Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye

Developmental Cell

Volumn 4, Issue 3, 2003, Pages 359-369

  Yang, Lihui ^a   Baker, Nicholas E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; GROWTH FACTOR RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; DROSOPHILA; EYE DEVELOPMENT; MITOSIS INHIBITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA; INSECTA;

EID: 0037343951     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(03)00059-5     Document Type: Article

References (76)

1. Baker, N.E., Yu, S.-Y., and Han, D. (1996). Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr. Biol. 6, 1290-1301.
2. Baker, N.E. (2001). Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12, 499-507.
3. Baker, N.E., and Yu, S.-Y. (2001). The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104, 699-708.
4. Baonza, A., Murawsky, C.M., Travers, A.A., and Freeman, M. (2002). Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis. Nat. Cell Biol. 4, 976-980.
5. Bergmann, A., Agapite, J., McCall, K., and Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.
6. Bergmann, A., Tugentman, M., Shilo, B.Z., and Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev. Cell 2, 159-170.
7. Biggs, W.H., III, Zavitz, K.H., Dickson, B.J., van der Straten, A., Brunner, D., Hafen, E., and Zipursky, S.L. (1994). The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J. 13, 1628-1635.
8. Brodsky, M.H., Sekelsky, J.J., Tsang, G., Hawley, R.S., and Rubin, G.M. (2000). mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 14, 666-678.
9. Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., and Hafen, E. (2001). An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11, 213-221.
10. Brunner, D., Ducker, K., Oellers, N., Hafen, E., Scholz, H., and Klambt, C. (1994). The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370, 386-389.
11. Chang, H.C., Solomon, N.M., Wassarman, D.A., Karim, F.D., Therrien, M., and Rubin, G.M. (1995). Phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80, 2121-2129.
12. Chen, C.-K., and Chien, C.-T. (1999). Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors. Proc. Natl. Acad. Sci. USA 96, 5055-5060.
13. Clifford, R.J., and Schupbach, T. (1994). Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. Genetics 137, 531-550.
14. Cooper, M.T.D., and Bray, S.J. (2000). R7 photoreceptor specification requires N activity. Curr. Biol. 10, 1507-1510.
15. Deuel, T.F. (1987). Polypeptide growth factors: roles in normal and abnormal cell growth. Annu. Rev. Cell Biol. 3, 443-492.
16. Dickson, B.J., Dominguez, M., van der Straten, A., and Hafen, E. (1995). Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80, 453-462.
17. Duchek, P., and Rorth, P. (2001). Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291, 131-133.
18. Eisenmann, D.M., and Kim, S.K. (1994). Signal transduction and cell fate specification during Caenorhabditis elegans vulval development. Curr. Opin. Genet. Dev. 4, 508-516.
19. Farley, F.W., Satterberg, B., Goldsmith, E.J., and Elion, E.A. (1999). Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p. Genetics 151, 1425-1444.
20. Ferrell, J.E.J. (1999). Building a cellular switch: more lessons from a good egg. Bioessays 21, 866-870.
21. Ferrell, J.E.J. (2002). Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell Biol. 14, 140-148.
22. Flores, G., Duan, H., Yan, H., Nagaraj, R., Fu, W., Zou, Y., Noll, M., and Banerjee, U. (2000). Combinatorial signaling in the specification of unique cell fates. Cell 103, 75-85.
23. Freeman, M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.
24. Freeman, M. (1997). Cell determination strategies in the Drosophila eye. Development 124, 261-270.
25. Gabay, L., Scholz, H., Golembo, M., Klaes, A., Shilo, B.Z., and Klambt, C. (1996). EGF receptor signalling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122, 3355-3362.
26. Golic, K.G. (1991). Site-specific recombination between homologous chromosomes in Drosophila. Science 252, 958-961.
27. Hafen, E., Dickson, B.J., Brunner, D., and Raabe, T. (1994). Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila. Prog. Neurobiol. 42, 287-292.
28. Halfar, K., Rommel, C., Stocker, H., and Hafen, E. (2001). Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. Development 128, 1687-1696.
29. Hay, B.A., Wolff, T., and Rubin, G.M. (1994). Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129.
30. Hou, X.S., Chou, T.-B., Melnick, M.B., and Perrimon, N. (1995). The Torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell 81, 63-71.
31. Huang, H., Potter, C.J., Tao, W., Li, D.M., Brogiolo, W., Hafen, E., Sun, H., and Xu, T. (1999). PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126, 5365-5372.
32. Huang, Y., and Fischer-Vize, J.A. (1996). Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat Facets ubiquitin-specific protease. Development 122, 3207-3216.
33. Karim, F.D., and Rubin, G.M. (1998). Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal discs. Development 125, 1-9.
34. Knoblich, J.A., and Lehner, C.F. (1993). Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J. 12, 65-74.
35. Kumar, J.P., Tio, M., Hsiung, F., Akopyan, S., Seger, R., Shilo, B.-Z., and Moses, K. (1998). Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125, 3875-3885.
36. Kurada, P., and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329.
37. Lage, P., Jan, Y.N., and Jarman, A.P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7, 166-175.
38. Lee, J.R., Urban, S., Garvey, C.F., and Freeman, M. (2001). Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell 107, 161-171.
39. Leevers, S.J., Weinkove, D., MacDougall, L.K., Hafen, E., and Waterfield, M.D. (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15, 6584-6594.
40. Lehmann, D.A., Patterson, B., Johnstone, L.A., Balzer, T., Britton, J.S., Saint, R., and Edgar, B.A. (1999). Cis-regulatory elements of the mitotic regulator, string/Cdc25. Development 126, 1793-1803.
41. Lesokhin, A., Yu, S.-Y., Katz, J., and Baker, N.E. (1999). Several levels of EGF Receptor signalling during photoreceptor specification in Ellipse, wild type, and null mutant Drosophila. Dev. Biol. 205, 129-144.
42. Melnick, M.B., Perkins, L.A., Lee, M., Ambrosio, L., and Perrimon, N. (1993). Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development 118, 127-138.
43. Miller, D.T., and Cagan, R.L. (1998). Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125, 2327-2335.
44. Moore, S.A. (1983). Comparison of dose-response curves for α-factor induced cell division arrest, agglutination, and projection formation of yeast cells. J. Biol. Chem. 258, 13849-13853.
45. Morata, G., and Ripoll, P. (1975). Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42, 211-221.
46. Morimoto, A.M., Jordan, K.C., Tietze, K., Britton, J.S., O'Neill, E.M., and Ruohola-Baker, H. (1996). Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis. Development 122, 3745-3754.
47. Murphy, L.O., Smith, S., Chen, R.-H., Fingar, D.C., and Blenis, J. (2002). Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 5560-564.
48. Nolo, R., Abbot, L.A., and Bellen, H.J. (2000). Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102, 349-362.
49. O'Neill, E.M., Rebay, I., Tjian, R., and Rubin, G.M. (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.
50. Poritz, M.A., Malmstrom, S., Kim, M.K., Rossmeissl, P.J., and Kamb, A. (2001). Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis. Yeast 18, 1331-1338.
51. Price, J.V., Clifford, R.J., and Schupbach, T. (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56, 1085-1092.
52. Prober, D.A., and Edgar, B.A. (2002). Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 16, 2286-2299.
53. Reich, A., and Shilo, B.Z. (2002). Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavand age. EMBO J. 21, 4287-4296.
54. Rohrbaugh, M., Ramos, E., Nguyen, D., Price, M., Wen, Y., and Lai, Z.C. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12, 576-581.
55. Sawamoto, K., Taguchi, A., Hirota, Y., Yamada, C., Jin, M.H., and Okano, H. (1998). Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway. Cell Death Differ. 5, 262-270.
56. Schlessinger, J., and Ullrich, A. (1992). Growth factor signaling by receptor tyrosine kinases. Neuron 9, 383-391.
57. Schnepp, B., Grumbling, G., Donaldson, T., and Simcox, A. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10, 2302-2313.
58. Simon, M.A. (2000). Receptor tyrosine kinases: specific outcomes from general signals. Cell 103, 13-15.
59. Spencer, S.A., Powell, P.A., Miller, D.T., and Cagan, R.L. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125, 4777-4790.
60. Srinivasan, A., Roth, K.A., Sayers, R.O., Shindler, K.S., Wong, A.M., Fritz, L.C., and Tomaselli, K. (1998). In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5, 1004-1016.
61. Therrien, M., Wong, A.M., Kwan, E., and Rubin, G.M. (1999). Functional analysis of CNK in RAS signaling. Proc. Natl. Acad. Sci. USA 96, 13259-13263.
62. Tio, M., and Moses, K. (1997). The Drosophila TGFalpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124, 343-351.
63. Tomlinson, A., and Ready, D.F. (1987). Neuronal differentiation in the Drosophila ommatidium. Dev. Biol. 120, 366-376.
64. Tomlinson, A., and Struhl, G. (2001). Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol. Cell 7, 487-495.
65. Urban, S., Lee, J.R., and Freeman, M. (2001). Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107, 173-182.
66. Urban, S., Lee, J.R., and Freeman, M. (2002). A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO J. 21, 4277-4286.
67. Vincent, J., Girdham, C., and O'Farrell, P. (1994). A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol. 164, 328-331.
68. Wassarman, D.A., Therrien, M., and Rubin, G.M. (1995). The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Dev. 5, 44-50.
69. Wasserman, J.D., Urban, S., and Freeman, M. (2000). A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev. 14, 1651-1663.
70. Weinkove, D., Neufeld, T.P., Twardzik, T., Waterfield, M.D., and Leevers, S.J. (1999). Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adapter. Curr. Biol. 9, 1019-1029.
71. Wolff, T., and Ready, D.F. (1993). Pattern formation in the Drosophila retina. In The Development of Drosophila melanogaster, M. Bate and A. Martinez Arias, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
72. Xu, C., Kauffmann, R.C., Zhang, J., Kladny, S., and Carthew, R.W.C. (2000). Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye. Cell 103, 87-97.
73. Xu, T., and Rubin, G.M. (1993). Analysis of genetic mosaics in the developing and adult Drosophila tissues. Development 117, 1223-1236.
74. Yang, L., and Baker, N.E. (2001). Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128, 1183-1191.
75. Yu, S.-Y., Yoo, S.J., Yang, L., Zapata, C., Srinivasan, A., Hay, B.A., and Baker, N.E. (2002). A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development 129, 3269-3278.
76. Zipursky, S.L., and Rubin, G.M. (1994). Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17, 373-397.