035882058 scopus 로고    scopus 로고
    • Deconstructing myc
    • Eisenman, R. N. Deconstructing myc. Genes Dev. 15, 2023-2030 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2023-2030
    • Eisenman, R.N.1
  • 6
    • 0037197920 scopus 로고    scopus 로고
    • Disentangling the MYC web
    • Levens, D. Disentangling the MYC web. Proc. Natl Acad. Sci. USA 9, 5757-5759 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.9 , pp. 5757-5759
    • Levens, D.1
  • 7
    • 0038185378 scopus 로고    scopus 로고
    • Genomic targets of the human c-Myc protein
    • Fernandez, P. C. et al. Genomic targets of the human c-Myc protein. Genes Dev. 17, 1115-1129 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1115-1129
    • Fernandez, P.C.1
  • 8
    • 0038523952 scopus 로고    scopus 로고
    • Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network
    • Orian, A. et al. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev. 17, 1101-1114 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1101-1114
    • Orian, A.1
  • 9
    • 0842278571 scopus 로고    scopus 로고
    • An integrated database of genes responsive to the Myc oncogenic transcription factor: Identification of direct genomic targets
    • Zeller, K. I., Jegga, A. G., Aronow, B. J., O'Donnell, K. A. & Dang, C. V. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 4, R69 (2003).
    • (2003) Genome Biol. , vol.4
    • Zeller, K.I.1    Jegga, A.G.2    Aronow, B.J.3    O'Donnell, K.A.4    Dang, C.V.5
  • 10
    • 0035881691 scopus 로고    scopus 로고
    • Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
    • Bouchard, C. et al. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev. 15, 2042-2047 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2042-2047
    • Bouchard, C.1
  • 11
    • 12944281162 scopus 로고    scopus 로고
    • Identification of CDK4 as a target of c-MYC
    • Hermeking, H. et al. Identification of CDK4 as a target of c-MYC. Proc. Natl Acad. Sci. USA 97, 2229-2234 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2229-2234
    • Hermeking, H.1
  • 13
    • 0012729772 scopus 로고    scopus 로고
    • A large scale genetic analysis of c-Myc-regulated gene expression patterns
    • O'Connell, B. C. et al. A large scale genetic analysis of c-Myc-regulated gene expression patterns. J. Biol. Chem. 278, 12563-12573 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 12563-12573
    • O'Connell, B.C.1
  • 14
    • 0030747725 scopus 로고    scopus 로고
    • Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
    • Sears, R., Ohtani, K. & Nevins, J. R. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol. Cell. Biol. 17, 5227-5235 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5227-5235
    • Sears, R.1    Ohtani, K.2    Nevins, J.R.3
  • 15
    • 0033578793 scopus 로고    scopus 로고
    • Drosophila myc regulates cellular growth during development
    • Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779-790 (1999). First papers (see also reference 30) implicating the Myc oncogene in the control of cellular growth and size in animal development.
    • (1999) Cell , vol.98 , pp. 779-790
    • Johnston, L.A.1    Prober, D.A.2    Edgar, B.A.3    Eisenman, R.N.4    Gallant, P.5
  • 16
    • 0034681265 scopus 로고    scopus 로고
    • Ras1 promotes cellular growth in the Drosophila wing
    • Prober, D. A. & Edgar, B. A. Ras1 promotes cellular growth in the Drosophila wing. Cell 100, 435-446 (2000).
    • (2000) Cell , vol.100 , pp. 435-446
    • Prober, D.A.1    Edgar, B.A.2
  • 17
    • 0032568795 scopus 로고    scopus 로고
    • Coordination of growth and cell division in the Drosophila wing
    • Neufeld, T. P., de la Cruz, A. F., Johnston, L. A. & Edgar, B. A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193 (1998). Shows that, as in yeast, cell division and cellular growth are separable processes in higher eukaryotes, and that tissue size is not measured in terms of the number of cell divisions, but in terms of mass.
    • (1998) Cell , vol.93 , pp. 1183-1193
    • Neufeld, T.P.1    De La Cruz, A.F.2    Johnston, L.A.3    Edgar, B.A.4
  • 18
    • 0042528364 scopus 로고    scopus 로고
    • Cyclin E ablation in the mouse
    • Geng, Y. et al. Cyclin E ablation in the mouse. Cell 114, 431-431 (2003).
    • (2003) Cell , vol.114 , pp. 431-431
    • Geng, Y.1
  • 19
    • 0034662959 scopus 로고    scopus 로고
    • CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest
    • CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest. Proc. Natl Acad. Sci. USA 97, 9498-9503 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9498-9503
    • Claassen, G.F.1    Hann, S.R.2
  • 20
    • 0034724389 scopus 로고    scopus 로고
    • Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
    • Coller, H. A. et al. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc. Natl Acad. Sci. USA 97, 3260-3265 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3260-3265
    • Coller, H.A.1
  • 21
    • 0035967099 scopus 로고    scopus 로고
    • Kip1 cyclin-dependent kinase inhibitor gene by c-Myc
    • Kip1 cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene 20, 1688-1702 (2001).
    • (2001) Oncogene , vol.20 , pp. 1688-1702
    • Yang, W.1
  • 22
    • 0034744957 scopus 로고    scopus 로고
    • INK4b expression by Myc through association with Miz-1
    • INK4b expression by Myc through association with Miz-1. Nature Cell Biol. 3, 392-399 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 392-399
    • Staller, P.1
  • 23
    • 0037099496 scopus 로고    scopus 로고
    • Cip1 decreases survival and synergizes with MYC in mutine lymphomagenesis
    • Cip1 decreases survival and synergizes with MYC in mutine lymphomagenesis. EMBO J. 21, 3739-3748 (2002).
    • (2002) EMBO J. , vol.21 , pp. 3739-3748
    • Martins, C.P.1    Berns, A.2
  • 24
    • 15844384256 scopus 로고    scopus 로고
    • Kip1-deficient mice
    • Kip1-deficient mice. Cell 85, 733-744 (1996).
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1
  • 25
    • 15844415946 scopus 로고    scopus 로고
    • Kip1
    • Kip1. Cell 85, 721-732 (1996).
    • (1996) Cell , vol.85 , pp. 721-732
    • Kiyokawa, H.1
  • 26
    • 0030010591 scopus 로고    scopus 로고
    • Kip1 display increased body see, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Kip1 display increased body see, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-720 (1996).
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1
  • 27
    • 0024586879 scopus 로고
    • Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos
    • Schmid, P., Schulz, W. A. & Hameister, H. Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos. Science 243, 226-229 (1989).
    • (1989) Science , vol.243 , pp. 226-229
    • Schmid, P.1    Schulz, W.A.2    Hameister, H.3
  • 28
    • 0027315650 scopus 로고
    • A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
    • Davis, A. C., Wims, M., Spotts, G. D., Hann, S. R. & Bradley, A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 7, 671-682 (1993).
    • (1993) Genes Dev. , vol.7 , pp. 671-682
    • Davis, A.C.1    Wims, M.2    Spotts, G.D.3    Hann, S.R.4    Bradley, A.5
  • 29
    • 0035856918 scopus 로고    scopus 로고
    • c-Myc regulates mammalian body size by controlling cell number but not cell size
    • Trumpp, A. et al. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 768-773 (2001). Shows that mammalian c-MYC controls organ and body size by regulating cell numbers.
    • (2001) Nature , vol.414 , pp. 768-773
    • Trumpp, A.1
  • 31
    • 0035668437 scopus 로고    scopus 로고
    • A P-insertion screen identifying novel X-linked essential genes in Drosophila
    • Bourbon, H. M. et al. A P-insertion screen identifying novel X-linked essential genes in Drosophila. Mech. Dev. 110, 71-83 (2002).
    • (2002) Mech. Dev. , vol.110 , pp. 71-83
    • Bourbon, H.M.1
  • 32
    • 1842816486 scopus 로고    scopus 로고
    • Drosophila Myc regulates organ size by inducing cell competition
    • de la Cova, C., Abrili, M., Bellosta, P., Gallant, P. & Johnston, L. A. Drosophila Myc regulates organ size by inducing cell competition. Cell 117, 107-116 (2004). Together with references 114 and 122, provides strong evidence that cell competition contributes significantly to the control of organ size.
    • (2004) Cell , vol.117 , pp. 107-116
    • De La Cova, C.1    Abrili, M.2    Bellosta, P.3    Gallant, P.4    Johnston, L.A.5
  • 33
    • 0030849451 scopus 로고    scopus 로고
    • Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
    • Mateyak, M. K., Obaya, A. J., Adachi, S. & Sedivy, J. M. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ. 8, 1039-1048 (1997).
    • (1997) Cell Growth Differ. , vol.8 , pp. 1039-1048
    • Mateyak, M.K.1    Obaya, A.J.2    Adachi, S.3    Sedivy, J.M.4
  • 34
    • 0033772338 scopus 로고    scopus 로고
    • An encore for ribosome biogenesis in the control of cell proliferation
    • Thomas, G. An encore for ribosome biogenesis in the control of cell proliferation. Nature Cell Biol. 2, E71-E72 (2000).
    • (2000) Nature Cell Biol. , vol.2
    • Thomas, G.1
  • 35
    • 0038579284 scopus 로고    scopus 로고
    • Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression
    • Conlon, I. & Raff, M. Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression. J. Biol. 2, 7 (2003).
    • (2003) J. Biol. , vol.2 , pp. 7
    • Conlon, I.1    Raff, M.2
  • 36
    • 0031613939 scopus 로고    scopus 로고
    • The minute genes in Drosophila and their molecular functions
    • Lambertsson, A. The minute genes in Drosophila and their molecular functions. Adv. Genet. 38, 69-134 (1998).
    • (1998) Adv. Genet. , vol.38 , pp. 69-134
    • Lambertsson, A.1
  • 37
  • 38
    • 1942485888 scopus 로고    scopus 로고
    • Negative regulation of dE2F1 by cydin-dependent kinases controls cell cycle timing
    • Reis, T. & Edgar, B. A. Negative regulation of dE2F1 by cydin-dependent kinases controls cell cycle timing. Cell 117, 253-264 (2004).
    • (2004) Cell , vol.117 , pp. 253-264
    • Reis, T.1    Edgar, B.A.2
  • 39
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6, 1915-1922 (1991).
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 40
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128 (1992). References 39 and 40 report the striking finding that an oncogene induces apoptosis.
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.I.1
  • 41
    • 0028263811 scopus 로고
    • c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington, E. A., Bennett, M. R., Fanidi, A. & Evan, G. I. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13, 3286-3295 (1994).
    • (1994) EMBO J. , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 42
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • Pelengaris, S., Khan, M. & Evan, G. I. Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109, 321-334 (2002). Shows that complex angiogenic and invasive tumours can be generated by driving proliferation and blocking apoptosis, without the need for additional mutations.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 43
    • 1642430733 scopus 로고    scopus 로고
    • Myc pathways provoking cell suicide and cancer
    • Nilsson, J. A. & Cleveland, J. L. Myc pathways provoking cell suicide and cancer. Oncogene 22, 9007-9021 (2003).
    • (2003) Oncogene , vol.22 , pp. 9007-9021
    • Nilsson, J.A.1    Cleveland, J.L.2
  • 44
    • 0033152390 scopus 로고    scopus 로고
    • c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
    • Juin, P., Hueber, A. O., Littlewood, T. & Evan, G. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes Dev. 13, 1367-1381 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1367-1381
    • Juin, P.1    Hueber, A.O.2    Littlewood, T.3    Evan, G.4
  • 46
    • 0038413713 scopus 로고    scopus 로고
    • c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner
    • Iaccarino, I., Hancock, D., Evan, G. & Downward, J. c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner. Cell Death Differ. 10, 599-608 (2003).
    • (2003) Cell Death Differ. , vol.10 , pp. 599-608
    • Iaccarino, I.1    Hancock, D.2    Evan, G.3    Downward, J.4
  • 48
    • 0035950521 scopus 로고    scopus 로고
    • Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1
    • Eischen, C. M. et al. Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene 20, 6983-6993 (2001).
    • (2001) Oncogene , vol.20 , pp. 6983-6993
    • Eischen, C.M.1
  • 49
    • 0033676967 scopus 로고    scopus 로고
    • Bax is a transcriptional target and mediator of c-myc-induced apoptosis
    • Mitchell, K. O. et al. Bax is a transcriptional target and mediator of c-myc-induced apoptosis. Cancer Res. 60, 6318-6325 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 6318-6325
    • Mitchell, K.O.1
  • 50
    • 0036333713 scopus 로고    scopus 로고
    • c-Myc functionally cooperates with Bax to induce apoptosis
    • Juin, P. et al. c-Myc functionally cooperates with Bax to induce apoptosis. Mol. Cell. Biol. 22, 6158-6169 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6158-6169
    • Juin, P.1
  • 51
    • 0037439054 scopus 로고    scopus 로고
    • c-MYC apoptotic function is mediated by NRF-1 target genes
    • Morrish, F., Giedt, C. & Hockenbery, D. c-MYC apoptotic function is mediated by NRF-1 target genes. Genes Dev. 17, 240-255 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 240-255
    • Morrish, F.1    Giedt, C.2    Hockenbery, D.3
  • 52
    • 0030667376 scopus 로고    scopus 로고
    • Requirement forthe CD95 receptor-ligand pathway in c-Myc-induced apoptosis
    • Hueber, A. O. et al. Requirement forthe CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science 278, 1305-1309 (1997).
    • (1997) Science , vol.278 , pp. 1305-1309
    • Hueber, A.O.1
  • 53
    • 0037186145 scopus 로고    scopus 로고
    • Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation
    • Amanullah, A., Liebermann, D. A. & Huffman, B. Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation. Oncogene 21, 1600-1610 (2002).
    • (2002) Oncogene , vol.21 , pp. 1600-1610
    • Amanullah, A.1    Liebermann, D.A.2    Huffman, B.3
  • 54
    • 0037044731 scopus 로고    scopus 로고
    • c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway
    • Klefstrom, J., Verschuren, E. W. & Evan, G. c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. J. Biol. Chem. 277, 43224-43232 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 43224-43232
    • Klefstrom, J.1    Verschuren, E.W.2    Evan, G.3
  • 55
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DMA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa, O. et al. c-Myc can induce DMA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell 9, 1031-1044 (2002).
    • (2002) Mol. Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1
  • 56
    • 0036279279 scopus 로고    scopus 로고
    • E2F1 and c-Myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination
    • Tanaka, H. et al. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination. Mol. Cell 9, 1017-1029 (2002).
    • (2002) Mol. Cell , vol.9 , pp. 1017-1029
    • Tanaka, H.1
  • 57
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • Green, D. R. & Evan, G. I. A matter of life and death. Cancer Cell 1, 19-30 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 19-30
    • Green, D.R.1    Evan, G.I.2
  • 58
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan, G. & Littlewood, T. A matter of life and cell death. Science 281, 1317-1322 (1998).
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 59
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt, C. A., McCurrach, M. E., de Stanchina, E., Wallace-Brodeur, R. R. & Lowe, S. W. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev. 13, 2670-2677 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    De Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 60
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • Jacobs, J. J. et al. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev. 13, 2678-2690 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1
  • 61
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser, A., Harris, A. W., Bath, M. L. & Gory, S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348, 331-333 (1990).
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Gory, S.4
  • 62
    • 0034775395 scopus 로고    scopus 로고
    • Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated tymphomagenesis
    • Eischen, C. M., Roussel, M. F., Korsmeyer, S. J. & Cleveland, J. L. Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated tymphomagenesis. Mol. Cell. Biol. 21, 7653-7662 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7653-7662
    • Eischen, C.M.1    Roussel, M.F.2    Korsmeyer, S.J.3    Cleveland, J.L.4
  • 63
    • 0029060361 scopus 로고
    • Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: Contrasting effects of homozygous and heterozygous p53 loss
    • Blyth, K. et al. Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene 10, 1717-1723 (1995).
    • (1995) Oncogene , vol.10 , pp. 1717-1723
    • Blyth, K.1
  • 64
    • 0029135433 scopus 로고
    • The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice
    • Elson, A., Deng, C., Campos-Torres, J., Donehower, L. A. & Leder, P. The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene 11, 181-190 (1995).
    • (1995) Oncogene , vol.11 , pp. 181-190
    • Elson, A.1    Deng, C.2    Campos-Torres, J.3    Donehower, L.A.4    Leder, P.5
  • 65
    • 0036168192 scopus 로고    scopus 로고
    • ARF differentially modulates apoptosis induced by E2F1 and Myc
    • Russell, J. L. et al. ARF differentially modulates apoptosis induced by E2F1 and Myc. Mol. Cell. Biol. 22, 1360-1368 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1360-1368
    • Russell, J.L.1
  • 66
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen, C. M., Weber, J. D., Roussel. M. F., Sherr, C. J. & Cleveland, J. L. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13, 2658-2669 (1999). Shows that induction of tumours by Myc in vivo selects for disruption of ARF-MDM2-p53 regulation.
    • (1999) Genes Dev. , vol.13 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 67
    • 0141706686 scopus 로고    scopus 로고
    • Tumor promotion by Mdm2 splice variants unable to bind p53
    • Fridman, J. S. et al. Tumor promotion by Mdm2 splice variants unable to bind p53. Cancer Res. 63, 5703-5706 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5703-5706
    • Fridman, J.S.1
  • 68
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
    • Alt, J. R., Greiner, T. C., Cleveland, J. L. & Eischen, C. M. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 22, 1442-1450 (2003).
    • (2003) EMBO J. , vol.22 , pp. 1442-1450
    • Alt, J.R.1    Greiner, T.C.2    Cleveland, J.L.3    Eischen, C.M.4
  • 69
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy, F. et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424-2433 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2424-2433
    • Zindy, F.1
  • 70
    • 0347994891 scopus 로고    scopus 로고
    • Art tumor suppressor promoter monitors latent oncogenic signals in vivo
    • Zindy, F. et al. Art tumor suppressor promoter monitors latent oncogenic signals in vivo. Proc. Natl Acad. Sci. USA 100, 15930-15935 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15930-15935
    • Zindy, F.1
  • 71
    • 0029993450 scopus 로고    scopus 로고
    • Role of the INK4a locus in tumor suppression and cell mortality
    • Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27-37 (1996).
    • (1996) Cell , vol.85 , pp. 27-37
    • Serrano, M.1
  • 72
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo, T. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659 (1997).
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1
  • 73
    • 0037447069 scopus 로고    scopus 로고
    • Drosophila p53 preserves genomic stability by regulating cell death
    • Sogame, N., Kim, M. & Abrams, J. M. Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl Acad. Sci. USA 100, 4696-4701 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4696-4701
    • Sogame, N.1    Kim, M.2    Abrams, J.M.3
  • 74
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek, V. et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genet. 19, 379-383 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 379-383
    • Korinek, V.1
  • 75
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essentials for homeostasis of the intestinal epithelium
    • Pinto, D., Gregorieff, A., Begthel, H. & Clevers, H. Canonical Wnt signals are essentials for homeostasis of the intestinal epithelium. Genes Dev. 17, 1709-1713 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 76
    • 18644373146 scopus 로고    scopus 로고
    • The α-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering, M. et al. The α-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1
  • 77
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512 (1998).
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1
  • 78
    • 0037193466 scopus 로고    scopus 로고
    • Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis
    • You, Z. et al. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J. Cell Biol. 157, 429-440 (2002).
    • (2002) J. Cell Biol. , vol.157 , pp. 429-440
    • You, Z.1
  • 79
    • 0037267333 scopus 로고    scopus 로고
    • Validating survivin as a cancer therapeutic target
    • Altieri, D. C. Validating survivin as a cancer therapeutic target. Nature Rev Cancer 3, 46-54 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 46-54
    • Altieri, D.C.1
  • 80
    • 0035893568 scopus 로고    scopus 로고
    • Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer
    • Zhang, T. et al. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res. 61, 8664-8667 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8664-8667
    • Zhang, T.1
  • 81
    • 0038498213 scopus 로고    scopus 로고
    • Survivin and molecular pathogenesis of colorectal cancer
    • Kim, P. J., Plescia, J., Clevers, H., Fearon, E. R. & Altieri, D. C. Survivin and molecular pathogenesis of colorectal cancer. Lancet 362, 205-209 (2003).
    • (2003) Lancet , vol.362 , pp. 205-209
    • Kim, P.J.1    Plescia, J.2    Clevers, H.3    Fearon, E.R.4    Altieri, D.C.5
  • 82
    • 3843060982 scopus 로고    scopus 로고
    • The Drosophila Sterile-20 kinase Slik controls cell proliferation and apoptosis during imaginal disc development
    • Hipfner, D. R. & Cohen, S. M. The Drosophila Sterile-20 kinase Slik controls cell proliferation and apoptosis during imaginal disc development. PLoS Biol. 1, 244-256 (2003).
    • (2003) PLoS Biol. , vol.1 , pp. 244-256
    • Hipfner, D.R.1    Cohen, S.M.2
  • 83
    • 0042232429 scopus 로고    scopus 로고
    • hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu, S., Huang, J., Dong, J. & Pan, D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts, Cell 114, 445-456 (2003).
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 84
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C. & Halder, G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nature Cell Biol. 5, 914-920 (2003).
    • (2003) Nature Cell Biol. , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 85
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci, S., Tapon, N. & Leopold, P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nature Cell Biol. 5, 921-927 (2003).
    • (2003) Nature Cell Biol. , vol.5 , pp. 921-927
    • Pantalacci, S.1    Tapon, N.2    Leopold, P.3
  • 86
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey, K. F., Pfleger, C. M. & Hariharan, I. K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457-467 (2003). References 83-86 clearly show the close coordination of apoptosis and proliferation control in vivo through the characterization of a tumour-suppressor protein complex in flies that might be relevant to cancer.
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 87
    • 0036670695 scopus 로고    scopus 로고
    • The bantam gene regulates Drosophila growth
    • Hipfner, D. R., Weigmann, K. & Cohen, S. M. The bantam gene regulates Drosophila growth. Genetics 161, 1527-1537 (2002)
    • (2002) Genetics , vol.161 , pp. 1527-1537
    • Hipfner, D.R.1    Weigmann, K.2    Cohen, S.M.3
  • 88
    • 0037418839 scopus 로고    scopus 로고
    • bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B. & Cohen, S. M. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36 (2003). Characterization of the first microRNA that controls growth and apoptosis.
    • (2003) Cell , vol.113 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 89
    • 0029954340 scopus 로고    scopus 로고
    • Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye
    • Du, W., Xie, J. E. & Dyson, N. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15, 3684-3692 (1996).
    • (1996) EMBO J. , vol.15 , pp. 3684-3692
    • Du, W.1    Xie, J.E.2    Dyson, N.3
  • 90
    • 0036715018 scopus 로고    scopus 로고
    • Interactions between Ras1, dMyc, and dP13K signaling in the developing Drosophila wing
    • Prober, D. A. & Edgar, B. A. Interactions between Ras1, dMyc, and dP13K signaling in the developing Drosophila wing. Genes Dev. 16, 2286-2299 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2286-2299
    • Prober, D.A.1    Edgar, B.A.2
  • 92
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    • Bergmann, A., Agapite, J., McCall, K. & Steller, H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341 (1998).
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 93
    • 0032582793 scopus 로고    scopus 로고
    • Ras promotes cell survival in Drosophila by downregulating hid expression
    • Kurada, P. & White, K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329 (1998).
    • (1998) Cell , vol.95 , pp. 319-329
    • Kurada, P.1    White, K.2
  • 94
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • Alavi, A., Hood, J. D., Frausto, R., Stupack, D. G. & Cheresh, D. A. Role of Raf in vascular protection from distinct apoptotic stimuli. Science 301, 94-96 (2003).
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3    Stupack, D.G.4    Cheresh, D.A.5
  • 95
    • 0037089089 scopus 로고    scopus 로고
    • Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases
    • Hindley, A. & Kolch, W. Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J. Cell Sci. 115, 1575-1581 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 1575-1581
    • Hindley, A.1    Kolch, W.2
  • 96
    • 17744378364 scopus 로고    scopus 로고
    • MEK kinase activity is not necessary for Raf-1 function
    • Huser, M. et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1940-1951
    • Huser, M.1
  • 97
    • 0037343951 scopus 로고    scopus 로고
    • Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye
    • Yang, L. & Baker, N. E. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev. Cell 4, 359-369 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 359-369
    • Yang, L.1    Baker, N.E.2
  • 98
    • 0043210684 scopus 로고    scopus 로고
    • A new genetic locus controlling growth and proliferation in Drosophila melanogaster
    • Raisin, S., Pantalacci, S., Breittmayer, J. P. & Leopold, P. A new genetic locus controlling growth and proliferation in Drosophila melanogaster. Genetics 164, 1015-1025 (2003).
    • (2003) Genetics , vol.164 , pp. 1015-1025
    • Raisin, S.1    Pantalacci, S.2    Breittmayer, J.P.3    Leopold, P.4
  • 99
    • 0036007420 scopus 로고    scopus 로고
    • Control of growth and organ size in Drosophila
    • Johnston, L. A. & Gallant, P. Control of growth and organ size in Drosophila. Bioessays 24, 54-64 (2002).
    • (2002) Bioessays , vol.24 , pp. 54-64
    • Johnston, L.A.1    Gallant, P.2
  • 100
    • 0037306190 scopus 로고    scopus 로고
    • Insulin/IGF and target of rapamycin signaling: A TOR de force in growth control
    • Oldham, S. & Hafen, E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13, 79-85 (2003).
    • (2003) Trends Cell Biol. , vol.13 , pp. 79-85
    • Oldham, S.1    Hafen, E.2
  • 101
    • 0034283029 scopus 로고    scopus 로고
    • The Drosophila cyclin D-Cdk4 complex promotes cellular growth
    • Datar, S. A., Jacobs, H. W., de la Cruz, A. F., Lehner, C. F. & Edgar, B. A. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 19, 4543-4554 (2000).
    • (2000) EMBO J. , vol.19 , pp. 4543-4554
    • Datar, S.A.1    Jacobs, H.W.2    De La Cruz, A.F.3    Lehner, C.F.4    Edgar, B.A.5
  • 102
    • 0034282517 scopus 로고    scopus 로고
    • Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression
    • Meyer, C. A. et al. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression, EMBO J. 19, 4533-4542 (2000).
    • (2000) EMBO J. , vol.19 , pp. 4533-4542
    • Meyer, C.A.1
  • 103
    • 0442278330 scopus 로고    scopus 로고
    • Drosophila cyclin D/Cdk4 requires hif-1 prolyl hydroxylase to drive cell growth
    • Frei, C. & Edgar, B. A. Drosophila cyclin D/Cdk4 requires hif-1 prolyl hydroxylase to drive cell growth. Dev. Cell 6, 241-251 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 241-251
    • Frei, C.1    Edgar, B.A.2
  • 104
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice, R. W., Zilian, O., Woods, D. F., Noll, M. & Bryant, P. J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9, 534-546 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 105
    • 0036926950 scopus 로고    scopus 로고
    • Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    • Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719-5730 (2002).
    • (2002) Development , vol.129 , pp. 5719-5730
    • Kango-Singh, M.1
  • 106
    • 0037162714 scopus 로고    scopus 로고
    • Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon, N. et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 467-178 (2002).
    • (2002) Cell , vol.110 , pp. 467-178
    • Tapon, N.1
  • 107
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu, T., Wang, W., Zhang, S., Stewart, R. A. & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053-1063 (1995).
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 108
    • 0037862059 scopus 로고    scopus 로고
    • NDR family of AGC kinases-essential regulators of the cell cycle and morphogenesis
    • Tamaskovic, R., Bichsel, S. J. & Hemmings, B. A. NDR family of AGC kinases-essential regulators of the cell cycle and morphogenesis. FEBS Lett. 546, 73-80 (2003).
    • (2003) FEBS Lett. , vol.546 , pp. 73-80
    • Tamaskovic, R.1    Bichsel, S.J.2    Hemmings, B.A.3
  • 109
    • 0035341895 scopus 로고    scopus 로고
    • The Ste20 group kinases as regulators of MAP kinase cascades
    • Dan, I., Watanabe, N. M. & Kusumi, A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11, 220-230 (2001).
    • (2001) Trends Cell Biol. , vol.11 , pp. 220-230
    • Dan, I.1    Watanabe, N.M.2    Kusumi, A.3
  • 110
    • 0142092607 scopus 로고    scopus 로고
    • A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila
    • Stewart, R. A., Li, D. M., Huang, H. & Xu, T. A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene 22, 6436-6444 (2003).
    • (2003) Oncogene , vol.22 , pp. 6436-6444
    • Stewart, R.A.1    Li, D.M.2    Huang, H.3    Xu, T.4
  • 111
    • 0038293152 scopus 로고    scopus 로고
    • Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
    • Cheung, W. L. et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113, 507-517 (2003).
    • (2003) Cell , vol.113 , pp. 507-517
    • Cheung, W.L.1
  • 112
    • 0033593316 scopus 로고    scopus 로고
    • Size control in animal development
    • Conlon, I. & Raff, M. Size control in animal development. Cell 96, 235-244 (1999).
    • (1999) Cell , vol.96 , pp. 235-244
    • Conlon, I.1    Raff, M.2
  • 113
    • 0019735708 scopus 로고
    • Differential mitotic rates and patterns of growth in compartments in the Drosophila wing
    • Simpson, P. & Morata, G. Differential mitotic rates and patterns of growth in compartments in the Drosophila wing. Dev. Biol. 85, 299-308 (1981). Provides evidence that faster-dividing cells out compete those that divide more slowly in developing tissues. Sets the stage for much of the recent progress in understanding size control.
    • (1981) Dev. Biol. , vol.85 , pp. 299-308
    • Simpson, P.1    Morata, G.2
  • 114
    • 1842665674 scopus 로고    scopus 로고
    • dMyc transforms cells into super-competitors
    • Moreno, E. & Basler, K. dMyc transforms cells into super-competitors. Cell 117, 117-129 (2004).
    • (2004) Cell , vol.117 , pp. 117-129
    • Moreno, E.1    Basler, K.2
  • 115
    • 0030018783 scopus 로고    scopus 로고
    • Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
    • Burke, R. & Basler, K. Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269 (1996).
    • (1996) Development , vol.122 , pp. 2261-2269
    • Burke, R.1    Basler, K.2
  • 116
    • 0036336681 scopus 로고    scopus 로고
    • A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing
    • Martin-Castellanos, C. & Edgar, B. A. A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development 129, 1003-1013 (2002).
    • (2002) Development , vol.129 , pp. 1003-1013
    • Martin-Castellanos, C.1    Edgar, B.A.2
  • 117
    • 0041689540 scopus 로고    scopus 로고
    • Wingless promotes cell survival but constrains growth during Drosophila wing development
    • Johnston, L. A. & Sanders, A. L. Wingless promotes cell survival but constrains growth during Drosophila wing development. Nature Cell Biol. 5, 827-833 (2003).
    • (2003) Nature Cell Biol. , vol.5 , pp. 827-833
    • Johnston, L.A.1    Sanders, A.L.2
  • 118
    • 0347765662 scopus 로고    scopus 로고
    • Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development
    • Giraldez, A. J. & Cohen, S. M. Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development 130, 6533-6543 (2003).
    • (2003) Development , vol.130 , pp. 6533-6543
    • Giraldez, A.J.1    Cohen, S.M.2
  • 119
    • 0029894568 scopus 로고    scopus 로고
    • Direct and long-range action of a DPP morphogen gradient
    • Nellen, D., Burke, R., Struhl, G. & Basler, K. Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368 (1996).
    • (1996) Cell , vol.85 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Struhl, G.3    Basler, K.4
  • 120
    • 0029967209 scopus 로고    scopus 로고
    • Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
    • Lecuit, T. et al. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393 (1996).
    • (1996) Nature , vol.381 , pp. 387-393
    • Lecuit, T.1
  • 121
    • 0033536214 scopus 로고    scopus 로고
    • Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    • Adachi-Yamada, T., Fujimura-Kamada, K., Nishida, Y. & Matsumoto, K. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature 400, 166-169 (1999).
    • (1999) Nature , vol.400 , pp. 166-169
    • Adachi-Yamada, T.1    Fujimura-Kamada, K.2    Nishida, Y.3    Matsumoto, K.4
  • 122
    • 0037129195 scopus 로고    scopus 로고
    • Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
    • Moreno, E., Basler, K. & Morata, G. Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416, 755-759 (2002). References 114 and 122 provide evidence that cells might compete for limiting levels of a survival ligand in vivo.
    • (2002) Nature , vol.416 , pp. 755-759
    • Moreno, E.1    Basler, K.2    Morata, G.3
  • 123
    • 0037118056 scopus 로고    scopus 로고
    • Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
    • Duman-Scheel, M., Weng, L., Xin, S. & Du, W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 417, 299-304 (2002).
    • (2002) Nature , vol.417 , pp. 299-304
    • Duman-Scheel, M.1    Weng, L.2    Xin, S.3    Du, W.4
  • 124
    • 0029830237 scopus 로고    scopus 로고
    • The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
    • Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. & Waterfield, M. D. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15, 6584-6594 (1996).
    • (1996) EMBO J. , vol.15 , pp. 6584-6594
    • Leevers, S.J.1    Weinkove, D.2    MacDougall, L.K.3    Hafen, E.4    Waterfield, M.D.5
  • 125
    • 0030995511 scopus 로고    scopus 로고
    • Developmental parameters of cell death in the wing disc of Drosophila
    • Milan, M., Campuzano, S. & Garcia-Bellido, A. Developmental parameters of cell death in the wing disc of Drosophila. Proc. Natl Acad. Sci. USA 94, 5691-5696 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5691-5696
    • Milan, M.1    Campuzano, S.2    Garcia-Bellido, A.3
  • 126
    • 0032954260 scopus 로고    scopus 로고
    • Human homologue of the Drosophiia melanogaster lats tumour suppressor modulates CDC2 activity
    • Tao, W. et al. Human homologue of the Drosophiia melanogaster lats tumour suppressor modulates CDC2 activity. Nature Genet 21, 177-181 (1999).
    • (1999) Nature Genet. , vol.21 , pp. 177-181
    • Tao, W.1
  • 127
    • 0032907439 scopus 로고    scopus 로고
    • Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
    • St John, M. A. et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nature Genet. 21, 182-186 (1999).
    • (1999) Nature Genet. , vol.21 , pp. 182-186
    • St. John, M.A.1
  • 128
    • 0036800399 scopus 로고    scopus 로고
    • Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma
    • Hisaoka, M., Tanaka, A. & Hashimoto, H. Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. Lab Invest 82, 1427-1435 (2002).
    • (2002) Lab. Invest. , vol.82 , pp. 1427-1435
    • Hisaoka, M.1    Tanaka, A.2    Hashimoto, H.3
  • 129
    • 0034697962 scopus 로고    scopus 로고
    • The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    • Sibilia, M. et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 102, 211-220 (2000).
    • (2000) Cell , vol.102 , pp. 211-220
    • Sibilia, M.1
  • 130
    • 0034696336 scopus 로고    scopus 로고
    • Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
    • Li, Y., Hively, W. P. & Varmus, H. E. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 19, 1002-1009 (2000).
    • (2000) Oncogene , vol.19 , pp. 1002-1009
    • Li, Y.1    Hively, W.P.2    Varmus, H.E.3
  • 131
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing sonic hedgehog
    • Oro, A. E. et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276, 817-821 (1997).
    • (1997) Science , vol.276 , pp. 817-821
    • Oro, A.E.1
  • 132
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale, J. & Beachy, P. A. The Hedgehog and Wnt signalling pathways in cancer. Nature 411, 349-354 (2001).
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 133
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer, S. P. et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851-856 (2003).
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1
  • 134
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman, D. M. et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425, 846-851 (2003).
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1
  • 135
    • 0036682468 scopus 로고    scopus 로고
    • Functions of FGF signalling from the apical ectodermal ridge in limb development
    • Sun, X., Mariani, F. V. & Martin, G. R. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 418, 501-508 (2002).
    • (2002) Nature , vol.418 , pp. 501-508
    • Sun, X.1    Mariani, F.V.2    Martin, G.R.3
  • 136
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CMS
    • Megason, S. G. & McMahon, A. P. A mitogen gradient of dorsal midline Wnts organizes growth in the CMS. Development 129, 2087-2098 (2002).
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2


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