Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells

Free Radical Biology and Medicine

Volumn 38, Issue 8, 2005, Pages 1002-1013

  Asikainen, Tiina M ^a   Ahmad, Aftab ^a   Schneider, Barbara K ^a   Ho, Wen Bin ^b   Arend, Michael ^b   Brenner, Mitchell ^b   Günzler, Volkmar ^b   White, Carl W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b FIBROGEN INC   (United States)

Author keywords

Free radicals; Hypoxia; Lung injury; Prematurity; Transcription factor; Vascular endothelial growth factor

Indexed keywords

DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CINNAMIC ACID DERIVATIVE; ENZYME INHIBITOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; SU 1498; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPITHELIUM CELL; FEASIBILITY STUDY; GLUCOSE INTAKE; HUMAN; HUMAN CELL; HYPOXIA; LUNG ALVEOLUS CELL; LUNG DEVELOPMENT; LUNG ENDOTHELIUM; PRIORITY JOURNAL; REGULATORY MECHANISM; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; LUNG; METABOLISM;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; CINNAMATES; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG; PROCOLLAGEN-PROLINE DIOXYGENASE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 15244342671     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.12.004     Document Type: Article

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