Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Nature Cell Biology

Volumn 5, Issue 10, 2003, Pages 914-920

  Udan, Ryan S ^a,b   Kango Singh, Madhuri ^b   Nolo, Riitta ^b   Tao, Chunyao ^b   Halder, Georg ^a,b,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; INHIBITOR OF APOPTOSIS PROTEIN; MUTANT PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL MUTANT; CELL PROLIFERATION; CELL SIZE; CONTROLLED STUDY; DEVELOPMENT; DOWN REGULATION; DROSOPHILA; GENE INDUCTION; MYOTONIC DYSTROPHY; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CELL CYCLE PROTEINS; CELL DIVISION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MORPHOGENESIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; WING;

ANIMALIA; MAMMALIA;

EID: 0141616617     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1050     Document Type: Article

References (34)

1. Conlon, I. & Raff, M. Size control in animal development. Cell 96, 235-244 (1999).
2. Green, D. R. & Evan, G. I. A matter of life and death. Cancer Cell 1, 19-30 (2002).
3. Dan, I., Watanabe, N. M. & Kusumi, A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11, 220-230 (2001).
4. Justice, R. W., Zilian, O., Woods, D. F., Noll, M. & Bryant, P. J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev, 9, 534-546 (1995).
5. Xu, T., Wang, W., Zhang, S., Stewart, R. A. & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053-1063 (1995).
6. Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719-5730 (2002).
7. Tapon, N. et al. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 468-478 (2002).
8. Newsome, T. P., Asling, B. & Dickson, B. J. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127, 851-860 (2000).
9. Baker, N. E. Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12, 499-507 (2001).
10. Neufeld, T. P., de la Cruz, A. F., Johnston, L. A. & Edgar, B. A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193 (1998).
11. Grether, M. E., Abrams, J. M., Agapite, J., White, K. & Steller, H. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9, 1694-1708 (1995).
12. White, K., Tahaoglu, E. & Steller, H. Cell killing by the Drosophila gene reaper. Science 271, 805-807 (1996).
13. Chen, P., Nordstrom, W., Gish, B. & Abrams, J. M. grim, a novel cell death gene in Drosophila. Genes Dev. 10, 1773-1782 (1996).
14. Christich, A. et al. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12, 137-140 (2002).
15. Wing, J. P. et al. Drosophila sickle is a novel grim-reaper cell death activator. Curr. Biol. 12, 131-135 (2002).
16. Srinivasula, S. M. et al. sickle, a novel Drosophila, death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Curr. Biol. 12, 125-130 (2002).
17. Tenev, T., Zachariou, A., Wilson, R., Paul, A. & Meier, P. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. EMBO J. 21, 5118-5129 (2002).
18. Yoo, S. J. et al. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nature Cell Biol. 4, 416-424 (2002).
19. Wang, S. L., Hawkins, C. J., Yoo, S. J., Muller, H. A. & Hay, B. A. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98, 453-463 (1999).
20. Lisi, S., Mazzon, I. & White, K. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 154, 669-678 (2000).
21. Goyal, L., McCall, K., Agapite, J., Hartwieg, E. & Steller, H. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19, 589-597 (2000).
22. Berger, J. et al. Genetic mapping with SNP markers in Drosophila. Nature Genet. 29, 475-481 (2001).
23. Cheung, W. L. et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113, 507-517 (2003).
24. Graves, J. D. et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17, 2224-2234 (1998).
25. Lee, K. K., Ohyama, T., Yajima, N., Tsubuki, S. & Yonehara, S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276, 19276-19285 (2001).
26. Creasy, C. L., Ambrose, D. M. & Chernoff, J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271, 21049-21053 (1996).
27. Kurada, P. & White, K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329 (1998).
28. Bergmann, A., Agapite, J., McCall, K. & Steller, H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341 (1998).
29. Yang, L. & Baker, N. E. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev. Cell 4, 359-369 (2003).
30. Deng, Y., Pang, A. & Wang, J. H. Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. J. Biol. Chem. 278, 11760-11767 (2003).
31. Johnston, L. A. & Gallant, P. Control of growth and organ size in Drosophila. BioEssays 24, 54-64 (2002).
32. Oldham, S. & Hafen, E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13, 79-85 (2003).
33. Turenchalk, G. S., St John, M. A., Tao, W. & Xu, T. The role of LATS in cell cycle regulation and tumorigenesis. Biochim. Biophys. Acta 1424, M9-M16 (1999).
34. Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415 (1993).