ARF differentially modulates apoptosis induced by E2F1 and Myc

Molecular and Cellular Biology

Volumn 22, Issue 5, 2002, Pages 1360-1368

  Russell, Jamie L ^a   Powers, John T ^a   Rounbehler, Robert J ^a   Rogers, Pamela M ^a   Conti, Claudio J ^a   Johnson, David G ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; GENE PRODUCT; PROTEIN P53; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE S PHASE; CONTROLLED STUDY; EMBRYO; EPIDERMIS; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INACTIVATION; MOUSE; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; EPIDERMIS; FIBROBLASTS; HUMANS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-MYC; S PHASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0036168192     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.5.1360-1368.2002     Document Type: Article

References (68)

1. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
2. Enhanced phosphorylation of p53 by ATM in response to DNA damage
3. mdm2 expression is induced by wild type p53 activity
4. ARF links the tumour suppressors RB and p53
5. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
6. p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
7. Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
8. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
9. Distinct roles for E2F proteins in cell growth control and apoptosis
10. ARF tumor suppressor
11. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
12. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
13. Human ARF binds E2F1 and inhibits its transcriptional activity
14. Over-expression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
15. The complexity of p53 modulation: Emerging patterns from divergent signals
16. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
17. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
18. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
19. Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53
20. Regulation of the specific DNA binding function of p53
21. Role for the p53 homologue p73 in E2F-1-induced apoptosis
22. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
23. A cell cycle regulator potentially involved in genesis of many tumor types
24. Tumor spectrum in ARF-deficient mice
25. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
26. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation
27. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
28. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
29. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
30. Phosphorylation of p53 serine 15 increases interaction with CBP
31. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
32. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
33. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
34. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses
35. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
36. p19ARF targets certain E2F species for degradation
37. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
38. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
39. p19ARF links the tumour suppressor p53 to Ras
40. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
41. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
42. E2F-1 induced apoptosis
43. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development
44. Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53
45. E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model
46. Arf, interacts with MDM2 and neutralizes MDM2s inhibition of p53
47. Signaling to p53: Breaking the MDM2-p53 circuit
48. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
49. Sequences 5′ of the bovine keratin 5 gene direct tissue-and-cell-type-specific expression of a lacZ gene in the adult and during development
50. Myc lacks E2F1's ability to suppress skin carcinogenesis
51. DNA damage activates p53 through a phosphorylation-acetylation cascade
52. Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
53. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
54. Role of the INK4a locus in tumor suppression and cell mortality
55. The Pezcoller lecture: Cancer cell cycles revisited
56. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
57. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
58. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
59. A role for ATR in the DNA damage-induced phosphorylation of p53
60. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
61. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
62. E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo
63. p53-independent functions of the p19(ARF) tumor suppressor
64. Nucleolar Arf sequesters Mdm2 and activates p53
65. The p53-mdm-2 autoregulatory feedback loop
66. p53 and E2F-1 cooperate to mediate apoptosis
67. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
68. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization