-
1
-
-
33847711354
-
Hypoxia signalling controls metabolic demand
-
10.1016/j.ceb.2007.02.003 17303407
-
Brahimi-Horn MC Chiche J Pouyssegur J Hypoxia signalling controls metabolic demand Current Opinion in Cell Biology 2007, 19(2):223-229 10.1016/j.ceb.2007.02.003 17303407
-
(2007)
Current Opinion in Cell Biology
, vol.19
, Issue.2
, pp. 223-229
-
-
Brahimi-Horn, M.C.1
Chiche, J.2
Pouyssegur, J.3
-
2
-
-
33947724515
-
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
-
10.1016/j.cell.2007.01.047 17418790
-
Fukuda R Zhang H Kim J Shimoda L Dang CV Semenza GL HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Cell 2007, 129(1):111-122 10.1016/j.cell.2007.01.047 17418790
-
(2007)
Cell
, vol.129
, Issue.1
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
3
-
-
34247614521
-
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
-
10.1016/j.ccr.2007.04.001 17482131
-
Zhang H Gao P Fukuda R Kumar G Krishnamachary B Zeller KI Dang CV Semenza GL HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity Cancer Cell 2007, 11(5):407-420 10.1016/j.ccr.2007.04.001 17482131
-
(2007)
Cancer Cell
, vol.11
, Issue.5
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.V.7
Semenza, G.L.8
-
4
-
-
33751192872
-
Regulation of Angiogenesis by Hypoxia and Hypoxia-Inducible Factors
-
10.1016/S0070-2153(06)76007-0 17118268
-
Hickey MM Simon MC Gerald PS Regulation of Angiogenesis by Hypoxia and Hypoxia-Inducible Factors Current Topics in Developmental Biology Academic Press 2006, 76:217-257 10.1016/S0070-2153(06)76007-0 17118268
-
(2006)
Current Topics in Developmental Biology
, vol.76
, pp. 217-257
-
-
Hickey, M.M.1
Simon, M.C.2
Gerald, P.S.3
-
5
-
-
34347227058
-
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
-
17555402
-
Semenza GL Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1 Biochem J 2007, 405(1):1-9 17555402
-
(2007)
Biochem J
, vol.405
, Issue.1
, pp. 1-9
-
-
Semenza, G.L.1
-
6
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
10.1126/stke.3062005re12 16234508
-
Wenger RH Stiehl DP Camenisch G Integration of oxygen signaling at the consensus HRE Sci STKE 2005, 306:rE12 10.1126/stke.3062005re12 16234508
-
(2005)
Sci STKE
, vol.306
-
-
Wenger, R.H.1
Stiehl, D.P.2
Camenisch, G.3
-
7
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
129695 12351678 10.1073/pnas.192342099
-
Ivan M Haberberger T Gervasi DC Michelson KS Gunzler V Kondo K Yang H Sorokina I Conaway RC Conaway JW Kaelin WG Jr. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor PNAS 2002, 99(21):13459-13464 129695 12351678 10.1073/pnas.192342099
-
(2002)
PNAS
, vol.99
, Issue.21
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Gunzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Conaway, R.C.9
Conaway, J.W.10
Kaelin Jr., W.G.11
-
8
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
10.1126/science.1059796 11292861
-
Jaakkola P Mole DR Tian YM Wilson MI Gielbert J Gaskell SJ Kriegsheim A Hebestreit HF Mukherji M Schofield CJ Maxwell PH Pugh CW Ratcliffe PJ Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 2001, 292(5516):468-472 10.1126/science.1059796 11292861
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
9
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
10.1126/science.1068592 11823643
-
Lando D Peet DJ Whelan DA Gorman JJ Whitelaw ML Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 2002, 295(5556):858-861 10.1126/science.1068592 11823643
-
(2002)
Science
, vol.295
, Issue.5556
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
10
-
-
18544386401
-
Hypoxia-inducible Factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
10.1074/jbc.C200273200 12042299
-
Hewitson KS McNeill LA Riordan MV Tian YM Bullock AN Welford RW Elkins JM Oldham NJ Shoumo B Gleadle JM Ratcliffe PJ Pugh CW Schofield CJ Hypoxia-inducible Factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J Biol Chem 2002, 277(29):26351-26355 10.1074/jbc.C200273200 12042299
-
(2002)
J Biol Chem
, vol.277
, Issue.29
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Shoumo, B.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
11
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
186346 12080085 10.1101/gad.991402
-
Lando D Peet DJ Gorman JJ Whelan DA White MF Bruick RK FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev 2002, 16:1466-1471 186346 12080085 10.1101/gad.991402
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
White, M.F.5
Bruick, R.K.6
-
12
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
10.1016/S0378-1119(01)00633-3 11574160
-
Taylor MS Characterization and comparative analysis of the EGLN gene family Gene 2001, 275(1):125-132 10.1016/S0378-1119(01)00633-3 11574160
-
(2001)
Gene
, vol.275
, Issue.1
, pp. 125-132
-
-
Taylor, M.S.1
-
13
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
125617 11566883 10.1093/emboj/20.18.5197
-
Masson N Willam C Maxwell PH Pugh CW Ratcliffe PJ Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation EMBO J 2001, 20(18):5197-5206 125617 11566883 10.1093/emboj/20.18.5197
-
(2001)
EMBO J
, vol.20
, Issue.18
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
14
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
10.1126/science.1059817 11292862
-
Ivan M Kondo K Yang H Kim W Valiando J Ohh M Salic A Asara JM Lane WS Kaelin WG Jr. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing Science 2001, 292(5516):464-468 10.1126/science.1059817 11292862
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
15
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
10.1038/20459 10353251
-
Maxwell PH Wiesener MS Chang GW Clifford SC Vaux EC Cockman ME Wykoff CC Pugh CW Maher ER Ratcliffe PJ The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 1999, 399(6733):271-275 10.1038/20459 10353251
-
(1999)
Nature
, vol.399
, Issue.6733
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
16
-
-
33846315497
-
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
-
1698668 16952279 10.1042/BJ20061151
-
Ehrismann D Flashman E Genn DN Mathioudakis N Hewitson KS Ratcliffe PJ Schofield CJ Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay Biochem J 2007, 401(1):227-234 1698668 16952279 10.1042/BJ20061151
-
(2007)
Biochem J
, vol.401
, Issue.1
, pp. 227-234
-
-
Ehrismann, D.1
Flashman, E.2
Genn, D.N.3
Mathioudakis, N.4
Hewitson, K.S.5
Ratcliffe, P.J.6
Schofield, C.J.7
-
17
-
-
33749410367
-
The length of peptide substrates has a marked effect on hydroxylation by the HIF prolyl 4-hydroxylases
-
10.1074/jbc.M604628200 16885164
-
Koivunen P Hirsila M Kivirikko KI Myllyharju J The length of peptide substrates has a marked effect on hydroxylation by the HIF prolyl 4-hydroxylases The Journal of Biological Chemistry 2006, 281:28712-28720 10.1074/jbc.M604628200 16885164
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 28712-28720
-
-
Koivunen, P.1
Hirsila, M.2
Kivirikko, K.I.3
Myllyharju, J.4
-
18
-
-
5644240828
-
Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes
-
10.1074/jbc.M406713200 15302861
-
Stolze IP Tian YM Appelhoff RJ Turley H Wykoff CC Gleadle JM Ratcliffe PJ Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes The Journal of Biological Chemistry 2004, 279(41):42719-42725 10.1074/jbc.M406713200 15302861
-
(2004)
The Journal of Biological Chemistry
, vol.279
, Issue.41
, pp. 42719-42725
-
-
Stolze, I.P.1
Tian, Y.M.2
Appelhoff, R.J.3
Turley, H.4
Wykoff, C.C.5
Gleadle, J.M.6
Ratcliffe, P.J.7
-
19
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
10.1126/science.1066373 11598268
-
Bruick RK McKnight SL A conserved family of prolyl-4-hydroxylases that modify HIF Science 2001, 294(5545):1337-1340 10.1126/science.1066373 11598268
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
20
-
-
17944375360
-
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
-
10.1016/S0092-8674(01)00507-4 11595184
-
Epstein AC Gleadle JM McNeill LA Hewitson KS O'Rourke J Mole DR Mukherji M Metzen E Wilson MI Dhanda A Tian YM Masson N Hamilton DL Jaakkola P Barstead R Hodgkin J Maxwell PH Pugh CW Schofield CJ Ratcliffe PJ C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation Cell 2001, 107(1):43-54 10.1016/S0092-8674(01)00507-4 11595184
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
21
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2 and PHD3 in the regulation of the hypoxia inducible factor
-
10.1074/jbc.M406026200 15247232
-
Appelhoff RJ Tian YM Raval RR Turley H Harris AL Pugh CW Ratcliffe PJ Gleadle JM Differential function of the prolyl hydroxylases PHD1, PHD2 and PHD3 in the regulation of the hypoxia inducible factor The Journal of Biological Chemistry 2004, 279(37):38458-38465 10.1074/jbc.M406026200 15247232
-
(2004)
The Journal of Biological Chemistry
, vol.279
, Issue.37
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
Pugh, C.W.6
Ratcliffe, P.J.7
Gleadle, J.M.8
-
22
-
-
0043234538
-
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-Inducible Factor HIF
-
10.1074/jbc.M304982200 12788921
-
Hirsilä M Koivunen P Günzler V Kivirikko KI Myllyharju J Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-Inducible Factor HIF J Biol Chem 2003, 278(33):30772-30780 10.1074/jbc.M304982200 12788921
-
(2003)
J Biol Chem
, vol.278
, Issue.33
, pp. 30772-30780
-
-
Hirsilä, M.1
Koivunen, P.2
Günzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
24
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
-
17114296 10.1073/pnas.0602235103
-
Cummins EP Berra E Comerford KM Ginouves A Fitzgerald KT Seeballuck F Godson C Nielsen JE Moynagh P Pouyssegur J Taylor CT Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity PNAS 2006, 103(48):18154-18159 1643842 17114296 10.1073/pnas.0602235103
-
(2006)
PNAS
, vol.103
, Issue.48
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
Ginouves, A.4
Fitzgerald, K.T.5
Seeballuck, F.6
Godson, C.7
Nielsen, J.E.8
Moynagh, P.9
Pouyssegur, J.10
Taylor, C.T.11
-
25
-
-
36348936212
-
Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor
-
10.1182/blood-2007-06-094441 17684156
-
Koditz J Nesper J Wottawa M Stiehl DP Camenisch G Franke C Myllyharju J Wenger RH Katschinski DM Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor Blood 2007, 110(10):3610-3617 10.1182/ blood-2007-06-094441 17684156
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3610-3617
-
-
Koditz, J.1
Nesper, J.2
Wottawa, M.3
Stiehl, D.P.4
Camenisch, G.5
Franke, C.6
Myllyharju, J.7
Wenger, R.H.8
Katschinski, D.M.9
-
26
-
-
35448982216
-
Hypoxia, glucose metabolism and the Warburg's effect
-
10.1007/s10863-007-9080-3 17661163
-
Bartrons R Caro J Hypoxia, glucose metabolism and the Warburg's effect Journal of Bioenergetics and Biomembranes 2007, 39(3):223-229 10.1007/ s10863-007-9080-3 17661163
-
(2007)
Journal of Bioenergetics and Biomembranes
, vol.39
, Issue.3
, pp. 223-229
-
-
Bartrons, R.1
Caro, J.2
-
27
-
-
34848898470
-
Hypoxia-inducible factors and cancer
-
10.1007/s12094-007-0055-y 17525038
-
Calzada MJ Del Peso L Hypoxia-inducible factors and cancer Clinical and Translational Oncology 2007, 9(5):278-289 10.1007/s12094-007-0055-y 17525038
-
(2007)
Clinical and Translational Oncology
, vol.9
, Issue.5
, pp. 278-289
-
-
Calzada, M.J.1
Del Peso, L.2
-
28
-
-
39749162172
-
Organ Protection by Hypoxia and Hypoxia-Inducible Factors
-
Academic Press Sies and Bernhard Br Helmut 219
-
Bernhardt WM Warnecke C Willam C Tanaka T Wiesener MS Eckardt KU Helmut Sies and Bernhard B Organ Protection by Hypoxia and Hypoxia-Inducible Factors Methods in Enzymology Academic Press Oxygen Biology and Hypoxia Sies and Bernhard Br Helmut 2007, 435 219, 221-245
-
(2007)
Methods in Enzymology
, vol.435
, pp. 221-245
-
-
Bernhardt, W.M.1
Warnecke, C.2
Willam, C.3
Tanaka, T.4
Wiesener, M.S.5
Eckardt, K.U.6
Helmut Sies Bernhard, B.7
-
30
-
-
39749142173
-
Hypoxia-Inducible Factor 1 Inhibitors
-
Academic Press Sies and Bernhard Br Helmut
-
Melillo G Helmut Sies and Bernhard B Hypoxia-Inducible Factor 1 Inhibitors Methods in Enzymology Academic Press Oxygen Biology and Hypoxia Sies and Bernhard Br Helmut 2007, 435 385-402 17998065
-
(2007)
Methods in Enzymology
, vol.435
, pp. 385-402
-
-
Melillo, G.1
Helmut Sies Bernhard, B.2
-
31
-
-
0038380470
-
Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
-
12709400
-
Warnecke C Griethe W Weidemann A Jürgensen JS Willam C Bachmann S Ivashchenko Y Wagner I Frei U Wiesener M Eckardt KU Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors The FASEB Journal 2003, 17(9):1186-1188 12709400
-
(2003)
The FASEB Journal
, vol.17
, Issue.9
, pp. 1186-1188
-
-
Warnecke, C.1
Griethe, W.2
Weidemann, A.3
Jürgensen, J.S.4
Willam, C.5
Bachmann, S.6
Ivashchenko, Y.7
Wagner, I.8
Frei, U.9
Wiesener, M.10
Eckardt, K.U.11
-
32
-
-
39749104199
-
Hypoxia-Inducible Factor Prolyl-Hydroxylase: Purification and Assays of PHD2
-
Academic Press Br HSB Oxygen Biology and Hypoxia Sies and Bernhard Br Helmut
-
Hewitson KS Schofield CJ Ratcliffe PJ Helmut Sies and Bernhard B Hypoxia-Inducible Factor Prolyl-Hydroxylase: Purification and Assays of PHD2 Methods in Enzymology Academic Press Br HSB Oxygen Biology and Hypoxia Sies and Bernhard Br Helmut 2007, 435:25-42 17998047
-
(2007)
Methods in Enzymology
, vol.435
, pp. 25-42
-
-
Hewitson, K.S.1
Schofield, C.J.2
Ratcliffe, P.J.3
Helmut Sies Bernhard, B.4
-
33
-
-
39749110067
-
Determination and Modulation of Prolyl-4-Hydroxylase Domain Oxygen Sensor Activity
-
Academic Press Sies and Bernhard Br Helmut 17998048
-
Wirthner R Balamurugan K Stiehl DP Barth S Spielmann P Oehme F Flamme I Katschinski DM Wenger RH Camenisch G Helmut Sies and Bernhard B Determination and Modulation of Prolyl-4-Hydroxylase Domain Oxygen Sensor Activity Methods in Enzymology Academic Press Oxygen Biology and Hypoxia Sies and Bernhard Br Helmut 2007, 435:43-60 17998048
-
(2007)
Methods in Enzymology
, vol.435
, pp. 43-60
-
-
Wirthner, R.1
Balamurugan, K.2
Stiehl, D.P.3
Barth, S.4
Spielmann, P.5
Oehme, F.6
Flamme, I.7
Katschinski, D.M.8
Wenger, R.H.9
Camenisch, G.10
Helmut Sies Bernhard, B.11
-
34
-
-
30744453007
-
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
-
1360697 16176182 10.1042/BJ20050675
-
Arquier N Vigne P Duplan E Hsu T Therond PP Frelin C D'Angelo G Analysis of the hypoxia-sensing pathway in Drosophila melanogaster Biochem J 2006, 393(2):471-480 1360697 16176182 10.1042/BJ20050675
-
(2006)
Biochem J
, vol.393
, Issue.2
, pp. 471-480
-
-
Arquier, N.1
Vigne, P.2
Duplan, E.3
Hsu, T.4
Therond, P.P.5
Frelin, C.6
D'Angelo, G.7
-
35
-
-
0037131271
-
Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1alpha
-
10.1074/jbc.M206922200 12186875
-
Chan DA Sutphin PD Denko NC Giaccia AJ Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1alpha The Journal of Biological Chemistry 2002, 277(42):40112-40117 10.1074/jbc.M206922200 12186875
-
(2002)
The Journal of Biological Chemistry
, vol.277
, Issue.42
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
36
-
-
18444368709
-
Structural basis for the recognition of hydroxyproline in HIF-1alpha by pVHL
-
10.1038/nature00767 12050673
-
Hon WC Wilson MI Harlos K Claridge TDW Schofield CJ Pugh CW Maxwell PH Ratcliffe PJ Stuart DI Jones EY Structural basis for the recognition of hydroxyproline in HIF-1alpha by pVHL Nature 2002, 417(6892):975-978 10.1038/nature00767 12050673
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 975-978
-
-
Hon, W.C.1
Wilson, M.I.2
Harlos, K.3
Claridge, T.D.W.4
Schofield, C.J.5
Pugh, C.W.6
Maxwell, P.H.7
Ratcliffe, P.J.8
Stuart, D.I.9
Jones, E.Y.10
-
37
-
-
11244279649
-
Many amino acid substitutions in a HIF-1alpha -like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: Substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation
-
10.1074/jbc.M410287200 15485863
-
Li D Hirsila M Koivunen P Brenner MC Xu L Yang C Kivirikko KI Myllyharju J Many amino acid substitutions in a HIF-1alpha -like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: Substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation The Journal of Biological Chemistry 2004, 279:5505- 55059 10.1074/jbc.M410287200 15485863
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 55051-55059
-
-
Li, D.1
Hirsila, M.2
Koivunen, P.3
Brenner, M.C.4
Xu, L.5
Yang, C.6
Kivirikko, K.I.7
Myllyharju, J.8
-
38
-
-
0037131159
-
Sequence Determinants in Hypoxia-inducible Factor-1a for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3
-
1828037 12181324 10.1074/jbc.M206955200
-
Huang J Zhao Q Mooney SM Lee FS Sequence Determinants in Hypoxia-inducible Factor-1a for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3 J Biol Chem 2002, 277(42):39792-39800 1828037 12181324 10.1074/jbc.M206955200
-
(2002)
J Biol Chem
, vol.277
, Issue.42
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
39
-
-
4043086934
-
Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation
-
15084514
-
Kageyama Y Koshiji M To KKW Tian YM Ratcliffe PJ Huang LE Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation FASEB J 2004, 18(9):1028-1030 15084514
-
(2004)
FASEB J
, vol.18
, Issue.9
, pp. 1028-1030
-
-
Kageyama, Y.1
Koshiji, M.2
To, K.K.W.3
Tian, Y.M.4
Ratcliffe, P.J.5
Huang, L.E.6
-
40
-
-
0028802599
-
The yeast tribrid system - Genetic detection of trans-phosphorylated ITAM-SH2-interactions
-
9636306
-
Osborne MA Dalton S Kochan JP The yeast tribrid system - genetic detection of trans-phosphorylated ITAM-SH2-interactions Biotechnology 1995, 13(13):1474-1478 9636306
-
(1995)
Biotechnology
, vol.13
, Issue.13
, pp. 1474-1478
-
-
Osborne, M.A.1
Dalton, S.2
Kochan, J.P.3
-
41
-
-
15244342671
-
Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
-
10.1016/j.freeradbiomed.2004.12.004 15780758
-
Asikainen TM Ahmad A Schneider BK Ho WB Arend M Brenner M Gunzler V White CW Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells Free Radical Biology and Medicine 2005, 38(8):1002-1013 10.1016/ j.freeradbiomed.2004.12.004 15780758
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.8
, pp. 1002-1013
-
-
Asikainen, T.M.1
Ahmad, A.2
Schneider, B.K.3
Ho, W.B.4
Arend, M.5
Brenner, M.6
Gunzler, V.7
White, C.W.8
-
42
-
-
0026724983
-
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives
-
10.1021/jm00092a016 1321909
-
Cunliffe CJ Franklin TJ Hales NJ Hill GB Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives Journal of Medicinal Chemistry 1992, 35(14):2652-2658 10.1021/jm00092a016 1321909
-
(1992)
Journal of Medicinal Chemistry
, vol.35
, Issue.14
, pp. 2652-2658
-
-
Cunliffe, C.J.1
Franklin, T.J.2
Hales, N.J.3
Hill, G.B.4
-
43
-
-
23444447955
-
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
-
15941769
-
Hirsila M Koivunen P Xu L Seeley T Kivirikko KI Myllyharju J Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway FASEB J 2005, 19(10):1308-1310 15941769
-
(2005)
FASEB J
, vol.19
, Issue.10
, pp. 1308-1310
-
-
Hirsila, M.1
Koivunen, P.2
Xu, L.3
Seeley, T.4
Kivirikko, K.I.5
Myllyharju, J.6
-
44
-
-
4644260710
-
Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress
-
10.1074/jbc.M403057200 15271983
-
Salnikow K Donald SP Bruick RK Zhitkovich A Phang JM Kasprzak KS Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress The Journal of Biological Chemistry 2004, 279(39):40337-40344 10.1074/jbc.M403057200 15271983
-
(2004)
The Journal of Biological Chemistry
, vol.279
, Issue.39
, pp. 40337-40344
-
-
Salnikow, K.1
Donald, S.P.2
Bruick, R.K.3
Zhitkovich, A.4
Phang, J.M.5
Kasprzak, K.S.6
-
45
-
-
0034616016
-
Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae. EVIDENCE FOR TWO PATHWAYS OF IRON UPTAKE
-
10.1074/jbc.275.14.10709 10744769
-
Yun CW Ferea T Rashford J Ardon O Brown PO Botstein D Kaplan J Philpott CC Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae. EVIDENCE FOR TWO PATHWAYS OF IRON UPTAKE The Journal of Biological Chemistry 2000, 275(14):10709-10715 10.1074/jbc.275.14.10709 10744769
-
(2000)
The Journal of Biological Chemistry
, vol.275
, Issue.14
, pp. 10709-10715
-
-
Yun, C.W.1
Ferea, T.2
Rashford, J.3
Ardon, O.4
Brown, P.O.5
Botstein, D.6
Kaplan, J.7
Philpott, C.C.8
-
46
-
-
0033574737
-
Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
-
10.1126/science.284.5413.455 10205047
-
Stebbins CE Kaelin WG Jr. Pavletich NP Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function Science 1999, 284(5413):455-461 10.1126/science.284.5413.455 10205047
-
(1999)
Science
, vol.284
, Issue.5413
, pp. 455-461
-
-
Stebbins, C.E.1
Kaelin Jr., W.G.2
Pavletich, N.P.3
-
47
-
-
0034963119
-
A Modular Polycistronic Expression System for Overexpressing Protein Complexes in Escherichia coli
-
10.1006/prep.2000.1363 11162410
-
Tan S A Modular Polycistronic Expression System for Overexpressing Protein Complexes in Escherichia coli Protein Expression and Purification 2001, 21(1):224-234 10.1006/prep.2000.1363 11162410
-
(2001)
Protein Expression and Purification
, vol.21
, Issue.1
, pp. 224-234
-
-
Tan, S.1
-
48
-
-
33745614894
-
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
-
1502536 16782814 10.1073/pnas.0601283103
-
McDonough MA Li V Flashman E Chowdhury R Mohr C Lienard BMR Zondlo J Oldham NJ Clifton IJ Lewis J McNeill LA Kurzeja RJM Hewitson KS Yang E Jordan S Syed RS Schofield CJ Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) PNAS 2006, 103(26):9814-9819 1502536 16782814 10.1073/pnas.0601283103
-
(2006)
PNAS
, vol.103
, Issue.26
, pp. 9814-9819
-
-
McDonough, M.A.1
Li, V.2
Flashman, E.3
Chowdhury, R.4
Mohr, C.5
Lienard, B.M.R.6
Zondlo, J.7
Oldham, N.J.8
Clifton, I.J.9
Lewis, J.10
McNeill, L.A.11
Kurzeja, R.J.M.12
Hewitson, K.S.13
Yang, E.14
Jordan, S.15
Syed, R.S.16
Schofield, C.J.17
-
49
-
-
36749095315
-
Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains
-
10.1042/BJ20071052
-
Villar D Vara-vega A Landázuri MO Del Peso L Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains Biochem J 2007 408 2 231 240 10.1042/BJ20071052 17725546
-
(2007)
Biochem J
, vol.408
, pp. 231-240
-
-
Villar, D.1
Vara-vega, A.2
Landázuri, M.O.3
Del Peso, L.4
-
51
-
-
37549028784
-
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein
-
10.1093/nar/gkm932 17986458 2175351
-
Bex C Knauth K Dambacher S Buchberger A A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein Nucl Acids Res 2007, 35(21):e142 10.1093/nar/gkm932 17986458 2175351
-
(2007)
Nucl Acids Res
, vol.35
, Issue.21
-
-
Bex, C.1
Knauth, K.2
Dambacher, S.3
Buchberger, A.4
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