Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer

Cancer Research

Volumn 61, Issue 24, 2001, Pages 8664-8667

  Zhang, T ^a   Otevrel, T ^a   Gao, Z ^a,a   Ehrlich, S M ^a   Fields, J Z ^a   Boman, B M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; SURVIVIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CORRELATION FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; CHROMOSOMAL PROTEINS, NON-HISTONE; COLON; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION; HT29 CELLS; HUMANS; INTESTINAL MUCOSA; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR STEM CELLS;

EID: 0035893568     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Identification of c-MYC as a target of APC pathway
2. Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice
3. β-catenin regulates expression regulates expression of cyclin D1 in colon carcinoma cells
4. Expression of CD44 in APC and Tcf mutant mice implies regulation by the WNT pathway
5. PPARδ is an APCregulated target of nonsteroidaI anti-inflammatory drugs
6. Inactivation of both APC alleles in human and mouse tumors
7. Inhibition of apoptosis during development of colorectal cancer
8. Apoptosis, and APC in colorectal tumorigenesis
9. Response of colon cancer cell lines to the introduction of AFC, a colon-specific tumor suppressor gene
10. Inhibiton of appotosis by survivin predicts shorter survival rates in colorectal cancer
11. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
12. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma
13. Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa
14. Transcriptional analysis of human survivin gene expression
15. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
16. Subcellular localization of the APC protein: Immunoelectron microscopic study of the association of the APC protein with catenin
17. The APC gene product in normal and tumor cells
18. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
19. Expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin
20. Expression of survivin and Bcl-2 in the normal human endometrium