Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

Genes and Development

Volumn 15, Issue 16, 2001, Pages 2042-2047

  Bouchard, Caroline ^a   Dittrich, Oliver ^b   Kiermaier, Astrid ^a   Dohmann, Karen ^b   Menkel, Annette ^b   Eilers, Martin ^a   Lüscher, Bernhard ^b,c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Chromatin; Differentiation; Gene transcription; HAT; HDAC; Oncogene

Indexed keywords

CYCLIN D2; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; MAX PROTEIN; MESSENGER RNA; MYC PROTEIN; PROTEIN; PROTEIN MAD1; PROTEIN MAD2; PROTEIN TRRAP; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOSOME; ONCOGENE MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

ACETYLATION; BACTERIAL PROTEINS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CYCLINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HISTONES; HL-60 CELLS; HUMANS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0035881691     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.907901     Document Type: Article

References (28)

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2. Function of the c-Myc oncoprotein in chromatin remodeling and transcription
3. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation
4. Mad proteins contain a dominant transcription repression domain
5. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
6. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function
7. Expression analysis with oligo-nucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
8. Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression
9. Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation
10. The Myc/Max/Mad network and the transcriptional control of cell behavior
11. The ATM-related cofactor Tral is a component of the purified SAGA complex
12. Identification of c-mycresponsive genes using rat cDNA microarray
13. Histone deacetylase activity is required for full transcriptional repression by mSin3A
14. Identification of CDK4 as a target of c-MYC
15. Differential activity of conditional MYC and its variant MYC-S in human mortal fibroblasts
16. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
17. Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression
18. Analysis of the DNA-binding activities of Myc-Max-Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells
19. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
20. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
21. Myc-enhanced expression of cull promotes ubiquitin-dependent proteolysis and cell cycle progression
22. Gene-target recognition among members of the myc superfamily and implications for oncogenesis
23. Dominant negative MYC blocks transformation by ABL oncogenes
24. Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity
25. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators
26. Mapping DNA target sites of chromatin proteins in vivo by formaldehyde crosslinking
27. Transactivation-defective c-mycS retains the ability to regulate proliferation and apoptosis
28. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells